Combing biophysical and 'omics methods for understanding the basis of blood clotting and haemostasis, and how to modify it
Lead Research Organisation:
University of Manchester
Department Name: Chemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Laubscher GJ
(2021)
TEG®, Microclot and Platelet Mapping for Guiding Early Management of Severe COVID-19 Coagulopathy.
in Journal of clinical medicine
Pretorius E
(2016)
A Bacterial Component to Alzheimer's-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease.
in Journal of Alzheimer's disease : JAD
Kell DB
(2015)
On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death.
in Integrative biology : quantitative biosciences from nano to macro
Kell DB
(2015)
The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen).
in Integrative biology : quantitative biosciences from nano to macro
Pretorius E
(2014)
Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases.
in Integrative biology : quantitative biosciences from nano to macro
Pretorius L
(2018)
Iron Dysregulation and Dormant Microbes as Causative Agents for Impaired Blood Rheology and Pathological Clotting in Alzheimer's Type Dementia.
in Frontiers in neuroscience
De Villiers S
(2019)
A Possible Role of Amyloidogenic Blood Clotting in the Evolving Haemodynamics of Female Migraine-With-Aura: Results From a Pilot Study.
in Frontiers in neurology
Kenny LC
(2017)
Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father.
in Frontiers in medicine
Kell DB
(2016)
A Dormant Microbial Component in the Development of Preeclampsia.
in Frontiers in medicine
Kell D
(2020)
The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria
in Frontiers in Immunology
Bezuidenhout JA
(2020)
Detection of Citrullinated Fibrin in Plasma Clots of Rheumatoid Arthritis Patients and Its Relation to Altered Structural Clot Properties, Disease-Related Inflammation and Prothrombotic Tendency.
in Frontiers in immunology
Visser MJE
(2019)
Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris.
in Frontiers in cellular and infection microbiology
Pretorius E
(2018)
The Potential of LPS-Binding Protein to Reverse Amyloid Formation in Plasma Fibrin of Individuals With Alzheimer-Type Dementia.
in Frontiers in aging neuroscience
Adams B
(2019)
Parkinson's Disease: A Systemic Inflammatory Disease Accompanied by Bacterial Inflammagens.
in Frontiers in aging neuroscience
Potgieter M
(2015)
The dormant blood microbiome in chronic, inflammatory diseases.
in FEMS microbiology reviews
Goodacre R
(2017)
Commentary on "Rapid identification of Streptococcus and Enterococcus species using diffuse reflectance-absorbance Fourier transform infrared spectroscopy and artificial neural networks".
in FEMS microbiology letters
Pretorius E
(2017)
Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability.
in Experimental biology and medicine (Maywood, N.J.)
Olsen I
(2020)
Is Porphyromonas gingivalis involved in Parkinson's disease?
in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Page MJ
(2022)
The Role of Lipopolysaccharide-Induced Cell Signalling in Chronic Inflammation.
in Chronic stress (Thousand Oaks, Calif.)
Pretorius E
(2015)
Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics.
in Cardiovascular diabetology
Pretorius E
(2022)
Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC).
in Cardiovascular diabetology
Pretorius E
(2017)
Substantial fibrin amyloidogenesis in type 2 diabetes assessed using amyloid-selective fluorescent stains.
in Cardiovascular diabetology
Description | Discovery of amyloid formation by clotting blood. Absolutely humungous discovery. Novel methods for analysing blood in control and unhealthy individuals. In particular, we discovered that blood clots into an unusual form, known as an amyloid form, and this has huge implications. |
Exploitation Route | Novel diagnostics. |
Sectors | Digital/Communication/Information Technologies (including Software),Education,Healthcare,Pharmaceuticals and Medical Biotechnology |
Description | Stellenbosch |
Organisation | University of Stellenbosch |
Country | South Africa |
Sector | Academic/University |
PI Contribution | Prof Douglas Kell appointed Extraordinary (Honorary) Professor, Department of Physiological Science, Stellenbosch University. Collaborative research in the areas of anti-microbial resistance, membrane transporters, dormant microbes as elements of supposedly non-communicable diseases, iron dysregulation, and enzyme improvement. |
Collaborator Contribution | Sharing of knowledge and analytical facilities at Stellenbosch and Liverpool. |
Impact | See publications. |
Start Year | 2017 |