India Partnering Award: Exploiting the microbial diversity of the Sundarbans mangrove delta to tackle infectious disease
Lead Research Organisation:
University of Birmingham
Department Name: Sch of Biosciences
Abstract
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People |
ORCID iD |
| Apoorva Bhatt (Principal Investigator) | |
| Robin May (Co-Investigator) |
| Description | The project studies isolatesfrom the Sundarbans delta in India, that produce antimicrobials. The award has allowed exchange of research staff, and a visiting postdoctoral scientist from Calcutta was able to visit Birmingham to isolate an active component from this strain that not only shows anti-mycobnacterial acitivity (agaisnt the tuberculosis causing pathogen), but also anti-fungal activity against a pathogenic fungus, Cryptococcus. |
| Exploitation Route | The new antibacterial and anti fungal discovered during this award set the stage for further characterisation and exploitation of these bioactive compounds. Furthermore, an additional discovery of silent cluster being induced by mycobacterial cell wall components sets the stage for deciphering this process and a potential grant application to the BBSRC. The outputs of this grant are currently written up as a manuscript for publication. |
| Sectors | Pharmaceuticals and Medical Biotechnology |
| Title | Draft Genome Sequence of Bioactive Strain Streptomyces sp. SMS_SU21, Isolated from Soil Sediment of the Sundarbans Mangrove Ecosystem |
| Description | Draft Genome Sequence of Bioactive Strain Streptomyces sp. SMS_SU21, Isolated from Soil Sediment of the Sundarbans Mangrove Ecosystem |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| Impact | The genome sequence has advanced our understanding of the potential of this strain to produce antimicrobials and now allows us to probe individual clusters to identify the anti bacterial and anti fungal produced by this actinomycete. |
| Description | Characterisation of natural products with bioactivity against pathogenic mycobacteria. |
| Organisation | University of Warwick |
| Department | Department of Chemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have provided the main antibacterial producer isolated from the Sundarbans by Dr.Sengupta and genomic data for the same. |
| Collaborator Contribution | Dr.Manuela Tosin was able to characterise the antimycobacterial using biochemical analytical techniques, including NMR, to provide a chemical structure for the bioactive compound. |
| Impact | We have currently written up a manuscript for publication, following which we intend to apply for funding to the BBSRC. |
| Start Year | 2020 |