Centre for Integrative Physiology and Pharmacology at Imperial
Lead Research Organisation:
Imperial College London
Department Name: Dept of Medicine
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
Julia Buckingham (Principal Investigator) |
Publications
John CD
(2007)
Formyl peptide receptors and the regulation of ACTH secretion: targets for annexin A1, lipoxins, and bacterial peptides.
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Borg C
(2007)
Biliopancreatic diversion in rats is associated with intestinal hypertrophy and with increased GLP-1, GLP-2 and PYY levels
in Obesity Surgery
Kuo YT
(2007)
The temporal sequence of gut peptide CNS interactions tracked in vivo by magnetic resonance imaging.
in The Journal of neuroscience : the official journal of the Society for Neuroscience
Borg CM
(2007)
Biliopancreatic diversion in rats is associated with intestinal hypertrophy and with increased GLP-1, GLP-2 and PYY levels.
in Obesity surgery
Birrell MA
(2007)
Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses.
in The Journal of biological chemistry
Rostene W
(2007)
Chemokines as modulators of neuroendocrine functions.
in Journal of molecular endocrinology
Morice AH
(2007)
ERS guidelines on the assessment of cough.
in The European respiratory journal
Borg CM
(2007)
Biliopancreatic diversion in rats is associated with intestinal hypertrophy and with increased GLP-1, GLP-2 and PYY levels.
in Obesity surgery
Birrell MA
(2008)
Impact of tobacco-smoke on key signaling pathways in the innate immune response in lung macrophages.
in Journal of cellular physiology
Morris A
(2008)
Comparison of Cigarette Smoke-Induced Acute Inflammation in Multiple Strains of Mice and the Effect of a Matrix Metalloproteinase Inhibitor on These Responses
in Journal of Pharmacology and Experimental Therapeutics
McCool FD
(2008)
Cough, basic science, and the clinician.
in Lung
Hemrajani C
(2008)
Role of NleH, a type III secreted effector from attaching and effacing pathogens, in colonization of the bovine, ovine, and murine gut.
in Infection and immunity
Liu YL
(2008)
The effects of pancreatic polypeptide on locomotor activity and food intake in mice.
in International journal of obesity (2005)
Neary NM
(2008)
No evidence of an additive inhibitory feeding effect following PP and PYY 3-36 administration.
in International journal of obesity (2005)
Stevenson CS
(2008)
Preclinical animal models of asthma and chronic obstructive pulmonary disease.
in Expert review of respiratory medicine
White NE
(2008)
Co-administration of SR141716 with peptide YY3-36 or oxyntomodulin has additive effects on food intake in mice.
in Diabetes, obesity & metabolism
John CD
(2008)
Annexin A1 and the formyl peptide receptor family: neuroendocrine and metabolic aspects.
in Current opinion in pharmacology
Catley MC
(2008)
Estrogen receptor beta: expression profile and possible anti-inflammatory role in disease.
in The Journal of pharmacology and experimental therapeutics
Solito E
(2008)
Annexin A1 in the brain--undiscovered roles?
in Trends in pharmacological sciences
Parkinson JR
(2008)
PYY3-36 injection in mice produces an acute anorexigenic effect followed by a delayed orexigenic effect not observed with other anorexigenic gut hormones.
in American journal of physiology. Endocrinology and metabolism
Patel SR
(2008)
Pyroglutamylated RFamide peptide 43 stimulates the hypothalamic-pituitary-gonadal axis via gonadotropin-releasing hormone in rats.
in Endocrinology
Belvisi MG
(2008)
Peroxisome proliferator-activated receptors as novel targets in lung disease.
in Chest
Description | As described in previous responses, the programme was responsible for training a number of MRes and PhD students in in vivo skills, and supporting in vivo training, and the careers of researchers working within in vivo research. |
Exploitation Route | The students trained have gone on to many different careers, including within academic science and industry. The research findings made have contributed significantly to the literature in a number of fields, which have been built on by other researchers. |
Sectors | Agriculture, Food and Drink,Education,Healthcare,Pharmaceuticals and Medical Biotechnology |
Description | The major aim of the centre was to train young scientists to perform the physiological and pharmacological studies needed to understand the functions of genes, identify new drug targets and biomarkers, explore the pharmacokinetic properties of novel drugs and to facilitate the development of new medicines. The training programmes associated with the Centre trained 48 students to MRes level in such skills, and at least 30 subsequently began PhD training. In addition, the research staff associated with the Centre have continued to be promoted, make new findings and to train their own teams in in vivo techniques. |
First Year Of Impact | 2012 |
Sector | Agriculture, Food and Drink,Education,Healthcare,Pharmaceuticals and Medical Biotechnology |
Impact Types | Societal,Economic |
Description | MRC clinical research fellowship (Anjali Amin). 'Role of T1R1/T1R3 in satiety' 2013-2016 |
Amount | £294,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 02/2013 |
End | 06/2016 |
Description | NC3Rs grant |
Amount | £270,000 (GBP) |
Funding ID | G0800720/1 |
Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
Sector | Public |
Country | United Kingdom |
Start |
Description | Reduction and refinement of murine models of bacterial infection |
Amount | £270,000 (GBP) |
Funding ID | G0800720/1 |
Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
Sector | Public |
Country | United Kingdom |
Start | 01/2009 |
End | 12/2011 |
Description | Animals in research workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Postgraduate students |
Results and Impact | Developed and delivered a workshop on the use of animals in research - with examples of how animals are used for PhD work as well as using daphnia to model changes in heart rate from exposure to different chemicals. |
Year(s) Of Engagement Activity | 2016 |
Description | Cheltenham Science Festival |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | CIMPP received a grant from the Society for Endocrinology to put on demonstrations at the Cheltenham Science Festival (June 2012). The students (Ellie Hughes, Helen Smith, Renee Schalks, Katherine Banks and Paul Holloway) created ways to present emotions, attraction, appetite and exercise in a programme entitled, 'How Are Your Hormones'. Hundreds of children and adults participated. |
Year(s) Of Engagement Activity | 2012 |
Description | Combat my Cough |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Event to keep our patients up to date with the work we are doing in our clinic and through our research to find a cure for chronic cough. The event provoked questions and discussion, and patients suggesting they would change behaviours. |
Year(s) Of Engagement Activity | 2013,2014,2015,2016 |
URL | https://www.combatmycough.com/events |
Description | Combat my Cough - Manchester |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Presentation explaining our research to a group of chronic cough patients from a specialist cough clinic in Manchester. |
Year(s) Of Engagement Activity | 2016 |
URL | https://www.combatmycough.com/events |
Description | Symposium (Animal Models and their Value in Predicting Drug Efficacy and Toxicity) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | A two day symposium (Animal Models and their Value in Predicting Drug Efficacy and Toxicity, hosted jointly by the CIMPP, King's and New York Academy of Science) attracted approx 200 delegates from academia, pharma and regulatory bodies; discussions were lively and emphasised (a) the importance of scientists informing their studies with a better understanding of disease complexity (reverse translation) and (b) bias in the literature resulting from difficulties of publishing 'negative data' from well designed studies. |
Year(s) Of Engagement Activity | 2011 |
Description | Talk at MRC Asthma Centre - "Environmental asthma triggers and sensory irritation in the airway: contribution to the asthma phenotype" (September 2016) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Talk on current research |
Year(s) Of Engagement Activity | 2016 |
Description | The Science Museum's Dana Centre, London |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | A series of public discussions at the Science Museum's Dana Centre was organised in 2011/12. Speakers (including students) from CIMPP talked openly about animal research in context with wider health issues such as neurodegeneration. In two events (Greying Matters and Brain Evolution) students put on displays and talked informally to the audience about their research. No Pain, No Gain Breathless Fat of the Land Greying Matters (in collaboration with the Society for Immunology) Magic of Medicine (with the British Pharmacological Society) Brain Evolution (with the British Neuroscience Association) |
Year(s) Of Engagement Activity | 2011 |
Description | Workshop on the use of animals in research |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Developed and delivered a workshop on the use of animals in research - with examples of how animals are used for PhD work as well as using daphnia to model changes in heart rate from exposure to different chemicals. |
Year(s) Of Engagement Activity | 2016 |