Combing biophysical and 'omics methods for understanding the basis of blood clotting and haemostasis, and how to modify it
Lead Research Organisation:
University of Manchester
Department Name: Chemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Pretorius L
(2018)
Iron Dysregulation and Dormant Microbes as Causative Agents for Impaired Blood Rheology and Pathological Clotting in Alzheimer's Type Dementia.
in Frontiers in neuroscience
De Villiers S
(2019)
A Possible Role of Amyloidogenic Blood Clotting in the Evolving Haemodynamics of Female Migraine-With-Aura: Results From a Pilot Study.
in Frontiers in neurology
Kenny LC
(2017)
Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father.
in Frontiers in medicine
Kell DB
(2016)
A Dormant Microbial Component in the Development of Preeclampsia.
in Frontiers in medicine
Kell D
(2020)
The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria
in Frontiers in Immunology
Bezuidenhout JA
(2020)
Detection of Citrullinated Fibrin in Plasma Clots of Rheumatoid Arthritis Patients and Its Relation to Altered Structural Clot Properties, Disease-Related Inflammation and Prothrombotic Tendency.
in Frontiers in immunology
Visser MJE
(2019)
Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris.
in Frontiers in cellular and infection microbiology
Pretorius E
(2018)
The Potential of LPS-Binding Protein to Reverse Amyloid Formation in Plasma Fibrin of Individuals With Alzheimer-Type Dementia.
in Frontiers in aging neuroscience
Adams B
(2019)
Parkinson's Disease: A Systemic Inflammatory Disease Accompanied by Bacterial Inflammagens.
in Frontiers in aging neuroscience
Potgieter M
(2015)
The dormant blood microbiome in chronic, inflammatory diseases.
in FEMS microbiology reviews
Description | Discovery of amyloid formation by clotting blood. Absolutely humungous discovery. Novel methods for analysing blood in control and unhealthy individuals. In particular, we discovered that blood clots into an unusual form, known as an amyloid form, and this has huge implications. |
Exploitation Route | Novel diagnostics. |
Sectors | Digital/Communication/Information Technologies (including Software),Education,Healthcare,Pharmaceuticals and Medical Biotechnology |
Description | Stellenbosch |
Organisation | University of Stellenbosch |
Country | South Africa |
Sector | Academic/University |
PI Contribution | Prof Douglas Kell appointed Extraordinary (Honorary) Professor, Department of Physiological Science, Stellenbosch University. Collaborative research in the areas of anti-microbial resistance, membrane transporters, dormant microbes as elements of supposedly non-communicable diseases, iron dysregulation, and enzyme improvement. |
Collaborator Contribution | Sharing of knowledge and analytical facilities at Stellenbosch and Liverpool. |
Impact | See publications. |
Start Year | 2017 |