Systems Cognitive Neuroscience of Healthy Ageing: Population-Representative Studies of Functional Plasticity and Neural Change
Lead Research Organisation:
University of Cambridge
Department Name: Psychology
Abstract
As greater numbers of us are living longer, it is increasingly important to understand how we can age healthily. Growing older involves dramatic changes to all aspects of our lives, but one of the most important concerns is our mental or 'cognitive' health. This research focuses on the cognitive abilities that enable us to function in the world, including memory, attention, emotion, language, action. We aim to understand how individuals can best retain these abilities into old age. Addressing this issue requires us to understand how brain structure and function support cognitive performance. Recent developments in neuroimaging technology show that as we age there is widespread loss of brain tissue in regions important for everyday cognition. Much research has focused on this tissue loss, and its role in cognitive decline in later life. However, other findings paint a more positive picture. While some cognitive abilities decline with normal ageing, many are spared. Moreover, cognitive decline doesn't occur abruptly at a pensionable age: cognitive abilities follow different trajectories across the lifespan, some remaining stable into our 80s, and some beginning to decline even in our 30s. Underpinning this complex pattern of spared and impaired cognition are complex interactions between neural structure and activity. A growing number of studies show that the brain responds flexibly to tissue loss, recruiting other brain regions to support neural function. This functional plasticity is possible because cognitive abilities, like memory or attention, are not underpinned by single brain regions, but by networks of regions. Successful ageing is therefore characterised by successful functional plasticity. Although ageing is often stereotyped as a time of mental restriction and inflexibility, cognitive neuroscience reveals that across the adult lifespan individuals make flexible use of available resources, including recruiting other regions and cognitive processes when necessary. Research Aims and Objectives Our aim is to identify what determines successful flexibility. This requires us to sample across the adult lifespan, measuring different aspects of neural structure and activity, and of cognitive performance. We will study a cohort of 700 participants aged 18 to 88, who will have a structural brain scan and perform key cognitive tests. Some members of this cohort will also participate in functional neuroimaging experiments to measure brain activity during cognitive tasks. We will ask (1) Is functional plasticity maintained across the lifespan and does it vary across cognitive abilities? (2) Are the distributed neural networks that support different cognitive abilities preserved in ageing? (3) Does the preservation of different cognitive functions vary, given the variability of neural change in different brain regions? Potential applications and benefits Our research will generate a unique resource of neuroimaging and cognitive measures about change across the adult lifespan, generating important benefits for academic researchers, the older community, and wider society. It will provide major contributions to ageing research, and provide a 'virtual brain and behaviour bank' acting as a continuing international resource for future research. Our focus on healthy ageing will be educationally important for all older adults. Few studies of ageing focus on healthy ageing, and the prevalent view of ageing is of deficit and ill-health. Our focus is on what characterizes older adults with preserved performance, a perspective with huge implications for how society views the ageing process. Moreover, our detailed analysis of neural and cognitive flexibility will help identify the conditions under which older adults may be aided by interventions. Finally, because our findings will help specify normal age-related deficits, they will show how normal ageing differs from pathological ageing in conditions such as Alzheimer's Disease.
Technical Summary
A population-based cohort of 3000 adults will be recruited with demographic and basic cognitive assessments (LoLa3000 cohort). Of these, 700 will be selected for the Virtual Brain and Behaviour Bank (LoLa700 cohort) comprising structural and functional neuroimaging (MRI & MEG), standardised neuropsychological tests, and specialised cognitive tests. From the multi-faceted neuroimaging data, several measures of neural structure and function will be derived, using a broad array of analysis tools, techniques and expertise. Structural MRI data will be analysed using SPM8 and the Dartel toolbox; FMRI using SPM8; DTI using FSLs probabilistic tractography; connectivity with PPI & DCM; and custom Matlab. MEG data will be analysed using tools from Elekta Neuromag, SPM8 (including DCM), Fieldtrip; and custom Matlab. Our 'automatic analysis' parallel processing tools will be used to facilitate rapid processing of the large quantities of MRI and MEG data. We will measure both local neural integrity and neural integration across cortical regions taking care to control for factors that are not related to neural function but which influence neuroimaging, such as changes in neuro-vascular coupling. The derived neural measures will be related to age and performance, and to current models from cognitive neuroscience. On a subset of 280 adults (LoLa280 cohort) further investigations of neuro-cognitive functions will use FMRI, MEG/EEG and further behavioural testing. These will allow investigation of the effect of ageing on the specific cognitive domains of Attention, Language, Motor & Learning, Memory, Emotion, and the relationship between these different domains. Formal statistical models will be used to examine the changes that occur with healthy ageing, and the reorganisation in terms of strategies and structures invoked to compensate for them. This approach offers hypothesis-driven insights into healthy ageing that are relevant to the general population.
Planned Impact
Life expectancy in the UK has increased by over 30 years in the last century. This reflects a wider international trend with major implications for the development of economic, social and health policy at local, national, and international levels. Cognitive change through the healthy lifespan is a topic of urgent scientific and social concern. Our team brings together highly experienced groups from Cambridge University Departments of Experimental Psychology, Psychiatry and Clinical Neurosciences, the Institute of Public Health and MRC Units in Cognition and Brain Sciences and Biostatistics, with a strong track record in top rank research publication and dissemination, and a common interest in understanding neurocognitive changes in healthy ageing. Beneficiaries of the research: Data derived from the three cohorts (LoLa3000, LoLa700, and LoLa280) and the Virtual Brain Bank will provide unique and rich resources. LoLa3000 will constitute a large, population-representative data sample on health and basic cognition; LoLa700 will include a uniquely detailed sample representing development across the adult human lifespan, relating major domains of cognitive function to structural and functional measures of brain function. LoLa280 offers a set of targeted intensive investigations of specific cognitive changes. The project's novel outcomes, methods, and database resources, will impact at multiple levels of a large and widely varied international community. These include academic research concerned with the epidemiology of neuro-cognitive change across the lifespan change; the development of pharmacological interventions for age-related disorders of cognitive function within both academic and private sectors; the formation of government policy, such as long-term care modelling and pensions; and the preparation of third-sector organisation reports, such as Dementia-UK, commissioned by the Alzheimer's Society. The project will also provide a world class training environment for members of the research support team to acquire specific skills in epidemiological and cognitive neuroscience research, including state-of-the-art neuroimaging analysis, and more general skills in time management, written and oral presentations and working as a team. Lay persons of all ages will benefit from the public dissemination of knowledge about the positive aspects of lifelong development of brain and cognition. Ensuring the benefits of this research?: The project's success is not only ensured by the track record of the applicants, but also by the substantial expertise of the collaborators who consist of highly respected researchers in cognitive ageing (Prof Patrick Rabbitt, University of Oxford), uni- and multi-variate statistics (Dr Ian Nimmo-Smith, MRC CBSU), functional connectivity analysis of neuroimaging data (Prof Paul Fletcher, University of Cambridge), MR physics (Dr Christian Schwarzbauer. MRC CBSU), human motor control (Prof Daniel Wolpert, University of Cambridge), emotional regulation (Dr Tim Dalgleish, MRC CBSU), and psychiatry (Prof Ian Goodyer, University of Cambridge). Behavioural and neuroimaging data from the LoLa 3000, LoLa700, and LoLa280 will be made into publicly available web-based, data resources for the international research community (see Data sharing and preservation) which we expect to form a significant, lasting international resource. In addition to dissemination of results through open-access peer-reviewed journals and conference presentations, where appropriate, the media will be informed of novel findings, through the University Press Office. Members of the LoLa cohorts will be kept informed of the research through a dedicated website and annual newsletter, highlighting the progress of the project and its results. The website will also be accessible by the wider public. Our work will be promoted at public events such as The Cambridge Science Festival and British Science Festival.
Organisations
- University of Cambridge (Lead Research Organisation, Project Partner)
- MRC Dementias Platform UK (Collaboration)
- University of Manchester (Collaboration)
- University of Oslo (Collaboration)
- UNIVERSITY OF CAMBRIDGE (Collaboration)
- University of Jyväskylä (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- Western University (Collaboration)
- Duke University (Collaboration)
- University of Oxford (Collaboration, Project Partner)
- Radboud University Nijmegen (Collaboration)
- Medical Research Council (MRC) (Collaboration)
- MRC Cognition and Brain Sciences Unit (Project Partner)
Publications
Gilmour J
(2014)
A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.
in Development (Cambridge, England)
Vaghari D
(2022)
A multi-site, multi-participant magnetoencephalography resting-state dataset to study dementia: The BioFIND dataset
in NeuroImage
Geerligs L
(2022)
A partially nested cortical hierarchy of neural states underlies event segmentation in the human brain.
in eLife
Madan Mohan V
(2022)
A perturbative approach to study information communication in brain networks
in Network Neuroscience
Xu L
(2023)
A Siamese Network With Node Convolution for Individualized Predictions Based on Connectivity Maps Extracted From Resting-State fMRI Data.
in IEEE journal of biomedical and health informatics
Kievit RA
(2016)
A watershed model of individual differences in fluid intelligence.
in Neuropsychologia
Title | Cam-CAN promotional videos |
Description | BBSRC made five promotional videos about the project displayed on the BBSRC website, Cam-CAN website, and You-Tube |
Type Of Art | Film/Video/Animation |
Year Produced | 2013 |
Impact | no actual impacts realised to date |
URL | http://www.youtube.com/watch?v=msiHdCsUq2s&feature=youtu.be |
Description | The Cam-CAN project promotes an approach to ageing that differs from most current conceptions of ageing in which ageing is considered to be a process of inevitable cognitive and physical decline. In contrast, our focus is on maturational changes across the lifespan and the dynamic and interactive nature of lifelong neural and cognitive changes that underpin the preservation of cognition throughout life. Our starting assumption is that good cognitive health is underpinned by the brain's ability to respond flexibly across the lifespan. To test this assumption we have obtained a unique set of in-depth imaging, cognitive and demographic data on a population-derived set of 700 individuals. The recruitment of these participants and the collection of such a vast array of data took 5 years. Our initial analyses and preliminary findings focus on understanding the range of factors that affect neural flexibility and their interaction. Some of our scientific highlights to date are: 1. Cognitive variability: Although ageing is widely believed to result in inevitable and across-the-board cognitive decline, in the Cam-CAN data we find a nuanced set of relationships, some of which change across age groups, reflecting the range of cognitive domains covered by our tasks and the specificity of our measures, which have been previously refined by experts within each domain. a. We find that ageing is associated with considerable variability across individuals in patterns of cognitive preservation and loss. b. The finding that some cognitive functions are preserved in some older individuals raises the key issue of why some people age successfully: a primary focus of our research. In younger adults, we find that good cognition is associated with good physical and brain health and high income, whereas in older people, brain health (particularly white matter) is the strongest predictor of cognitive preservation. 2. Brain structural changes a. Many studies have reported global age-related declines in Grey Matter (GM). In our cohort however, overall GM reduction across the age groups is weaker than typically reported. Our sample may provide a more accurate assessment of age-related GM changes because it is i) more uniform and population-representative, ii) minimizes cohort effects by sampling a wide range of abilities/education levels across the lifespan, and iii) excludes people with premorbid dementia. b. We find that the brain becomes less structurally connected with age. c. Results of our novel method for assessing patterns of in vivo myelin - a tissue that is an important component of WM tracts, and which continues developing well into later adulthood - provided new evidence that myelin mediates age-related changes in cognitive function. 3. Brain functional changes a. The dynamic range of an individual's neural activity (as measured in fMRI and MEG) is emerging as a key indicator of cognitive health in our sample, with increased neural responsivity important for maintaining cognitive function, and reduced responsivity being associated with poorer physical health (e.g. poor vascular dynamics), especially for fluid cognitive abilities. b. Cognitive processes are enabled by interactions within and between neural networks. This functional connectivity is important for maintaining cognition throughout life. Decreases in GM at older ages alters the functional connectivity architecture of the brain, with lower connectivity within domain-specific functional networks but increased connectivity between networks. In addition, we find that ageing seems to be associated with reduced flexibility of "reorganizing" functional networks in the face of changing cognitive demands (different tasks). 4. Differentiating age-related vascular and neural changes: Unique to our cohort, we obtain MEG as well as fMRI data. MEG is a more direct measure of neural activity than fMRI, and is essential for separating neural and vascular effects that are confounded in the fMRI signal. We find that vascular reactivity is lower in the older age groups, and this is independent of any age-related changes in neural reactivity. This provides us with methods for uncoupling neural and vascular effects in neurocognitive studies. 5. Lifestyle factors a. Preliminary results reinforce the beneficial effects of exercise: people who engage in vigorous recreational exercises like jogging, swimming or regular physical activity (e.g. via active transport for their journey to/from work) have increased heart rate variability and reduced resting heart rate, both markers of good physical health. Exercise also shows both direct cognitive benefits to long-term memory, as well as indirect benefits to simple reaction time tests, through the mediating benefits to the brain's white matter. The association of exercise with good neurocognitive health suggests a role in delaying the onset of age-related and dementia-related cognitive decline. |
Exploitation Route | The Cam-CAN project is continuing to develop a number of resources that have been made available to others in our recent protocol paper (Shafto et al, BMC Neurology, 2014; Taylor et al, Neuroimage, 2017). This describes our recruitment methods, research framework, and research design (cohort characteristics). Specific statistical and methodological developments, and the 700 datasets are being developed for open use and in collaborations. Our framework - aimed at identifying preservation and flexibility across the adult lifespan- contributes a new approach that can be used by future researchers, and provides examples that are an alternative to studies which consider ageing as analogous to disease processes. In addition to published examples of our findings, a detailed description of our protocol is now published online (Shafto et al, 2014) which provides a detailed description of how we measure a range of cognitive, neural, and epidemiological factors that contribute to successful cognitive ageing. Because our approach requires measuring complex cognitive and neural measures on a large scale, and the nature of their interactions, we have developed and continue to develop statistical and data processing tools which are likely to be very useful to others. For example: (1) new tools for large-scale processing of multimodal data which is often done by hand, including identifying artefacts in MEG data, processing outliers in behavioural data, and automating onset identification in fMRI data; (2) comparing across imaging modalities not only for simple event processing or resting state network characteristics, but for complex cognitive tasks including language comprehension; (3) developing approaches for comparing across and combining measures from a very wide range of diverse cognitive domains which is rare in studies of cognitive ageing. Finally, much of the Cam-CAN data has been made publically available, and to date has been downloaded to 260 users around the world - in the USA, Asia, Australia and Europe. This has resulted in 3 publications from researchers outside the Cam-CAN Research Team (all currently in press/under review). CamCan has also been integrated into a large consortium of European cohorts under the "Lifebrain" initiative. Lifebrain integrates data from 6000 European participants collected in 7 European countries. The goal is to determine the risk and protective factors influencing brain health in order to better prevent mental illness and neurodegenerative disorders. We are continually seeking funding for another wave of testing to turn the CamCan into a longitudinal study, which would substantailly increase its value as a neuroscientifically importnat aging cohort. |
Sectors | Healthcare |
URL | http://www.cam-can.org/ |
Description | Because the aims of the Cam-CAN project are about driving basic research into healthy cognitive ageing and changing attitudes and stereotyes of ageing, the impact of our findings is likely to be seen over the long term. So far we have given a large number of public lectures in a variety of contexts. In these lectures we discuss our findings in the context of resilience and preservation, a framework which the public enjoys and takes seriously. Over time, we expect that our findings will have economic, societal, and public policy implications over and above the scientific impact of our research. Our findings provide a detailed characterization of the brain functions which remain flexible and therefore potentially amenable to underpin learning, retraining and preservation. We anticipate that these findings will support evidence-based development of lifespan education programs, products, and policies relevant to social programmes to aid the preservation of cognitive functions across the lifespan and maintain employment in older people. More broadly, as our research focuses on the factors underpinning successful ageing across the life span, our findings have the potential to overturn negative stereotypes of ageing and improve well being in later life. |
Sector | Healthcare |
Impact Types | Cultural Societal Economic Policy & public services |
Description | BB/H008217/1 BBSRC LoLa Scheme (PI L Tyler) Systems Cognitive Neuroscience of Healthy Ageing: Population-Representative Studies of Functional Plasticity and Neural Change - shared with L Tyler, F Matthews, W Marslen Wilson, J Duncan, R Henson, A Calder |
Amount | £4,990,000 (GBP) |
Funding ID | BB/H008217/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2010 |
End | 09/2015 |
Description | British Academy Fellowship to Kamen Tsvetanov |
Amount | £269,600 (GBP) |
Funding ID | Multi-scale network dynamics of the ageing brain: Modelling neurocognitive function and dysfunction |
Organisation | The British Academy |
Sector | Academic/University |
Country | United Kingdom |
Start | 11/2016 |
End | 10/2019 |
Description | Campbell, K. L. (PI), Olsen, R. K., Geerligs, L., & White, S., Associative memory across the adult lifespan: Neural mechanisms and a novel technique for remediation. |
Amount | $340,425 (CAD) |
Organisation | Canadian Institutes of Health Research |
Sector | Public |
Country | Canada |
Start | 01/2022 |
End | 01/2027 |
Description | European Research Council Advanced Investigator Grant. Language dynamics: a neurocognitive approach to incremental interpretation. |
Amount | € 2,185,000 (EUR) |
Funding ID | 669820 |
Organisation | European Research Council (ERC) |
Sector | Public |
Country | Belgium |
Start | 09/2015 |
End | 09/2020 |
Description | Isaac Newton Trust. Language Dynamics: A Neurocognitive Approach to Incremental Interpretation. |
Amount | £20,121 (GBP) |
Funding ID | MINUTE 15.40(K) |
Organisation | University of Cambridge |
Department | Isaac Newton Trust |
Sector | Academic/University |
Country | United Kingdom |
Start | 01/2017 |
End | 12/2017 |
Description | LifeBrain: Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts |
Amount | € 10,000,000 (EUR) |
Funding ID | 732592 |
Organisation | European Commission H2020 |
Sector | Public |
Country | Belgium |
Start | 01/2017 |
End | 12/2021 |
Description | Netherlands Organisation for Scientific Research (NWO) Rubicon grant: Linda Geerligs |
Amount | £134,371 (GBP) |
Funding ID | 446-13-013 |
Organisation | Netherlands Organisation for Scientific Research (NWO) |
Sector | Public |
Country | Netherlands |
Start | 08/2014 |
End | 08/2016 |
Description | New therapeutics in Alzheimer's disease (NTAD) |
Amount | £800,000 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 04/2018 |
End | 04/2021 |
Description | Wellcome Trust Fellowship: Rogier Kievit |
Amount | £250,000 (GBP) |
Funding ID | 107392/Z/15/Z |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 07/2015 |
End | 07/2019 |
Title | BioFIND |
Description | First DPUK MEG dataset for studying dementia |
Type Of Material | Database/Collection of data |
Year Produced | 2021 |
Provided To Others? | Yes |
Impact | Researchers can login into DPUK servers and analyse this unique rich dataset of resting-state MEG (plus MRI) data. Preprint describing dataset: https://www.medrxiv.org/content/10.1101/2021.05.19.21257330v1. At least one paper published so far with novel analysis by Vaghari et al (2022) Neuroimage (in Publications section of this return). |
URL | https://portal.dementiasplatform.uk/CohortDirectory/Item?fingerPrintID=BioFIND |
Title | Cam-CAN open dataset |
Description | Lifestyle, cognitive, brain data on healthy ageing adults |
Type Of Material | Database/Collection of data |
Year Produced | 2016 |
Provided To Others? | Yes |
Impact | Over 2000 requests; over 100 papers published using data |
URL | https://camcan-archive.mrc-cbu.cam.ac.uk/dataaccess/ |
Title | CamCAN data access portal |
Description | We have made the raw data from a unique dataset of cognitive and brain measures from nearly 700 adults from 18-88 years of age drawn from a population-representative cohort (CamCAN) available to researchers (subject to web-based agreement and committee review) |
Type Of Material | Database/Collection of data |
Year Produced | 2016 |
Provided To Others? | Yes |
Impact | Over 1000 researchers have requested the data for their research (at March 2022), with more requests being received all the time. |
URL | https://camcan-archive.mrc-cbu.cam.ac.uk/dataaccess/ |
Title | Chinese Color Nest Project (CCNP) |
Description | CCNP takes its pilot stage (2013 - 2022) of the first ten-year. It aims at establishing protocols on the Chinese normative brain development trajectories across the human lifespan. It implements a structured multi-cohort longitudinal design (or accelerated longitudinal design), which is particularly viable for lifespan trajectory studies, and optimal for recoverable missing data. The CCNP pilot comprises three connected components: developing CCNP (devCCNP, baseline age = 6-18 years, 12 age cohorts, 3 waves, interval = 15 months), maturing CCNP (matCCNP, baseline age = 18-60 years, 14 age cohorts, 3 waves, interval = 39 months) and ageing CCNP (ageCCNP, baseline age = 60-84 years, 12 age cohorts, 3 waves, interval = 27 months). The developmental component of CCNP (devCCNP, 2013-2022), also known as "Growing Up in China", a ten-year's pilot stage of CCNP, has established follow-up cohorts in Chongqing (,CKG, Southwest China) and Beijing (PEK, Northeast China). It is an ongoing project focused on longitudinal developmental research as creating and sharing a large-scale multimodal dataset for typically developing Chinese children and adolescents (ages 6.0-17.9 at enrollment) carried out in both school- and community-based samples. The devCCNP houses longitudinal data about demographics, biophysical measures, psychological and behavioral assessments, cognitive phenotyping, ocular-tracking, as well as multimodal magnetic resonance imaging (MRI) of brain's resting and naturalistic viewing function, diffusion structure and morphometry. With the collection of longitudinal structured images and psychobehavioral samples from school-age children and adolescents in multiple cohorts, devCCNP has constructed a full school-age brain template and its growth curve reference for Han Chinese which demonstrated the difference in brain development between Chinese and American school-aged children.To access the data, investigators must complete the application file Data Use Agreement on CCNP (DUA-CCNP) at http://deepneuro.bnu.edu.cn/?p=163 and have it reviewed and approved by the Chinese Color Nest Consortium (CCNC). All terms specified by the DUA-CCNP must be complied with. Meanwhile, the baseline CKG Sample on brain imaging are available to researchers via the International Data-sharing Neuroimaging Initiative (INDI) through the Consortium for Reliability and Reproducibility (CoRR). More information about CCNP can be found at: http://deepneuro.bnu.edu.cn/?p=163 or https://github.com/zuoxinian/CCNP. Requests for further information and collaboration are encouraged and considered by the CCNC, and please read the Data Use Agreement and contact us via deepneuro@bnu.edu.cn. The CCNP data will be fully available to the research community when acquisition is completed for the pilot CCNP. At this stage, the CCNP data are only available to researchers and collaborators of CCNC. |
Type Of Material | Database/Collection of data |
Year Produced | 2023 |
Provided To Others? | Yes |
URL | https://www.scidb.cn/en/detail?dataSetId=c81f0e90a51b4cfca348ce4da6ca734e |
Title | New multivariate measure of connectivity for fMRI |
Description | Matlab code associated with a published methods paper for a novel way of measuring functional connectivity with fMRI |
Type Of Material | Data analysis technique |
Year Produced | 2016 |
Provided To Others? | Yes |
Impact | Several researchers have asked about it, and some twitter discussion - do not know how many have downloaded code from website below |
URL | http://imaging.mrc-cbu.cam.ac.uk/imaging/Geerligs_DistCor |
Title | developing Chinese Color Nest Project (devCCNP) Lite |
Description | CCNP takes its pilot stage (2013 - 2022) of the first ten-year. It aims at establishing protocols on the Chinese normative brain development trajectories across the human lifespan. It implements a structured multi-cohort longitudinal design (or accelerated longitudinal design), which is particularly viable for lifespan trajectory studies, and optimal for recoverable missing data. The CCNP pilot comprises three connected components: developing CCNP (devCCNP, baseline age = 6-18 years, 12 age cohorts, 3 waves, interval = 15 months), maturing CCNP (matCCNP, baseline age = 18-60 years, 14 age cohorts, 3 waves, interval = 39 months) and ageing CCNP (ageCCNP, baseline age = 60-84 years, 12 age cohorts, 3 waves, interval = 27 months). The developmental component of CCNP (devCCNP, 2013-2022), also known as "Growing Up in China", a ten-year's pilot stage of CCNP, has established follow-up cohorts in Chongqing (CKG, Southwest China) and Beijing (PEK, Northeast China). It is an ongoing project focused on longitudinal developmental research as creating and sharing a large-scale multimodal dataset for typically developing Chinese children and adolescents (ages 6.0-17.9 at enrollment) carried out in both school- and community-based samples. The devCCNP houses longitudinal data about demographics, biophysical measures, psychological and behavioral assessments, cognitive phenotyping, ocular-tracking, as well as multimodal magnetic resonance imaging (MRI) of brain's resting and naturalistic viewing function, diffusion structure and morphometry. With the collection of longitudinal structured images and psychobehavioral samples from school-age children and adolescents in multiple cohorts, devCCNP has constructed a full school-age brain template and its growth curve reference for Han Chinese which demonstrated the difference in brain development between Chinese and American school-aged children.*This dataset contains only T1-weighted MRI, Resting-state fMRI and Diffusion Tensor MRI data of devCCNP.To access the devCCNP Lite data, investigators must complete the application file Data Use Agreement on CCNP (DUA-CCNP) at http://deepneuro.bnu.edu.cn/?p=163 and have it reviewed and approved by the Chinese Color Nest Consortium (CCNC). All terms specified by the DUA-CCNP must be complied with. Meanwhile, the baseline CKG Sample on brain imaging are available to researchers via the International Data-sharing Neuroimaging Initiative (INDI) through the Consortium for Reliability and Reproducibility (CoRR). More information about CCNP can be found at: http://deepneuro.bnu.edu.cn/?p=163 or https://github.com/zuoxinian/CCNP. Requests for further information and collaboration are encouraged and considered by the CCNC, and please read the Data Use Agreement and contact us via deepneuro@bnu.edu.cn. |
Type Of Material | Database/Collection of data |
Year Produced | 2024 |
Provided To Others? | Yes |
URL | https://www.scidb.cn/en/detail?dataSetId=40493741c1e746f8a11f0b96cb7a4e1f |
Description | Cam-CAN Collaboration: Affiliated members from University of Cambridge |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | This collaboration consists of a number of researchers and graduate students who are not employed on the Cam-CAN project but have an interest in the data and who are willing to make a useful contribution to the analysis and data interpretation. Such researchers are given affiliated status with the project and access to relevant parts of the data. |
Collaborator Contribution | Expertise and a useful contribution to the analysis and data interpretation. |
Impact | Outputs will be recorded under relevant Researchfish sections |
Start Year | 2011 |
Description | Cam-CAN Collaboration: Affiliation at Duke University, USA |
Organisation | Duke University |
Country | United States |
Sector | Academic/University |
PI Contribution | This collaboration is with a post-doctoral researcher employed on the Cam-CAN project until he moved on to a new role in Duke University in 2013. Although no longer employed on the Cam-CAN project, he has a continued interest in the data and is willing to make a useful contribution to the analysis and data interpretation. As an ex-member of staff he has been given affiliated status with the project. |
Collaborator Contribution | Expertise and a useful contribution to the analysis and data interpretation. |
Impact | Outputs will be reported on relevant sections in Researchfish. |
Start Year | 2013 |
Description | Cam-CAN Collaboration: Affiliation at University of Manchester |
Organisation | University of Manchester |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | This collaboration is with a post-doctoral researcher employed on the Cam-CAN project until he moved on to a new role in the University of Manchester in 2013. Although no longer employed on the Cam-CAN project, he has a continued interest in the data and is willing to make a useful contribution to the analysis and data interpretation. As an ex-member of staff he has been given affiliated status with the project. |
Collaborator Contribution | Expertise and a useful contribution to the analysis and data interpretation. |
Impact | Outputs will be recorded in the relevant Researchfish section. |
Start Year | 2013 |
Description | Cam-CAN Collaboration: Donders Institute |
Organisation | Radboud University Nijmegen |
Department | Donders Institute for Brain, Cognition and Behaviour |
Country | Netherlands |
Sector | Academic/University |
PI Contribution | This collaboration consists of a team of researchers from the Donders Institute who are not employed on the Cam-CAN project but who are willing to lend their expertise to analyse relevant sections of Cam-CAN data which they will be given access to. |
Collaborator Contribution | Expertise and a contribution to the analysis and data interpretation. |
Impact | Outputs will be reported under relevant sections of Researchfish. |
Start Year | 2014 |
Description | Cam-CAN Collaboration: University of Edinburgh |
Organisation | University of Edinburgh |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | This is a research collaboration with Dr Alexa Morcom, whereby a Cam-CAN dataset is shared to investigate a specific research question. |
Collaborator Contribution | Expertise and a contribution to data analysis and interpretation. |
Impact | Outputs will be reported on the relevant section of Researchfish. |
Start Year | 2014 |
Description | Cam-CAN Collaboration: University of Oxford |
Organisation | University College Oxford |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | This is a research collaboration between Dr Cader and Dr Symmonds at University of Oxford and project Co-I Professor Henson, using Cam-CAN data to address a specific research question. |
Collaborator Contribution | Expertise and a useful contribution to the analysis and data interpretation. |
Impact | Outputs will be added to relevant sections of Researchfish. |
Start Year | 2014 |
Description | Cam-CAN: student visitor |
Organisation | University of Jyvaskyla |
Country | Finland |
Sector | Academic/University |
PI Contribution | The Cam-CAN team hosted a visiting PhD student, Juho Strommer, from the University of Jyvaskyla, Finland, for 6 months, providing training, support, and data access. |
Collaborator Contribution | He will make a useful contribution to the analysis and data interpretation. |
Impact | Outputs will be recorded in relevant sections on Researchfish. |
Start Year | 2014 |
Description | CamCAN |
Organisation | University of Cambridge |
Department | Department of Psychology |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | CamCAN started in 2010 with a BBSRC LoLa grant to Tyler (PI) - I was a PI. Staff employed at CBU by this grant contributed to data acquisition, analysis and reporting. Since the grant finished in 2015, CamCAN has continued with one post-doc for 2 years plus half of my open-ended RA, both funded by my CBU QQ programme, to continue data analysis and maintain CamCAN momentum. Small costs also covered for website development and domain name. |
Collaborator Contribution | Prof Tyler at the University of Cambridge Psychology Department continues to lead the project and make executive decisions. Her grant has supported some further administration and research support for publications. Prof Brayne and IPH, and Bullmore at Psychiatry, also occasionally contribute some time (as do PLs Duncan and Dalgleish, and PLT Kievit) |
Impact | Taylor, J.R., Williams, N., Cusack, R., Auer, T., Shafto, M.A., Dixon, M., Tyler, L.K., Cam-CAN, Henson, R.N. (2017). The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data repository: Structural and functional MRI, MEG, and cognitive data from a cross-sectional adult lifespan sample. NeuroImage. 144, 262-269. doi: 10.1016/j.neuroimage.2015.09.018. Wolpe, N., Ingram, J., Tsvetanov, K., Geerligs, L., Kievit, R., Henson, R., Wolpert, D., Cam-CAN & Rowe, J. (in press). Ageing increases reliance on sensorimotor prediction through structural and functional differences in frontostriatal circuits. Nature Communications. [Cam-CAN Author list 12] Kievit, R. A., Davis, S. W., Griffiths, J., Correia, M., Cam-CAN, Henson, R. N. A. (in press). A watershed model of individual differences in fluid intelligence. Neurophychologia. [Cam-CAN Author list 12] Henson, R.N., Campbell, K.L., Davis, S.W., Taylor, J.R., Emery, T., Erzinclioglu, S., Cam-CAN & Kievit, R.A. (2016). Multiple determinants of lifespan memory differences. Scientific Reports, 6(32527) [Cam-CAN Author list 12] Blenkmann, A., Hughes, L. E., Kochen, S., Bekinschtein, T. A., Cam-CAN, Rowe, J. B. (2016). Convergent evidence for hierarchical prediction networks from human electrocorticography and magnetoencephalography. Cortex. 82, pp. 192-205. [Cam-CAN Author list 12] Ronan, L., Alexander-Bloch, A. F., Wagstyl, K., Farooqi, S., Brayne, C., Tyler, L. K., Cam-CAN, Fletcher, P. C. (2016). Obesity associated with increased brain-age from mid-life. Neurobiology of Ageing. [Cam-CAN Author list 12] Geerligs, L., Cam-CAN & Henson, R.N. (2016). Functional connectivity and structural covariance between regions of interest can be measured more accurately using multivariate distance correlation. Neuroimage, 135, 16-31. [Cam-CAN Author list 12] Shafto, M. A., James, L. E., Abrams, L., Cam-CAN. Tyler, L. K. (2016). Age-Related Increases in Verbal Knowledge Are Not Associated With Word Finding Problems in the Cam-CAN Cohort: What You Know Won't Hurt You. Journals of Gerontology B: Psychological Sciences. 0(0), 1-7. DOI: 10.1093/geronb/gbw074. [Cam-CAN Author list 12]. Campbell, K. L., Samu, S., Davis, S. W., Geerligs, L., Mustafa, A., CamCAN, Tyler, L. K. (2016). Robust Resilience of the Frontotemporal Syntax System to Aging. Journal of Neuroscience. 36(19): 5214-5227; doi: 10.1523/JNEUROSCI.4561-15.2016. [Cam-CAN Author list 12]. Tsvetanov, K. A., Henson, R. N. A., Tyler, L. K., Razi, A., Geerligs, L., Ham, T., Rowe, J. (2016). Extrinsic and intrinsic brain network connectivity maintains cognition across the lifespan despite accelerated decay of regional brain activation. The Journal of Neuroscience. 36(11), 3115-3126. [Cam-CAN Author list 12]. Green, E., Shafto, M. A., Matthews, F. E., Cam-CAN., White, S. R. (2015). Adult Lifespan Cognitive Variability in the Cross-Sectional Cam-CAN Cohort. International Journal of Environmental Research and Public Health<. 2015, 12(12), 15516-15530. doi: 10.3390/ijerph121215003. [Cam-CAN Author list 12]. Campbell, K. L., Shafto, M.A., Wright, P., Tsvetanov, K.A., Geerligs, L., Cusack, R., Cam-CAN, & Tyler, L.K. (2015). Idiosyncratic responding during movie-watching predicted by age differences in attentional control. Neurobiology of Aging. doi: 10.1016/j.neurobiolaging.2015.07.028 [Cam-CAN Author list 11]. Geerligs, L., Rubinov, M., Cam-CAN, & Henson, R.N. (2015). State and trait components of functional connectivity: individual differences vary with mental state. Journal of Neuroscience, 35(41), 13949 -13961. doi:10.1523/jneurosci.1324-15.[Cam-CAN Author list 11]. Tsvetanov, K.A., Henson, R.N.A., Tyler, L.K., Davis, S.W., Shafto, M., Taylor, J.R., Williams, N., Cam-CAN, & Rowe, J.B. (2015). The effect of ageing on fMRI: correction for the confounding effects of vascular reactivity evaluated by joint fMRI and MEG in 335 adults. Human Brain Mapping, 36(6), 2248-2269. doi: 10.1002/hbm.22768 [Cam-CAN Author list 11]. Shafto, M.A., Tyler, L.K. (2014). Language in the aging brain: The network dynamics of cognitive decline and preservation. Science, 346(6209), pp. 583-587. DOI: 10.1126/science.1254404. Kievit, R.A., Davis, S.W., Mitchell, D.J., Taylor, J.R., Duncan, J., Cam-CAN, & Henson, R.N.A. (2014). Distinct aspects of frontal lobe structure mediate age-related differences in fluid intelligence and multitasking. Nature Communications, 5, 5658. DOI: 10.1038/ncomms6658. [Cam-CAN Author list 7]. Shafto, M.A., Tyler, L.K., Dixon, M., Taylor, J.R., Rowe, J.B., Cusack, R., Calder, A.J., Marslen-Wilson, W.D., Duncan, J., Dalgleish, T., Henson, R.N., Brayne, C., Cam-CAN, & Matthews, F.E. (2014). The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study protocol: a cross-sectional, lifespan, multidisciplinary examination of healthy cognitive ageing. BMC Neurology, 14(204). doi:10.1186/s12883-014-0204-1. [Cam-CAN Author list 10]. 5 U-tube videos: https://youtu.be/msiHdCsUq2s |
Start Year | 2010 |
Description | CamCAN |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Even though BBSRC grant finished, we coordinate the project, in terms of local researchers and international researchers requesting data. |
Collaborator Contribution | Various projects using the CamCAN cohort data. Also part of DPUK. |
Impact | see http://www.cam-can.org/index.php?content=publications |
Start Year | 2016 |
Description | CamCAN collaboration Oslo |
Organisation | University of Oslo |
Country | Norway |
Sector | Academic/University |
PI Contribution | This is a research collaboration between Prof Fjell at University of Oslo and project Co-I Professor Henson, using Cam-CAN data to address a specific research question. |
Collaborator Contribution | Prof Fjell will compare data on a few CamCAN tasks with those from several other European ageing cohorts on similar tasks. |
Impact | This may serve as pilot data for an EU Horizon 2020 bid. |
Start Year | 2016 |
Description | CamCAN student projects |
Organisation | University of Cambridge |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | 6 Part II (3rd Year) University of Cambridge undergraduate student projects, and 3 Summer Students, contributed to CamCAN research |
Collaborator Contribution | Research findings |
Impact | Contributions to papers |
Start Year | 2013 |
Description | Collaboration: Affiliated members at MRC Biostatistics Unit |
Organisation | University of Cambridge |
Department | MRC Biostatistics Unit |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | This collaboration consists of a number of researchers and graduate students who are not employed on the Cam-CAN project but have an interest in the data and who are willing to make a useful contribution to the analysis and data interpretation. Such researchers are given affiliated status with the project under the guidance of Co-Is at the Unit. |
Collaborator Contribution | Expertise and a useful contribution to the analysis and data interpretation. |
Impact | Outputs will be recorded in relevant sections of Researchfish. |
Start Year | 2011 |
Description | Collaboration: Affiliated members from MRC Cognition and Brain Sciences Unit |
Organisation | Medical Research Council (MRC) |
Department | MRC Cognition and Brain Sciences Unit |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | This collaboration consists of a number of researchers and graduate students who are not employed on the Cam-CAN project but have an interest in the data and who are willing to make a useful contribution to the analysis and data interpretation. Such researchers are given affiliated status with the project and are working under direction of project Co-Is. |
Start Year | 2011 |
Description | Collaboration: Affiliated members from University of Western Ontario |
Organisation | Western University |
Country | Canada |
Sector | Academic/University |
PI Contribution | This collaboration consists of a number of researchers and graduate students who are not employed on the Cam-CAN project but have an interest in the data and who are willing to make a useful contribution to the analysis and data interpretation. Such researchers are given affiliated status with the project. They are working under one of the project Co-I's, Rhodri Cusack |
Collaborator Contribution | Expertise and a useful contribution to the analysis and data interpretation |
Impact | Outputs will be recorded in appropriate Researchfish sections. |
Start Year | 2011 |
Description | Dementia Platform UK |
Organisation | MRC Dementias Platform UK |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | CamCAN contributes to DPUK, and helps them improve service (eg for MEG data) |
Collaborator Contribution | DPUK also share CamCAN data |
Impact | Papers mainly |
Start Year | 2018 |
Description | LifeBrain |
Organisation | University of Oslo |
Country | Norway |
Sector | Academic/University |
PI Contribution | Even though our large Horizon 2020 grant now finished, CamCAN remains an active partner in the European-wide LifeBrain consortium of cohorts |
Collaborator Contribution | Many papers, meetings and discussions about healthy ageing |
Impact | Numbers publications already reported, as well as previous grant income in other section |
Start Year | 2022 |
Description | LifeBrain |
Organisation | University of Oslo |
Country | Norway |
Sector | Academic/University |
PI Contribution | We contribute data from our CamCAN and CALM cohorts to this European Horizon 2020 funded harmonization of healthy ageing cohorts |
Collaborator Contribution | Multiple cohorts across Europe contribute cognitive, brain and genetic data. |
Impact | see https://www.lifebrain.uio.no/publications/ |
Start Year | 2017 |
Title | Automated Analysis (AA) of neuroimaging data |
Description | The CamCAN project necessitated several extensions of the AA software used around world for batching large, multimodal neuroimaging datasets, particularly DTI and MEG |
Type Of Technology | Software |
Year Produced | 2015 |
Open Source License? | Yes |
Impact | Enabled all our analysis and publications, and other sites in future |
URL | https://github.com/rhodricusack/automaticanalysis |
Title | Software Toolbox for converting volumes to surfaces |
Description | Converts MNI space volumes to high-res FreeSurfer surfaces |
Type Of Technology | Software |
Year Produced | 2015 |
Open Source License? | Yes |
Impact | 200-300 downloads |
URL | https://github.com/dprice80/mni2fs |
Description | Annual CamCAN newsletter |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Study participants or study members |
Results and Impact | Sent to approx 2500 participants who took part in the CamCAN study of healthy adult ageing |
Year(s) Of Engagement Activity | 2011,2012,2013,2014,2015,2016,2017,2018,2019,2020,2021,2022 |
URL | https://www.cam-can.org/index.php?content=newsletter |
Description | Article in The Times |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Article in The Times: https://www.thetimes.co.uk/article/solving-puzzles-gets-harder-as-we-grow-old-9twswm532rg |
Year(s) Of Engagement Activity | 2014 |
URL | https://www.thetimes.co.uk/article/solving-puzzles-gets-harder-as-we-grow-old-9twswm532rg |
Description | BBSRC YouTube videos |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | A series of videos created by BBSRC about CamCAN project and released on You Tube http://youtu.be/msiHdCsUq2s (Part #1: Cam-CAN project overview) http://youtu.be/fexu3VNzY-k (Part #2: MRI brain imaging) http://youtu.be/eq8wHT8qYJs (Part #3: MEG brain waves) http://youtu.be/-DhCfxn_XnA (Part #4: Motor learning experiment) http://youtu.be/HRSTrioN-EE (Part #5: Hitchcock emotional movie response) |
Year(s) Of Engagement Activity | 2013 |
URL | http://youtu.be/msiHdCsUq2s |
Description | BNA Festive Symposium on ageing |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | I co-organised, co-chaired and presented at the British Neuroscience Association's (BNA) annual "Festive Symposium" on the "Seven ages of (hu)man". |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.bna.org.uk/mediacentre/events/bna-festive-symposium-2020/ |
Description | Buzzfeed featured article based on BBSRC press release, Oct-2015 (Campbell et al) |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Campbell, K. et al. BuzzFeed featured article (http://www.buzzfeed.com/arranafrood/scary-science-a-geekas-guide-to-halloween-1mmog) based on the press release (http://www.bbsrc.ac.uk/news/health/2015/150814-pr-young-minds-think-alike-older-people-more-distractible/), Campbell et al. (2015) "Young minds think alike - and older people are more distractible". Dissemination of results |
Year(s) Of Engagement Activity | 2015 |
Description | Cam-CAN Newsletter |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Newsletter distributed to all participants who have completed a Cam-CAN Home Interview. Provides updates on the project progress. See http://www.cam-can.org/takingpart/index.html for copies. no actual impacts realised to date |
Year(s) Of Engagement Activity | 2011,2012,2013,2014,2015 |
Description | CamCAN & LifeBrain Open Day |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Study participants or study members |
Results and Impact | Approximately 60 members of CamCAN attended an evening of talks about CamCAN's successes, and helped design a new international survey on Brain Health organised by our EU LifeBrain partners |
Year(s) Of Engagement Activity | 2019 |
Description | Cambridge Science Festival 2013 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | The Cambridge Science Festival is a city-wide event which showcases to the general public the variety of science going on across Cambridge. Prof. Tyler was invited to give a keynote speech entitled 'Healthy ageing and the brain: the good news.' Feedback on the day was very positive. |
Year(s) Of Engagement Activity | 2013 |
URL | https://www.sciencefestival.cam.ac.uk/ |
Description | Cambridge University Newsletter |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Participants in your research or patient groups |
Results and Impact | 'On the shoulders of volunteers': Article in Newsletter distributed to staff of the University of Cambridge which discusses use of human participants in research and includes information on the Cam-CAN research project Newsletter no actual impacts realised to date |
Year(s) Of Engagement Activity | 2011 |
Description | Cheltenham Science Festival |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Dr Meredith Shafto gave a short talk and participated in the panel discussion at the Times Cheltenham Science Festival - Session S34 'Your Ageing Brain'. Wednesday 8th June 2011, 6.30pm, at Cheltenham Town Hall no actual impacts realised to date |
Year(s) Of Engagement Activity | 2011 |
URL | http://www.sciencenewsline.com/biology/2011122004440047.html |
Description | Daily Mail Article |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Daily Mail article on our paper by Chan et al (2018) in Neurobiology of Aging about how midlife activities protect against cognitive decline in old age |
Year(s) Of Engagement Activity | 2018 |
URL | https://www.dailymail.co.uk/health/article-6053643/Having-hobbies-middle-age-help-reduce-chances-get... |
Description | First BBSRC Showcase for Industry Event |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Cam-CAN project presented by poster by Dr Shafto at First BBSRC Showcase for Industry Event in Cambridge on 28th September 2012. no actual impacts realised to date |
Year(s) Of Engagement Activity | 2012 |
Description | Importance for mid-life activities for late-life cognition |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Interviewed on the BBC Radio 4 Series "All in the Mind" on 22 Dec 2020 |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.bbc.co.uk/programmes/m000qjhl |
Description | Interview for Mosley podcast |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | CamCAN volunteer interviewed by Michael Mosley for his PodCast "Just One Thing" about ageing |
Year(s) Of Engagement Activity | 2023 |
URL | https://www.bbc.co.uk/sounds/play/m001npnv?partner=uk.co.bbc&origin=share-mobile |
Description | Invited talk - Max Planck Institute (Kievit et al) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Invited talk at the Max Planck institute for Human Development, Berlin, titled 'Relating mind to brain using psychometric models: Theory and applications for neurocognitive aging.' no actual impacts realised to date |
Year(s) Of Engagement Activity | 2014 |
Description | Invited talk: Joint determinants of prefrontal ageing: Selective frontal grey and white matter differentially mediate age-related changes in fluid intelligence and multitasking |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Invited talk at the MRC Cognition and Brain Sciences Unit Wednesday Lunchtime Seminar talk, Cambridge, 7 May 2014. Authors: Kievit, R.A., Davis, S.W., Mitchell, D.M., Taylor, J.R., Duncan, J., Cam-CAN, & Henson, R.N.A. no impact to date |
Year(s) Of Engagement Activity | 2014 |
Description | Invited talk: Max Planck Institute, Nov2014 (Henson) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Henson, R. Cambridge Centre for Ageing & Neuroscience: Preliminary Results. Invited talk given at Max Planck Institute for Human Development, Berlin, Germany, 12 November 2014. Dissemination of results and collaborative research discussion tool |
Year(s) Of Engagement Activity | 2014 |
Description | Invited talk: University of Giessen, Dec2014 (Kievit) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Kievit, R.A. Integrating brain and behaviour in ageing populations using Structural Equation Modelling: Theory and applications. Invited talk at the University of Giessen, Germany, 4 December 2014. Dissemination of results |
Year(s) Of Engagement Activity | 2014 |
Description | Invited talk: University of Plymouth, Jan2015 (Kievit) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Kievit, R.A. The frontal lobe hypothesis revisited: A psychometric approach to neurocognitive ageing. Invited talk given at Dept of Psychology, University of Plymouth, 14 January 2015. Dissemination of results and discussion about research |
Year(s) Of Engagement Activity | 2015 |
Description | James Rowe CamCAN Talks |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Talk: Is it enough to be BOLD? FMRI across the lifespan, copenhagen University 28/1/16 Public engagement: "Meg and Me" ISSF award and presentation at Cambridge Science Festival March 2015, Saber Sami, Tim Rittman, James Rowe MRC workshop on Vascular Ageing, March 2015 DPUK national symposium, May 2015,delegate and lead for Synaptic Health Theme |
Year(s) Of Engagement Activity | 2015 |
Description | Kamen CamCAN Talks |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | • Tsvetanov KA, Henson RNA, Tyler LK, Razi A, Geerligs L, Ham T, Cam-CAN, Rowe JB."Increased extrinsic and intrinsic connectivity maintains cognition across the lifespan coupled with age-related decay in regional neuronal activity". Society for Neuroscience Annual Scientific Meeting, Chicago, USA, 17-21 October 2015 [Conference Talk] • Tsvetanov KA. "The effect of extrinsic and intrinsic brain network connectivity on cognition across the lifespan", Cambridge Connectome Consortium, Cambridge, UK, 24 November 2015 [Invited Talk] • Tsvetanov KA. "fMRI studies of ageing: correction for the confounding effects of vascular reactivity evaluated by joint fMRI and MEG", International Conference on Aging and Cognition, Dortmund, Germany, 23-25 April 2015 [Conference Talk] • Tsvetanov KA. "Using MEG to disentangle neural and vascular contributions to BOLD resting state variability", MEG UK Annual Meeting, Nottingham, UK, 8-10 January 2014 [Conference Talk] Media interest about HBM article • Human brains age less than previously though, Cam-CAN Newsletter 2015 [cites Tsvetanov et al. 2015 HBM] • Interview with MedicalReaseach.com, March 20, 2015 [cites Tsvetanov et al 2015 HBM] • Your brain might not be as 'old' as you think, University of Cambridge Research Features, Mach 09, 2015 [cites Tsvetanov et al. 2015 HBM] • BBSRC news stories and features, March 05, 2015 [cites Tsvetanov et al. 2015 HBM] |
Year(s) Of Engagement Activity | 2015 |
Description | MRC-CBU Open Evening |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | MRC Cognition and Brain Sciences Open Evening for the Cambridge Science Festival no actual impacts realised to date |
Year(s) Of Engagement Activity | 2013 |
Description | Matthias CamCAN MEG |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | SfN invited talk: "Brain networks subserving cognition decline with age", followed by question and answer press conference |
Year(s) Of Engagement Activity | 2015 |
URL | https://www.sfn.org/Press-Room/News-Release-Archives/2015/Research-Reveals-New-Insights-Into-the-Agi... |
Description | Media Interest: Nature Communications Kievit et al |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | The Medical Research Council issued a press release following publication of the of Kievit et al. Nature Communications, 5, 568, paper - http://www.mrc.ac.uk/news-events/news/cognitive-abilities-age-at-different-rates-because-our-brains-age-differently/. The same article was picked up and reported by additional agencies/organisations: o BBSRC: http://www.bbsrc.ac.uk/news/health/2014/141218-pr-cognitive-abilities-age-different-rates.aspx. o British Geriatrics Society, 17 December 2014: http://www.bgs.org.uk/index.php/fallsresources-315/3501-different-rates-cognitive-deterioration o The Times, 19 December 2014: http://www.thetimes.co.uk/tto/health/news/article4301407.ece o The Daily Mail, 18 December 2014: http://www.dailymail.co.uk/health/article-2878849/Different-parts-brain-age-different-rates-Older-people-multitask-long-lose-ability-pay-bill.html o Alzheimer UK, 18 December 2014: http://www.alzheimersresearchuk.org/news-detail/11222/Thinking-skills-decline-at-different-rates-as-we-age/ o Women's Brain Health Initiative, 18 December 2014: http://womensbrainhealth.org/think-outside-the-box/different-parts-of-the-brain-age-at-different-rates o Health Canal, 18 December 2014: http://www.healthcanal.com/brain-nerves/58593-cognitive-abilities-age-at-different-rates-as-our-brains-get-older.html o National Headlines, 18 December 2014: http://www.nationalheadlines.co.uk/862264/different-parts-of-the-brain-age-at-different-rates-older-people-can-still-multitask-long-after-they-lose-the-ability-to-pay-a-bill/ o GM journal, 18 December 2014: http://www.gmjournal.co.uk/cognitive_abilities_age_at_different_rates_because_our_brains_age_differently_25769818814.aspx o Fitzwilliam College: https://www.fitz.cam.ac.uk/about/newsitem-5-242 o Panorama Armenian news, 20 December 2014: http://www.panorama.am/en/popular/2014/12/20/brain-ageing/ o University of Cambridge daily news digest, 22 December 2014: http://universityofcambridge.cmail1.com/t/ViewEmail/j/AE7F077A0D268A41/DFD295083F34F412C9C291422E3DE149 o Cambridge Neuroscience, 22 December 2014: http://www.neuroscience.cam.ac.uk/news/article.php?permalink=0a50eef884 Public engagement in the research being conducted |
Year(s) Of Engagement Activity | 2014 |
Description | Media interest in Elife paper |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Our Elife paper on functional compensation in older people was chosen for a press release by the University of Cambridge, and subsequently taken up at several media outlets |
Year(s) Of Engagement Activity | 2024 |
URL | https://www.cam.ac.uk/research/news/strongest-evidence-to-date-of-brains-ability-to-compensate-for-a... |
Description | Media: BBC Radio 4 Frontiers |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Professors Tyler & Henson, and two of our research participants, contributed to the science feature show 'Frontiers' episode 'Ageing and the brain' broadcast on BBC Radio 4 on 11 June 2014. The show examined the latest understanding of age-related cognitive decline. Included an interview with Professor Tyler. Increase in interest in our research from the public, recorded by increase in e-mail enquiries. |
Year(s) Of Engagement Activity | 2014 |
URL | http://www.bbc.co.uk/podcasts/series/frontiers |
Description | Media: BBSRC Business Magazine |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Article in BBSRC Business Magazine, Autumn 2013, pp16-17 'Brain imaging provides clues on how to age well'. no actual impacts realised to date |
Year(s) Of Engagement Activity | 2013 |
Description | Media: South Bank Show |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Professor Tyler provided advice for the preparation of a South Bank Show film about King Lear, regarding how the brain changes with age. no actual impacts realised to date. |
Year(s) Of Engagement Activity | 2014 |
Description | Plenary talk BioMag conferece (DP) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | A plenary talk was given at the BIOMAG international conference in the USA in August 2018 to 300 people. Disseminated findings and methods about a large on going cohort study to an mainly academic audience from all levels of research. enabled discussion, informed about new methods and advertised the large data that can be shared from the study. |
Year(s) Of Engagement Activity | 2018 |
URL | http://www.biomag2018.org/ |
Description | Public engagement - U3A (Henson et al) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Presentation to the Science Group of the U3A Sevenoaks Branch, Kent, titled 'Age, Brain & Cognition'. no actual impacts realised to date |
Year(s) Of Engagement Activity | 2013 |
Description | Public lecture - British Academy, London, September 2011 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Public lecture given by Professor LK Tyler entitled "The resilient brain: cognition and ageing". This was a Joint British Academy/British Psychological Society Prize Lecture, given at the British Academy, London, in September 2011. no actual impacts realised to date |
Year(s) Of Engagement Activity | 2011 |
Description | Public lecture - Newcastle, October 2011 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Public lecture given by Professor LK Tyler entitled "The resilient brain: cognition and ageing". This was a Joint British Academy/British Psychological Society Prize Lecture in association with the School of Psychology, Newcastle University (part of the InSights Public Lecture series), in October 2011. no actual impacts realised to date |
Year(s) Of Engagement Activity | 2011 |
Description | Public lecture: Cambridge Science Festival 2015 "Aging artists and creativity" |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Joint lecture exploring psychology and art, generated interesting questions and discussion with public audience. no notable impact |
Year(s) Of Engagement Activity | 2015 |
Description | Question Time-style discussion on the topic of ageing |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Prof LK Tyler was a panel member of the Babraham Institute Conference on Ageing and Basic Bioscience Conference BBSRC supported Public Event: Question Time-style discussion on the topic of ageing. The Guildhall, Cambridge, UK, 22 September 2012. no actual impacts realised to date |
Year(s) Of Engagement Activity | 2012 |
Description | Radio broadcast: 'Health Matters' |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Meredith Shafto gave 15min interview on radio station Swindon 150.5FM no actual impacts realised to date |
Year(s) Of Engagement Activity | 2010 |
Description | Radio broadcast: 'Naked Scientists' |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Professor Tyler interviewed on BBC Radio Cambridgeshire 'The Naked Scientists' programme on 30 September 2012. Broadcast focused on ageing 'Why senior moments are not inevitable'. no impacts realised to date |
Year(s) Of Engagement Activity | 2012 |
URL | http://www.thenakedscientists.com/HTML/podcasts/show/20120930/ |
Description | Rik Henson CamCAN Talks |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | - Invited talk by Henson for CamCAN at 2015 DALLAS AGING & COGNITION CONFERENCE, USA: "Combining MRI, fMRI and MEG to study neural bases of age-related changes in cognition: evidence from the CamCAN project". http://vitallongevity.utdallas.edu/events/dacc - Invited talk by Henson for CamCAN at the 2015 Memory Disorders Research Society (MDRS) conference: "Multiple determinants of ageing memories: results from a large, population-representative cohort" UK: http://www.mdrs2015.psychol.cam.ac.uk/ - Invited talk by Henson for CamCAN at the 2016 IBRO workshop in Budapest: "Cambridge Centre for Ageing & Neuroscience (CamCAN): some preliminary results" UK: http://www.ibro2016.hu/ |
Year(s) Of Engagement Activity | 2015,2016 |
Description | Rogier Lab News |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Kievit, R. A. & Henson, R. N. A. (2015). How age is affecting your mind. Laboratory News. http://www.labnews.co.uk/features/how-age-is-affecting-your-mind-23-04-2015/ |
Year(s) Of Engagement Activity | 2015 |
URL | http://www.labnews.co.uk/features/how-age-is-affecting-your-mind-23-04-2015/ |
Description | Speaker at British Academy/British Museum event: Old Masters: creativity and the aging brain |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Drilling down into the subjects of lifelong creative endeavour, the neuroplasticity of the older brain and the correlation between ageing and heightened risk-taking, Prof. Tyler took part in panel discussion (including Martin Gayford, Writer and art critic for The Spectator; and Dr Angus Lockyer, Lecturer in the History of Japan, SOAS) exploring ageing and creativity across global art history, as well as the enduring example of Katsushika Hokusai, the self-declared 'old man crazy to paint'.The event was recorded and is available online (see link below). |
Year(s) Of Engagement Activity | 2017 |
URL | https://www.britac.ac.uk/events/old-masters-creativity-and-ageing-brain |
Description | Talk - University of Oxford |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | Invited Departmental Seminar, Department of Experimental Psychology, University of Oxford titled 'Neurobiology of language: a dual systems approach' no actual impacts realised to date |
Year(s) Of Engagement Activity | 2013 |
Description | Talk: A watershed model for executive functions: Theory, application and extensions for psychopathology |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Kievit, R.A. A watershed model for executive functions: Theory, application and extensions for psychopathology. Informal talk given at the Department of Developmental Psychiatry, 8 October 2014. Dissemination of results |
Year(s) Of Engagement Activity | 2014 |
Description | Talk: Cambridge Centre for Ageing & Neuroscience (CamCAN): Some Prelim Results |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Informal talk given by Prof Henson at the Oxford Centre for Human Brain Activity, University of Oxford, 4 June 2014. no impact to date |
Year(s) Of Engagement Activity | 2014 |
Description | Talk: Healthy ageing and the brain: the good news |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Lecture given by Professor LK Tyler at University of Cambridge Science Festival, March 2013. no actual impacts realised to date |
Year(s) Of Engagement Activity | 2013 |
Description | Talk: MEGUK, Jan2015 (Treder) |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Treder, M., Kitzbichler, M., Price, D., Geerligs, L., Cam-CAN & Bullmore,E. Spectral similarity analysis of resting state MEG in healthy ageing. Talk given at MEG UK, Aston University, Birmingham, UK, 9 January 2015. Dissemination of results |
Year(s) Of Engagement Activity | 2015 |
Description | Talk: The science (and art) of imaging a population |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Talk given by Dr FM to the Rotary Club of South Cambridge, 26 November 2012. no actual impacts realised to date |
Year(s) Of Engagement Activity | 2012 |
Description | Talk: UMC, Groningen, Netherlands, July 2015 (Geerligs) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Geerligs, L. Functional networks in the healthy ageing brain. Talk given to undergraduate and masters students at the Summer School on Healthy Ageing, University Medical Center, Groningen, The Netherlands, 6-10 July 2015. Dissemination of results |
Year(s) Of Engagement Activity | 2015 |
Description | Treder SfN press conference |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Media (as a channel to the public) |
Results and Impact | Our research on relating resting-state brain activity (recorded with MEG) to cognitive performance across the ages was reported in a symposium at the 2015 annual meeting of the international Society for Neuroscience (approx 20,000 scientists attending), which then attracted a subsequent press conference. |
Year(s) Of Engagement Activity | 2015 |
Description | Tyler CamCAN Talks 2015 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | • Language function and the resilient aging brain. Invited talk at 33rd European Workshop on Cognitive Neuropsychology "An Interdisciplinary approach", Bressanone, Italy, 25-30 January 2015. • Language function and the ageing brain. Invited talk in symposium "The Changing Brain - Insights from Lifespan Cognitive Neuroscience" at the 22nd Cognitive Neuroscience Society Annual Meeting, San Francisco, USA, 28-31 March 2015. • The Resilient Brain: Cognition and Ageing. Invited talk given to the Reform Club, London, 16 September 2015. • The adaptive brain: brain and cognition in ageing . Invited talk in symposium: 'Language and the aging brain". Society for the Neurobiology of Language, Chicago, October 2015 |
Year(s) Of Engagement Activity | 2015 |