Combing biophysical and 'omics methods for understanding the basis of blood clotting and haemostasis, and how to modify it
Lead Research Organisation:
University of Manchester
Department Name: Chemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Pretorius E.
(2017)
A Bacterial Component to Alzheimer's-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease
in Advances in Alzheimer's Disease
Pretorius E
(2014)
Eryptosis as a marker of Parkinson's disease.
in Aging
Esteve C
(2017)
Mass spectrometry imaging shows major derangements in neurogranin and in purine metabolism in the triple-knockout 3×Tg Alzheimer mouse model.
in Biochimica et biophysica acta. Proteins and proteomics
Kell DB
(2018)
No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases.
in Biological reviews of the Cambridge Philosophical Society
Vuuren MJV
(2020)
Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson's Disease.
in Biomolecules
Grobbelaar LM
(2021)
SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19.
in Bioscience reports
Koperdanova M
(2015)
Interpreting raised serum ferritin levels.
in BMJ (Clinical research ed.)
Pretorius E
(2022)
Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC).
in Cardiovascular diabetology
Pretorius E
(2021)
Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin.
in Cardiovascular diabetology
Pretorius E
(2017)
Substantial fibrin amyloidogenesis in type 2 diabetes assessed using amyloid-selective fluorescent stains.
in Cardiovascular diabetology
Pretorius E
(2015)
Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics.
in Cardiovascular diabetology
Page MJ
(2022)
The Role of Lipopolysaccharide-Induced Cell Signalling in Chronic Inflammation.
in Chronic stress (Thousand Oaks, Calif.)
Olsen I
(2020)
Is Porphyromonas gingivalis involved in Parkinson's disease?
in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Pretorius E
(2017)
Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability.
in Experimental biology and medicine (Maywood, N.J.)
Goodacre R
(2017)
Commentary on "Rapid identification of Streptococcus and Enterococcus species using diffuse reflectance-absorbance Fourier transform infrared spectroscopy and artificial neural networks".
in FEMS microbiology letters
Potgieter M
(2015)
The dormant blood microbiome in chronic, inflammatory diseases.
in FEMS microbiology reviews
Adams B
(2019)
Parkinson's Disease: A Systemic Inflammatory Disease Accompanied by Bacterial Inflammagens.
in Frontiers in aging neuroscience
Pretorius E
(2018)
The Potential of LPS-Binding Protein to Reverse Amyloid Formation in Plasma Fibrin of Individuals With Alzheimer-Type Dementia.
in Frontiers in aging neuroscience
Visser MJE
(2019)
Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris.
in Frontiers in cellular and infection microbiology
Bezuidenhout JA
(2020)
Detection of Citrullinated Fibrin in Plasma Clots of Rheumatoid Arthritis Patients and Its Relation to Altered Structural Clot Properties, Disease-Related Inflammation and Prothrombotic Tendency.
in Frontiers in immunology
Kell DB
(2020)
The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria.
in Frontiers in immunology
Kell DB
(2016)
A Dormant Microbial Component in the Development of Preeclampsia.
in Frontiers in medicine
Description | Discovery of amyloid formation by clotting blood. Absolutely humungous discovery. Novel methods for analysing blood in control and unhealthy individuals. In particular, we discovered that blood clots into an unusual form, known as an amyloid form, and this has huge implications. |
Exploitation Route | Novel diagnostics. |
Sectors | Digital/Communication/Information Technologies (including Software) Education Healthcare Pharmaceuticals and Medical Biotechnology |
Description | Stellenbosch |
Organisation | University of Stellenbosch |
Country | South Africa |
Sector | Academic/University |
PI Contribution | Prof Douglas Kell appointed Extraordinary (Honorary) Professor, Department of Physiological Science, Stellenbosch University. Collaborative research in the areas of anti-microbial resistance, membrane transporters, dormant microbes as elements of supposedly non-communicable diseases, iron dysregulation, and enzyme improvement. |
Collaborator Contribution | Sharing of knowledge and analytical facilities at Stellenbosch and Liverpool. |
Impact | See publications. |
Start Year | 2017 |