Controlling stem cell divisions in time and space
Lead Research Organisation:
University of Oxford
Department Name: Biochemistry
Abstract
Animals and plants are multicellular (metazoan), and are made up of cells descended from a single original cell, the fertilized egg. Complex organisms such as humans are composed of trillions of cells, whereas simple organisms may consist of just a few hundred cells. During development from egg to adult, cells of all metazoan organisms therefore need to divide, or proliferate, in order to increase in number. However, it is equally as important that cells stop proliferating at the appropriate time and differentiate (take on specialised roles appropriate to their individual circumstances of position, ancestory and timing). Proliferation and differentiation therefore need to be in perfect balance to ensure that tissues and organs develop with the correct size and functionality. Stem cells have particularly important properties. They have the ability to self-renew (make more of themselves) as well as give rise to daughters that differentiate. They do this by dividing asymmetrically: one daughter cell retains the stem cell fate of further proliferation, whereas the other daughter stops dividing in order to differentiate. Stem cells can also sometimes divide symmetrically, with both daughters retaining the ability to proliferate further, helping to expand the number of progenitor cells for particular purposes. Stem cells sometimes retain the ability to proliferate throughout the lifetime of the organism in order to generate (and sometimes re-generate) particular tissues and organs. For example, hematopoietic stem cells generate blood cells throughout the lifetime of many organisms, and epidermal stem cells constantly generate new skin cells. Stem cell divisions must therefore be very tightly controlled, so that the conflicting demands of proliferation vs. differentiation are correctly balanced. Understanding how stem cell divisions are controlled is crucial to 21st century biological research because it may be possible to harness these cells in order to produce any required cell type on demand, for example new spinal cord neurons for patients with spinal injury. It is also thought that stem cells are at the heart of carcinogenesis. However, we have much to understand about the basic biology of stem cells before potential therapies can become routine. All properties of cells are ultimately under genetic control, which dictates that the appropriate RNA and protein molecules are produced at the correct time and place. Human development is an incredibly complicated process, involving trillions of cells and many thousands of genes, therefore before we can begin to understand human development and human stem cells, we need to investigate a simpler system. This is where the tiny worm Caenorhabditis elegans comes in. Many of the genes that are important for C. elegans development are remarkably similar to human genes, therefore studying C. elegans development will ultimately shed light on the biology of higher animals including humans. C. elegans have cells called seam cells. These are stem cells, in that they divide throughout development to give rise to more stem cells, as well as daughters that differentiate by becoming skin cells and neurons. Our aim is to understand which genes are important for controlling the correct pattern of seam cell divisions. Previously, we have isolated two genes, rnt-1 and bro-1, as being important for this process. Strikingly, the human counterparts of both these genes, Runx and CBFb, are also involved in stem cell development, including haematopoietic and epidermal stem cells. This means we are studying a conserved process, and lessons gained from studying the problem in C. elegans are very likely to be applicable to higher organisms including humans. In this proposal, we are seeking to understand more about how rnt-1 and bro-1 control seam cell divisions, and also to isolate new genes involved in this process.
Technical Summary
This application proposes to use C. elegans as model system for studying the control of stem cell division patterns. During development, cells must stop proliferating and differentiate at the appropriate time. This decision is particularly pertinent in stem cells, which both self-renew and give rise to differentiated cells that can generate particular cell types over the lifetime of an organism. In C. elegans, the seam cells offer a paradigm for the stem cell mode of division. They are multipotent neuroectodermal cells that divide symmetrically to expand the pool of progenitor cells, and asymmetrically to contribute various differentiated cell types (as well as more stem cells). Our previous work has sought to analyse mutants with defects in seam cell proliferation and differentiation. We have identified rnt-1, a homologue of the Runx family of transcription factors, and bro-1, a CBFb (Runx DNA binding partner) homologue, as being key players in the decision between proliferation and differentiation. Loss of function of bro-1 or rnt-1 results in a failure of seam cell proliferation whereas over-expression results in too much proliferation, at the expense of differentiation. The experiments described in this proposal build on a substantial body of pilot data aimed at identifying the molecular mechanisms responsible for the correct dynamic regulation of rnt-1 and bro-1 during development. Methods proposed include mutant/RNAi analysis of gene function, lineage analysis, use of transgenic gene expression reporter strains/ immunofluorescence, and site directed mutagenesis of regulatory regions. We also aim to use targeted RNAi screens to identify novel pathways operating in parallel to rnt-1/bro-1 to regulate stem cell division patterns. Given that Runx/CBFb genes are also heavily involved in regulating stem cell lineages in mammalian systems, for example in haematopoietic stem cells, we expect knowledge gained from C. elegans to be generally applicable.
People |
ORCID iD |
Alison Woollard (Principal Investigator) |
Publications
Brabin C
(2012)
Finding a niche for seam cells?
in Worm
Braun T
(2009)
RUNX factors in development: lessons from invertebrate model systems.
in Blood cells, molecules & diseases
Ding SS
(2017)
Non-muscle myosin II is required for correct fate specification in the Caenorhabditis elegans seam cell divisions.
in Scientific reports
Gilbert SPR
(2020)
Caudal-dependent cell positioning directs morphogenesis of the C. elegans ventral epidermis.
in Developmental biology
Hughes S
(2017)
RUNX in Invertebrates.
in Advances in experimental medicine and biology
Katsanos D
(2017)
Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number.
in PLoS biology
Van Der Horst SEM
(2019)
C. elegans Runx/CBFß suppresses POP-1 TCF to convert asymmetric to proliferative division of stem cell-like seam cells.
in Development (Cambridge, England)
Woollard A
(2014)
Telling it like it is.
in eLife
Description | 1) miRNA control of the timing of rnt-1 expression and interaction with other heterochronic genes Using a series of transgenic sensor strains, we have found direct evidence of mir-48/84/241 mediated down-regulation of rnt-1 at particular developmental stages. This control prevents premature cell cycle re-entry, and acts in parallel to the alternative let-7 miRNA family target hbl-1, with rnt-1 working in the seam cells and hbl-1 working in the surrounding hypodermis. 2) Investigation of rnt-1/bro-1 cis-regulatory architecture Using a 1-hybrid screen we identified the GATA factor ELT-1 as being a direct upstream regulator of bro-1. Further analysis revealed that bro-1 has dual roles in regulating seam cell divisions, both promoting proliferation by directly activating bro-1, and preventing inappropriate differentiation by regulating the fusogen eff-1. 3) ) RNAi screen for rnt-1/bro-1 synthetic lethals Several interesting synthetic lethal genes were isolated in our screen, including the Meis homologue unc-62 and the caudal/cdx homologue pal-1. |
Exploitation Route | peer-reviewed academic publication, further funding, dissemination to the wider scientific (and non-scientific) sector |
Sectors | Healthcare Pharmaceuticals and Medical Biotechnology |
Description | BBSRC DTP studentship |
Amount | £75,000 (GBP) |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2012 |
End | 09/2015 |
Description | EPA Cephalosporin Fund |
Amount | £64,000 (GBP) |
Organisation | University of Oxford |
Department | E P A Cephalosporin Fund |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 04/2013 |
End | 04/2014 |
Description | WT studentship |
Amount | £100,000 (GBP) |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2015 |
End | 09/2018 |
Description | WT studentship |
Amount | £100,000 (GBP) |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2012 |
End | 09/2015 |
Description | Collaboration with Research group at Imperial College |
Organisation | Imperial College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | contribution of expertise and preliminary data to successful grant application by partner (new investigator grant) |
Collaborator Contribution | future data discussion and sharing |
Impact | successful funding application for collaborator Manuscript in submission |
Start Year | 2012 |
Description | Collaboration with research group at UCL |
Organisation | University College London |
Department | Biosciences |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | expertise and collaboration |
Collaborator Contribution | access to automated lineage determining facility |
Impact | manuscript in preparation |
Start Year | 2015 |
Description | "Genetics as revolution" talk to student society in Dublin |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | "Genetics as revolution" talk for student Genetics Society at Trinity College, Dublin |
Year(s) Of Engagement Activity | 2016 |
Description | BBC Nature article in animal models |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | comments on article further interest |
Year(s) Of Engagement Activity | 2013 |
URL | http://www.bbc.co.uk/nature/25430552 |
Description | Bright Club Show |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Bright Club show "Rise of the worm people" part of Oxford Festival of Nature |
Year(s) Of Engagement Activity | 2016 |
Description | Daily Express article on GFP |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Interest in article further interest |
Year(s) Of Engagement Activity | 2013 |
URL | http://www.express.co.uk/life-style/health/450310/Could-Jellyfish-be-the-key-to-a-longer-life |
Description | Delivery of Science Communication training sessions |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Talk sparked questions and discussion Increased interest in science communication and public engagement |
Year(s) Of Engagement Activity | 2014 |
Description | Guardian comment on previous interview |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | comments on article further media interest |
Year(s) Of Engagement Activity | 2013 |
URL | http://www.theguardian.com/commentisfree/2013/aug/05/in-praise-of-alison-woollard |
Description | Guardian interview on Christmas Lectures |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | comments on article further media interest |
Year(s) Of Engagement Activity | 2013 |
URL | http://www.theguardian.com/science/2013/aug/05/christmas-lectures-ethical-challenges-genetics |
Description | Imascientist online engagement platform |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | Yes |
Geographic Reach | National |
Primary Audience | Schools |
Results and Impact | AMA (ask me anything) engagement platform - stimulated many questions unknown |
Year(s) Of Engagement Activity | 2014 |
URL | http://xmaslectures.imascientist.org.uk |
Description | Independent interview on Christmas Lectures |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Article sparked interest in the Christmas Lectures high levels of interest |
Year(s) Of Engagement Activity | 2013 |
URL | http://www.independent.co.uk/news/people/profiles/dr-alison-woollard-ive-got-the-performing-bug-9020... |
Description | Interactive lectures blog |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | Yes |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | comments on article requests for further information |
Year(s) Of Engagement Activity | 2014 |
URL | http://rigb.org/blog/2014/april/lobster |
Description | Invited lecture at overseas institution |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Academic talk at the University of Applied Sciences, Nijmegen and Arnhem A couple of students have applied to do internships in my lab |
Year(s) Of Engagement Activity | 2013,2014 |
Description | Invited lecture at overseas institution |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Academic lecture at the BRIC institute, Copenhagen I am now collaborating with a member of the audience |
Year(s) Of Engagement Activity | 2012 |
Description | Invited speaker and assessor HAN University, Netherlands |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Undergraduate students |
Results and Impact | Sharing of research practice and knowledge between institutions. Sharing of best practice in teaching. Funded under ERASMUS+ |
Year(s) Of Engagement Activity | 2018 |
Description | JBS Haldane Lecture |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | JBS Haldane award lecture of the Genetics Society, hosted at the Royal Institution. Available online |
Year(s) Of Engagement Activity | 2015 |
Description | Life Scientific Radio 4 interview |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | "Life scientific" interview on Radio 4. I talked about my research on nematode worms. |
Year(s) Of Engagement Activity | 2017 |
Description | MPLS Christmas lectures |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | visit from Oxfordshire schools to university museum. Presented talk on development and ageing |
Year(s) Of Engagement Activity | 2014 |
Description | Open Day |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Schools |
Results and Impact | Open Day for Department - members of my team put on practical demonstrations |
Year(s) Of Engagement Activity | 2015 |
Description | Oxford Christmas Lectures 2017 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Schools |
Results and Impact | 500 pupils attended for the Oxford Christmas Lectures held in the Natural History Museum. Talk on research including ageing and development |
Year(s) Of Engagement Activity | 2017 |
Description | Oxford SciBar talk |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Pub based talk and discussion evening, sparked debate and enthusiasm |
Year(s) Of Engagement Activity | 2015 |
Description | Oxfrod bright club |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Oxford bright club science comedy set at pub. well attended, sparked enthusiasm and debate |
Year(s) Of Engagement Activity | 2015 |
Description | Panel Discussion at eSCAMPS symposium (Cambridge) |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Panel discussion sparked many questions and further discussion invitations to give further talks |
Year(s) Of Engagement Activity | 2013 |
Description | Participation in KPMG consulting Genome Day |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Talk and Panel discussion sparked discussion. Report produced by KPMG as a result. |
Year(s) Of Engagement Activity | 2014 |
Description | Participation in Royal Institution Family Fun Day |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | Yes |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Talk sparked questions and discussion Very positive feedback and increased interest in genetics |
Year(s) Of Engagement Activity | 2014 |
Description | Participation in Science comedy event for Ada Lovelace day |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | Yes |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Talk sparked discussion and questions I've been asked to do other similar activities |
Year(s) Of Engagement Activity | 2014 |
URL | http://www.scienceoxford.com/live/whats-on-events/ada-lovelace-night |
Description | Pint of Science Festival |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Talk with demonstrations as part of the Pint of Science festival. In a pub, excellent feedback from audience |
Year(s) Of Engagement Activity | 2015 |
Description | Podcast for Ashmolean Museum |
Form Of Engagement Activity | Engagement focused website, blog or social media channel |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Made a podcast "Mighty Hermaphrodite" for the Ashmolean museum, Oxford, as part of their programmes to involve scientists with their collections in order to engage new audiences and spark interest across disciplines |
Year(s) Of Engagement Activity | 2018 |
Description | Public Lecture (Aston Insights) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | Yes |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Talk sparked questions and discussion afterwards Some school children in the audience contacted me for further information about studying genetics |
Year(s) Of Engagement Activity | 2014 |
Description | Public lecture STFC Daresbury |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Public lecture which sparked much debate |
Year(s) Of Engagement Activity | 2015 |
Description | Radio Show Singapore |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | Yes |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | show sparked media interest unknown |
Year(s) Of Engagement Activity | 2014 |
URL | https://www.youtube.com/watch?v=DH_7VMawXAc |
Description | Radio Show Singapore |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | Yes |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Talk sparked media interest positive feedback and further interest |
Year(s) Of Engagement Activity | 2014 |
Description | Radio show |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | Yes |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Show sparked interested feedback feedback and further interest |
Year(s) Of Engagement Activity | 2013 |
URL | http://www.bbc.co.uk/programmes/b03kpnjn |
Description | Reddit AMA |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | Yes |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Many questions unknown |
Year(s) Of Engagement Activity | 2014 |
URL | http://www.reddit.com/r/science/comments/204qe3/science_ama_series_prof_alison_woollard/ |
Description | Reflections on Life Fantastic blog |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | Yes |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | comments on article requests for further information/activities |
Year(s) Of Engagement Activity | 2014 |
URL | http://thenode.biologists.com/of-worms-and-women-reflections-on-the-life-fantastic-christmas-lecture... |
Description | Research Seminar Cambridge |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Talk sparked questions and discussion possible future collaboration |
Year(s) Of Engagement Activity | 2014 |
Description | Royal Institution Christmas Lectures 2013 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | Yes |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | These lectures were broadcast to a global TV audience, viewing figures in the UK around 4 million This activity is likely to lead to (and has already led to) many more engagement activities. Many positive feedback letters (more than 50) |
Year(s) Of Engagement Activity | 2013 |
URL | http://www.rigb.org/christmas-lectures |
Description | Royal Institution advent calendar film series |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | films sparked media interest, questions and comments requests for further information |
Year(s) Of Engagement Activity | 2013 |
URL | http://www.rigb.org/advent/01 |
Description | STAR Lecture, Singapore |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | Yes |
Geographic Reach | National |
Primary Audience | Schools |
Results and Impact | Talk sparked questions, discussion and media interest unkown |
Year(s) Of Engagement Activity | 2014 |
URL | https://www.facebook.com/video.php?v=10152708550318482 |
Description | School talk (Wycome Abbey) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | well attended talk which sparked questions and debate |
Year(s) Of Engagement Activity | 2015 |
Description | School visit (Kingston upon Thames) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Talk at school, included section on careers in life sciences |
Year(s) Of Engagement Activity | 2014 |
Description | School visit (Oxford) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | visit to local primary school to engage |
Year(s) Of Engagement Activity | 2015 |
Description | School visit (Winchester) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Talk sparked questions and discussion Increased interest in studying biology A Level |
Year(s) Of Engagement Activity | 2014 |
Description | Science comedy SciBar |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Oxford SciBar science comedy evening. Talk made into podcast for greater reach. Sparked questions and enthusiasm |
Year(s) Of Engagement Activity | 2015 |
Description | Science show at FameLab |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Comedy show (interval entertainment) about research at Oxfordshire regional FameLab finals |
Year(s) Of Engagement Activity | 2018 |
Description | Seminar Oxford |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | Research seminar University of Oxford |
Year(s) Of Engagement Activity | 2016 |
Description | Seminar Warwick |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Research seminar University of Warwick |
Year(s) Of Engagement Activity | 2016 |
Description | Sheffield University Graduate Students Symposium |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Talk sparked discussion about careers in science and science communication Further interest from audience in science communication |
Year(s) Of Engagement Activity | 2014 |
Description | Sun article on natural superheroes |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | comments on article further interest |
Year(s) Of Engagement Activity | 2013 |
URL | http://beta.thesun.co.uk/sol/homepage/features/5351216/Real-life-superpowers.html |
Description | Talk about Public Engagement activities (Oxford) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Talk sparked questions and discussion afterwards After my talk several members of the audience are planning public engagement activities of their own |
Year(s) Of Engagement Activity | 2014 |
Description | Talk at Applied Biology meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Talk describing uses of C. elegans in food security research and toxicity testing |
Year(s) Of Engagement Activity | 2017 |
Description | Talk at Cheltenham Science Festival |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | Yes |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Talk sparked questions and discussion positive feedback |
Year(s) Of Engagement Activity | 2014 |
Description | Talk at Crick Institute, part of Graduate Student symposium |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Postgraduate students |
Results and Impact | Talk on research and careers in science at Crick Institute graduate student symposium |
Year(s) Of Engagement Activity | 2017 |
Description | Talk at Genetics Society Summer studentship symposium |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Undergraduate students |
Results and Impact | Talk on research and careers to students awarded a Genetics Society summer studentship |
Year(s) Of Engagement Activity | 2017 |
Description | Talk at Green Man Festival |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | Yes |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Talk sparked questions and discussion unknown |
Year(s) Of Engagement Activity | 2014 |
Description | Talk at Matthew Arnold school |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Talk on Developmental and ageing biology, and also on being a scientist, Matthew Arnold school |
Year(s) Of Engagement Activity | 2016 |
Description | Talk at UCL student retreat |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Undergraduate students |
Results and Impact | Talk on research and careers at Cumberland Lodge UCL Biology undergraduate retreat |
Year(s) Of Engagement Activity | 2018 |
Description | Talk on public engagement at Genetics Society science communication course |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Postgraduate students |
Results and Impact | Talk on effective public engagement at the Genetics Society "Communicating your science" workshop |
Year(s) Of Engagement Activity | 2016 |
Description | Telegraph article on de-extinction |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | comments on article further interest |
Year(s) Of Engagement Activity | 2013 |
URL | http://www.telegraph.co.uk/science/dinosaurs/10533240/A-real-life-Jurassic-Park-Birds-could-be-theor... |
Description | Telegraph interview on ageing research |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | article sparked comments and questions further interest |
Year(s) Of Engagement Activity | 2013 |
Description | Women in Science symposium UCL |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Talk sparked questions and discussion Unknown |
Year(s) Of Engagement Activity | 2014 |
Description | participation in British Society for Gene and Cell Therapy public outreach day |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Talk sparked questions and discussion afterwards Impacts unknown |
Year(s) Of Engagement Activity | 2014 |
Description | radio show Australia |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | Yes |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Show sparked interest in my research unknown |
Year(s) Of Engagement Activity | 2013 |
URL | http://www.abc.net.au/radionational/programs/scienceshow/christmas-lectures-13007jpg/5120890 |
Description | research seminar CRUK London |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | Yes |
Geographic Reach | Local |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Talk sparked questions and discussion possible future collaboration |
Year(s) Of Engagement Activity | 2014 |
Description | research seminar Nijmegen |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Undergraduate students |
Results and Impact | Research seminar Nijmegen, Netherlands. Talk sparked interest and enthusiasm |
Year(s) Of Engagement Activity | 2016 |