Development and exploitation of animal biotechnologies
Lead Research Organisation:
University of Edinburgh
Department Name: The Roslin Institute
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
Genetic modification in the mouse has provided increasingly sophisticated tools for investigating all aspects of development and physiology of this model vertebrate. The Roslin Institute has a strong track record in development and application of genetic modification technologies in farm animal species. These have provided powerful tools to answer fundamental biological questions while at the same time providing the platform for the development of novel commercial opportunities. This theme aims to enhance animal transgenesis through novel stem cell based approaches and direct embryo manipulation methodologies. We will exploit novel strategies for animal stem cell derivation, based on the induction of pluripotent stem cells (iPS cells) by expression of key transcription factors in differentiated cells, as exemplified by Takahashi and Yamanaka. We will develop robust culture protocols for such cells and use them as tools for genetic modification and develop differentiation protocols, for applications in animal production and basic bioscience underpinning animal and human health. In parallel, for poultry, we have established and advanced the culture of chicken primordial germ cells, the precursors of the gametes, which will enable us to develop cell-based methods for genetic modification of poultry. We will develop more sophisticated genetic modification technologies, using these novel cell-based systems and by direct in vivo manipulation, including gene knockout and gene targeting in pigs, sheep, cattle and poultry. These technologies will be applied in a wide range of programmes, in collaborative projects, jointly with other ISPs, external collaborators and industry.
Planned Impact
unavailable
Organisations
- University of Edinburgh (Lead Research Organisation)
- National University of San Martin (Collaboration)
- University of Maryland, College Park (Collaboration)
- Centre for Process Innovation (CPI) (Collaboration)
- Cobb Europe (Collaboration)
- Genus plc (Collaboration)
- University of Turin (Collaboration)
- Washington State University (Collaboration)
- UNIVERSITY OF DUNDEE (Collaboration)
- École Normale Supérieure, Paris (Collaboration)
- French National Institute of Agricultural Research (Collaboration)
- BioSourcing SA (Collaboration)
Publications
Alton EW
(2014)
Toxicology study assessing efficacy and safety of repeated administration of lipid/DNA complexes to mouse lung.
in Gene therapy
Amilon KR
(2018)
Generation of Functional Myocytes from Equine Induced Pluripotent Stem Cells.
in Cellular reprogramming
Arends MJ
(2016)
Animal and cellular models of human disease.
in The Journal of pathology
Ballantyne M
(2021)
Avian Primordial Germ Cells Are Bipotent for Male or Female Gametogenesis.
in Frontiers in cell and developmental biology
Breton A
(2013)
Derivation and characterization of induced pluripotent stem cells from equine fibroblasts.
in Stem cells and development
Bruce A
(2013)
Novel GM animal technologies and their governance.
in Transgenic research
Burkard C
(2018)
Pigs Lacking the Scavenger Receptor Cysteine-Rich Domain 5 of CD163 Are Resistant to Porcine Reproductive and Respiratory Syndrome Virus 1 Infection.
in Journal of virology
| Title | Photography |
| Description | Photographs for the new website of The Genetics Society from 2016 to present. |
| Type Of Art | Image |
| Year Produced | 2016 |
| Impact | Impact through all members of the Genetics Society, its website and social media. Also, conference photos. see: https://www.research.ed.ac.uk/portal/files/47857104/GS_Conference_DougV.jpg |
| URL | http://www.genetics.org.uk |
| Title | Posters: Chromatin, Epigenetics, and Transcriptional Regulation Meeting - UoE Network |
| Description | Poster for each meeting since 2014 |
| Type Of Art | Artwork |
| Year Produced | 2013 |
| Impact | Our network across five campuses (Roslin, IGMM, SCRM/QMRI, KB, BMS) connects more than 150 scientists working on related topics within the UoE, with the aim of promoting a strong research community. Meetings take place three times a year and are an opportunity for students, postdocs and PIs to present their work to a specialised audience for feedback and discussion. The meetings aim to foster dialogue between scientists of all levels and promote collaborations between the Edinburgh labs and Institutes. Network interaction between PIs, postdocs and PhD students will take place at the social after the talks (note to late-comers: HRB card entry is required after 6pm). Please see our posters on the notice boards. |
| URL | https://www.research.ed.ac.uk/portal/files/52878194/Poster_Douglas_Vernimmen_21_Feb_2018.jpg |
| Title | Promotional video for The Genetics Society |
| Description | Welcome to the Genetics Society! Our Learned Society acts to support and promote research and teaching of genetics in the UK. It covers the study of genomes, genes and gene action, and embraces scales ranging from the molecular and cellular to the population and ecosystem level. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2018 |
| Impact | The Genetics Society runs two scientific meetings a year, and provide funding for undergraduate summer projects, fieldwork, training, specialist interest groups, scientific meeting organisation, conference attendance and travel. We also award a number of named Medals and Prize Lectures to outstanding and distinguished geneticists each year. Our members come both from the UK and overseas: we maintain links with several genetics societies in other countries. Membership is open to anyone with an interest in genetics research or teaching. |
| URL | https://www.youtube.com/watch?v=AN3RIf2Aydk |
| Description | We have generated iPSCs from different large animal species and have demonstrated their ability to differentiate into several cell types that are relevant to important production and health traits in livestock. We have generated bovine iPSCs from multiple animals using an inducible viral expression vector and have successfully differentiated them into mammary-like cells that secrete milk proteins (Cravero et al., 2015). Our studies led to the generation for the first time of functional motorneurons and skeletal myotubes from equine iPSCs, and have continuing similar studies using bovine and porcine iPSCs which will provide in vitro systems to identify genes and genetic variants important for meat production in those species. We have generated an HPRT deficient rat as a model of the human neurological disorder Lesch-Nyhan Disease (Meek et al., 2016). The rats exhibit altered metabolism in the brain and loss of serotonin and dopamine - in line with some of the changes observed in brains of Lesch-Nyhan patients and HPRT deficient mice. In addition we have made the novel finding that female HPRT-deficient rats have reduced fertility, suggesting that engagement of the purine salvage pathway is essential for either oocyte maturation or early preimplantation embryonic development. Vitamin C (ascorbic acid), an essential antioxidant and enzyme cofactor, is a common supplement in media formulations used to maintain pluripotency in human ESCs and aid reprogramming of somatic cells to the pluripotent state. We have shown that vitamin C, but not its stereoisomer D-isoascorbic acid, increases the rate of growth and reduces background differentiation in rat ESC cultures. We also have evidence that vitamin C antagonises differentiation factors activated by Wnt/b-catenin signalling but not the Ras/MAPK pathway. We have determined that a novel ESC variant of the Gab1 signalling protein, which is involved in LIF receptor signalling and highly expressed in rodent stem cells, supports ESC survival and is dependent on membrane localisation of this adaptor protein. As well as using standard homologous recombination methodology to target genes in rat embryonic stem cells (ESCs), we have applied gene editing approaches to increase the efficiency of homology-dependent gene targeting. We used TALEN gene editors to promote homologous recombination and targeting of the rat genes for IAPP, CFTR, and neurotrophin receptor p75NTR. The efficiencies for these experiments ranged between 20-90%, thus greatly simplifying gene targeting protocols in rat ESC. We have also used Cre recombinase excision to modify targeted loci to eliminate selection cassettes and engineer point mutations (CFTR) and floxed exons (p75NTR). From these experiments we have generated transgenic rats carrying constitutive and conditional (floxed) alleles of p75NTR. We find that rats lacking the p75NTR protein through deletion of exon 2 of rat p75NTR are healthy and fertile. We have also generated a cystic fibrosis transmembrane conductance regulator (CFTR) knock-in rat that carries the G551D mutation. The G551D mutation is responsible for around 5% of mutant alleles in patients with cystic fibrosis (CF). These animals are being bred to homozygosity for phenotype characterisation. Using a combination of CRISPR/Cas9 and homology directed-repair in ovine zygotes, we have generated a transgenic sheep that is heterozygous for the G551D mutation. These animals will be bred to homozygosity and their phenotype characterised. Several novel and widely applicable fluorescent reporter transgenic chicken lines have been generated for use in developmental biology and infection studies: ubiquitous TdTomato for transplantation studies; lox-stop-loxGFP for CRE recombinase-activated lineage tracing; splitGFP to trace virus infection by delivery of complementary peptide by viruses that leads to GFP fluorescence in infected cells (utilising the support of the National Avian Research Facility). We have developed methods for efficient gene knockout and gene modification using artificial site-specific nucleases in chicken primordial germ cells. These genetic changes are recovered by injection of the genetically-altered primordial germ cells into host chicken embryos which are then incubated and hatched. When the resulting birds reach sexual maturity a proportion of their offspring carry the genetic change introduced at the chosen locus. We first demonstrated gene editing of primordial germ cells using zinc finger nucleases then produced targeted chickens carrying a knockout of the DDX4 gene using TALENs. We have more recently shown that the CRISPR-cas9 system can be used very efficiently to generate genetically-altered chickens with single nucleotide changes or introduction of specific additional sequences by homologous recombination. The development of these "genome-editing" technologies means that we now have very efficient methods for introduction of precise genetic changes in the chicken that are equivalent to those available in the mouse. We have similarly developed the use of zinc finger nucleases, TALENs and CRISPRs to generate gene targeted mutations and introduced exquisitely specific genetic changes in pigs and sheep. We have developed the technology for injection of zygotes from these species, resulting in high frequency of production of animals carrying heterozygous, double heterozygous and homozygous mutations at targeted loci. These technologies have been demonstrated to be applicable in development of animal models and we have made significant advances, in collaboration with another Roslin Institute BBSRC programme, in developing pigs with the potential for resistance to two major pathogens, African swine fever and porcine reproductive and respiratory virus. A further cross-programme collaboration has modelled the integration of genome editing into animal breeding. |
| Exploitation Route | Our research into aspects of isolation and propagation of embryonic stem cells will inform improvements to protocols for production of, for example, human ESCs. The technologies for derivation, differentiation and genome editing of large animal iPSCs will provide powerful in vitro models for the genetic dissection of important production traits in food production animals and the identification of appropriate intervention targets to increase food production. The technologies for genome editing of farmed animals may be transferred to other species of food production animals. The development of large animal models of human diseases will be utilised by the pharmaceutical industry in development and testing of new treatments. The potential of genome editing to confer valuable genetic traits will be incorporated in animal breeding programmes. |
| Sectors | Agriculture Food and Drink Pharmaceuticals and Medical Biotechnology |
| Description | Our work on the role of beta-catenin signalling in regulating the differentiation of rat embryonic stem cells contributed to the rational basis for the titration of the GSK3 inhibition in medium used to propagate naïve human embryonic stem cells. The potential for generating and using large animals of human genetic diseases, using the resources, skills and expertise only available at the Roslin Institute in the UK, is under discussion with potential collaborators and medical research funders. The development of genome edited chickens with mutations that when homozygous lead to production of sterile embryos is under development, with a commercial partner, as a route to production of hosts for recovering breeds from cultured primordial germ cells. The application of genome editing in pigs to develop animals that are resilient/resistant to major pathogens is progressing through cross-programme collaboration and with industry involvement. We have a wide programme in public dialogue relating to the regulatory, policy, animal welfare and public concerns relating to the application of genome engineering technologies in animal breeding. We maintain our commitment to openness in animal research and regularly discuss these technologies in this context. |
| Sector | Agriculture, Food and Drink |
| Impact Types | Policy & public services |
| Description | Global Challenges Research Fund Strategy Advisory Group |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| URL | http://www.rcuk.ac.uk/funding/gcrf/sagtor |
| Description | Nuffield genome editing project |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Description | RSB genome editing |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Description | Agri-tech Catalyst |
| Amount | £850,000 (GBP) |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2015 |
| End | 01/2018 |
| Description | BBSRC EastBio |
| Amount | £90,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 12/2019 |
| Description | CONICYT training grants |
| Amount | £179,600 (GBP) |
| Organisation | National Commission for Scientific and Technological Research (CONICYT) |
| Sector | Public |
| Country | Chile |
| Start | 01/2017 |
| End | 12/2020 |
| Description | Chromatin, Epigenetics and Transcriptional Regulation - UoE Network 2018 |
| Amount | £1,100 (GBP) |
| Organisation | University of Edinburgh |
| Department | The Institute for Academic Development (IAD) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 11/2017 |
| End | 07/2018 |
| Description | Coming of Age: The Legacy of Dolly at 20 |
| Amount | £5,000 (GBP) |
| Organisation | The Genetics Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2016 |
| End | 09/2016 |
| Description | EastBio |
| Amount | £98,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2015 |
| End | 12/2019 |
| Description | Fellowship |
| Amount | £129,999 (GBP) |
| Organisation | British Society for Haematology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2013 |
| End | 08/2017 |
| Description | General Scheme - Bruce Whitelaw - Preparation of reagents for vectorisation of RNA decoy vector into lentivirus vector |
| Amount | £22,126 (GBP) |
| Funding ID | WT 6001354 |
| Organisation | Genus plc |
| Sector | Private |
| Country | United Kingdom |
| Start | 05/2015 |
| End | 01/2016 |
| Description | General Scheme - Consortium - Gerry McLachlan for RI - The Development Collaboration (DCA) - funding amount confidential as stipulated by funder |
| Amount | £0 (GBP) |
| Funding ID | WH/3897302 |
| Organisation | Boehringer Ingelheim |
| Sector | Private |
| Country | Germany |
| Start | 07/2018 |
| End | 12/2022 |
| Description | General Scheme - consortium funding - Gerry McLachlan for RI - Lenti viral gene therapy (RCA) - funding amount confidential as stipulated by funder |
| Amount | £0 (GBP) |
| Funding ID | WH/3896880 |
| Organisation | Boehringer Ingelheim |
| Sector | Private |
| Country | Germany |
| Start | 07/2018 |
| End | 12/2020 |
| Description | Grants |
| Amount | £250,000 (GBP) |
| Organisation | Horserace Betting Levy Board |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2013 |
| End | 08/2017 |
| Description | Japan Partnering Award |
| Amount | £25,000 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2014 |
| End | 10/2018 |
| Description | Portfolio Awards - Consortium Funding - Gerry McLachlan for RI - Respiratory Gene Therapy Portfolio (RGTP) |
| Amount | £1,472,247 (GBP) |
| Funding ID | WH/3695144 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 09/2022 |
| Title | A sterile surrogate host chicken that can be used to revive cryopreserved chicken breeds |
| Description | We have developed a genetically modified chicken that can be used to revive cryopreserved chicken breeds. We used precision gene editing tools to produce a chicken with a mutation in the gene DDX4. When bred to homozygosity, the chicken does not produce any eggs. This sterile chicken can be used as a host recipient for the transplantation of oocytes from other breeds of chicken. When stem cells from a rare chicken breed are transplanted into embryos from this chicken, the offspring produced will be from the rare breed of chicken. |
| Type Of Material | Model of mechanisms or symptoms - non-mammalian in vivo |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| Impact | This research has led to a publication in a major scientific journal. Many press articles reported this discovery and reported the positive uses of gene editing technology for preserving rare breeds of chicken. We have communicated these results to our Japanese partner of our Japan Partner Award. This chicken is currently being used tested in an Innovate UK project to develop and resurrect a rare breed of chicken. |
| URL | https://www.theguardian.com/science/2017/feb/17/sterile-genetically-modified-chickens-protect-rare-b... |
| Title | Culturing of chicken stem cells for the cryopreservation of chicken breeds |
| Description | We have developed serum free culture conditions for propagating the stem cells that make sperm or eggs in chicken. These stem cells are taken from a chicken embryo and cultured in vitro to increase their numbers. These cells can then be cryopreserved safely and indefinitely. At a later time, the cells are introduced into a surrogate host embryo and the offspring from this host bird will come from the introduced cells. Our culture methods allows us to propagate these cells from any breed of chicken. These cells can be stored in liquid nitrogen and used to establish a frozen biobank for poultry breeds. |
| Type Of Material | Cell line |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | We have communicated this cell culture technology to many research laboratories with the goal that they would be able to replicate our findings and begin to biobank breeds of chicken using cultured stem cells. These laboratories are in Japan, Israel, UAE, Iran, France, Hungary, USA, Germany. We have worked closely through our Japan Partner Award with Dr Tagami's laboratory in Tsukuba so that his researchers could implement our cell culture methodology. |
| URL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682126/ |
| Title | In vitro Generation of pig macrophages from stem cells |
| Description | The generation of functionally active monocytes and macrophages from pluripotent pig stem cells |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2019 |
| Provided To Others? | No |
| Impact | This work may provide an in vitro experimental platform for: - Investigation of the pig innate immune system - Investigation of pig macrophage/pathogen interactions - Functional analysis of genetic variation in pigs |
| Title | Mutant rat carrying a floxed Neurotrophin p75NTR allele |
| Description | Neurotrophin p75NTR is involved in regulating neuronal survival, stem cells and nociception. Using a TALEN gene editor and homologous recombination we have generated rat embryonic stem cells(ESC) in which we have flanked exon 2 of the rat p75NTR gene with LoxP recombination sites to generate a " floxed" p75NTR allele . We used a correctly targeted rat ESC line to generated a mutant rat that carries the floxed p75NTR allele. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Provided To Others? | No |
| Impact | This is the first description of a floxed p75NTR allele in the rat. When mutant rats carrying the floxed p75NTR allele are bred with rats that express CRE recombinase in a tissue restricted pattern this allows conditional deletion of the p75NTR gene in a tissue specific manner. |
| Title | Neurotrophin p75NTR knock-out rat |
| Description | Neurotrophin p75NTR is involved in regulating neuronal survival, stem cells and nociception. Using a TALEN gene editor and homologous recombination we have generated rat embryonic stem cells(ESC) in which we have deleted exon 2 of the rat p75NTR gene. Using these targeted rat ESCs we have generated a mutant rat that lacks the p75NTR protein. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Provided To Others? | No |
| Impact | This is the first p75NTR knock-out rat generated using rat ESCs, and deletion of exon 2 appears to generate a complete null allele that should allow researchers to accurately assess the role of p75NTR in neurogenesis, the brain and nocioception. |
| Title | Rex1-EGFP knock-in transgenic rat |
| Description | We have generated a transgenic rat in which we have knocked-in a EGFP-IRESneo reporter gene into the first exon of the rat rex1 gene. The rex1 gene is highly expressed in undifferentiated embryo stem cells and in some cells within the germ lineage. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Provided To Others? | No |
| Impact | The rex1-EGFP knock-in gene allows the characterisation of the rex1 expression pattern in vivo in the rat. It also allows the identification and purification of rex1 expressing cells from rat tissues, and the induction or maintenance of the undifferentiated stem cell state in reprogrammed rat cells. |
| Title | Rex1-egfp knock-in rat embryonic stem cells |
| Description | The rex1-EGFP rat embryonic stem cell (ESC) line carries an egfp reporter knocked into the rat rex1 gene. Since rex1 expression is tightly associated with the undifferentiated embryonic stem cell state, the egfp reporter provides a way to monitor the differentiation status in live stem cell cultures, and purify subpopulations of cells from rat ESC cultures. |
| Type Of Material | Cell line |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | We have used the rex1-egfp reporter to characterise and refine the culture conditions for propagating undifferentiated rat embryonic stem cells. |
| Title | animal iPSCs |
| Description | My group has generated novel equine and bovine iPSC lines |
| Type Of Material | Cell line |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | These cell lines have provided a novel tool for modelling disease in animals - our and other labs internationally are currently testing their potential and applicability. |
| Description | Bio-Sourcing goat project |
| Organisation | BioSourcing SA |
| Country | Belgium |
| Sector | Private |
| PI Contribution | Design and testing of gene expression systems in vitro |
| Collaborator Contribution | Resourcing of project |
| Impact | ongoing research |
| Start Year | 2017 |
| Description | Collaboration with industrial partner: Cobb Europe |
| Organisation | Cobb Europe |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | This Innovate UK project allowed us to build a collaboration with Cobb Europe. The researchers (PI and postdoctorate researcher) working on the Innovate project communicated monthly with Cobb Europe management. We |
| Collaborator Contribution | We have ongoing conference calls and steering committee meetings to govern the interactions between myself, Cobb Europe, and other researchers and management at the Roslin Institute. |
| Impact | In the first instance, the outputs form this collaboration will be listed under the Innovate grant. Future outputs occurring from our continuing collaboration will be listed here. |
| Start Year | 2015 |
| Description | Equine iPSCs for disease modelling |
| Organisation | French National Institute of Agricultural Research |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Provided equine iPSCs |
| Collaborator Contribution | Establish potential of equine iPSCs for disease modelling |
| Impact | None yet |
| Start Year | 2016 |
| Description | Evaluation and validation of membraneGFP transgenic embryos for in vivo imaging |
| Organisation | University of Dundee |
| Department | School of Life Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We developed a lentiviral vector to deliver a transgene designed to express membrane-localised Green Fluorescent Protein (GFP) ubiquitously in chicken embryos. We generated a transgenic line carrying this vector and provided chicken embryos to the Weijer lab for them to evaluate and develop in vivo imaging technologies. |
| Collaborator Contribution | The Weijer lab advised on transgene design and developed in vivo imaging using light sheet microscopy. |
| Impact | This collaboration lead to a publication Rozbiki et al. (2015) Nature Cell Biology 17, 397-408 and the use of this research tool in the Weijer lab is ongoing, funded by new grants. |
| Start Year | 2012 |
| Description | Evaluation of Notch-reporter transgenic embryos |
| Organisation | École Normale Supérieure, Paris |
| Department | Institute of Biology |
| Country | France |
| Sector | Academic/University |
| PI Contribution | We developed a line of transgenic chickens carrying a transgene that would express green fluorescent protein as a reporter of notch signalling activity. |
| Collaborator Contribution | The partners utilised embryos from this line to exemplify its utility in experiments to understand vertebrate embryo development. |
| Impact | A paper has been published. |
| Start Year | 2016 |
| Description | Influenza resistant livestock |
| Organisation | University of Maryland |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Design and testing of constructs targeting influenza virus |
| Collaborator Contribution | Project implementation |
| Impact | Constructs and animals |
| Start Year | 2016 |
| Description | Mammary cells from bovine iPSCs |
| Organisation | University of Turin |
| Department | Molecular Imaging Center |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | Hosted an italian PhD student for 6 months to generate bovine iPSCs |
| Collaborator Contribution | Provided PhD student Differentiated bovine iPSCs (generated at Roslin) into mammary-like cells Led manuscript preparation |
| Impact | Generation of Induced Pluripotent Stem Cells from Bovine Epithelial Cells and Partial Redirection Toward a Mammary Phenotype In Vitro. Cravero D, Martignani E, Miretti S, Accornero P, Pauciullo A, Sharma R, Donadeu FX, Baratta M. Cell Reprogram. 2015 Jun;17(3):211-20. doi: 10.1089/cell.2014.0087. |
| Start Year | 2011 |
| Description | Pig breeding with Genus |
| Organisation | Genus plc |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Developed and demonstrated gene editing in pig zygotes. |
| Collaborator Contribution | Supply of animal resources and funds. |
| Impact | Several publications, presentations at scientific meetings, media opportunities and joint research grants. |
| Start Year | 2010 |
| Description | Purification technologies |
| Organisation | Centre for Process Innovation (CPI) |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We developed lab scale purification of recombinant proteins from the eggs of transgenic hens. |
| Collaborator Contribution | Working with the CPI we have developed a scalable purification process, yielding high quality, pure and biologically active recombinant protein. |
| Impact | Outcomes will be described in publications in 2018. |
| Start Year | 2015 |
| Description | Surrogate Sires |
| Organisation | Genus plc |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Design and strategy to produce germless pigs and cattle |
| Collaborator Contribution | Project design and implementation |
| Impact | publication and patents |
| Start Year | 2015 |
| Description | Surrogate Sires |
| Organisation | Washington State University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Design and strategy to produce germless pigs and cattle |
| Collaborator Contribution | Project design and implementation |
| Impact | publication and patents |
| Start Year | 2015 |
| Description | iPSCs for equine cloning |
| Organisation | National University of San Martin |
| Country | Argentina |
| Sector | Academic/University |
| PI Contribution | Provided equine cells for testing |
| Collaborator Contribution | Tested the potential of iPSCs for equine cloning |
| Impact | Manuscript published in 2016 |
| Start Year | 2015 |
| Title | DOMAIN 5 OF CD163 FOR USE IN ANTIVIRAL COMPOSITIONS AGAINST PRRS, AND TRANSGENIC ANIMALS |
| Description | The present invention relates to methods and compositions useful for the prevention and/or treatment of PRRS in animals, typically domestic pigs. The invention relates to proteins which comprise fragments of CD163, nucleic acid constructs encoding such proteins, and methods of modifying expression or activity of CD163 in vivo. |
| IP Reference | WO2015011483 |
| Protection | Patent application published |
| Year Protection Granted | 2015 |
| Licensed | Commercial In Confidence |
| Impact | scientific publications |
| Title | GENETICALLY MODIFIED ANIMALS AND METHODS FOR MAKING THE SAME |
| Description | Compositions and methods for use of TALENs to make genetically modified livestock are set forth. The methods may include reporters for selecting cells or embryos that have been modified by TALENs for use as progenitor cells to make founder animals. |
| IP Reference | WO2012116274 |
| Protection | Patent application published |
| Year Protection Granted | 2012 |
| Licensed | Commercial In Confidence |
| Impact | scientific publications and research funding - media coverage |
| Title | GENETICALLY-EDITED SWINE |
| Description | The present invention relates to genetically-edited swine comprising an introgressed heterologous nucleic acid sequence in the RELA gene. In particular it relates to genetically- edited swine comprising an introgressed warthog allele in the RALA gene of domestic pigs. The invention also related to methods of producing such swine, and cells derived from swine having such introgressed sequences. |
| IP Reference | WO2017055844 |
| Protection | Patent application published |
| Year Protection Granted | 2017 |
| Licensed | Commercial In Confidence |
| Impact | scientific publications and research grants |
| Title | Gene edited pigs with altered RelA activity |
| Description | production of pigs with altered NFkB activity |
| IP Reference | EP1216564.3 |
| Protection | Patent application published |
| Year Protection Granted | 2012 |
| Licensed | Commercial In Confidence |
| Impact | scientific publications and research funds |
| Title | NANOS KNOCK-OUT THAT ABLATES GERMLINE CELLS |
| Description | The present invention provides livestock animals and methods to create recipient animals for spermatogonial stem cell transplantation through modulation of the NANOS gene. In one embodiment genome editing issued to create animals with insertions or deletions (indels) that inactivate or otherwise modulate NANOS gene activity so that resulting males lack functional germ cells yet retain functional somatic cells, and females are fertile. These males can then be transplanted with donor spermatogonial stem cells and used for breeding. |
| IP Reference | WO2016011029 |
| Protection | Patent application published |
| Year Protection Granted | 2016 |
| Licensed | Commercial In Confidence |
| Impact | scientific publication |
| Title | Use of transgenic techniques to manipulate sex ratio or progeny |
| Description | Using genetic engineering to alter sex ration of offspring in farm breeding |
| IP Reference | US61/971,869 |
| Protection | Patent application published |
| Year Protection Granted | 2014 |
| Licensed | Commercial In Confidence |
| Impact | research funds |
| Company Name | Roslin Technologies |
| Description | Roslin Technologies utilises biotechnology to develop sustainable food products, to combat the issues of food security, animal health and environmental change. |
| Year Established | 2016 |
| Impact | Roslin Technology (commercial partner of Roslin Institute) is currently offering a commercial biobanking service to the poultry industry to biobank commercial chicken flocks using the technology partially developed in this grant. The commercial partner of this grant, Cobb Vantress, Inc, has granted Roslin Technology the right to commercially exploit the non-patentable IP from this project and has made use of this commercial biobanking service offered by Roslin Technology. I, Mike McGrew, am a consultant for the commercial biobanking service. |
| Website | http://www.roslintech.com |
| Description | "Can genome editing contribute to future livestock production", National Science Day Celebration, Central University Haryana, India, 28th February 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Study participants or study members |
| Results and Impact | Invitation to speak on "Can genome editing contribute to future livestock production". This was at an online National Science Day Celebration, Central University Haryana, India, 28th February 2021 |
| Year(s) Of Engagement Activity | 2021 |
| Description | "Curious Minds" lecture series for the Perthshire Society of Natural Science. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Participation in the "Curious Minds" lecture series for the Perthshire Society of Natural Science. The Society runs this public lecture series in collaboration with Culture Perth and Kinross. |
| Year(s) Of Engagement Activity | 2019 |
| Description | 2 Day Mini Science Festival for Primary Schools: Eastgate Theatre, Peebles |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Primary school children from P3-P7 from 4 primary schools attended workshops on "Brilliant Biology" activities involving DNA extraction from strawberries, personalised model chromosome building to reflect individual traits such as hair colour, eye colour, and a lung biology activity. |
| Year(s) Of Engagement Activity | 2017,2018,2019 |
| Description | 2nd Edinburgh Rat Genetics Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Stimulate interactions between local scientists, to share data and resources |
| Year(s) Of Engagement Activity | 2017 |
| Description | 9th International Sheep Veterinary Congress, Harrogate |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Presentation for 300 scientists on the benefits of animal biotechnology to the sheep industry |
| Year(s) Of Engagement Activity | 2017 |
| Description | Academic Wine and Cheese Lecture, University of Edinburgh |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Presented to University students on GM technology and implications for research |
| Year(s) Of Engagement Activity | 2017 |
| Description | Animal Biotechnology Workshop, Charlottesville |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Other audiences denotes scientists. Attended an international workshop on animal biotechnology regulations where plans for international harmonisation of regulations was proposed. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Article in the Times: "Help on the Way for Squirrel Nutkin as Scientists gun for Grey's Anatomy |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Entry in the Times Newspaper, with research contribution for the Roslin Institute. Grey squirrels could be wiped out in the UK by 2050 under plans to protect trees and the red squirrel population by editing the genes of the invasive species to stop the production of females. |
| Year(s) Of Engagement Activity | 2021 |
| Description | BBC Country File interview |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | TV interview on genetically engineered pigs on mainstream BBC Country File programme |
| Year(s) Of Engagement Activity | 2013 |
| Description | BBC Radio 4 Interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Interviewed by BBC radio on topic of genetic engineering of animals. |
| Year(s) Of Engagement Activity | 2017 |
| Description | BBC at the Edinburgh Festivals: The Human Body. Lung Biology activity |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Lung biology activity |
| Year(s) Of Engagement Activity | 2017 |
| Description | BBSRC Conclave, New Delhi |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Other audiences denotes scientists. UK scientific delegation to India to identify roadmap for "smart farms" |
| Year(s) Of Engagement Activity | 2017 |
| Description | Brainstorming workshop on somatic cell derived bovine gametes/embryos |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Brainstorming Workshop on Somatic Cell derived Bovine Gametes/Embryos Attended by heads of Indian organisations NDDB, DBT, the company TAG, and international research scientists (New Delhi, 25-26th June 2018) Presented talk entitled " Pluripotent stem cells: Achievements and Challenges" |
| Year(s) Of Engagement Activity | 2018 |
| Description | British Science Association, Science Week Public Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Public lecture on Cystic Fibrosis Gene Therapy |
| Year(s) Of Engagement Activity | 2016 |
| Description | British Society for Gene and Cell Therapy. Public Engagement Day. 2015 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Lung Biology, Cystic Fibrosis and Gene Therapy activity. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Cabaret of Dangerous Ideas: Dolly the Sheep: major discovery or minor distraction? Presenter, Edinburgh Festival Fringe. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation with two colleagues, one a stem cell biologist and one a histrian of science in society, discussing the impact on research and society of the birth of Dolly the Sheep 20 years ago. Potential of GM technologies to confer resistance to diseases in farmed animals was discussed. Plenty of opportunity for audience contributions to debate. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.youtube.com/watch?v=LClmL5C9YJE&feature=youtu.be |
| Description | Centre for Tropical Livestock and Genetic Health Visit, Gates Foundation |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Supporters |
| Results and Impact | Invited to Bill Gates visit to Easter Bush Campus |
| Year(s) Of Engagement Activity | 2017 |
| Description | Chair of Session 3A: Large Animal Transgenesis, TT2020 Conference, Israel |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chair of the above online conference which sparked questions and discussion. Chance also to join in other sessions online. Most of the audience were fellow scientists |
| Year(s) Of Engagement Activity | 2020 |
| Description | Collaborators' meeting, India |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Indian partnerships in industry and science meeting |
| Year(s) Of Engagement Activity | 2019 |
| Description | Come Dine With The Future |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | What will we be eating in 50 years time? H Sang and 4 other presenters described what will be on their dinner menu, considering advances in technology and challenges of sustainability |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.youtube.com/watch?v=Bkta-s7z9DY |
| Description | Consumers are being asked their views on eating meat from "gene-edited" animals as researchers aim to eradicate livestock disease through a survey |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | An online survey is seeking public opinions on the technology, with the responses to inform work at the University of Edinburgh's Roslin Institute. Scientists have already used gene editing to produce pigs that are resistant to the fatal disease known as Porcine Reproductive and Respiratory Syndrome. It involves altering the DNA code of an animal or plant at precise points to introduce specific characteristics. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Continuing Professional Development Talk on Animal Genetics, Glasgow |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Continuing Professional Development Talk on Animal Genetics, Glasgow to scientists and post graduate students. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Costing the Earth |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | BBC radio interview on genetically engineered livestock for BBC Radio 4 Costing the Earcth |
| Year(s) Of Engagement Activity | 2013 |
| Description | CropTec 2016: Hopes for the future - New breeding technologies |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Described the basics of gene editing technologies, illustrated with examples of the potential of the technology in agriculture, discussed the challenges of applying the technologies. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.croptecshow.com/index.php |
| Description | Cutting edge Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk on genome edited livestock at international science festival |
| Year(s) Of Engagement Activity | 2016 |
| Description | DBT Indian visit to Roslin |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Delegated visit to discuss joint development of research programmes in livestock sector for enhancing health and productivity of farm animals. |
| Year(s) Of Engagement Activity | 2020 |
| Description | DBT workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Indian Department of Biotechnology workshop on GM Livestock in Bangalore |
| Year(s) Of Engagement Activity | 2016 |
| Description | Department of International Development Scientific Meeting, Nairobi |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | International event involving 100 stakeholders of the DFID and the Bill and Melinda Gates Foundation to take forward the Centre for Tropical Livestock and Genetic Health initiative |
| Year(s) Of Engagement Activity | 2017 |
| Description | Dolly @20 Memorial Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Public event retelling stories about Dolly the Sheep |
| Year(s) Of Engagement Activity | 2016 |
| Description | Dolly at 20 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Presentation of research work to interested members of the public |
| Year(s) Of Engagement Activity | 2016 |
| Description | Dolly at 20 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Graphic display of research work to audience at Dolly at 20 event |
| Year(s) Of Engagement Activity | 2016 |
| Description | Dolly@20 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Public event to celebrate the life of Dolly the Sheep and the impact that her creation has had on science and society |
| Year(s) Of Engagement Activity | 2016 |
| Description | Edinburgh Rat Genetics Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Industry/Business |
| Results and Impact | A number of laboratories in Edinburgh are using genetically engineered rats to study interesting areas of biology. The purpose of this first workshop was to present interesting new data on using rats as an experimental model, to share technology, resources and experiences amongst our local colleagues - and hopefully provide a forum for developing new ideas and collaborations. Presentations were made by researchers across the university (Roslin Institute, Medical School, IGMM, SCRM and Centre for Integrative Physiology). Based on this initial workshop, there was interest amongst the attendees to have another meeting in 6-months time, to discuss the applications of CRISPR/Cas gene editing technology and invite a keynote speaker. The programme of this workshop was organised by the Burdon laboratory Edinburgh Rat Genetics Workshop - December 1st Roslin Institute (Room B006) Programme: 9.30-9.45 Tom Burdon Welcome and summary of progress using Rat ESCs 9.45-10.30 John Mullins Introduction to transgenesis in rat, and utility in studying Cardiovascular Biology Robert Menzies Cardiovascular studies in transgenic rats 10.30 -11.00 Phil Coan Hypertensive rat models Break for coffee - 11.00-11.30 11.30-12.00 Richard Meehan Chromatin and Methylation in the rat 12.00- 12.30 Peter Kind Fragile X syndrome/Autism rat models 12.30 -13.00 Tilo Kunath Parkinsons disease rat model |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.roslin.ed.ac.uk/events/edinburgh-rat-genetics-workshop/ |
| Description | Edinburgh-Tsukuba Symposium: Stem cells and regenerative medicine |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented talk at Symposium entitled " Tuning Self-renewal in rat ESCs" on April 16th 2018 at Tsukuba Medical Research Institute, Japan. Promoted collaborative discussions. |
| Year(s) Of Engagement Activity | 2018 |
| Description | EuroScience Open Forum Meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Genome editing involves altering some of the individual letters that make up an organism's genetic code at precise points. The technology can be used to introduce beneficial characteristics into plants and animals, such as resistance to a specific disease or improved adaptation to different environments. The changes introduced are the same as those that could occur spontaneously in nature. In this session, we will showcase how genome editing is being researched in institutions across Europe for treatment or prevention of animal diseases. The goal of the research presented here is to improve the health and welfare of farmed animals around the world, and to improve the security of food supplies in low and middle-income countries. We will start by introducing the technology and how it works, and explore how it is being used to manage a range of diseases in salmon, pigs, and cattle. A representative from a company specialised in providing genetic solutions to the farm industry will speak about how the sector is looking at the problem. Presentations will be followed by a panel discussion and Q&A session in which the audience will be asked to consider the perspective of different groups (e.g. farmers, consumers, policy makers, researchers, low and middle income countries) and will have the opportunity to put questions to the speakers. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Eurostemcell publication |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Online article |
| Year(s) Of Engagement Activity | 2015 |
| Description | Expert Reaction to the successful development of gene drives in mice, interview with Science Media Centre |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Industry/Business |
| Results and Impact | Expert Comment to Science Media Centre |
| Year(s) Of Engagement Activity | 2019 |
| Description | Exploiting the genome: How far can we go? |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Curiosity is part of human nature. We learn from experience and when the knowledge is acquired, we try to exploit it, for good...or evil! In 1953, Watson and Crick revealed the structure of DNA and fifty years later the entire human genome was sequenced. Since then we have sequenced the genomes of over 10 other species and many more are on their way to being completed. Together with the power of molecular cloning technology, it is now possible to genetically modify organisms with a particular purpose, such as increasing resistance to a particular disease, or to generate new bio-products. This public lecture was organised by the British Science Association. |
| Year(s) Of Engagement Activity | 2014 |
| URL | https://www.youtube.com/watch?v=mCSj5lTslbU |
| Description | Flutterby Fundraisers annual "The Big Night Oot for CF" Charity Ball. Presentation entitled : Progress towards Gene Therapy for CF |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Delivered a Research Update at an Annual fundraising ball for a charity that supports our CF Gene Therapy research |
| Year(s) Of Engagement Activity | 2017 |
| Description | Food Evolution Film |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Participated in academic film on food biotechnology |
| Year(s) Of Engagement Activity | 2017 |
| Description | Garth Vet Group, National Association, Yorkshire |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Talk given to scientists, vets and others at the Garth Vet Group, Yorkshire on animal biotechnology |
| Year(s) Of Engagement Activity | 2019 |
| Description | Gene Editing Technical Conference, Manchester |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Symposium for 300 scientists and students |
| Year(s) Of Engagement Activity | 2015 |
| Description | Gene Editing in Livestock, Washington DC |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Attendance and participation in the above event talk on Genome Editing Livestock |
| Year(s) Of Engagement Activity | 2019 |
| Description | Genome Editing and the Future of Farming |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | On the 6th September The Roslin Institute opened its doors to an array of delegates from the worlds of research, industry and policy to discuss genome editing and its role in the future of farming, with many international colleagues including from USDA and OECD. The global challenge of food security is time critical as we will need to produce 70% more food by 2050 without destroying the environment. Innovations in food production techniques are urgently required. Editing the genomes of crops and livestock offers new possibilities to address this complex issue. The meeting discussed the status of the technologies in crops and farmed animals and the associated regualtory and societal challenges were debated, lead by presenters with a broad array of relevant expertise. My role was as chair of a session. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.nib.ac.uk/reporting-on-the-first-nib-specialist-meeting-genome-editing-and-the-future-of-... |
| Description | Glasgow Skeptics: open meeting in Glasgow |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | "Would you eat a GM chicken?" A presentation about GM farm animals with a focus on flu resistance via GM, plenty of discussion after the talk. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Guardian Newspaper interview entitled: "Expert Reaction to the successful development of gene drives in mice" |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Interview with the Guardian newspaper on growing human organs in other animals |
| Year(s) Of Engagement Activity | 2019 |
| Description | Hendrix Genetcic workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Closed industry workshop on application of genetic engineering technology |
| Year(s) Of Engagement Activity | 2016 |
| Description | Hendrix Genetics Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Invited participant at a closed industry meeting with Hendrix Genetics |
| Year(s) Of Engagement Activity | 2016 |
| Description | International ITU Mol Biol & Genetics Congress, Istanbul 2017. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | An international congress for undergraduate students. ~300 participants. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.mbgkongre.itu.edu.tr/ |
| Description | International Society for Animal Genetics Conference, Lleida, Spain |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Other audiences denotes scientists. Scientific symposium of 400 academic and students |
| Year(s) Of Engagement Activity | 2019 |
| Description | International Society for Animal Genetics Conference, Salt Lake City |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Symposium for 200 scientists and students discussing Genome Modification of Livestock |
| Year(s) Of Engagement Activity | 2016 |
| Description | International Sympoisum on Animal Geneticw, Dublin |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Other audiences denotes scientists. Presented at scientific symposium to 400 students and students. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Interview for national news, Financial Times |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | "Are these the chickens of the future?"article by science journalist that coordinated to include interviews with myself on GM, Dr Ian Dunn on behaviour and welfare and Dr John Hickey on breeding genetics. This article brought together key aspects of the application of research to poultry breeding and production. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.ft.com/content/863e034e-d5c8-11e5-829b-8564e7528e54 |
| Description | Invited Lecture at WSU Pullman University, US |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Invited talk to discuss development and application of gene expression systems in genetically engineered animals, with Q&A |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited talk at the University of Edinburgh Cheese and Wine Lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Talk given to University of Edinburgh students on Genetically engineering disease resistance into livestock with Q&A |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited talk to Midlothian Farmers' Association |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Industry/Business |
| Results and Impact | Invited talk on Genome editing in livestock with Q&A |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited talk to the Esk Valley Trust AGM, entitled, "Genetically engineering disease resistance into livestock" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Supporters |
| Results and Impact | Invited talk at the AGM of the charitable organisation Esk Valley Trust with Q&A |
| Year(s) Of Engagement Activity | 2018 |
| Description | Invited talk to the Progress Education Trust |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Participation in a free-to-attend evening event in Edinburgh about the ethical and scientific boundaries of genome editing with Q&A |
| Year(s) Of Engagement Activity | 2019 |
| Description | Invited talk, Pint of Science, which is a science festival that aims to communicate contemporary scientific developments to the public in an interesting, engaging and approachable way by bringing scientists to the pub and other accessible places |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk on Genetically engineering disease resistance in livestock with Q&A |
| Year(s) Of Engagement Activity | 2018 |
| Description | Jedburgh Grammar: CF Gene Therapy Lecture to Higher/Advanced Higher Biology Pupils |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Presentation about genetic mutations, genotypes & phenotypes and advances in gene therapy for CF |
| Year(s) Of Engagement Activity | 2017,2018 |
| Description | MSc Lecture on Genome Modification of Livestock |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | MSc lecture fo 100 students on Genome Modificatio of Livestock |
| Year(s) Of Engagement Activity | 2019 |
| Description | Member of organising committee for symposium " Coming of Age:The Legacy of Dolly at 20" |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | I was a member of the committee that organised a Symposium celebrating of the legacy of cloning of Dolly the sheep at the Roslin Institute - the first cloned mammal from an adult somatic cells. The whole event consisted of a public lecture by Sir Ian Wilmut (https://media.ed.ac.uk/channel/Dolly%20at%2020%20Public%20Lecture/52163171) followed by a one-day symposium at which many internationally reknown scientist presented their work in the area of cloning and stem cells. The symposium was nationally advertised and open to all academics, but additionally was organised so that students were encouraged to attend, at reduced rates with the support of the genetics society. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://dolly.roslin.ed.ac.uk/events-archive/symposium/ |
| Description | Midlorthian Science Festival Debate |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Constructive and lengthy debate Invited back to next festival |
| Year(s) Of Engagement Activity | 2014 |
| Description | Mini Symposium on pluripotent stem cells |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Attendance at a Mini symposium, held at Kumamoto University - Institute of Molecular Embryology and Genetics. Presented talk entitled " A beta adaptor for stem cell survival" |
| Year(s) Of Engagement Activity | 2018 |
| Description | NERC Public Engagement Strategy information event "Public engagement: discussing GM animals" |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented on "Public engagement: discussing GM animals" to illustrate the benefits, interest and challenges of public engagement on a potentailly controversial topic |
| Year(s) Of Engagement Activity | 2016 |
| Description | National Academy of Science Colloquium Workshop, LA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | National Academy of Scinces Colloquium Life 2.0, The Promise and Challenge of a CRISPR Path to a Sustainable Plant, Attended conference and gave talk on genome editing which I agreed could be made public |
| Year(s) Of Engagement Activity | 2019 |
| Description | National Institute of Bioscience Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Workshop for funders, scientists and post graduate students to promote the National Institute of Bioscience. |
| Year(s) Of Engagement Activity | 2015 |
| Description | News artcile on BBC news website |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | A press release was developed relating to our publication in BMC Biotechnology describing production and purification of bioactive proteins in the eggs of transgenic hens. This article was written by Pallab Ghosh of BBC and attracted a lot of attention and other news articles across the world. Contacts have been received from interested businesses. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.bbc.co.uk/news/uk-scotland-47022070 |
| Description | Nuffield Council Meeting on Bioethics |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Member of the Nuffield Council of Bioethics. Acting in an advisory capacity |
| Year(s) Of Engagement Activity | 2019 |
| Description | Nuffield Council bioethics workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Workshop exploring bioethics of genome editing technology and applications |
| Year(s) Of Engagement Activity | 2015,2016 |
| Description | Our Changing World Series |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | University of Edinburgh showcase lecture on genome editing animals for food security |
| Year(s) Of Engagement Activity | 2016 |
| Description | Our Changing World Series, University of Edinburgh |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Opportunity to dialogue with the public on GM issues. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Participation in a working group of the Nuffield Council on Bioethics |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Supporters |
| Results and Impact | The Council has begun a new in-depth inquiry on the ethical issues raised by the use of genome editing techniques in farmed animals. This is the third inquiry of genome editing programme, which began in 2016 with genome editing: an ethical review, and was followed by genome editing and human reproduction, published in July 2018. The genome editing and farmed animals working group includes individuals with expertise in law, philosophy, genetics, biotechnology, political theory, animal welfare, animal health, food and society, sociology, and economics. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Peebles High School Careers Event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Sessions with individual or groups of pupils interested in careers in science. Advice on subject choices, degree programmes and shared my own experience in terms of pathways to current position. |
| Year(s) Of Engagement Activity | 2017,2018,2019 |
| Description | Pigs in a dish: a new recipe for livestock research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | The talk given on 23/7/2020 was part of a University of Edinburgh's 3Rs symposium open to personal and project licence holders at the University of Edinburgh (only individuals involved at some level with the use of animals for scientific purposes), some vets working at other establishments, who have an interest in research involving animals and the 3Rs, and animal care staff. The talk was on pluripotent Livestock ES cells and their potential for replacement of some animal use, and how they can complement in vivo research. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Plant and Animal Genomics Workshop, USA |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Workshop Lead in the above workshop/conference, leading on Animal Genetics. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Presentation to 10 industry influencers about animal biotechnology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Industry/Business |
| Results and Impact | networking with industrial partners to promote Roslin Institute science and work |
| Year(s) Of Engagement Activity | 2016 |
| Description | Presentation to retired scientists |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | presentation with Q&A to retired scientists on transgenic animals |
| Year(s) Of Engagement Activity | 2015 |
| Description | Press article on new research project publication |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Sample of coverage from press release on recent publication |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://uk.reuters.com/article/uk-health-birdflu-chickens/scientists-edit-chicken-genes-to-make-them... |
| Description | Press release |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Advertisement of research finding through national newspaper and TV |
| Year(s) Of Engagement Activity | 2014 |
| Description | Progressional Education Trust Workshop |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited to give a presentation and take part in a debate to the public on genetic engineering. PET advances public understanding of science, law and ethics in the fields of human genetics, assisted reproduction, embryology and stem cell research. Its vision is to improve the choices for people affected by infertility or genetic conditions. Its mission is to educate and debate the responsible application of reproductive and genetic science. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Published article received press coverage |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Published article discussed in public online forum |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.bbc.co.uk/news/uk-scotland-edinburgh-east-fife-39006713 |
| Description | Published article receiving press coverage |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Press article in the Telegraph describing biobanking of chicken breeds using GM chicken hosts in a positive light |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.telegraph.co.uk/news/2017/02/17/rarechickensbrought-back-brink-extinction-edinburgh-unive... |
| Description | Published article receiving press coverage |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Press article on gene targeted chicken used to study germ cell development and to develop surrogate host chickens for rare breed conservation |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.ft.com/content/10000b26-f52c-11e6-8758-6876151821a6 |
| Description | RSB Teachers Annual Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Talk on genome editing to teachers conference |
| Year(s) Of Engagement Activity | 2016 |
| Description | Request for interview as part of Social Science PhD on Genome Editing |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Industry/Business |
| Results and Impact | One to one interview with Fiona Coyle a PhD Student to contribute to her social science PhD on Genome Editing and reports emerging from this |
| Year(s) Of Engagement Activity | 2019 |
| Description | Royal Dick School of Veterinary Studies and Roslin Insitute Away Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Colleagues strategic away day to take forward and enhance the working of the Campus |
| Year(s) Of Engagement Activity | 2020 |
| Description | Royal Highland Show: Flu-fighters and Genetic Toolbox activity |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Genetic Toolbox activity on genome editing of farm animals |
| Year(s) Of Engagement Activity | 2017 |
| Description | Royal Society Dinner |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other audiences |
| Results and Impact | Invited dinner with other scientists to the Royal Society to debate genetic engineering technologies |
| Year(s) Of Engagement Activity | 2016 |
| Description | Royal Society Genome Editing Public Consultation |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Participated in Royal Society consultation of genome editing technology |
| Year(s) Of Engagement Activity | 2017 |
| Description | SALAAM Scientific Conference, Sonderberg |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Scientific symposium to detail how the Action Group could continue. |
| Year(s) Of Engagement Activity | 2016 |
| Description | SALAAM Training School |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Teaching and training modules providing theoretical and practical programmes to build capacity, knowledge and skills. |
| Year(s) Of Engagement Activity | 2015 |
| Description | SUSS |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Talk on impact of genome editing technology on society at annual Scottish universities science school. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Scientific Conference, Utrecht |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Scientific event to identify with other scientists a road map for animal biotechnology in Europe |
| Year(s) Of Engagement Activity | 2017 |
| Description | Talk Science at the British Library |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Debate and discussion "Biotech on the farm - food for thought?", with a live audience in central London and video avaliable watched<500 times. Audience asked interesting and challenging questions. It was clear that GM as such was not seen by many as a problem as there was more concern about the involvement of multinational companies in food production. |
| Year(s) Of Engagement Activity | 2014 |
| URL | https://www.youtube.com/watch?v=KgYIiMM5Z_w |
| Description | Talk at the University of Kent; "Genetically engineering disease resistance onto livestock" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Talk at the University of Kent; "Genetically engineering disease resistance onto livestock" with Q&A for audience |
| Year(s) Of Engagement Activity | 2019 |
| Description | TedX Glasgow "Why do we need GM chickens?" |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Other audiences |
| Results and Impact | TedX Glasgow is a volunteer-run event attended by a an audience from school children to people supported by their employers to attend for personal development. The talks are very varied addressing a wide range of topics and so this was an opportunity to talk about GM technology in a Scottish context and in the context of sustainable agriculture. There was an oportunity at the end of the day to meet members of the audience freely and I had a lot of interesting discussions. The Youtube video has ~1390 views. https://www.youtube.com/watch?v=DUbqrh5otWs |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.youtube.com/watch?v=DUbqrh5otWs |
| Description | The Food Chain |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | BBC World Service radio interview on genetically engineered livestock for The Food Chain |
| Year(s) Of Engagement Activity | 2018 |
| Description | Transgenic Animal Research Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Symposium for 100 scientists and students on transgenic animals with Q&A |
| Year(s) Of Engagement Activity | 2015 |
| Description | Transgenic Animal Research Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Attendance at above conference as an invited speaker on Genome Modification of Livestock. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Transgenic Animal Research Conference, Tahoe, US |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Other audiences denotes scientist. Presented at scientific symposium for 100 students and scientists |
| Year(s) Of Engagement Activity | 2017 |
| Description | U3A Talk - Rewriting Livestock, Biggar Library |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Invited talk to general public on genome editing of livestock |
| Year(s) Of Engagement Activity | 2019 |
| Description | US film team documentary on GM animals |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Filmed interview for documentary |
| Year(s) Of Engagement Activity | 2015 |
| Description | University Delegation to Bangalore India |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | University delegation to visit scientists in India to establish collaborative activities |
| Year(s) Of Engagement Activity | 2017 |
| Description | University delegation visit to Jilin University, China |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Part of a University delegation to China to visit Jilin University scientists to establish links between University vet schools |
| Year(s) Of Engagement Activity | 2016 |
| Description | University of Kent, invited speaker |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Invited speaker on animal biotechnology |
| Year(s) Of Engagement Activity | 2019 |
| Description | editorial on uses of GM |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Presented to reporters at AAAS, Boston USA |
| Year(s) Of Engagement Activity | 2017 |
| Description | named biotechnology speaker on US Ste |Department Economic Bureau Outreach Fund |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | International workshop top engage stakeholders in genetic engineering technology and applications |
| Year(s) Of Engagement Activity | 2015 |