Role of Wnt in the decline of oligodendrocyte generation in the ageing brain
Lead Research Organisation:
University of Portsmouth
Department Name: Inst of Biomedical and Biomolecular Sc
Abstract
The massive computing power of the brain depends on the insulation of nerve cell connections with myelin sheaths, by cells known as oligodendrocytes (OLs). Bundles of these 'myelinated' connections form the white matter that is very prominent in the human cortex. Although a loss of cortical white matter and myelin has been documented in cognitive decline, the causes are unknown.
There is evidence that OLs are continuously lost and regenerated from a pool of OL progenitors (OPs). For unknown reasons, the ability of OPs to generate OLs declines with age, which underlies the loss of myelin and cognitive functions. The applicant has identified a key factor that drives OL generation in the adult brain and which is deregulated in ageing. This factor is known as Wnt (pronounced wint), and the aim of this project is to determine the mechanisms by which Wnt controls OP generation and OL/myelin loss in the ageing mouse brain. This will provide new knowledge on the mechanisms underlying myelin loss in ageing brain and may ultimately lead to the identification of new cellular targets for protecting myelin and preserving cognitive function.
This fundamental research fits the BBSRC Research Priority of 'Healthy ageing across the lifecourse'.
There is evidence that OLs are continuously lost and regenerated from a pool of OL progenitors (OPs). For unknown reasons, the ability of OPs to generate OLs declines with age, which underlies the loss of myelin and cognitive functions. The applicant has identified a key factor that drives OL generation in the adult brain and which is deregulated in ageing. This factor is known as Wnt (pronounced wint), and the aim of this project is to determine the mechanisms by which Wnt controls OP generation and OL/myelin loss in the ageing mouse brain. This will provide new knowledge on the mechanisms underlying myelin loss in ageing brain and may ultimately lead to the identification of new cellular targets for protecting myelin and preserving cognitive function.
This fundamental research fits the BBSRC Research Priority of 'Healthy ageing across the lifecourse'.
Technical Summary
Oligodendrocytes are specialised to form myelin in the CNS. Myelin is essential for rapid neuronal connectivity that underlies the massive computing power of the human brain. Studies in humans have shown loss of myelin and white matter shrinkage after the age of 50 is associated with decline of higher cognitive functions. Fate-mapping studies in mice provide direct evidence that this is normally replaced by oligodendrocytes newly generated from endogenous oligodendrocyte precursors (OPs). However, for unknown reasons there is a decrease in the regenerative capacity of OPs in the ageing brain. The mechanisms regulating oligodendrogliogenesis in the adult and aging brain are unresolved. However, the applicant provides several new lines of evidence of a fundamental role for deregulation of Wnt signalling. In recent studies, the applicant has identified a major role for Wnt in driving oligodendrogliogenesis and myelination in vivo in the mouse brain (Azim et al., 2014a,b). Now, in pilot studies on the optic nerve, an archetypal CNS white matter tract, we show that Wnt signalling continues to drive oligodendrogliogenesis in the mature adult nerve but not in old-age (18 months, equivalent to age 60 in humans). Furthermore, we show that multiple elements of Wnt signalling that control oligodendrocyte generation are severely altered in ageing white matter. To take this work forward, the applicant has developed a Cre/LoxP mouse line that targets Wnt signalling in OPs. These mice provide a major new advance that will enable the applicant to achieve the aims of this project and test the hypothesis that deregulation of Wnt signalling underlies the decreased regenerative capacity of OPs in the ageing brain. The planned epxeriments will generate new fundamental knowledge on the functions of Wnt in oligodendrocyte cell biology and mechanisms of cognitive decline in the ageing brain.
Planned Impact
The main beneficiaries of the research will be other scientists, and dissemination of research findings will be through the normal routes of publications, reviews and presentations at meetings. In the longer term, this research is also likely to be of interest to clinicians, patient groups, and the wider public. We will publicise the support we receive for this project and explain the research through public forums. Where possible, we will make ourselves available to speak to local and national media on the importance of this research to the public and how grant support drives this much needed fundamental research.
It is not anticipated that any directly patentable data will arise from this project, but the longer term plan is to use the information gained in this research to identify new potential therapeutic targets for promoting a healthy brain in ageing and across the lifecourse. This would have considerable wider impact. We will use several routes to communicate this to potential user groups and the general public. We will present live demonstrations to local schools and the public, and write articles for specialised magazines for patients who may benefit from the findings of this research project. In addition, this project is directly relevant to ageing research and as a member of the University of Portsmouth Ageing Network (UPAN) and Alzheimer's Research UK (ARUK) Southern Network co-ordinated out of Southampton University, the applicant will have a direct route to communicate this research to potential end-users and interst groups.
It is not anticipated that any directly patentable data will arise from this project, but the longer term plan is to use the information gained in this research to identify new potential therapeutic targets for promoting a healthy brain in ageing and across the lifecourse. This would have considerable wider impact. We will use several routes to communicate this to potential user groups and the general public. We will present live demonstrations to local schools and the public, and write articles for specialised magazines for patients who may benefit from the findings of this research project. In addition, this project is directly relevant to ageing research and as a member of the University of Portsmouth Ageing Network (UPAN) and Alzheimer's Research UK (ARUK) Southern Network co-ordinated out of Southampton University, the applicant will have a direct route to communicate this research to potential end-users and interst groups.
People |
ORCID iD |
Arthur Butt (Principal Investigator) |
Publications
Vanzulli I
(2020)
Disruption of oligodendrocyte progenitor cells is an early sign of pathology in the triple transgenic mouse model of Alzheimer's disease.
in Neurobiology of aging
Silva JHCE
(2020)
Amburana cearensis: Pharmacological and Neuroprotective Effects of Its Compounds.
in Molecules (Basel, Switzerland)
Rodríguez JJ
(2016)
Complex and differential glial responses in Alzheimer's disease and ageing.
in Current Alzheimer research
Rivera AD
(2022)
Drug connectivity mapping and functional analysis reveal therapeutic small molecules that differentially modulate myelination.
in Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Rivera AD
(2022)
Epidermal Growth Factor Pathway in the Age-Related Decline of Oligodendrocyte Regeneration.
in Frontiers in cellular neuroscience
Rivera AD
(2019)
Astrocytes are direct cellular targets of lithium treatment: novel roles for lysyl oxidase and peroxisome-proliferator activated receptor-? as astroglial targets of lithium.
in Translational psychiatry
Rivera AD
(2022)
Resolving the age-related decline in central nervous system myelin turnover and drug discovery for oligodendroglial rejuvenation.
in Neural regeneration research
Rivera AD
(2021)
Keeping the ageing brain wired: a role for purine signalling in regulating cellular metabolism in oligodendrocyte progenitors.
in Pflugers Archiv : European journal of physiology
Rivera A
(2024)
The Genomic Intersection of Oligodendrocyte Dynamics in Schizophrenia and Aging Unravels Novel Pathological Mechanisms and Therapeutic Potentials
in International Journal of Molecular Sciences
Description | We have: (1) developed a new transgenic mouse strain; (2) discovered new cellular and molecular targets in the ageing brain; and (3) identified potential drugs to protect ageing white matter. These data have been presented at a number of conferences, to the public in lectures and lab visits, and in parliament. A number of full papers have been published. In addition, we have patented some of the findings and set up a spin-out company to pursue these findings. |
Exploitation Route | We have identified a series of small molecules that have the capacity to protect ageing white matter. This led to a patent and a spin-out company to pursue these findings. |
Sectors | Pharmaceuticals and Medical Biotechnology |
Description | Project Grant |
Amount | £25,000 (GBP) |
Funding ID | 40 |
Organisation | Multiple Sclerosis Society |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 03/2016 |
End | 03/2019 |
Title | Aging mouse oligodendrocyte progenitor cells |
Description | Microarray dataset |
Type Of Material | Database/Collection of data |
Year Produced | 2021 |
Provided To Others? | Yes |
Impact | The data was published in a paper |
Title | Lithium effects on astrocytes in the optic nerve dataset |
Description | Evidence that astrocytes are direct targets of lithium and identificaion of unique astroglial transcriptional networks that regulate specific molecular changes in astrocytes associated with BD and schizophrenia, together with Alzheimer's disease (AD). Deposited in GEO (https://www.ncbi.nlm.nih.gov/geo/) and identified by the accession number: GSE132397. |
Type Of Material | Database/Collection of data |
Year Produced | 2019 |
Provided To Others? | Yes |
Impact | This study unravels new pathophysiological mechanisms in astrocytes that have potential as novel biomarkers and potential therapeutic targets for regulating astroglial responses in diverse neurological disorders. |
URL | https://www.ncbi.nlm.nih.gov/geo/ |
Description | Olivier Raineteau, INSERM, Lyons |
Organisation | École normale supérieure de Lyon (ENS Lyon) |
Department | INSERM U846 (Stem-cell and Brain Research Institute) |
Country | France |
Sector | Public |
PI Contribution | Experimental design, hosting researchers, writing and publishing papers |
Collaborator Contribution | Experimental design, hosting researchers, writing and publishing papers |
Impact | Publications |
Start Year | 2017 |
Description | Professor Silvia Lima Costa, Bahia University, Brazil |
Organisation | Federal University of Bahia |
Country | Brazil |
Sector | Academic/University |
PI Contribution | Experimental design, hosting researchers, writing and publishing papers, hosting and attending bilateral workshops |
Collaborator Contribution | Funding (Brazil), experimental design, hosting researchers, writing and publishing papers, hosting and attending bilateral workshops |
Impact | Bilateral meetings and publications. |
Start Year | 2017 |
Description | Southampton University |
Organisation | University of Southampton |
Department | Southampton Medical School |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Data production and analysis, experimental design, paper writing |
Collaborator Contribution | Provision of tissue, analysis, design, writing |
Impact | Two publications and presentations at meetings |
Start Year | 2017 |
Title | Assay |
Description | Diagnosing, prognosing or following progression of neuropsychiatric or neurodegenerative diseases by measuring the amount of lysyl oxidase (LOX) or lysyl oxidase like (LOXL) isoforms in a sample from a subject. |
IP Reference | 1911182.2 |
Protection | Patent application published |
Year Protection Granted | |
Licensed | No |
Impact | In development |
Title | PHARMACEUTICAL COMPOSITIONS FOR USE IN THE TREATMENT OF BRAIN INJURIES OR DEMYELINATING DISORDERS |
Description | The invention is in the field of neuroregenerative medicine. Controlling the fate of neural stem cells represents a key therapeutic strategy in neuroregenerative medicine. The inventors used in silico genomic approaches, searchable platform-independent expression database/connectivity map (SPIED/CMAP) strategy, to identify small molecules that are predicted to regulate transcriptional changes associated with neurogenesis in the subventricular zone (SVZ) neurogenic niche. The approach was validated by demonstrating that two of the identified small molecules, inhibiting PI3K/Akt and GSK3ß respectively, were able to differentially direct the fate of NSCs in vivo, to promote oligodendrogenesis and neurogenesis, in the postnatal and adult SVZ. The present invention thus relates to methods and pharmaceutical composition for use in the treatment of brain injuries or demyelinating disorders, and in particular to PI3K or GSK3ß inhibitors for use in treating brain injuries, such as perinatal hypoxia/ischemia, or demyelinating disorders such as periventricular leukomalacias or multiple sclerosis. |
IP Reference | WO2018178194 |
Protection | Patent application published |
Year Protection Granted | 2018 |
Licensed | No |
Impact | None to date |
Company Name | Gliagenesis Limited |
Description | GliaGenesis Limited is a UK-based biotech company focused on developing therapies for neurodegenerative diseases utilizing astrocytes. |
Year Established | 2017 |
Impact | None to date |
Website | http://www.oxandia.co.uk |
Description | 2016 Science Together: Science Postgraduate Research Conference (UoP) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | The Research Student, Ashik Kalam, presented his spinal cord injury data to a general science audience. He was congratulated on his presentation and it parked new interest in the field. |
Year(s) Of Engagement Activity | 2016 |
Description | ARUK Network Meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | ARUK Southern Network meeting for public, clinicians and scientists |
Year(s) Of Engagement Activity | 2016 |
Description | American Society of Neuroimmune Pharmacology, Krakow |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited talk on our ageing research to clinical audience |
Year(s) Of Engagement Activity | 2016 |
Description | Bahia Brazil Neurochemistry Workshop Oct-10-2019 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Oral presentation that sparked questions and discussions and future collaborations |
Year(s) Of Engagement Activity | 2019 |
Description | Christine Rose research exchange |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | New collaborator fr9om Christine Rose group invited to my lab to exchange technical expertise |
Year(s) Of Engagement Activity | 2016 |
Description | Fishbourne CE promary school talk |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Talk to primary school children on brain research |
Year(s) Of Engagement Activity | 2016 |
Description | Glial meeting in Salvador Brazil |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The PDRA Dr Andrea Rivera was invited to present our data at a Glial meeting in Salvador Brazil, which sparked questions and lively discussions, leading to collaborations. |
Year(s) Of Engagement Activity | 2017 |
Description | ISRT network meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | ISRT network meeting with clinicians, researchers, charities, industry and people with spinal injury |
Year(s) Of Engagement Activity | 2016 |
Description | IoP Lectures |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Postgraduate students |
Results and Impact | Oral presentation that sparked questions and discussions |
Year(s) Of Engagement Activity | 2019 |
Description | IoP lectures |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Postgraduate students |
Results and Impact | IoP lectures on glial cells |
Year(s) Of Engagement Activity | 2016 |
Description | Italy, Aqua Therme May 2017 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Public meeting on brain health during ageing, resulting in lively discussions and the plan to organise a larger meeting in 2018. |
Year(s) Of Engagement Activity | 2017 |
Description | KCL lectures |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Undergraduate students |
Results and Impact | KCL lectures on MS and ageing |
Year(s) Of Engagement Activity | 2016 |
Description | King's College Lectures |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Undergraduate students |
Results and Impact | Oral presentation that sparked questions and discussions |
Year(s) Of Engagement Activity | 2019 |
Description | Lab Tour |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | The PI provided a guided tour of his labs and an overview of the research. The audience were very excited about the research. |
Year(s) Of Engagement Activity | 2016 |
Description | Lab Visits for Ageing |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | 30 people visited my labs as part of the ageing recognition outreach activities |
Year(s) Of Engagement Activity | 2016 |
Description | Living with Dementia 2017 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Dementia meeting in which we presented a science café on our research |
Year(s) Of Engagement Activity | 2016 |
Description | Living with Dementia, Southampton UK Jan 2016 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | A mixed audience of PPI, academics, clinicians and funders, with the purpose of promoting understanding and bilateral communication. Considerable interest amongst PPI. |
Year(s) Of Engagement Activity | 2016 |
Description | Living with MS 18th of November, Southampton |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Living with MS 18th of November, Southampton - stand organiser and oral presentation, sparked questions and lively discussions. |
Year(s) Of Engagement Activity | 2017 |
Description | Lyons neural stem cell group meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Meeting with Olivier Raineteau and Kasum Azim on taking our research forward in an open and collaborative way |
Year(s) Of Engagement Activity | 2016 |
Description | MS Society Networking meeting July 2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Poster presentation that sparked questions and discussions |
Year(s) Of Engagement Activity | 2019 |
Description | MS Society visit |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Supporters |
Results and Impact | Visit to my labs from MS Society to discuss research |
Year(s) Of Engagement Activity | 2016 |
Description | MS patients and supporters lab visit |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | The local MS group came to visit our labs |
Year(s) Of Engagement Activity | 2016 |
Description | Meeting in Padua, Italy, Nov-25-2019 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Discussions resulting in future collaborations |
Year(s) Of Engagement Activity | 2019 |
Description | Meeting in Prague, Czech Republic March-4-2020 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Discussions for future collaborations |
Year(s) Of Engagement Activity | 2020 |
Description | Milan University Dec 2017 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | Presentation to potential research collaborators, which sparked a new collaboration. |
Year(s) Of Engagement Activity | 2017 |
Description | NUDZ Prague Sep-19-2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Oral presentation that sparked questions and discussions and future collaborations |
Year(s) Of Engagement Activity | 2019 |
Description | Neurochemistry conference, Milan Aug-31-2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Oral presentation that sparked questions and discussions and future collaborations |
Year(s) Of Engagement Activity | 2019 |
Description | Neuroglia Meeting Lubjana, Slovenia Nov-7-2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Oral presentation that sparked questions and discussions and future collaborations |
Year(s) Of Engagement Activity | 2019 |
Description | Neuroglia Meeting Tblisi, Georgia Sep-27-2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Oral presentation that sparked questions and discussions and future collaborations |
Year(s) Of Engagement Activity | 2019 |
Description | PDRA Dr Andrea Rivera Joined BBSRC Skills and Career Postdoctoral advisory Group October 2017 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Joined BBSRC Skills and Career Postdoctoral advisory Group October 2017 |
Year(s) Of Engagement Activity | 2017 |
Description | Paris Boris Zalc March-13-2020 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Discussions and future collaborations |
Year(s) Of Engagement Activity | 2020 |
Description | Paris meeting with Kaz, Olivier and Carlos Sep-10-2019 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Oral presentation that sparked questions and discussions and future collaborations |
Year(s) Of Engagement Activity | 2019 |
Description | Pint of Science 2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Public talk in pub, generated questions and discussions. |
Year(s) Of Engagement Activity | 2019 |
Description | Pint of Science Talk |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | Presentation at the Pint of Science in Portsmouth |
Year(s) Of Engagement Activity | 2016 |
Description | Pint of Science, Portsmouth |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | The PI, Professor Arthur Butt, presented a talk on the brain as part of the Pint of Science week. There was considerable feedback and interest from the audience. |
Year(s) Of Engagement Activity | 2016 |
Description | Public Talk - inaugral |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Public Lecture on research in my group |
Year(s) Of Engagement Activity | 2016 |
Description | Public Talk, Connelli, Italy |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Public Talk in Connelli, Italy, on our work focusing on maintaining a healthy brain across the lifecourse. Over 100 people attended the talk, ranging from general public to local and national politicians and media. |
Year(s) Of Engagement Activity | 2018 |
Description | Purine Meeting, Santiago, Spain Sep-5-2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Oral presentation that sparked questions and discussions and future collaborations |
Year(s) Of Engagement Activity | 2019 |
Description | Romanian Physiological Society |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited seminar on ageing research to clinicians and researchers |
Year(s) Of Engagement Activity | 2016 |
Description | Seminar Herriott Watts University |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Seminar and laboratory visit, leading to collaboration and new techniques introduced to our lab. |
Year(s) Of Engagement Activity | 2016 |
Description | Seville collaborative meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Exchanged expertise with Seville group |
Year(s) Of Engagement Activity | 2016 |
Description | Signalling meeting, Limerick, Ireland Nov-13-2019 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Oral presentation that sparked questions and discussions and future collaborations |
Year(s) Of Engagement Activity | 2019 |
Description | Stem4Britain presentation at the House of Parliament 12/03/2018 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Stem4Britain presentation at the House of Parliament 12/03/2018, sparked questions and discussions with MPs and others |
Year(s) Of Engagement Activity | 2018 |
Description | Strasbourg Brain Ageing Conference March-16-2020 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Oral presentation that sparked questions and discussions and future collaborations |
Year(s) Of Engagement Activity | 2020 |
Description | Talk to local MS group |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Patients, carers and/or patient groups |
Results and Impact | Presented MS research to the local MS group |
Year(s) Of Engagement Activity | 2016 |
Description | Turin University and Medical School, Dec 2017 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Talks with potential collaborators that sparked discussions and potential for collaborative research. |
Year(s) Of Engagement Activity | 2017 |
Description | Visit Christine Rose Germany |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Talk with Christine Rose group and exchange of ideas and arrange future lab visits |
Year(s) Of Engagement Activity | 2016 |
Description | Visit lab in Lyons, INSERM |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The PI visited the lab of Olivier Raineteau in Lyons for a workshop to exchange research ideas. This led to new collaborations. |
Year(s) Of Engagement Activity | 2016 |
Description | Visits by Silvia Lima Costa and Suzanna Braga July-Aug 2017 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Brazilian colleagues visited my labs and we held a workshop for the exchange of ideas, resulting in lively discussions and future collaborations. |
Year(s) Of Engagement Activity | 2017 |
Description | Workshop Portsmouth-Bahia, Brazil July 2019 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Oral presentations that sparked questions and discussions and future collaborations |
Year(s) Of Engagement Activity | 2019 |
Description | iBrain Lecture University of Dusseldorf |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Postgraduate students |
Results and Impact | Presentation of new data on brain ageing and pharmaceutical interventions, which sparked questions and discussions afterwards. |
Year(s) Of Engagement Activity | 2017 |