UK-China partnership: Chromosomal Instability aiding Genetic Variants (CIVa) linked to human ageing
Lead Research Organisation:
Queen Mary University of London
Department Name: Sch of Biological & Behavioural Sciences
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Dang D
(2023)
Deep learning techniques and mathematical modeling allow 3D analysis of mitotic spindle dynamics.
in The Journal of cell biology
Efstathiou C
(2021)
Electrically tunable lenses - eliminating mechanical axial movements during high-speed 3D live imaging.
in Journal of cell science
Song X
(2021)
Counteraction between Astrin-PP1 and Cyclin-B-CDK1 pathways protects chromosome-microtubule attachments independent of biorientation
in Nature Communications
Description | Islam et al., 2024 is a new publication of naturally occurring genetic variants, in ethnic populations, that can drive chromosomal instability seen in cancers. |
Exploitation Route | Through the workshops organised in Beijing, Tokyo and London, we have collaborative research papers. |
Sectors | Education Healthcare Other |
URL | http://www.draviamlab.uk/beijing_workshop.html |
Description | Cooperativity and forces in molecular interactions governing chromosome stability |
Amount | £717,412 (GBP) |
Funding ID | BB/X014975/1 |
Organisation | Queen Mary University of London |
Sector | Academic/University |
Country | United Kingdom |
Start | 01/2024 |
End | 01/2026 |
Description | High-throughput Lattice Light Sheet Microscopy : Imaging Across Scales. |
Amount | £386,205 (GBP) |
Funding ID | MR/X013847/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2022 |
End | 03/2023 |
Description | How are mono-oriented chromosome-microtubule attachments protected to prevent errors in mitosis and associated cellular ageing? |
Amount | £403,927 (GBP) |
Funding ID | BB/W002698/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 11/2022 |
End | 09/2025 |
Title | AI guided software SpinX |
Description | AI method to track spindle, chromosome, cell division and movements. |
Type Of Material | Technology assay or reagent |
Year Produced | 2023 |
Provided To Others? | Yes |
Impact | The software is now deployed in Zeiss Arivis |
URL | https://doi.org/10.1083/jcb.202111094 |
Description | Cell Dynamics And Chromosomal Stability Workshop |
Organisation | Tohoku University |
Country | Japan |
Sector | Academic/University |
PI Contribution | Workshop held with collaborators (UK, Japan, China, Switzerland researchers) |
Collaborator Contribution | Talks, exchange of ideas. |
Impact | Manuscript being prepared with Tanaka group, Tohoku. A software solution developed and explained for their purpose. |
Start Year | 2023 |
Description | How are mono-oriented chromosome-microtubule attachments protected to prevent errors in mitosis and associated cellular ageing? |
Organisation | Queen Mary University of London |
Department | School of Biological and Chemical Science QMUL |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Conducted Super-resolution imaging; trained personnel on timelapse recording; and secured funding to expand the work. |
Collaborator Contribution | Comparison across model systems; modelling of structures |
Impact | Funding: https://gtr.ukri.org/projects?ref=BB%2FW002698%2F1 |
Start Year | 2022 |
Description | Interview with BBC Radio4 (international via BBC sounds) |
Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | BBC Radio 4 Today program discussed advances in Cell Biology, Healthcare through microscopy and image analysis supported by breakthroughs in Artificial Intelligence, and long-term live imaging. |
Year(s) Of Engagement Activity | 2024 |
URL | https://www.linkedin.com/posts/viji-m-draviam-sastry-ab189a3_ai-drugdevelopment-activity-71476183283... |
Description | Online seminars with Beijing Agricultural university |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | 30 researchers attended an online meeting to discuss human variants. |
Year(s) Of Engagement Activity | 2009,2021 |
Description | Workshop for international visibility |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Dr Wu presented movies generated using the Lattice Light Sheet (LLS7) Microscope (recently funded using the MRC-Alert call) and Elyra super-resolution microscope (funded by the BBSRC Alert call) |
Year(s) Of Engagement Activity | 2024 |
URL | http://www.draviamlab.uk/london_workshop_2024_March.html |