Other Countries Partnering Award, South Korea: Genome editing and transgenic technologies for virus-host interaction studies in birds
Lead Research Organisation:
The Pirbright Institute
Department Name: Avian Oncogenic Viruses
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Venugopal Nair (Principal Investigator) | |
| YONGXIU YAO (Co-Investigator) |
Publications
Lee HJ
(2017)
Precise gene editing of chicken Na+/H+ exchange type 1 (chNHE1) confers resistance to avian leukosis virus subgroup J (ALV-J).
in Developmental and comparative immunology
Lee HJ
(2019)
Sequential disruption of ALV host receptor genes reveals no sharing of receptors between ALV subgroups A, B, and J.
in Journal of animal science and biotechnology
Lee HJ
(2017)
Acquisition of resistance to avian leukosis virus subgroup B through mutations on tvb cysteine-rich domains in DF-1 chicken fibroblasts.
in Veterinary research
Zhang Y
(2018)
Application of CRISPR/Cas9 Gene Editing System on MDV-1 Genome for the Study of Gene Function.
in Viruses
| Description | The major objective of the grant to develop collaboration has been achieved through the initiation of innovative research and by the successful award of the 5 year Royal Society International Research Professorship Award to the two Principal Investigators. We have also demonstrated that innovative gene editing approaches can be used to induce genetic resistance to avian leukosis virus infections. Having demonstrated genetic resistance to the subgroups A, B and J in cell culture systems, we are now in the process of developing chicken lines. Once genetic resistance of these chicken lines can be demonstrated, we will initiate field studies to confirm this. |
| Exploitation Route | The key findings are being used to generate innovative research in improving genetic resistance to avian diseases |
| Sectors | Agriculture, Food and Drink,Communities and Social Services/Policy,Manufacturing, including Industrial Biotechology |
| URL | http://www.pirbright.ac.uk/news/2017/02/pirbright-professor-receives-prestigious-joint-royal-society-award |
| Description | The proof of principle of introducing de novo genetic resistance to different avian leukosis viruses through gene editing of specific receptors in cell culture systems demonstrated as part of this grant is currently translated through collaboration with a commercial company to develop disease-resistant chickens. We have filed a patent on the application of this technology in South Korea. Also we are in discussions with poultry breeding companies in China on the potential applications in selective breeding. The findings have helped to secure additional funding from the Royal Society to continue the collaborative work. |
| First Year Of Impact | 2019 |
| Sector | Agriculture, Food and Drink,Education,Manufacturing, including Industrial Biotechology |
| Impact Types | Societal,Economic |
| Description | Member of the Board of the Jenner Vaccine Foundation |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Impact | Helping with the strategic decisions of the Board of the Jenner Vaccine Foundation |
| Description | Innovations in control of avian infectious diseases for sustainable growth and food security in low and middle income countries |
| Amount | £355,000 (GBP) |
| Organisation | The Royal Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2016 |
| End | 11/2021 |
| Description | Global Alliance for Research on Avian Diseases |
| Organisation | Global Alliance for Research on Avian Diseases |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | This alliance led by Pirbright has participation from over 40 countries and comprises of academics and industry professionals. This forum helps in working together, identifies the challenges and opportunities for improved control of avian diseases |
| Collaborator Contribution | Two successful international meetings were organised as part of this alliance, one in London in 2015 and most recent one in Hanoi, Vietnam in January 2018 |
| Impact | Organisation of two successful international meetings and development of significant collaborations |
| Start Year | 2015 |
| Description | UK Korea collaboration |
| Organisation | Seoul National University |
| Country | Korea, Republic of |
| Sector | Academic/University |
| PI Contribution | This collaboration has brought in Pirbright Institute's experience in Virology |
| Collaborator Contribution | Partner's experience in genetics and genomics as well as gene editing and transgenic technology |
| Impact | The visits by the Seoul partners to Pirbright and subsequent discussions on research collaboration has initiated a number of projects. This has also led to the award of the Royal Society International Professorship to Prof. Nair and Prof. Jae Yong Han from Seoul National University |
| Start Year | 2015 |
| Title | A METHOD FOR PRODUCING AVIAN LEUKOSIS VIRUS(ALV)-RESISTANT AVIAN LINE USING CRISPR/CAS9 SYSTEM |
| Description | Patent describes a method for generating avian leukosis virus-resistant chicken line using CRISPR/Cas9-based gene editing approaches |
| IP Reference | 10-2018-0011871 Korea |
| Protection | Patent application published |
| Year Protection Granted | 2018 |
| Licensed | Commercial In Confidence |
| Impact | The technology allows introduction of de novo genetic resistance against avian leukosis viruses using gene editing technologies |
| Description | AN INTERVIEW WITH PROFESSOR VENUGOPAL NAIR |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Professor Venugopal Nair is a Research Group Leader at The Pirbright Institute, a visiting Professor of Avian Virology at the Department of Zoology, and a Jenner Investigator at the Jenner Institute, University of Oxford. He is also a member of the Microbiology Society, and in this interview, he tells us more about his research into viral diseases of livestock. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://microbiologysociety.org/membership/meet-our-members/focus-area-viruses/an-interview-with-pro... |
| Description | Interview for CGTN on the importance of poultry disease control in China and the significance of collaboration |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | It was an interview by the editor for CGTN on the contribution of Pirbright and the Chinese collaborations on controlling poultry diseases and improving avian health |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://newseu.cgtn.com/news/2020-01-28/British-and-Chinese-scientists-join-forces-to-fight-avian-di... |
| Description | Invitation to give keynote talk on 'Control of avian diseases: Challenges and opportunities' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave the Keynote talk on 'Control of avian diseases: Challenges and opportunities' at this International Symposium organized with an aim to gather international virology experts from both human and veterinary fields to share research experience, update findings and contribute their expertise through presentation and interactive discussion. The topics will cover a wide range of virology research common in both human and animal aspects. In addition, technological platforms such as vaccine development, and novel assays will be emphasized and addressed. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.biotec.or.th/virus-symposium2018/index.php |
| Description | Invited talk on 28th September 2020 on ''Challenges and opportunities for control of infectious animal diseases including zoonosis' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | International Webinar of 'Epistemological approaches to animal disease control programmes with special reference to rabies' |
| Year(s) Of Engagement Activity | 2020 |
| Description | Organising and giving Keynote talk at the GARAD meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Global Alliance of Poultry industry professional and academia to discuss about the advances in control strategies of diseases |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://Garad.org |
| Description | Second Symposium of the UK-China Centre of Excellence for Research on Avian Diseases held in March 2016 in Binzhou, Shandong Province, China |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The second international meeting of the UK-China CERAD was attended by a number of delegates from both UK and China and reviewed the progress. Plans were drawn of further activities and plans for securing additional grants. |
| Year(s) Of Engagement Activity | 2016 |