Gen2NCE - a genomics-driven platform for novel bioactive natural product discovery
Lead Research Organisation:
University of Warwick
Department Name: Chemistry
Abstract
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Organisations
People |
ORCID iD |
Gregory Challis (Principal Investigator) |
Description | The aim of this project was to obtain a full market and IP landscape on technology that was developed during a previous BBSRC-funded project. We have found that there are no existing filed patents that would prevent us from using our technology in an industrial setting. Also from the market research that was performed in this project we have learnt a lot about the costs of developing new pharmaceuticals and agrochemicals. This has allowed us to position our technology to allow us to spin out a company to support these two industries. We were also able to begin some early discussions with a range of agrochemical partners. From the findings of this grant we were able to apply for a BBSRC follow on fund grant to allow us to develop specific aspects of our platform. |
Exploitation Route | Using the results of this project and with further support from ICURe and the Warwick impact Fund we have spun out a new company Erebagen, which will be looking to exploit the technology to support drug and agrochemical discovery. We have been able to apply for Innovate UK follow on funding to allow us to begin activities as a company. The IP landscaping work performed in this grant has demonstrated key areas of our technology where we have an advantage over others working in the sector and in July 2020 we filed a patent application to protect elements of the technology. |
Sectors | Agriculture Food and Drink Pharmaceuticals and Medical Biotechnology |
Description | To establish a spin out company. |
First Year Of Impact | 2020 |
Sector | Agriculture, Food and Drink,Pharmaceuticals and Medical Biotechnology |
Impact Types | Economic |
Description | GEN2NCE - a synthetic biology platform for natural product discovery |
Amount | £198,477 (GBP) |
Funding ID | BB/T017163/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 07/2020 |
End | 03/2022 |
Description | ICURe Follow on Funding Grant |
Amount | £209,834 (GBP) |
Funding ID | 44930 |
Organisation | Innovate UK |
Sector | Public |
Country | United Kingdom |
Start | 08/2021 |
End | 08/2023 |
Title | METHOD FOR SCREENING FOR BIOACTIVE NATURAL PRODUCTS |
Description | The present invention relates to methods for screening for the presence of a biosynthetic gene cluster (BGC) in a cell, via the identification of proximal positive 5 regulatory genes, e.g. large ATP-binding regulators of the LuxR family (LAL) genes. |
IP Reference | US2023295612 |
Protection | Patent / Patent application |
Year Protection Granted | 2023 |
Licensed | Yes |
Impact | Licensed to Erebagen Ltd, who are further developing the intellectual property |
Company Name | Erebagen |
Description | Erebagen develops software that uses bioinformatics to discover compounds for pharmaceuticals development. |
Year Established | 2020 |
Impact | 2 FTE scientific post currently in the company. |