A new vessel in the fleet: exploring how enteric tracheal plasticity drives metabolic adaptation in Drosophila
Lead Research Organisation:
Imperial College London
Department Name: Institute of Clinical Sciences
Abstract
Our gastrointestinal tract has important functions that go beyond digesting the food we eat. It can also communicate with organs such as the brain to change our appetite or how our body stores excess nutrients. This communication is, however, incompletely understood; what kind of information is the digestive tract able to sense, and how can it relay it to other organs? If we were able to understand better how this happens, it may be possible to use drugs to "trick" the digestive system into making us eat less or get less fat. Investigating this in humans or model systems such as mice is complex, however; they have many cells of many different kinds that are not always easy to probe to identify the ones that matter, and to understand how they signal or receive information. Instead, we tackle this question in the fruit fly Drosophila melanogaster: a simpler model system that shares 60% of our genes. Drosophila has a functionally sophisticated yet genetically tractable digestive tract. We recently found that the fly vessels that, like our vascular system, deliver oxygen to the gut cells play an important and previously unrecognized role in this communication. Indeed, these vessels -the so-called trachea- change their branching in response to specific nutrients. This somehow allows flies to cope with malnutrition and also affects how much fat they store in their bodies. This proposal seeks to understand what the branching of trachea does to other gut cells and how these gut cells, in turn, are able to affect metabolism and the fly's response to malnutrition. Our experimental design will first take an unbiased approach to characterize how differences in tracheal branching affect the expression of genes in the gut, and will then focus on a subset of these changes to understand how they affect the metabolism of the gut cells and their signalling to other organs. We anticipate that our research will both shed light on fundamental mechanisms of inter-organ communication and also identify potential new drug targets for the treament of nutrition-related diseases and conditions.
Technical Summary
Incompletely understood signals and metabolic adaptations emanating from the gastrointestinal tract contribute to both increasingly prevalent metabolic disorders as well as to the sustained metabolic improvements resulting from bariatric surgery. Our previous work has made use of the analogous, yet genetically tractable, digestive system of the fruit fly Drosophila melanogaster to explore the mechanisms by which this organ communicates with other internal organs to maintain homeostasis. Our recent work identified an important and previously unrecognized role for enteric trachea (the fly vessels that, like our vascular system, deliver oxygen to the gut cells) in driving metabolic adaptations to malnutrition that enhance survival. This proposal will now seek to identify and characterize the intestinal changes responsible for these adaptations. Temporally and spatially restricted genetic manipulations of enteric tracheal branching will be combined with tissue-specific transcriptional profiling of the Drosophila midgut to provide a comprehensive characterisation of how tracheal plasticity impacts intestinal gene expression. Subsequent work will focus on a subset of these changes to establish how these intestinal adaptations modulate organismal physiology. We anticipate that our research will both shed light on fundamental mechanisms of inter-organ communication and also identify potential new drug targets for the treament of nutrition-related diseases and conditions.
Planned Impact
The research will contribute to the nation's culture, and has the potential to generate wealth and improve health:
1. Culture. We will continue to reach out to public audiences through engaging presentations and innovative workshop formats in order to increase their awareness of the utility of fruit flies as model systems for biomedical research. Specific activities will include:
a) My participation in workshops such as the recent "Fabrics of life" workshop where I and other scientists disseminated the latest in scientific research to the arts community. During the 2014 "Big Data"-themed event, I engaged with architecture and textile design students and professionals, and students had the chance to brainstorm ways of translating scientific principles into design models.
b) My team's and/or my own contribution to hands-on activities for the general public, implemented within the framework of the annual Imperial College festival, the National Science & Engineering week, local school visits and the bi-annual school workshops in the Imperial College Teaching Labs. These will allow the general public to meet scientists and learn about their daily work. Modules will be based on the research outlined in this proposal, and will be aimed at highlighting the similarities between the digestive and vascular/respiratory systems of flies and humans, as well as their physiological significance. We have previously run - and evaluated quantitatively - similar activities, and we know that they can help bridge the gap between scientists and the general public.
2. Health. This project has the potential to identify genes and pathways which could become drug targets for the treatment of malnutrition or metabolic disorders involving the digestive tract. The impact of this has the potential to be very high, given the high prevalence of these disorders. Indeed, there are ca. 925 million undernourished people in the world, most of them in the developing world. At the same time, the worldwide prevalence of obesity has recently doubled and 35% of adults aged 20+ (most of whom are found in developed countries) are now overweight.
3. Economy. The proposed research has the potential to foster the economic competitiveness of the UK by providing candidate intestinal drug targets for the treatment of the abovementioned disorders. British biotech companies such as Alimentary Innervations or GSK have R&D departments devoted to the development of such targets. As soon as we foresee that any of our results may have commercial implications, we will liaise with Imperial Innovations: Imperial College's technology transfer company. Services provided to academics include the identification, protection and licensing of IP; support, advice and mentoring in the creation of new companies; and provision of seed funds and links to organisations
providing further funding.
1. Culture. We will continue to reach out to public audiences through engaging presentations and innovative workshop formats in order to increase their awareness of the utility of fruit flies as model systems for biomedical research. Specific activities will include:
a) My participation in workshops such as the recent "Fabrics of life" workshop where I and other scientists disseminated the latest in scientific research to the arts community. During the 2014 "Big Data"-themed event, I engaged with architecture and textile design students and professionals, and students had the chance to brainstorm ways of translating scientific principles into design models.
b) My team's and/or my own contribution to hands-on activities for the general public, implemented within the framework of the annual Imperial College festival, the National Science & Engineering week, local school visits and the bi-annual school workshops in the Imperial College Teaching Labs. These will allow the general public to meet scientists and learn about their daily work. Modules will be based on the research outlined in this proposal, and will be aimed at highlighting the similarities between the digestive and vascular/respiratory systems of flies and humans, as well as their physiological significance. We have previously run - and evaluated quantitatively - similar activities, and we know that they can help bridge the gap between scientists and the general public.
2. Health. This project has the potential to identify genes and pathways which could become drug targets for the treatment of malnutrition or metabolic disorders involving the digestive tract. The impact of this has the potential to be very high, given the high prevalence of these disorders. Indeed, there are ca. 925 million undernourished people in the world, most of them in the developing world. At the same time, the worldwide prevalence of obesity has recently doubled and 35% of adults aged 20+ (most of whom are found in developed countries) are now overweight.
3. Economy. The proposed research has the potential to foster the economic competitiveness of the UK by providing candidate intestinal drug targets for the treatment of the abovementioned disorders. British biotech companies such as Alimentary Innervations or GSK have R&D departments devoted to the development of such targets. As soon as we foresee that any of our results may have commercial implications, we will liaise with Imperial Innovations: Imperial College's technology transfer company. Services provided to academics include the identification, protection and licensing of IP; support, advice and mentoring in the creation of new companies; and provision of seed funds and links to organisations
providing further funding.
People |
ORCID iD |
Irene Miguel-Aliaga (Principal Investigator) |
Publications
Miguel-Aliaga, I
(2022)
Let's talk about (biological) sex
in Nat Rev Mol Cell Biol
Kim S
(2021)
Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila
in Cell Metabolism
Millington JW
(2021)
Female-biased upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity.
in eLife
Mineo A
(2021)
Defend or reproduce? Muscle-derived glutamate determines an immune-reproductive energetic tradeoff.
in Cell metabolism
Hiiragi T
(2021)
20 years of Developmental Cell: Looking forward.
in Developmental cell
Cable J
(2021)
Metabolic decisions in development and disease-a Keystone Symposia report.
in Annals of the New York Academy of Sciences
Hadjieconomou D
(2020)
Enteric neurons increase maternal food intake during reproduction.
in Nature
Redhai S
(2020)
An intestinal zinc sensor regulates food intake and developmental growth.
in Nature
Ameku T
(2020)
Food, microbes, sex and old age: on the plasticity of gastrointestinal innervation
in Current Opinion in Neurobiology
Brown K
(2020)
An interview with Irene Miguel-Aliaga.
in Development (Cambridge, England)
Title | BBC Radio 4 interview |
Description | BBC Radio 4 interview |
Type Of Art | Performance (Music, Dance, Drama, etc) |
Year Produced | 2016 |
Impact | n/a |
URL | http://www.bbc.co.uk/programmes/b0713p30 |
Title | BBC audio slideshow |
Description | BBC audio slideshow |
Type Of Art | Image |
Year Produced | 2011 |
Impact | n/a |
URL | http://www.bbc.co.uk/news/science-environment-12686745 |
Title | Contributed images to "The Cell: An Image Library" |
Description | Contributed images to "The Cell: An Image Library" |
Type Of Art | Image |
Year Produced | 2012 |
Impact | n/a |
URL | http://www.cellimagelibrary.org/ |
Title | Contributed images to the University of Cambridge's 800th anniversary light show. One of them was also the exclusive image used for the posters and flyers advertising the event |
Description | Contributed images to the University of Cambridge's 800th anniversary light show. One of them was also the exclusive image used for the posters and flyers advertising the event |
Type Of Art | Image |
Year Produced | 2010 |
Impact | n/a |
Title | Contributed video to Imagine Science Films Festival |
Description | Contributed video to Imagine Science Films Festival |
Type Of Art | Image |
Year Produced | 2014 |
Impact | n/a |
URL | http://old.imaginesciencefilms.org/events/neural-imagining-the-brain-seen-on-film/ |
Title | My lab contributed a video to the University of Cambridge "Under the microscope" series, accessible on YouTube |
Description | My lab contributed a video to the University of Cambridge "Under the microscope" series, accessible on YouTube |
Type Of Art | Film/Video/Animation |
Year Produced | 2012 |
Impact | n/a |
URL | http://www.youtube.com/watch?v=CDg2Keu3HT8 |
Description | We have found that the gastrointestinal tract is highly adaptable and can change and resize in response to different situations (e.g. food availability). Interestingly it does so differently in males and females. |
Exploitation Route | Our findings may help explain why some disorders are more prevalent in males or females, and underscore the need to study the effects of any therapeutic intervention in both genders. |
Sectors | Healthcare,Culture, Heritage, Museums and Collections |
URL | http://www.miguelaliagalab.com/ |
Description | Our ongoing analysis of how the gut adapts to various situations including reduced tracheation has revealed unexpected sex differences in intestinal physiology, some of which we recently published in the journal Nature. They have been covered by radio and newspapers internationally and have resulted in multiple invitations to speak at many conferences. We are also making the public aware of such differences though several of our public engagement initiatives (listed under the relevant section) |
First Year Of Impact | 2017 |
Sector | Education,Culture, Heritage, Museums and Collections |
Impact Types | Cultural,Societal |
Description | CSC Institute Planning and Operations Team member |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | Imporvements in research budget expenditure |
Description | Deputy Chair of Athena Swan Opportunities committee |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Membership of a guideline committee |
Impact | Maximise opportunity for women and otehr minorities |
Description | Member of BBSRC Pool of Experts |
Geographic Reach | National |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | How research budget is allocated - optimised value for money |
Description | Member of Faculty of Medicine Imperial College Research Fellowships Panel |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Membership of a guideline committee |
Description | Member of Imperial College European Advisory Group |
Geographic Reach | Europe |
Policy Influence Type | Membership of a guideline committee |
Description | Member of Wellcome Trust Pool of Prospective Committee Members |
Geographic Reach | National |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | Research budget allocation - imporved value for money |
Description | Member of promotion panel, Institut Curie, Paris, France |
Geographic Reach | Europe |
Policy Influence Type | Membership of a guideline committee |
Description | Postdoctoral mentor to Dr S Chakrabarti |
Geographic Reach | Asia |
Policy Influence Type | Influenced training of practitioners or researchers |
Description | Postdoctoral mentor to Dr Santiago Vernia |
Geographic Reach | Local/Municipal/Regional |
Policy Influence Type | Influenced training of practitioners or researchers |
Description | Bruno Hudry EMBO Advanced Fellowship |
Amount | £82,096 (GBP) |
Organisation | European Molecular Biology Organisation |
Sector | Charity/Non Profit |
Country | Germany |
Start | 01/2016 |
End | 01/2018 |
Description | IntraGutSex |
Amount | € 2,485,217 (EUR) |
Funding ID | ERCAdG 787470 "IntraGutSex" |
Organisation | European Research Council (ERC) |
Sector | Public |
Country | Belgium |
Start | 09/2018 |
End | 09/2023 |
Description | Postdoctoral Fellowship to Tomotsune Ameku |
Amount | £82,600 (GBP) |
Organisation | Japan Society for the Promotion of Science (JSPS) |
Sector | Public |
Country | Japan |
Start | 04/2018 |
End | 04/2020 |
Title | Collection of Data: Transcriptional datasets in Hudry et al 2016 Nature |
Description | Hudry, B., Khadayate, S., Miguel-Aliaga, I. (2016) The sexual identity of adult intestinal stem cells controls organ size and plasticity. Nature 530:344-8. Recommended in F1000 and highlighted by Cell Stem Cell Preview, Curr Biol Dispatch and Nature News and Views |
Type Of Material | Database/Collection of data |
Provided To Others? | No |
Impact | n/a |
Description | E A Bach |
Organisation | New York University |
Country | United States |
Sector | Academic/University |
PI Contribution | Exchanged scientific data and conducted experiments. |
Collaborator Contribution | Exchanged scientific data and conducted experiments. |
Impact | Chinmo prevents transformer alternative splicing to maintain male sex identity. |
Start Year | 2018 |
Description | J Y Yew |
Organisation | Temasek Polytechnic |
Country | Singapore |
Sector | Academic/University |
PI Contribution | Exchanged scientific data and conducted experiments. |
Collaborator Contribution | Exchanged scientific data and conducted experiments. |
Impact | Endocrine remodelling of the adult intestine sustains reproduction in Drosophila. |
Start Year | 2015 |
Description | K B Jensen |
Organisation | University of Copenhagen |
Department | Biotech Research and Innovation Center (BRIC) |
Country | Denmark |
Sector | Academic/University |
PI Contribution | Exchanged scientific data and conducted experiments. |
Collaborator Contribution | Exchanged scientific data and conducted experiments. |
Impact | Ret receptor tyrosine kinase sustains proliferation and tissue maturation in intestinal epithelia. |
Start Year | 2017 |
Description | Nikolai Windbichler |
Organisation | Imperial College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Exchanged scientific data and conducted experiments. |
Collaborator Contribution | Cultural, societal |
Impact | n/a |
Start Year | 2015 |
Description | Y N Jan |
Organisation | Howard Hughes Medical Institute |
Country | United States |
Sector | Charity/Non Profit |
PI Contribution | Exchanged scientific data and conducted experiments. |
Collaborator Contribution | Exchanged scientific data and conducted experiments. |
Impact | The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion. |
Start Year | 2015 |
Description | "Gastronauts 2020: A Symposium for Gut-Brain Matters", Nantes, France. |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | "Gastronauts 2020: A Symposium for Gut-Brain Matters", Nantes, France. Symposium co-organiser. |
Year(s) Of Engagement Activity | 2020 |
URL | http://thinkgastronauts.com/nantes/ |
Description | 10th Meeting of the Latin American Society for Developmental Biology, Buenos Aires, Argentina. |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | 10th Meeting of the Latin American Society for Developmental Biology - Invited Speaker |
Year(s) Of Engagement Activity | 2019 |
URL | http://lasdb2019.com/ |
Description | 1st LMS/Helmholtz Munich Symposium on Metabolism, London, UK. |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | 1st LMS/Helmholtz Munich Symposium on Metabolism, London, UK. - Organiser |
Year(s) Of Engagement Activity | 2019 |
URL | https://lms.mrc.ac.uk/german-and-uk-scientists-forge-path-for-future-european-collaborations/ |
Description | 2020 Oxford Autumn School in Neuroscience (virtual) - invited speaker |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | 2020 Oxford Autumn School in Neuroscience (virtual) |
Year(s) Of Engagement Activity | 2020 |
URL | https://talks.ox.ac.uk/talks/id/22dd2e41-7bdd-4b3e-b0a2-8acb3e137ad8/ |
Description | 25th European Drosophilia Research Conference, London UK - Workshop co-organiser and Chair |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | 25th European Drosophilia Research Conference, London UK - Workshop co-organiser and Chair |
Year(s) Of Engagement Activity | 2017 |
Description | 27th European Drosophila Reseach Conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | 27th European Drosophila Reseach Conference - IGFL, Lyon. Workshop co-organiser and chair. |
Year(s) Of Engagement Activity | 2021 |
URL | https://edrc2021.sciencesconf.org/ |
Description | 6th Biennial Symposium on Growth and Reeneration - Invited Speaker |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | 6th Biennial Symposium on Growth and Reeneration - Invited 6th Biennial Symposium on Growth and Reeneration - Invited Speaker, Begur, Spain |
Year(s) Of Engagement Activity | 2021 |
Description | ASCB/EMBO Meeting Program Committee Member |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | ASCB/EMBO Meeting Program Committee Member |
Year(s) Of Engagement Activity | 2020 |
Description | ASCB/EMBO Meeting Program Committee Member and Symposium Chair (Virtual) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | ASCB/EMBO Meeting Program Committee Member and Symposium Chair (Virtual) |
Year(s) Of Engagement Activity | 2020,2021 |
URL | https://www.ascb.org/cellbiovirtual2020/program/ |
Description | BBC Radio 4 and World Service interviews |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Radio interview about our recent Nature paper |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.bbc.co.uk/programmes/b0713p30 |
Description | Contribution to "A Picture of Health" multimedia project. |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Contribution to "A Picture of Health" multimedia project. |
Year(s) Of Engagement Activity | 2021 |
URL | https://lms.mrc.ac.uk/public-engagement-2/science-arts-projects/a-picture-of-health/ |
Description | Contribution to EXP-editions, The Living Library of Knowledge |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Schools |
Results and Impact | How we contribute to research, culture, education and economic prosperity, for the benefit not just of the UK but of users and partners around the world |
Year(s) Of Engagement Activity | 2021 |
URL | https://exp-editions.com |
Description | Distinguished Seminar |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Beatson Institute, Glasgow UK. Distinguished Seminar (Virtual) |
Year(s) Of Engagement Activity | 2021 |
URL | http://www.beatson.gla.ac.uk/Seminars/seminars.html |
Description | EMBO Conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | EMBO Conference "Molecular and Develoipmental Biology of Droisophila" - Organising Committee Member |
Year(s) Of Engagement Activity | 2014,2015,2017,2018,2019 |
URL | http://events.embo.org/18-drosophila-crete/ |
Description | EMBO Conference "Molecular and Developmental Biology of Drosophila" |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | EMBO Conference "Molecular and Developmental Biology of Drosophila". Organising committee co-chair. |
Year(s) Of Engagement Activity | 2020 |
URL | http://events.embo.org/20-drosophila/ |
Description | EMBO Conference - Molecular and Developmental Biology of Drosophila - Organising Committee Co-Chair (2020-2026) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | EMBO Conference - Molecular and Developmental Biology of Drosophila - Organising Committee Co-Chair (2020-2026) |
Year(s) Of Engagement Activity | 2020,2021 |
URL | http://events.embo.org/20-drosophila/ |
Description | EMBO Symposium "Inter-organ Communication in Development and Disease", EMBL Heidelberg, Germany |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | EMBO Symposium "Inter-organ Communication in Development and Disease", EMBL Heidelberg, Germany. Symposium co-organiser |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.ascb.org/event/embo-embl-symposium-inter-organ-communication-in-physiology-and-disease/ |
Description | EMBO Workshop - Cell and Developmental Systems - Invited Speaker |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | EMBO Workshop - Cell and Developmental Systems - Invited Speaker - Arolla Switzerland |
Year(s) Of Engagement Activity | 2021 |
Description | EMBO meeting "Gender and Cancer Susceptibility". Les Diablerets, Switzerland. |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Third sector organisations |
Results and Impact | EMBO meeting "Gender and Cancer Susceptibility". Les Diablerets, Switzerland. |
Year(s) Of Engagement Activity | 2019 |
Description | EMBO-EMBL symposium "Inter-organ communication in physiology and disease", Heidelberg, Germany. Co-organiser. |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Co-organiser - EMBO-EMBL symposium "Inter-organ communication in physiology and disease", Heidelberg, Germany. |
Year(s) Of Engagement Activity | 2022 |
URL | https://iubmb.org/event/embo-embl-symposium-inter-organ-communication-in-physiology-and-disease/ |
Description | EMBO/EMBL Symposium - Metabolism Meets Epigenetics - Invited Speaker |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | EMBO/EMBL Symposium - Metabolism Meets Epigenetics - Invited Speaker, Heidlberg, Germany |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.embo-embl-symposia.org/symposia/2021/EES21-12/index.html |
Description | ERC Conference - invited speaker |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | ERC Conference - Gender Dimension in Research - invited speaker, Brussels, Belgium (virtua) |
Year(s) Of Engagement Activity | 2020 |
URL | https://erc.europa.eu/event/sex-and-gender-dimension-frontier-research |
Description | IST |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Invited Speaker - IST Vienna, Australia |
Year(s) Of Engagement Activity | 2021 |
URL | https://ist.ac.at/en/home/ |
Description | Imperial Festival |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | We contributed an interactive installation to demonstrate the use of Drosophila to replace and reduce animal experimentation |
Year(s) Of Engagement Activity | 2018 |
URL | http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/eventssummary/event_17-8-2017-12-52-36 |
Description | Imperial Fringe: Food of Tomorrow event |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Public/other audiences |
Results and Impact | An evening on the future of food and how we will feed the next generation. Food of tomorrow was the latest in Imperial College's Fringe series of public evening events exploring the livelier side of science. Based on the College's ground-breaking research, the Fringe programme runs throughout the year to give our friends and supporters an opportunity to meet our researchers and find out more about our work. |
Year(s) Of Engagement Activity | 2016 |
Description | Insect Hormone Workshop - International Advisory Committee Member |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | International Advisory Committee Member |
Year(s) Of Engagement Activity | 2021 |
URL | https://insecthormones.org/ |
Description | International Insect Hormone Meeting. Member of the International Organizing Committee. |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | International Insect Hormone Meeting. Member of the International Organizing Committee. |
Year(s) Of Engagement Activity | 2019 |
URL | https://insecthormones.org/ |
Description | International Society of Developmental Biology (ISDB) Congress - Invited Speaker |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | International Society of Developmental Biology (ISDB) Congress - Invited Speaker - Algarve, Portugal |
Year(s) Of Engagement Activity | 2021 |
URL | https://isdb2021.com/ |
Description | Janelia Workshop - Invited Speaker |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Janelia Workshop on Ceullar Mechanisms of Brain-Body Interactions (virtual) - invited speaker |
Year(s) Of Engagement Activity | 2021 |
URL | https://janeliaconf.smapply.io/prog/CMBBI/ |
Description | Keystone Symposium - Metabolic Decisions in Development and Disease |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Keystone Symposium "Metabolic Decisions in Development and Disease" - Symposium Co-Organiser |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.keystonesymposia.org/ks/Online/Events/2021C6/Details.aspx?EventKey=2021C6 |
Description | Keystone Virtual Symposium - "Metabolic Decisions in Development and Disease" |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Keystone Virtual Symposium - "Metabolic Decisions in Development and Disease" - Co-Organiser . Santa Fe, New Mexico. USA |
Year(s) Of Engagement Activity | 2021 |
URL | https://virtual.keystonesymposia.org/ks/live/653/page/5413 |
Description | Lecturer, "Human Culture: the human experience of materials applied to eating food" post-graduate student project, Design Products (Royal College of Art). |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Undergraduate students |
Results and Impact | n/a |
Year(s) Of Engagement Activity | 2016 |
Description | Meeting Co-Organiser - "Gastonauts: A Symposium for Gut-Brain Matters" |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Meeting Co-Organiser - "Gastonauts: A Symposium for Gut-Brain Matters", Nantes, France. |
Year(s) Of Engagement Activity | 2021 |
URL | https://www.sciencesconf.org/browse/conference/?confid=8608 |
Description | Meeting Organiser - EMBO-EMBL Symposium "Inter-organ communication in physiology and disease" |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Meeting Organiser - EMBO-EMBL Symposium "Inter-organ communication in physiology and disease", Heidelberg. Germany. Co-Organiser. |
Year(s) Of Engagement Activity | 2020,2021 |
URL | https://www.embo-embl-symposia.org/symposia/2020/EES20-02/ |
Description | My lab contributed a talk to the University of the Third Age visit |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | n/a |
Year(s) Of Engagement Activity | 2016 |
Description | Nature paper press coverage |
Form Of Engagement Activity | A magazine, newsletter or online publication |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | Wide press coverage for our 2016 Nature paper. Achieved an Altmetric = 270. Daily Telegraph - p7 i (the paper for today) - p2 Press and Journal (Scotland) - p15 Daily Mail (online only) - http://www.dailymail.co.uk/sciencetech/article-3451482/Organs-know-male-female.html Medical News Today - http://www.medicalnewstoday.com/articles/306695.php Medical Xpress - http://medicalxpress.com/news/2016-02-deeper-sexual-nature.html Yahoo! News - https://uk.news.yahoo.com/organ-stem-cells-sexual-identity-181117114.html BT.com - http://home.bt.com/news/science-news/organ-stem-cells-have-sexual-identity-11364040903895 Irish Examiner - http://www.irishexaminer.com/examviral/science-world/organ-stem-cells-have-sexual-identity-382540.html CBS Radio News Internaitonal press |
Year(s) Of Engagement Activity | 2016 |
Description | Pint of Science 2019 event: "Tomorrow's medicine, today!" |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Public/other audiences |
Results and Impact | Lab contribution to Pint of Science 2019 event: "Tomorrow's medicine, today!" |
Year(s) Of Engagement Activity | 2019 |
URL | https://pintofscience.co.uk/event/how-did-we-become-us |
Description | Rank Prize Symposium |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | "Exploring the impact of Nutrition on the Ageing Process" - invited speaker, Grasmere, UK |
Year(s) Of Engagement Activity | 2021 |
URL | http://www.rankprize.org/index.php/symposia |
Description | Seminar Series - Cambridge |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Developmental Biology Seminar Series (virtual) - University of Cambridge, UK |
Year(s) Of Engagement Activity | 2021 |
URL | https://talks.cam.ac.uk/talk/index/156601 |
Description | Webinar Series |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | "Frontiers in Biology", Stanford University, USA |
Year(s) Of Engagement Activity | 2021 |
URL | https://frontiers-in-biology.stanford.edu/ |
Description | Workshop co-organiser. Brainy Tongue: The Sensory Logic of the Gastronomic Brain, San Sebastian, Spain, featuring world-renowned chefs and neurobiologists. Included open session featured by media worldwide |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | n/a |
Year(s) Of Engagement Activity | 2016 |
URL | http://www.bbc.co.uk/news/business-37800097 |