Developing the Nanokick Bioreactor for Commercialisation and Cell Therapy

Lead Research Organisation: University of Glasgow
Department Name: College of Medical, Veterinary &Life Sci

Abstract

There is a >£1B market emerging for engineered bone graft, including products containing mesenchymal stem cells (MSCs). However, MSCs don't produce bone, osteoblasts do. Previous BBSRC funding has helped develop our Nanokick bioreactor for chemical-free supply of osteogenic, bone forming, cells. Here, we will address technical, regulatory and commercial objectives towards manufacture of a genuinely scalable allogeneic cell therapy for bone grafting. We have already secured funding for a first-in-man study in 2021. However, this project will address the regulatory and process specific technological challenges to supplying clinical grade cells for large trials and, ultimately, as a marketed therapeutic product. This same challenge of scalable manufacture has slowed or ceased progress of many cellular therapies, therefore the processes being developed here are expected to have wider impact in the cell therapy sector.

Publications

10 25 50
 
Description This project is ongoing. Currently, it has been shown that nanovibrational stimulation can be applied to stem cells en-mass using commercial cell stacks with osteogenesis being observed. We have also shown nanovibration is possible in hollow fibre bioreactors, this is important for manufacturing scale-up. We have successfully transferred the process to GMP facilities, this allows us to start to manufacture our cell therapy. We are in discussion with MHRA to achieve clinical trials licence and have been talking to Cell and Gene Therapy Catapult to do health economics. We are also exploring IP space,
Exploitation Route The results will demonstrate a path to vibrate stem cells at commercial scales and the next step will involve establishing commercial GMP manufacturing of cells. The bioreactor is now in our GMP partners lab and we are working through maximising cell expansion and fully GMPising there processes.
Sectors Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

 
Description Impacts are at an early stage, however initial public engagement activities have taken place and discussion with investors regarding commercialising the cell therapy. It is notable that this project runs alongside a clinical trial of the cells that we plan to commercialise and so the impact will go on to be significant.
First Year Of Impact 2000
Sector Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology
Impact Types Societal,Economic

 
Description GMP manufacture of nanovibrated mesenchymal stem cells
Geographic Reach Europe 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Glasgow Orthopaedic Research Initiative
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Healickick (EU grant) translational day
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact Preparing surgeons for the technologies and getting advice how to best present the technologies in product form
 
Description 'EPSRC and SFI Centre for Doctoral Training in Engineered Tissues for Discovery, Industry and Medicine
Amount £7,013,578 (GBP)
Funding ID EP/S02347X/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 05/2019 
End 12/2027
 
Description (HEALIKICK) - A modular strategy for the repair of critical sized bone fractures
Amount € 5,243,536 (EUR)
Funding ID 874889 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 05/2020 
End 05/2025
 
Description Doctoral Training Partnership 2020-2021 University of Strathclyde
Amount £41,886 (GBP)
Funding ID EP/T517938/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 09/2022 
End 04/2026
 
Description Doctoral Training Partnership 2020-2021 University of Strathclyde, Johnson-Love, Olivia
Amount £40,345 (GBP)
Funding ID EP/T517938/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 09/2020 
End 04/2024
 
Description Early diagnosis and intervention of osteoporosis using nanovibrational stimulation
Amount £48,807 (GBP)
Funding ID ST/S000852/1 
Organisation Science and Technologies Facilities Council (STFC) 
Sector Public
Country United Kingdom
Start 11/2018 
End 10/2020
 
Description Mechanobiology-based medicine
Amount £302,859 (GBP)
Funding ID EP/W004623/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 08/2021 
End 12/2022
 
Title Nanovibrational Stimulation of Mesenchymal Stem Cells Induces Therapeutic Reactive Oxygen Species and Inflammation for Three- Dimensional Bone Tissue Engineering 
Description  
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
URL http://researchdata.gla.ac.uk/id/eprint/1037
 
Title Nanovibrational stimulation inhibits osteoclastogenesis and enhances osteogenesis in co-cultures 
Description Models of bone homeostasis could be useful in drug discovery, particularly if the model is one that replicates bone regeneration with reduction in osteoclast activity. Here we use nanovibrational stimulation to achieve this in a 3D co-culture of primary human osteoprogenitor and osteoclast progenitor cells. We show that 1000 Hz frequency, 40 nm amplitude vibration reduces osteoclast formation and activity in human mononuclear CD14+ve blood cells and enhances osteogenesis/reduces osteoclastogenesis in a co-culture of primary human bone marrow stromal cells and bone marrow hematopoietic cells. Further, we use metabolomics to identify Akt (protein kinase C) as a potential mediator. Akt is known to be involved in bone differentiation via transforming growth factor beta 1 (TGF?1) and bone morphogenetic protein 2 (BMP2) and it has been implicated in reduced osteoclast activity via Guanine nucleotide-binding protein subunit a13 (Ga13). With further validation, our nanovibrational bioreactor could be used to help provide humanised 3D models for drug screening. 
Type Of Material Database/Collection of data 
Year Produced 2021 
Provided To Others? Yes  
Impact New information on bone homeostasis and potential developmentof 3D bone models for drug screening 
URL http://researchdata.gla.ac.uk/id/eprint/1230
 
Description COllaboration with Atelerix 
Organisation Atelerix
Country United Kingdom 
Sector Private 
PI Contribution Thi sis a joint PhD project in which we are designing in vitro stem cell niches
Collaborator Contribution Provision and tailoring of hydrogel materials
Impact Early collaboration
Start Year 2021
 
Description Collaboration with Bone Cancer Research Trust 
Organisation Bone Cancer Research Trust
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution We are developing models of sarcoma that are useful for bone cancer research
Collaborator Contribution They are supporting us with training placements, access to patients and advice.
Impact Development of better tissue models and enhanced training.
Start Year 2020
 
Description Collaboration with Dr Ciro Chiappini, King's College London 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of a Nanokick bioreactor
Collaborator Contribution Testing of the device and experience with biological assays
Impact Disciplines: cell engineering, physics.
Start Year 2021
 
Description Collaboration with Dr David Hoey, Trinity College Dublin 
Organisation Trinity College Dublin
Country Ireland 
Sector Academic/University 
PI Contribution Provision of a Nanokick bioreactor
Collaborator Contribution Testing of the device and experience with new cellular assays
Impact Disciplines: cell engineering, physics.
Start Year 2021
 
Description Collaboration with Dr Tom Hodgkinson, Royal College of Surgeons in Ireland 
Organisation Royal College of Surgeons in Ireland
Country Ireland 
Sector Academic/University 
PI Contribution Provision of a Nanokick bioreactor
Collaborator Contribution Testing of the device and experience with chondrocyte culture.
Impact Disciplines: cell engineering, physics.
Start Year 2020
 
Description Collaboration with Histocell 
Organisation Histocell
Country Spain 
Sector Private 
PI Contribution Provision of nanovibration protocols and devices.
Collaborator Contribution GMP manufacturing of cellular therapies.
Impact Disciplines: Cell engineering, physics, GMP manufacturing.
Start Year 2019
 
Description Collaboration with Histocell 
Organisation Histocell
Country Spain 
Sector Private 
PI Contribution We are working with Histocell to implement bone cell therapies and novel bone-related materials
Collaborator Contribution Implementation of our technologies in GMP labs and guidance on manufacture, regulation and ethics.
Impact Working towards cell therapies and novel scaffold technologies.
Start Year 2018
 
Description Collaboration with Max Planck Institute of Colloids and Interfaces 
Organisation Max Planck Society
Department Max Planck Institute of Colloids and Interfaces
Country Germany 
Sector Charity/Non Profit 
PI Contribution We are providing cells and materials
Collaborator Contribution They are testing our cells and materials
Impact Development of novel cell therapies and biomaterials for bone regeneration
Start Year 2020
 
Description Collaboration with Prof Jan De Boer, Technische Universiteit Eindhoven 
Organisation Eindhoven University of Technology
Country Netherlands 
Sector Academic/University 
PI Contribution Provision of a Nanokick bioreactor
Collaborator Contribution Testing of the device and experience with new cell types
Impact Disciplines: cell engineering, physics.
Start Year 2020
 
Description Collaboration with Prof Wojciech Chrzanowski, University of Sydney 
Organisation University of Sydney
Country Australia 
Sector Academic/University 
PI Contribution Provision of a Nanokick bioreactor
Collaborator Contribution Testing of the device and experience with new cell types
Impact Disciplines: cell engineering, physics.
Start Year 2021
 
Description Collaboration with Prof. Manuel Salmeron-Sanchez, University of Glasgow 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution This is a long standing collaboration in which members of both laboratories work on projects together. Project team members within our research team focus on the cellular contribution and outputs of the system, as departmentally being situated in the UofG school of Molecular, Veterinary and Life Sciences. Although this definitions is not all encompassing.
Collaborator Contribution This is a long standing collaboration in which members of both laboratories work on projects together. Project team members within the partners research team focus on biomedical aspects of the system, including materials as this lab is within the school of Science and Engineering at UofG. Although this definitions is not all encompassing
Impact Within the scope of this project no outputs have resulted so far. This collaboration is multi-disciplinary as Prof. Salmeron-Sanchez's group is within the engineering department of UofG. This collaboration is in conjuncture with the Sir Bobby Charlton Foundation project ( previously Find a Better Way project).
Start Year 2011
 
Description Collaboration with Prof. Stuart Reid, University of Strathclyde 
Organisation University of Strathclyde
Department Department of Biomedical Engineering
Country United Kingdom 
Sector Academic/University 
PI Contribution As a joint project between institutes we collaborate in the characterisation and development of the Nanokick bioreactor and associated consumables for commercialisation.
Collaborator Contribution They design and build the bioreactors.
Impact This is a long standing collaboration in which we designed and build the nanovibrational bioreactor (Nanokick). We have worked together, produced patents and publications as well as securing further funding. This collaboration is multi-disciplinary as Prof. Reid's group is within the engineering department of University of Strathclyde and specialises in Physics and applications in biomedical engineering. This collaboration is in conjuncture with the Sir Bobby Charlton Foundation project ( previously Find a Better Way project).
Start Year 2011
 
Description Collaboration with University of Navarra 
Organisation University of Navarra
Country Spain 
Sector Academic/University 
PI Contribution Provision of cells and materials
Collaborator Contribution testing of cells and materials
Impact Developing bone technologies together
Start Year 2020
 
Description Collaboration with University of Valencia 
Organisation University of Valencia
Country Spain 
Sector Academic/University 
PI Contribution We are providing cellular analysis
Collaborator Contribution They are providing the bioreactor and know-how
Impact Development of a new magnetic bioreactor for use in bone cell differentiation
Start Year 2022
 
Title Nanovibrated mesenchymal stem cells for orthopaedic regeneration 
Description Bone primed cells for orthopaedic regeneration 
Type Therapeutic Intervention - Cellular and gene therapies
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2022
Development Status Actively seeking support
Impact Change in working of GMP cell manufacturer 
 
Description Cell block science 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact Presented at prisoner outreach day at HMP Shotts
Year(s) Of Engagement Activity 2019
 
Description Centre for Doctoral Training Retreat 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Retreat to The Burn for formal PGR student training in entrepreneurship
Year(s) Of Engagement Activity 2021
 
Description Centre for the Cellular Microenvironment symposium 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact We organised an open symposium with expert speakers from the UK, EU and US - and from academic and industry
Year(s) Of Engagement Activity 2019
 
Description Centre for the Cellular Microenvironment (CeMi) seminar series 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Internal presentation within centre to raise awareness of current projects, skillsets and equipment. This presentation is aimed improve knowledge exhcnage and foster colaboration within an inter disciplinary centre containing physic, engineering and biological groups.
Year(s) Of Engagement Activity 2016,2017,2018,2019,2020,2021,2022
 
Description Centre for the Cellular Microenvironment GLORI mini symposium 2022 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact We organised an open symposium with expert speakers from the UK, EU and US - and from academic and industry
Year(s) Of Engagement Activity 2019,2020,2021
 
Description Centre for the Cellular Microenvironment seminar by Dr Monica P. Tsimbouri 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact We organise seminar series that a variety of people have access to them and attendance ranges from local to international as they are online.
Year(s) Of Engagement Activity 2021
 
Description Change Champion helping to organise and interface with academics regarding the Advanced Research Centre at UofG 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact In the role of a Change Champion deputy my role was to assist in the organisation and planning of the building of a new centre for advanced research within Glasgow. This centre would consist of a large inter disciplinary cohort, to encourage collaboration, and would therefore require a wide degree of specialisations. At these events i was required to interface with companies, academics and univeristy professionals to exchange information and then disseminate this to my own colleagues.
Year(s) Of Engagement Activity 2020,2021
 
Description Conference - GLORI 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact ~ 50-60 undergraduate, postgraduate, lecturers, professors alongside surgical practitioners and industrial sponsors attended the Glasgow Orthopaedic Research Initiative (GLORI) conferences. At these conferences MS presented posters and further discussed the research presented with a selection of each of these demographics.
Year(s) Of Engagement Activity 2015,2018,2020
 
Description Conference Presentation - WBC 2020 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Have been accepted for presentation at the 2020 World Biomaterials Congress, Glasgow.
Year(s) Of Engagement Activity 2020
 
Description Conference Presentation - World Biomaterials Congress 2020 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Was accepted to present an oral presentation at the World Biomaterials Congress, hosted virtually.
Year(s) Of Engagement Activity 2020
 
Description Conference organisation CCE-GLORI 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact The local CCE-GLORI workshop is organised by Dr Monica P. Tsimbouri every year. It is a workshop where postgraduate students present their work to their peers and supervisors and discussion then follows the talks.
This is highly beneficial to students and promotes collaboration.
Year(s) Of Engagement Activity 2019
 
Description Conference organisation-GLORI2020 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Dr Monica P. Tsimbouri organises GLORI bi-annually. This conference encourages collaboration between the basic sciences, applied sciences, engineering and clinic. This has the aim of bringing the latest ideas in basic materials research into use to deliver the next-generation of orthopaedic care. It combines expertise from orthopaedic surgeons, plastic surgeons, biologists, engineers and chemists.
The conference is free for attendance and involves oral and poster presentations from professionals, scientists, clinicians and postgraduate students. It is always well attended.
It is sponsored by industry who are also involved in the conference.
Year(s) Of Engagement Activity 2020
 
Description Discussion with potential industrial partners 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Approached and opened dialogue with several industrial businesses to present data and techniques developed within these grants in aid of developing a working business relationship and partnership. These companies include, Ceramysis, Histocell, FibreCell Systems.
These discussions were conducted with researched within this grant and associated professional practitioners, such as surgeons with corresponding industrial representatives.
Year(s) Of Engagement Activity 2020,2021,2022
 
Description Dr Monica Tsimbouri, Change Champion helping to organise and interface with academics regarding the Advanced Research Centre at UofG 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact In the role of a Change Champion deputy my role was to assist in the organisation and planning of the building of a new centre for advanced research within Glasgow university. This centre consists of a large inter disciplinary cohort, to encourage collaboration, and would therefore require a wide degree of specialisations.
At these events i was required to interface with companies, academics and univeristy professionals to exchange information and then disseminate this to my own colleagues.
Year(s) Of Engagement Activity 2021
 
Description Dr P. Tsimbouri helped organise the: Joint symposium with UCL: Mind & Body Healing October 2020 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Dr P. Tsimbouri helped organise, chaired and also delivered an oral presentation to the: Joint symposium with UCL: Mind & Body Healing October 2020.
The symposium was open to the scientific community and the general public. Talk presentations were delivered from members of the UofG and UCL research teams on their research work.
Year(s) Of Engagement Activity 2020
URL https://www.gla.ac.uk/explore/avenue/noticeboard/headline_744729_en.html
 
Description European Society for Biomaterials Keynote (Dalby) Talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote conference talk
Year(s) Of Engagement Activity 2021
 
Description Explorathon Nov 2020: Fantastic Proteins & Where to Find Them 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Short video clips on our fantastic proteins collagen, fibronectin, laminin, & piezo posted throughout the day on the Explorathon 2020 Facebook live event.
Year(s) Of Engagement Activity 2020
URL https://www.explorathon.co.uk/events/fantastic-proteins/
 
Description Healickick (EU grant) translation day 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Discussion between academics and surgeons around technologies we have developed.
Year(s) Of Engagement Activity 2021
 
Description Institute seminar presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact An institute and school hosted seminar series, highlighting and discussing work from within MCSB at Glasgow University.
The presentation was to other post doctoral researchers and students within primarily MVLS.
Year(s) Of Engagement Activity 2021,2022
 
Description Invited talk at British Orthopaedic Research Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Discussed research training of junior surgeons
Year(s) Of Engagement Activity 2021
 
Description Invited talk for SULSA/Rheinland-Pfalz Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact ECR talk at the First Scottish - Rheinland-Pfalz Life Sciences and Biotechnology Conference in the "Development of Advanced Therapies and Vaccines" symposium.
Year(s) Of Engagement Activity 2022
 
Description Joint conference of the Centres for Doctoral Training - Future Leaders in Regenerative Medicine 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact A joint meeting, hosted by the UK Society for Biomaterials, focussing on research developments of like-minded EPSRC CDTs
Year(s) Of Engagement Activity 2021
 
Description Joint symposium with UCL: Mind & Body Healing October 2020 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Open to the public and scientific community. Presentations from UofG and UCL on research work.
Year(s) Of Engagement Activity 2020
URL https://www.gla.ac.uk/explore/avenue/noticeboard/headline_744729_en.html
 
Description Keynote talk (Dalby) at Tissue Engineerign and Regenerative medicien International Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote talk at a major conference
Year(s) Of Engagement Activity 2021
 
Description Media interest BBC (nanokicking) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Talk sparked public interest

Many interested enquirers.
Year(s) Of Engagement Activity 2012
 
Description Media interest BBC (orthopaedic materials) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Sparked public interest

Enquieries from the public
Year(s) Of Engagement Activity 2013
 
Description Media interest BBC (stem cell growth) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Talk sparked public interest

Enquieries from the public
Year(s) Of Engagement Activity 2011
 
Description Monthly technical meeting Healkick/SBCF 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Study participants or study members
Results and Impact These regular focused technical meetings involve presentations and discussions of current work from three projects related to the Sir Bobby Charlton Foundation (SBCF, previously Find A Better Way) funded project. These meetings include throuble-shooting of current methodologies and issues associated, and in-depth knowledge exchange between collaborators. The outcomes of these discussions usually lead to new areas for development and possibilities of new collaborations including industrial engagement arising for UKRI nanokick projects.
Year(s) Of Engagement Activity 2017,2018,2019,2020,2021
 
Description Online lecture produced for Henry Stewart talks 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Online talk: Preclinical translation of mesenchymal stem cell therapies
Year(s) Of Engagement Activity 2021
 
Description Poster Presentation - BBSRC open day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Supporters
Results and Impact Was invited to present a poster regarding the work supprorted by the BBSRC at an instiute wide event attended by fellow BBSRC grant holders and BBSRC represenatatives, including executive chair.
Year(s) Of Engagement Activity 2020
 
Description Poster Session - BBSRC 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact ~30 researchers funded by the BBSRC presented posters to fellow post doctoral researchers, principle investigators and BBSRC staff, including Professor Melanie Welham (BBSRC Executive Chair). This poster session involved presenting current research funded within this project and subsequent questions and discussion following.
Year(s) Of Engagement Activity 2020
 
Description Presentation and Lab session for Stem Cell Engineering for Regenerative Medicine MSC course 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact A presentation and discussion regarding the work performed within the research group and within this project followed by a lab session, with experiments planned around work from within this project. The students performed 2 weeks of experiments within the lab.
Year(s) Of Engagement Activity 2021
 
Description Presentation at Wold Biomaterials Congress 2020 - Online 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact A conference presentation: Therapeutic refinement of tissue engineered cellular implants for non-union fracture repair
Year(s) Of Engagement Activity 2020
 
Description Public engagement-#Run2Jordan 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact University of Glasgow and Strathclyde came together, and took part in the biggest CeMi fitness challenge to date!
The aim was to raise as much as possible, a team from the CeMi run, walked and cycled the distance from Glasgow to the Sir Bobby Charlton Rehabilitation Centre in Amman, Jordan, that is 5436k! #RunToJordan

We managed to raise £1,719!
Year(s) Of Engagement Activity 2020
URL https://glasgow.thecemi.org/2020/08/04/runtojordan/
 
Description Research Presentation for Departmental Seminars 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact PostGraduate researchers within the Institute of Molecular, Cell and Systems Biology and other related institutes from around UofG are invited to present and discuss current research with questions afterwards. The audience includes primarily postgraduates but also includes technicians and other associated lab members and external researchers relevant to the field.
Year(s) Of Engagement Activity 2019,2020
 
Description Research Presentation for internal Biomaterials seminars 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Researchers from biomedical engineering and other related subjects from around UofG are invited to present and discuss current research with discussion afterwards. The audience includes undergraduates, postgraduates, lecturers, professors, other associated lab members and external researchers relevant to the field.
Year(s) Of Engagement Activity 2015,2016,2017,2018,2019,2020
 
Description Research Presentation for internal departmental seminars 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Presenatation at the Institute of Molecular Cell and Systems Biology PDRA seminar series outlining current research and future work.
Year(s) Of Engagement Activity 2020,2021
 
Description Social Media management for the CeMi 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact This social media platform, Instagram has 102 followers (at time of writing), ranging from members of the general public to professional organisations relevant to the groups field. This output aims to highlight and engage this audience with current ongoing work and researchers at the institute.
Year(s) Of Engagement Activity 2018,2019,2020
 
Description Strategic Board Meetings - SBCF 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Supporters
Results and Impact Presentation or research within poster presentation and subsequent follow-up discussions and questions to board members of related charitable foundation (Sir Bobby Charlton Foundation) in conjuncture with collaborative orthogonal project (formally Find a Better Way).
Year(s) Of Engagement Activity 2020,2021,2022
 
Description Strategic Board Meetings - SBCF 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Supporters
Results and Impact Poster presentation and subsequent follow-up discussions with board members of related charitable foundation the Sir Bobby Charlton Foundation (formally Find a Better Way).
Year(s) Of Engagement Activity 2019,2020
 
Description Strategic collaborative meetings - Sir Bobby Charlton Foundation 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Study participants or study members
Results and Impact These regular focused strategy meetings involve presentations and discussions of current work from two projects related to the Sir Bobby Charlton Foundation (SBCF, previously Find A Better Way) funded project. These meetings include in-depth knowledge exchange with industrial partners and service providers we are collaborating with to bring the system to market. The outcomes of these discussions usually lead to new areas for development and possibilities of new collaborations.
Year(s) Of Engagement Activity 2019,2020
 
Description Strategic collaborative meetings - SBCF 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Study participants or study members
Results and Impact Participation in focused strategy meetings regarding the Sir Bobby Charlton Foundation (previously Find A Better Way) project presenting and discussing current work from both projects. Meetings include in-depth knowledge exchange with industrial partners and service providers we are working with to bring the system to market.
These discussions have highlighted further areas of examination for projects and garnered enhanced collaboration.
Year(s) Of Engagement Activity 2019,2020,2021,2022
 
Description Strategic collaborative meetings - Sir Bobby Charlton Foundation 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Study participants or study members
Results and Impact These regular focused strategy meetings involve presentations and discussions of current work from two projects related to the Sir Bobby Charlton Foundation (SBCF, previously Find A Better Way) funded project. These meetings include in-depth knowledge exchange with industrial partners and service providers we are collaborating with to bring the system to market. The outcomes of these discussions usually lead to new areas for development and possibilities of new collaborations.
Year(s) Of Engagement Activity 2019,2020,2021
 
Description Studentship Interviews and Assistance - CDT 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Assistance in the introduction and selection of students for PhD positions within a the LifeTimeCDT programme to be held throughout the UK. Students were shown around the institute and guided through training activities, additionally MS participated in part of the group interview process.
Year(s) Of Engagement Activity 2019,2020
 
Description TCES 2010 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation paper presentation
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Dr Monica P Tsimbouri. exiting discussion after talk

Interested parties continued discussion
Year(s) Of Engagement Activity 2010
 
Description TCES 2012 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation paper presentation
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Dr P Tsimbouri. talk sparked questions and discussion afterwards

Engagement with company Reps and received very good discount on equipment.
Year(s) Of Engagement Activity 2012
 
Description TERMIS EU 2011 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation paper presentation
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Dr Monica P Tsimbouri. Talk sparked questions and discussion afterwards

There was further discussion during a later session about my talk
Year(s) Of Engagement Activity 2011
 
Description Talk in Portugal 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited talk for Dalby at University of Aviero
Year(s) Of Engagement Activity 2022
 
Description TheGlasgowCeMi Instagram social media page 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact The Glasgow CeMi Instagram page (formally Mimeresearch) has been set up to improve public engagement and improve the visibility of teh researchers and science being performed at the centre. This social media page has been contacted by external reserarchers, industrial companies and prospective students. It currently has at the time of writing 123 followers.
Year(s) Of Engagement Activity 2019,2020,2021,2022
URL https://www.instagram.com/theglasgowcemi/
 
Description UKSB 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation paper presentation
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Dr M. P. Tsimbouri. Interesting discussion following presentation

Discussion lead to problem solving for a fellow scientist
Year(s) Of Engagement Activity 2010
 
Description lifETIME CDT student day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Stakeholders in the Centre for Doctoral Training engage with CDT students to enhance student training and careers. This is followed by discussion with the CDT advisory board.
Year(s) Of Engagement Activity 2021