How the gut reacts to stress: changes in intestinal stem cell behaviour in response to perturbation of the enteric nervous system.
Lead Research Organisation:
Quadram Institute
Department Name: Gut Health and Food Safety
Abstract
France
People |
ORCID iD |
Maria Pin Arias (Principal Investigator) |
Description | We have discovered that proliferation of small intestinal cells is enhanced in situations of chronic stress |
Exploitation Route | By elucidating the mechanisms of interaction between the enteric nervous system and the epithelium, new strategies could be developed to reduce the impact of nervous stress on inflammatory bowel disease patients |
Sectors | Healthcare Pharmaceuticals and Medical Biotechnology |
Description | Michel Neunlist |
Organisation | National Institute of Health and Medical Research (INSERM) |
Department | DR2 INSERM |
Country | France |
Sector | Public |
PI Contribution | Mathematical modelling of epithelial stem cell proliferation and differentiation during acute and chronic stress |
Collaborator Contribution | Technology to experimentally evaluate the enteric nervous system and confocal microscopy |
Impact | N/A |
Start Year | 2015 |