The development of novel AOX inhibitors for the cacao pathogen Moniliophthora perniciosa
Lead Research Organisation:
University of Sussex
Department Name: Sch of Life Sciences
Abstract
Brazil
People |
ORCID iD |
Anthony Moore (Principal Investigator) |
Description | This grant was for a travel award to enable Professor Moore to visit UNICAMP, Campinas Brazil to discuss the opportunities for a collaboration with Prof. Pieriera on testing our current anti-fungals on the fungus Witches broom which attacks the cocoa plant. We also discussed the long term possibility that should the anti-fungals prove successful what commercialisation routes would be available in Brazil. I met a graduate student whilst at UNICAMP and we discussed the possibility for this student spending 6 months in my laboratory to purify the fungal protein and check inhibitor sensitivity. |
Exploitation Route | We arranged for Mario Barsottini to come to Brighton for 6 months the outcome of which proved highly successful in the development of novel techniques to rapidly assay the effect of these inhibitors on Moniliophthora perniciosa |
Sectors | Agriculture Food and Drink |
Description | Expression and purification of M. perniciosa AOX |
Organisation | State University of Campinas |
Country | Brazil |
Sector | Academic/University |
PI Contribution | We have provided both the expertise, intellectual input and trained the staff. We have taught them how to successfully express rAOX |
Collaborator Contribution | They have provided the intellectual expertise on understanding the nature of the M. perinciosa pathogen. |
Impact | Outcomes include the successful identification of inhibitors which can inhibit the growth of M. perniciosa and the submission of a grant to cover joint travel expenses between Brazil and Uk covered by BBSRC-FAPESP memorandum of Agreement. |
Start Year | 2017 |
Company Name | AlternOx Scientific |
Description | AlternOx Scientific develops treatments for drug-resistant fungal species. |
Year Established | 2020 |
Impact | None yet - only established in Feb 2020. |
Website | https://www.alternox.com/ |