Taiwan Partnering Award: Artificial intelligence applications to identify regulatory genomic signatures of diet and lifestyle disease risk factors
Lead Research Organisation:
King's College London
Department Name: Genetics and Molecular Medicine
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
| Jordana Bell (Principal Investigator) | |
| Sarah Berry (Co-Investigator) |
Publications
Christiansen C
(2024)
Enhanced resolution profiling in twins reveals differential methylation signatures of type 2 diabetes with links to its complications
in eBioMedicine
Christiansen C
(2022)
Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers.
in Genome medicine
Costeira R
(2023)
Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome.
in Clinical epigenetics
Hellbach F
(2024)
Usual dietary intake and change in DNA methylation over years: EWAS in KORA FF4 and KORA fit
in Frontiers in Nutrition
Hellbach F
(2023)
Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS.
in European journal of nutrition
Karabegovic I
(2021)
Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption.
in Nature communications
| Title | Additional file 1 of Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers |
| Description | Additional file 1: Supplementary Figures 1 - 5. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| URL | https://springernature.figshare.com/articles/presentation/Additional_file_1_of_Adipose_methylome_int... |
| Title | Additional file 1 of Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers |
| Description | Additional file 1: Supplementary Figures 1 - 5. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2022 |
| URL | https://springernature.figshare.com/articles/presentation/Additional_file_1_of_Adipose_methylome_int... |
| Description | The UK-Taiwan award analyses a subset of the data generated in the DIMENSION project. The key findings to date contributed to a publication on epigenetic signatures of caffeine intakes (Karabegovic et al. 2021). On-going work includes epigenetic exploration of B-vitamins intake and dynamic diet-epigenetic links related to the postprandial response. |
| Exploitation Route | Basis of diet biomarkers, as well as basis for validation and replication studies, and for future experimental work on the molecular signatures of nutrition. |
| Sectors | Agriculture Food and Drink Healthcare |
| Title | Additional file 2 of Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers |
| Description | Additional file 2: Table S1. Statistically significant adipose tissue CpGs in relation to visceral fat accumulation at Bonferroni 5% (VF-DMPs). Table S2. Pathway Analysis (IPA) results. Table S3. Statistically significant associations between methylation and gene expression at VF-DMPs. Table S4. meQTLs. Table S5. Diet VF-DMPs. Table S6. Diet-VF mediation by methylation. Table S7. Effect sizes for statistically significant associations with metabolites. Table S8. Metabolic Phenotype results and Replication. Table S9. Validation and Replication Cohort Characteristics. Table S10. GTEx median expression levels in SAT, VAT and Whole Blood. Table S11. Results from Differentially methylated region analysis. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Adipose_methylome_integrat... |
| Title | Additional file 2 of Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers |
| Description | Additional file 2: Table S1. Statistically significant adipose tissue CpGs in relation to visceral fat accumulation at Bonferroni 5% (VF-DMPs). Table S2. Pathway Analysis (IPA) results. Table S3. Statistically significant associations between methylation and gene expression at VF-DMPs. Table S4. meQTLs. Table S5. Diet VF-DMPs. Table S6. Diet-VF mediation by methylation. Table S7. Effect sizes for statistically significant associations with metabolites. Table S8. Metabolic Phenotype results and Replication. Table S9. Validation and Replication Cohort Characteristics. Table S10. GTEx median expression levels in SAT, VAT and Whole Blood. Table S11. Results from Differentially methylated region analysis. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| URL | https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Adipose_methylome_integrat... |
| Description | "Genetic impacts on human methylome variation", CANSSI Ontario STAGE program International Speaker Seminar Series, Toronto, Canada, November 2021 (delivered online). |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at an international seminar series host by University of Toronto |
| Year(s) Of Engagement Activity | 2021 |
| Description | "Genetic impacts on human methylome variation", Epigenetic Inheritance Symposium, ETH Zurich, Switzerland, August 2021 (delivered online). |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at a symposium on epigenetics |
| Year(s) Of Engagement Activity | 2021 |
| Description | "Genetic impacts on human methylome variation", FASEB conference "The Epigenome in Human Health and Diseases", University of Lorraine, October 2021 (delivered online). |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at an international conference |
| Year(s) Of Engagement Activity | 2021 |
| Description | "Twin studies for epigenomic markers in obesity", European Association for the Study of Obesity (EASO)'s 28th annual European Congress on Obesity (ECO2021), May 2021 (delivered online). |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at a scientific conference on obesity |
| Year(s) Of Engagement Activity | 2021 |
| Description | Diet and the human methylome: towards improvement of cardio-metabolic health |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at the seminar series 'Paediatric Allergy and Nutrition Research' across multiple departments at King's College London, March 2023. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Dr Tsai's seminar at the Department of Twin Research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Tsai and her research team members undertook a research visit to Dr Bell's research group at King's College London in September 2023. Dr Tsai gave a seminar to the department. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Epigenetics in twins: drivers and consequences |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at the International Society for Twin Studies, Twin Congress 2023, Budapest, Hungary, June 2023 |
| Year(s) Of Engagement Activity | 2023 |
| Description | Epigenomics and human nutrition |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited talk at the University of Naples Federico II (UNINA), Italy, January 2024. (delivered online). |
| Year(s) Of Engagement Activity | 2023 |
| Description | Genetic and environmental impacts on the human methylome: towards improvement of cardio-metabolic health |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at the Department of Molecular and Medical Genetics, King's College London, November 2023. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Genetic impacts on DNA methylation levels in the context of DOHAD |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at the international DOHAD congress, Vancouver, August 2022. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Genetic impacts on DNA methylation variance (XZ) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Selected oral presentation at the FASEB conference on The Epigenome in Human Health and Diseases, University of Lorraine, France, November 2021. Zhang* and Bell. Genetic impacts on DNA methylation variance |
| Year(s) Of Engagement Activity | 2021 |
| Description | Genetic impacts on DNA methylation variance in monozygotic twins capture gene-environment interactions and cell-type effects (XZ) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference presentation at the Epigenomics of Common Diseases conference in Hinxton, November 2023. Zhang*, Yet, Villicaña, Hottenga, Boomsma, van Dongen, and Bell. Genetic impacts on DNA methylation variance in monozygotic twins capture gene-environment interactions and cell-type effects. |
| Year(s) Of Engagement Activity | 2023 |
| Description | High-dimensional integrative data analysis for personalized medicine |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited talk at the Karolinska Institute, Stockholm, Sweden, October 2023. (delivered online) |
| Year(s) Of Engagement Activity | 2023 |
| Description | Human DNA methylation trajectories of the postprandial metabolic response to food (RC) |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Selected talk at the 22nd International Congress of Nutrition (22nd IUNS-ICN) - in Tokyo, Japan. December 2022: Ricardo Costeira*, Lidia Daimiel Ruiz, Lucy Sinke, Colette Christiansen, Bastiaan Heijmans, Eline Slagboom, Melanie Waldenberger, Sarah Berry, José M Ordovás, Jordana T Bell. Human DNA methylation trajectories of the postprandial metabolic response to food. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Networking event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Tsai and members of her research group visited Dr Bell's research group at King's College London in September 2023. During this time, we organised a networking event where Dr Tsai's group met and discussed research ideas with members of the Department of Twin Research. |
| Year(s) Of Engagement Activity | 2023 |