Centre for Integrative Physiology and Pharmacology at Imperial
Lead Research Organisation:
Imperial College London
Department Name: Dept of Medicine
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
People |
ORCID iD |
Julia Buckingham (Principal Investigator) |
Publications
Abuirmeileh A
(2012)
Exendin-4 treatment enhances L-DOPA evoked release of striatal dopamine and decreases dyskinetic movements in the 6-hydoxydopamine lesioned rat.
in The Journal of pharmacy and pharmacology
Addison ML
(2011)
A role for metalloendopeptidases in the breakdown of the gut hormone, PYY 3-36.
in Endocrinology
Agahi A
(2014)
Models and strategies in the development of antiobesity drugs.
in Veterinary pathology
Alam FM
(2013)
Non-invasive monitoring of Streptococcus pyogenes vaccine efficacy using biophotonic imaging.
in PloS one
Alamshah A
(2016)
L-arginine promotes gut hormone release and reduces food intake in rodents.
in Diabetes, obesity & metabolism
Andreu N
(2012)
Rapid measurement of antituberculosis drug activity in vitro and in macrophages using bioluminescence.
in The Journal of antimicrobial chemotherapy
Andreu N
(2010)
Optimisation of bioluminescent reporters for use with mycobacteria.
in PloS one
Baker K
(2017)
Characterisation of a murine model of the late asthmatic response.
in Respiratory research
Basharat S
(2014)
Leptin fails to blunt the lipopolysaccharide-induced activation of the hypothalamic-pituitary-adrenal axis in rats.
in The Journal of endocrinology
Beale KE
(2011)
Accurate measurement of body weight and food intake in environmentally enriched male Wistar rats.
in Obesity (Silver Spring, Md.)
Beale KE
(2014)
The physiological role of arcuate kisspeptin neurons in the control of reproductive function in female rats.
in Endocrinology
Belvisi MG
(2008)
Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways.
in British journal of pharmacology
Belvisi MG
(2009)
Cough sensors. III. Opioid and cannabinoid receptors on vagal sensory nerves.
in Handbook of experimental pharmacology
Belvisi MG
(2008)
Peroxisome proliferator-activated receptors as novel targets in lung disease.
in Chest
Belvisi MG
(2011)
Transient receptor potential A1 channels: insights into cough and airway inflammatory disease.
in Chest
Belvisi MG
(2011)
Bronchodilator activity of bitter tastants in human tissue.
in Nature medicine
Belvisi MG
(2009)
Targeting PPAR receptors in the airway for the treatment of inflammatory lung disease.
in British journal of pharmacology
Bewick GA
(2009)
Mice with hyperghrelinemia are hyperphagic and glucose intolerant and have reduced leptin sensitivity.
in Diabetes
Birrell MA
(2009)
TRPA1 agonists evoke coughing in guinea pig and human volunteers.
in American journal of respiratory and critical care medicine
Birrell MA
(2008)
Impact of tobacco-smoke on key signaling pathways in the innate immune response in lung macrophages.
in Journal of cellular physiology
Birrell MA
(2007)
Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses.
in The Journal of biological chemistry
Birrell MA
(2013)
Selectivity profiling of the novel EP2 receptor antagonist, PF-04418948, in functional bioassay systems: atypical affinity at the guinea pig EP2 receptor.
in British journal of pharmacology
Birrell MA
(2010)
Do the current house dust mite-driven models really mimic allergic asthma?
in The European respiratory journal
Birrell MA
(2015)
The role of adenylyl cyclase isoform 6 in ß-adrenoceptor signalling in murine airways.
in British journal of pharmacology
Boateng EK
(2015)
Heterogeneous responses of dorsal root ganglion neurons in neuropathies induced by peripheral nerve trauma and the antiretroviral drug stavudine.
in European journal of pain (London, England)
Borg C
(2007)
Biliopancreatic diversion in rats is associated with intestinal hypertrophy and with increased GLP-1, GLP-2 and PYY levels
in Obesity Surgery
Borg CM
(2007)
Biliopancreatic diversion in rats is associated with intestinal hypertrophy and with increased GLP-1, GLP-2 and PYY levels.
in Obesity surgery
Borg CM
(2007)
Biliopancreatic diversion in rats is associated with intestinal hypertrophy and with increased GLP-1, GLP-2 and PYY levels.
in Obesity surgery
Boughton CK
(2013)
Neuromedin B stimulates the hypothalamic-pituitary-gonadal axis in male rats.
in Regulatory peptides
Boughton CK
(2013)
Can neuropeptides treat obesity? A review of neuropeptides and their potential role in the treatment of obesity.
in British journal of pharmacology
Boughton CK
(2010)
Alarin stimulates food intake and gonadotrophin release in male rats.
in British journal of pharmacology
Buckingham JC
(2012)
Integrating pharmacology and clinical pharmacology in universities.
in British journal of clinical pharmacology
Buckley J
(2011)
EP4 receptor as a new target for bronchodilator therapy.
in Thorax
Bueter M
(2010)
Vagal sparing surgical technique but not stoma size affects body weight loss in rodent model of gastric bypass.
in Obesity surgery
Bueter M
(2010)
Gastric bypass increases energy expenditure in rats.
in Gastroenterology
Bueter M
(2011)
Alterations of sucrose preference after Roux-en-Y gastric bypass.
in Physiology & behavior
Catley MC
(2008)
Estrogen receptor beta: expression profile and possible anti-inflammatory role in disease.
in The Journal of pharmacology and experimental therapeutics
Clark AR
(2012)
Maps and legends: the quest for dissociated ligands of the glucocorticoid receptor.
in Pharmacology & therapeutics
Clarke D
(2010)
TNFa and IFN? Synergistically Enhance Transcriptional Activation of CXCL10 in Human Airway Smooth Muscle Cells via STAT-1, NF-?B, and the Transcriptional Coactivator CREB-binding Protein
in Journal of Biological Chemistry
Clarke DL
(2010)
TNFa and IFN? synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-?B, and the transcriptional coactivator CREB-binding protein.
in The Journal of biological chemistry
Cooke JH
(2009)
Peripheral and central administration of xenin and neurotensin suppress food intake in rodents.
in Obesity (Silver Spring, Md.)
Corander MP
(2010)
The effects of neurokinin B upon gonadotrophin release in male rodents.
in Journal of neuroendocrinology
Cotroneo E
(2015)
Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat.
in Circulation research
Curtis AE
(2010)
A kisspeptin-10 analog with greater in vivo bioactivity than kisspeptin-10.
in American journal of physiology. Endocrinology and metabolism
De Alba J
(2010)
House dust mite induces direct airway inflammation in vivo: implications for future disease therapy?
in The European respiratory journal
De Backer I
(2016)
Insights into the role of neuronal glucokinase.
in American journal of physiology. Endocrinology and metabolism
Description | As described in previous responses, the programme was responsible for training a number of MRes and PhD students in in vivo skills, and supporting in vivo training, and the careers of researchers working within in vivo research. |
Exploitation Route | The students trained have gone on to many different careers, including within academic science and industry. The research findings made have contributed significantly to the literature in a number of fields, which have been built on by other researchers. |
Sectors | Agriculture Food and Drink Education Healthcare Pharmaceuticals and Medical Biotechnology |
Description | The major aim of the centre was to train young scientists to perform the physiological and pharmacological studies needed to understand the functions of genes, identify new drug targets and biomarkers, explore the pharmacokinetic properties of novel drugs and to facilitate the development of new medicines. The training programmes associated with the Centre trained 48 students to MRes level in such skills, and at least 30 subsequently began PhD training. In addition, the research staff associated with the Centre have continued to be promoted, make new findings and to train their own teams in in vivo techniques. |
First Year Of Impact | 2012 |
Sector | Agriculture, Food and Drink,Education,Healthcare,Pharmaceuticals and Medical Biotechnology |
Impact Types | Societal Economic |
Description | MRC clinical research fellowship (Anjali Amin). 'Role of T1R1/T1R3 in satiety' 2013-2016 |
Amount | £294,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 02/2013 |
End | 06/2016 |
Description | NC3Rs grant |
Amount | £270,000 (GBP) |
Funding ID | G0800720/1 |
Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
Sector | Public |
Country | United Kingdom |
Start |
Description | Reduction and refinement of murine models of bacterial infection |
Amount | £270,000 (GBP) |
Funding ID | G0800720/1 |
Organisation | National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) |
Sector | Public |
Country | United Kingdom |
Start | 01/2009 |
End | 12/2011 |
Description | Animals in research workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Postgraduate students |
Results and Impact | Developed and delivered a workshop on the use of animals in research - with examples of how animals are used for PhD work as well as using daphnia to model changes in heart rate from exposure to different chemicals. |
Year(s) Of Engagement Activity | 2016 |
Description | Cheltenham Science Festival |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | CIMPP received a grant from the Society for Endocrinology to put on demonstrations at the Cheltenham Science Festival (June 2012). The students (Ellie Hughes, Helen Smith, Renee Schalks, Katherine Banks and Paul Holloway) created ways to present emotions, attraction, appetite and exercise in a programme entitled, 'How Are Your Hormones'. Hundreds of children and adults participated. |
Year(s) Of Engagement Activity | 2012 |
Description | Combat my Cough |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Event to keep our patients up to date with the work we are doing in our clinic and through our research to find a cure for chronic cough. The event provoked questions and discussion, and patients suggesting they would change behaviours. |
Year(s) Of Engagement Activity | 2013,2014,2015,2016 |
URL | https://www.combatmycough.com/events |
Description | Combat my Cough - Manchester |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Presentation explaining our research to a group of chronic cough patients from a specialist cough clinic in Manchester. |
Year(s) Of Engagement Activity | 2016 |
URL | https://www.combatmycough.com/events |
Description | Symposium (Animal Models and their Value in Predicting Drug Efficacy and Toxicity) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | A two day symposium (Animal Models and their Value in Predicting Drug Efficacy and Toxicity, hosted jointly by the CIMPP, King's and New York Academy of Science) attracted approx 200 delegates from academia, pharma and regulatory bodies; discussions were lively and emphasised (a) the importance of scientists informing their studies with a better understanding of disease complexity (reverse translation) and (b) bias in the literature resulting from difficulties of publishing 'negative data' from well designed studies. |
Year(s) Of Engagement Activity | 2011 |
Description | Talk at MRC Asthma Centre - "Environmental asthma triggers and sensory irritation in the airway: contribution to the asthma phenotype" (September 2016) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Talk on current research |
Year(s) Of Engagement Activity | 2016 |
Description | The Science Museum's Dana Centre, London |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | A series of public discussions at the Science Museum's Dana Centre was organised in 2011/12. Speakers (including students) from CIMPP talked openly about animal research in context with wider health issues such as neurodegeneration. In two events (Greying Matters and Brain Evolution) students put on displays and talked informally to the audience about their research. No Pain, No Gain Breathless Fat of the Land Greying Matters (in collaboration with the Society for Immunology) Magic of Medicine (with the British Pharmacological Society) Brain Evolution (with the British Neuroscience Association) |
Year(s) Of Engagement Activity | 2011 |
Description | Workshop on the use of animals in research |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Developed and delivered a workshop on the use of animals in research - with examples of how animals are used for PhD work as well as using daphnia to model changes in heart rate from exposure to different chemicals. |
Year(s) Of Engagement Activity | 2016 |