Transmission and Epidemiology

Lead Research Organisation: The Pirbright Institute
Department Name: UNLISTED

Abstract

The Pirbright Institute provides the UK with capacity to predict, detect, understand and respond to incursions of viral pathogens of livestock and viruses that spread from animals to humans. Pirbright represents a hub of world class facilities and expertise for the study of exotic and endemic viral diseases in the natural host, therefore enabling our research to be directly translated into future control measures.
Understanding the spread of viruses is central to the development of effective control measures. To study viral transmission at multiple scales, we will use a combination of transmission experiments, field studies and mathematical modelling. Challenge experiments will be carried out primarily in target species to quantify the probability of transmission and to dissect how transmission is influenced by the host (e.g. immune parameters) viral factors (e.g. strains) and the environment. This work will be closely linked to other projects/expertise at Pirbright and will use the unique high containment facilities at Pirbright for the experimental infection of target species with pathogenic viruses. Field studies will be carried out in endemic settings to generate basic epidemiological data, while observational and intervention studies will evaluate vaccination and other control measures in the field. This part of the work will be closely linked to the relevant reference laboratories and will be made possible by Pirbright’s extensive network of collaborators around the world. Finally, mathematical modelling will be used to analyse transmission at each scale and to link the different scales, as well as to identify specific barriers to control and eradication. The ability of this programme to link data from different scales (from within individual animals to global surveillance) is an example of how strategic funding can be used to maximise the impact of otherwise separate projects. Transmission experiments (with for example swine and avian influenza viruses) offer clear opportunities to undertake studies that are not possible with related human viruses and will provide insights that advance the broader field of virology. Anticipated outcomes of this project are: definition of transmission parameters of viral diseases at multiple scales and the consequences for disease control; strategies to ensure rapid detection of viruses to facilitate disease control; expert advice to the UK on the spread and control of viral diseases (in particular, foot-and-mouth disease and bluetongue) and to the European Commission; engagement with vaccine manufacturers on design and assessment of vaccination programmes; accurate disease intelligence for the livestock industry.

Organisations

Publications

10 25 50
 
Description The Transmission and Epidemiology ISPG has been active for tthree years and we have continued to address the following Objectives: (1) Defining the key factors driving virus transmission between individuals; (2) Identifying the key factors driving transmission between populations; (3) Developing the ability to predict the scale of an outbreak and (4) Designing and evaluating new interventions. In studies of Avian influenza virus (AIV), we have been involved in epidemiological investigations of wild-domestic bird transmission in Egypt and bird-human transmission in Pakistan (1). We have found that FMDV can be modelled at a range of different scales but that datasets underpinning such models remain prone to error for a variety of reasons including differences in surveillance approaches and the uncertainty of carrier status. We have characterized emerging FMDV strains in the Middle East, North and Southern Africa and Southern Asia, inferring spread through phylogenetics and gaining insight into (2) and (3). Economic estimates have also been made of an outbreak of FMDV which occurred in Kenya, allowing assessment of the cost: benefit of intervention strategies and lumpy skin disease virus (LSDV) in Nigeria. LSDV has risen in profile during the course of the ISPG and we have had a significant impact in this area, contributing to the modelling of LSDV outbreaks in Albania, inferring routes of transmission of the virus (1,2), and then in the Balkans as a means of assessing vaccine efficacy (4). We carried out a systematic review of Rift Valley fever virus (RVFV) prevalence in livestock, wildlife and humans and also reviewed reproducibility and relevance of insect-arbovirus systems as a whole (1-4). Within the reporting period we published 90 peer-reviewed publications. Within engagement activities, we have carried out over 167 relevant activities and the emergence of African swine fever virus (ASFV) was a major focus, resulting in a wide array of international meetings, conference and presentations and media activity. Other highlights included dedicated activities have involved activities focussed on virus transmission at the Cheltenham science festival over several years alongside an array of other work aimed at demographics ranging from primary schools to retirement groups. We continue to be an intrinsic part of policy making providing evidence to EFSA on LSDV, RVFV and ASFV which has had a specific impact on legislation towards these diseases at a European level. At a national level we have taken part in a series of outbreak exercises including a dedicated meeting on zoonotic incursion in the UK involving the Chief Scientific Advisor and stakeholder groups.
Exploitation Route These studies will be taken forwards both internally and externally. Data generated in both the UK and overseas will continue to be used in an iterative fashion to improve modeling assessments of disease spread. These influence policy decision making at a UK, European and Global scale through involvement in networks and interactions with the reference laboratories at Pirbright. In addition, links within this ISPG and industry in both validating and commercialization of diagnostic assays and vaccines will lead to substantial progress in disease control in the medium to long-term.
Sectors Agriculture, Food and Drink,Environment,Healthcare

 
Description Data produced as part of studies within this ISPG has been used in a variety of policy decision making for the UK, which currently has heightened surveillance for African swine fever virus (ASFV), lumpy skin disease virus (LSDV), Avian influenza virus (AIV) and bluetongue virus (BTV). In addition, the highly contagious nature of foot and mouth disease virus (FMDV) its proven ability to emerge without warning in northern Europe presents a constant threat to UK agriculture. We also contribute to risk assessment of high impact zoonotic viruses such as Rift Valley fever virus (RVFV). Within the ISPG we have provided a direct influence on the response to outbreaks through our activity on expert groups at a UK (Defra; SAGE); European (EU; EFSA) and global (OIE) scale through both the specific underpinning evidence we provide through our studies. Specific examples include working with EFSA on predictive models of LSDV transmission and RVFV incursion, alongside developing established models for BTV transmission and FMDV within host development. These modelling studies also include economic assessments of virus impact as a means of predicting the likely requirement for response, particularly in resource poor communities. In addition, fundamental detection of viruses under field environments has been examined for several viruses within the ISPG enabling assessment of transmission probability and informing models of virus spread.
First Year Of Impact 2017
Sector Agriculture, Food and Drink
Impact Types Societal,Economic,Policy & public services

 
Description Analysis and interpretation of post-vaccination monitoring data in turkish Thrace
Geographic Reach Europe 
Policy Influence Type Participation in a national consultation
Impact The analysis involved an assessment of the likely protection of current foot-and-mouth disease (FMD) vaccination practices in Turkish Thrace to emerging viral lineages in the region. This region borders FMD free Europe so is of high strategic importance. The output of this analysis were used in international meetings with an impact on vaccination policy.
 
Description Annual Report to OIE on Activities
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact Report of advice, training and diagnosis of African swine fever virus given internationally to OIE (World Animal Health Organisation)
 
Description BBSRC-Newton Fund Agricultural Data Re-use Advisory Group
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Advice on re-usability of data generated in research projects.
 
Description Contributing to the chapter on Marek's disease for the OIE Terrestrial Manual
Geographic Reach Multiple continents/international 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact The contribution to the Terrestrial Manual on the recent advances in the diagnosis and control of Marek's disease will impact on improved and better control of the disease to reduce losses and improved food security
URL http://www.oie.int/
 
Description EFSA expert group on Lumpy Skin Disease vaccination
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact The role in this committee was engaging with European countries on their vaccination campaigns for lumpy skin disease and methods of vaccine evaluation using field-derived data.
 
Description EFSA working group on Rift Valley fever
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact Analysis of data on Rift Valley fever; assessment of risk of introduction to European Union; advice to European Commission on control measures
 
Description EFSA working group on lumpy skin disease
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact Collation of data on lumpy skin disease outbreaks in Europe and neighbouring regions; provision of advice to European Commission and to affected countries on control and surveillance
URL https://www.efsa.europa.eu/en/efsajournal/pub/6010
 
Description EFSA working group on lumpy skin disease
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact The models developed to describe the spread of lumpy skin disease virus (LSDV) within and between farms have been used to inform disease control policy following incursion of LSDV to south-eastern Europe. Specifically, the models were used to assess the impact of vaccination on disease spread. They were also used to investigate the duration of a vaccination campaign to prevent re-emergence of LSDV and to help design surveillance programmes to detect the re-emergence of the virus or its re-introduction from neighbouring countries. The results have been communicated to the European Commission and to affected countries via the European Food Safety Authority.
URL https://efsa.onlinelibrary.wiley.com/doi/full/10.2903/j.efsa.2018.5452
 
Description EFSA working group on lumpy skin disease
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact Report to the European Commission on the spread and control of lumpy skin disease in the Balkans
URL http://www.efsa.europa.eu/en/efsajournal/pub/5176
 
Description EFSA working group on lumpy skin disease
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
Impact Advice to European Commission and affected countries about control and surveillance for lumpy skin disease
URL https://efsa.onlinelibrary.wiley.com/doi/full/10.2903/j.efsa.2018.5452
 
Description Invited Expert FAO European Commission on Agriculture
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
URL http://www.fao.org/europe/commissions/eca/eca-40/en/
 
Description Invited participant, UK SAGE exercise on a zoonotic outbreak
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact Participation in a simulated outbreak of Rift Valley fever to UK to identify gaps in response, including detection, implementation of control measures (for livestock and humans) and communication.
 
Description Led workshop on vaccine field trials
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Lumpy Skin Disease Control Strategy for Great Britain
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Member of the British Society for Immunology Forum
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact The BSI is very active in lobbying MPs and Government on subjects to do with clinical immunology and immunisations.
URL https://www.immunology.org/
 
Description Organised seminar series on Sequencing, Virus Evolution and Molecular Biology at Pirbright (with Luca Ferretti and Graham Freimanis)
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
 
Description POSTnote Report on Climate and vector-diseases in humans in the UK
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description Participation in the Management of the Oxford DTP
Geographic Reach Multiple continents/international 
Policy Influence Type Influenced training of practitioners or researchers
Impact As part of the Management committee of the Oxford-Pirbright-Oxford Brookes-Diamond doctorate Training Partnership, contributed to the success of the DTP in meeting the objectives, recruitment and review
URL http://www.biodtp.ox.ac.uk/
 
Description Scientific Advisory Group for Emergencies Exercise (Royal Society: 11/06/19): Examined simulated emergence of arbovirus in the UK with main decision making bodies and personnel.
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description BBSRC - responsive mode
Amount £187,370 (GBP)
Funding ID BB/S007911/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 03/2019 
End 03/2022
 
Description BBSRC GCRF Impact Accelerator Award
Amount £5,000 (GBP)
Funding ID BB/GCRF-IAA/17/16 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2018 
End 02/2018
 
Description BBSRC Responsive Mode IPA
Amount £302,086 (GBP)
Funding ID BB/R002606/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2018 
End 06/2019
 
Description Biotechnology and Biological Sciences Research Council (BBSRC) and University of Oxford joint Doctoral Training Project
Amount £100,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2018 
End 08/2022
 
Description Commonwealth Scholarship. Molecular determinants impacting avian influenza H9N2 virus evolution, replication fitness and virulence
Amount £200,000 (GBP)
Funding ID LKCS-2019- 665 
Organisation British Council 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2019 
End 10/2022
 
Description FLI- TPI joint PhD studentships Avian influenza immunology markers.
Amount £100,000 (GBP)
Organisation Friedrich Loeffler Institute 
Sector Academic/University
Country Germany
Start 07/2018 
End 06/2022
 
Description GCRF Networks in Vector Ecology
Amount £1,035,634 (GBP)
Funding ID BB/R005362/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 07/2017 
End 06/2020
 
Description H2020 work programme topic 9 Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy, work topic SFS-10-2017 Research and approaches for emerging diseases in plants and terrestrial livestock
Amount € 5,986,250 (EUR)
Organisation European Commission H2020 
Sector Public
Country Belgium
Start 05/2018 
End 04/2023
 
Description International Workshops
Amount £10,000 (GBP)
Funding ID BB/R021198/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 05/2018 
End 05/2019
 
Description Japan Partnering Award
Amount £49,500 (GBP)
Funding ID BB/P025803/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2017 
End 08/2021
 
Description Microbiology Society - travel award
Amount £420 (GBP)
Funding ID GA001689 
Organisation Microbiology Society 
Sector Learned Society
Country United Kingdom
Start 09/2019 
End 09/2019
 
Description Newton Fund: UK-China-Philippines-Thailand Swine and Poultry Research Initiative. Understanding antigenic diversity, zoonotic potential and immunological prevention of avian influenza viruses affecting poultry.
Amount £497,995 (GBP)
Funding ID BB/R012679/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2018 
End 12/2020
 
Description OIE Twinning: Development of capacity for independent assessment of FMDV vaccines in Africa
Amount $1,466,186 (USD)
Organisation World Organisation for Animal Health 
Sector Public
Country France
Start 04/2019 
End 03/2021
 
Description Pirbright Institute PhD studentship
Amount £100,000 (GBP)
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 09/2018 
End 08/2022
 
Description Reducing the Economic and Zoonotic Impact of Avian Influenza (REZIAI): delivering novel vaccines and diagnostics from laboratory to the field.
Amount £400,000 (GBP)
Funding ID BB/S013792/1 
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 02/2019 
End 01/2021
 
Description Responsive mode: Rapid acquisition of mammalian characteristics by avian influenza virus in single host infections.
Amount £535,337 (GBP)
Funding ID BB/R007292/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 06/2018 
End 01/2021
 
Description The Global Challenges Research Fund
Amount £640,473 (GBP)
Organisation Research Councils UK (RCUK) 
Sector Public
Country United Kingdom
Start 04/2019 
End 03/2024
 
Description The Pirbright Institute - University of Surrey PhD studentship
Amount £100,000 (GBP)
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 10/2019 
End 03/2023
 
Description Understanding the importance of the PI3K pathway in modulating influenza virus replication in chickens and ducks
Amount £100,000 (GBP)
Organisation The Pirbright Institute 
Sector Academic/University
Country United Kingdom
Start 10/2020 
End 04/2024
 
Description iCASE studentship: Production and assessment of antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry
Amount £100,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2019 
End 09/2023
 
Title Detection of HA antigens of avian influenza viruses 
Description Assay for detection of recombinant HVT expressing HA antigens of avian influenza viruses 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? Yes  
Impact This new method will help to detect recombinant HVT vaccine expressing HA antigen in infected cell. 
 
Title NGS for PPR virus whole genome sequencing 
Description We have finalised a protocol to sequence the whole genome of PPR virus 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact The method has been described and shard with project partners and a draft has been written for publishing the methods 
 
Title FMDV LIMS and webtools 
Description The Integrative Biology and Bioinformatics (IBB) group has been supplying state-of-the-art bioinformatics tools to the World Reference Labs for the Foot-and-Mouth Disease Virus. All tools revolve around a database of genomic sequences and metadata for FMDV samples. Some tools allow members of the lab to enter, process and annotate new data into the database, generating several kinds of reports. Other web-based tools (the "FMDV Toolbox") allow external users to query the database in several ways. Bioinformatics workflows are hosted on the IBB cluster, and have been implemented as REST web services so as to be decoupled from the web interface. The web interface is currently being redeveloped with the help of a specialised company. 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact The reports generated by our system are used to inform FMDV policy-makers both within the UK and in the rest of the world. External users can compare their sequences to those contained in the database, and get useful biological insights. 
URL https://mallorn.pirbright.ac.uk/FMDVToolbox
 
Title GCRF portal on transboudary diseases 
Description The Integrative Biology and Bioinformatics group is developing a GCRF-funded Portal on Transboundary Diseases. It will be an easy way for all scientists, and those from LMI countries in particular, to access data about several viral diseases generated at Pirbright. The portal will be country-based, presenting the user with a map and dispatching them to the information relevant to the selected region. From that information the user will be able to reach specialised websites for diseases present in the country, and data generated at Pirbright (such as sequences for FMDV, several Capripox viruses, and ASFV). Sequences relevant to the portal are currently being generated. Bioinformatics workflows are hosted on the IBB cluster, and have been implemented as REST web services so as to be decoupled from the web interface. The web interface is currently being developed with the help of a specialised company. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? No  
Impact The portal will benefit scientists from LMI countries, and all scientist, allowing them to access/download genetic and other data relevant to animal diseases present in a country of choice and studied and Pirbright. Some of the data (for instance the FMDV data generated by the World Reference Lab) is already use to inform policy at international level. Being able to access information in a systematic way will increase the potential for it to be put to good use. 
 
Title Genome browser for mosquitos at different developmental stages 
Description The database integrates and makes available the results of the bioinformatics analysis of several experiments involving high-throughput sequencing of mosquito cells at different developmental stages generated within the Vector-borne Viral Disease group at the Pirbright Institute. 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact The genome browser allows the researchers to meaningfully mine and integrate the large amount of data produced by their experiments, guiding subsequent experimental hypothesis-driven validation in the lab. 
 
Title Method to predict vaccine matching in-silico 
Description Every time a novel viral strain emerges, it is essential to know whether existing vaccines are effective against it. Several lab techniques are available in order to do so, the most widespread one arguably being VNT (virus neutralisation test). However VNT is expensive, difficult to implement and not very reproducible due to batch effects. Being able to reliably predict VNT-derived antibody titres with the computer would be a game changer in the field. We have developed an in-silico model based on machine learning that is able to effectively predict VNT outcomes out of sequencing data. We have shown that the method performs well for FMDV and also, apparently, for influenza. 
Type Of Material Computer model/algorithm 
Year Produced 2018 
Provided To Others? No  
Impact We are currently in the process of validating and optimising the method. If preliminary results are confirmed, the method could be put to good use in a number of fields, and become the basis for a more effective policy making when managing and controlling devastating livestock diseases such as FMDV. 
 
Title South-African buffalo FMDV sequences 
Description We have sequenced FMDV buffalo samples originated from a EEID project entitled: Persistence of a Highly Contagious Pathogen: Ecological and Evolutionary Mechanisms in Foot-And-Mouth Disease Virus. This project aims to understand why a highly contagious pathogen such as FMDV, which induces a rapid host immunity and depletes the supply of susceptible host, is able to persist in isolated buffalo populations and thus avoid auto-extinction. The centre piece of the project is a cohort study which involves an established FMDV-positive breeding herd of ca. 70 buffalo in a 900-hectare enclosure surrounded by double game fencing housing buffalo in isolation from other herds in the Kruger National Park (South Africa). The entire herd is being monitored for three years (animals are sampled every 2 months (serum, tonsil swabs, probang) to trace FMDV transmission events, allowing us to define FMD infection dynamics across the susceptible calf cohorts and amongst adults. So far, FMDV genomes from 101 samples have been deep sequenced by illumina. Samples from the last year captures are currently being analysed and virus is currently being isolated. The second experiment is an experimental study, which involves a group of naïve buffalo experimentally infected with either a SAT-1, SAT-2 or SAT-3 virus. The infected buffalo were then allowed to mingle with susceptible animals and transmission of FMDV to naïve animals was monitored during the acute infection but also from persistently infected animals. So far, FMDV genomes from 48 samples obtained at days 2, 30 and 160 of the experiment have been deep sequenced. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? No  
Impact The samples sequenced come from South Africa, which is an LMIC, While FMDV infection in cattle is very well studied, the mechanisms of persistence in buffalo, which is thought to be the natural reservoir of the infection, are not well understood. Such understanding would be essential to inform better policies to understand and manage FMDV, which is an economically important scourge of cloven hooved animals in LMICs. All the sequences will be made available on the Transboundary Portal which is being developed at Pirbright. 
 
Title Viral assembly pipeline 
Description The Integrative Biology and Bioinformatics group has developed a data analysis pipeline to obtain sensitive and robust viral assemblies out of high-throughput sequencing data. In spite of the relatively short genomic length of most viruses, assembling of viral sequences can be challenging due to several reasons, such as: low amount of material in the sample, which might require amplification, introducing biases, and/or generates low-quality sequences; uneven coverage due to low-quality material or the genomic material of the virus being RNA; the viral nucleic acid being almost lost in the background of nucleic acid of the host. Our pipeline overcomes most of those problems, and is even able to detect different viral strains being present together in the same sample. It can also be used on metagenomic environmental samples. 
Type Of Material Data analysis technique 
Year Produced 2017 
Provided To Others? No  
Impact The pipeline is being deployed as the tool of choice for the nascent sequencing facility at Pirbright. It has been used by several groups at Pirbright, and the FMDV World Reference Lab, in order to assemble very different kinds of viruses. 
 
Title Viral variant calling pipeline 
Description The Integrative Biology and Bioinformatics group has developed a data analysis pipeline to obtain sensitive and robust variant calling for viral sequences out of high-throughput sequencing data. In spite of the relatively short genomic length of most viruses, calling variant for viral sequences can be challenging due to several reasons, such as: low amount of material in the sample, which might require amplification, introducing biases, and/or generates low-quality sequences; very high genome coverage, which slows down most existing variant callers; the presence of a potentially very high number of different haplotypes for RNA viruses, which is an unusual scenario in variant calling. Our fast and sensitive Bayesian pipeline overcomes most of those problems. 
Type Of Material Data analysis technique 
Year Produced 2017 
Provided To Others? No  
Impact The pipeline is being deployed as the tool of choice for the nascent sequencing facility at Pirbright. It has been used by several groups at Pirbright, and the FMDV World Reference Lab, in order to assemble very different kinds of viruses. 
 
Title WRL FMDV sequences for transboundary portal 
Description We have generated a collection of sequences of FMDV (foot-and-mouth disease virus) from samples collected by the FMDV World Reference Laboratory at Pirbright. Those full-genome sequences sample a number of recent exotic strains across different regions/countries of the world, focusing mainly on LMICs in North Africa, Middle East and South East Asia. The main represented FMDV types are O and A. Part of the sequences have already been made available through GenBank -- all will be soon downloadable from the Transboundary Portal which is being developed at Pirbright. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
Impact Knowledge of the sequenced strains is essential to inform policy for FMDV control in the LMIC countries where the samples were collected. That chimes very well with the GCRF focus of the project. At a more global scale, knowledge of the features and sequence evolution of the virus in time and across different countries is essential in order to accurately model its behaviour. In general FMDV is a scourge of cloven-hoofed animals, and controlling it better is essential in order to alleviate the huge economic toll claimed by the virus in LMICs. 
 
Title Zimbabwe FMDV sequences 
Description Foot-and-mouth disease virus (FMDV) causes an acute vesicular disease in domestic cloven-hooved animals. However, in the African buffalo (Syncerus caffer) clinical disease is rarely observed and following infection virus is persistently carried in the oesophageal-pharyngeal area of the upper respiratory tract. During the 1990s oesophageal-pharyngeal scrapings were collected from free-living African buffalo in multiple herds in six different geographic areas of Zimbabwe. We sequenced over 140 FMD viruses each belonging to one of the Southern African Territories (SAT) serotypes (SAT 1, SAT 2 and SAT 3) from primary bovine thyroid cells. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? No  
Impact This dataset has been generated from samples collected in Zimbabwe, which is a low-income country. Those viral sequences will be essential to help elucidating the nature of persistent FMDV infection in African buffalo, which is supposed to be the main virus reservoir in vivo. As the samples track viral infection and evolution over several years and across a number of different herds in different national parks and conservatories, the dataset will also inform better animal management and conservation. A better understanding of FMDV persistence would also be essential to mitigate the economic burden generated by the disease, which is a scourge of cloven-hoofed animals in LMICs. All the sequences will be made available through the Transboundary Pathogen portal that is being developed at Pirbright. 
 
Description Alain Kohl, Joseph Hughes and Quan Gu, CVR Glasgow 
Organisation University of Glasgow
Department MRC - University of Glasgow Centre for Virus Research
Country United Kingdom 
Sector Academic/University 
PI Contribution The aim of this collaboration is to generate reference transcriptomes for two mosquito species of veterinary and human health importance. We generated samples and sequencing data. We also analysed transcriptome data.
Collaborator Contribution Alain Kohl generated samples. Joseph Hughes and Quan Gu generated reference transcriptomes and helped with data analysis.
Impact Outcomes of this collaborations have been poster presentations at national and international conferences. This collaboration is multi-disciplinary as it involves virologists and bioinformaticians.
Start Year 2016
 
Description Anopheles reannotation 
Organisation Centre for Genomic Regulation (CRG)
Country Spain 
Sector Academic/University 
PI Contribution Provided RNA-sequencing data (produced by Jaroslaw Krzywinski and analysed by us)
Collaborator Contribution Using the data to produce a reannotation of Anopheles Gambiae
Impact No outputs yet
Start Year 2017
 
Description Avian influenza H7N9 virus evolution: defining the impact of internal genes on virus infection in avian and mammalian species 
Organisation Animal and Plant Health Agency
Country United Kingdom 
Sector Public 
PI Contribution Provision of samples and reagents for research
Collaborator Contribution Provision of samples, reagents for research and research facilities
Impact Research output entitled "A restriction digestion and ligation independent technique for cloning influenza gene segments into pHW2000" was presented at January 17th to 19th 2018. Fortuna Hotel, Lang Ha Street, Hanoi, VietNam (Presented by postdoctoral scientist Dr Sushant Bhat
Start Year 2016
 
Description BBSRC - Oxford University iCASE Studentship (October 2019- September 2023). Production and assessment of antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry production 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution This collaboration between The Pirbright Institute (UK), Oxford University (UK) and industrial partners in Italy. This project will conceived and developed bu MI. The PhD student (Holly Everest) in my group is investigating the antiviral prophylactic properties of natural biomolecules against avian influenza and Newcastle disease viruses affecting poultry production.
Collaborator Contribution The partners in Italy will produce and purify natural antiviral molecules effective against avian influenza and other poultry viruses.
Impact This project started in January 2020.
Start Year 2020
 
Description BBSRC-UC Davis workshop, 16-18 October 
Organisation University of California, Davis
Department UC Davis College of Biological Sciences
Country United States 
Sector Academic/University 
PI Contribution Presented on "Reproducibility and relevance in vector infection studies". Followed up with discussion of potential publication and funding opportunities.
Collaborator Contribution Various presentations on vectors and vector-borne diseases including, facilities, challenges, opportunities.
Impact Discussion of potential joint publications and grant applications; no tangible impacts yet.
Start Year 2017
 
Description BBSRC-UC Davis workshop, 16-18 October 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Presented on "Reproducibility and relevance in vector infection studies". Followed up with discussion of potential publication and funding opportunities.
Collaborator Contribution Various presentations on vectors and vector-borne diseases including, facilities, challenges, opportunities.
Impact Discussion of potential joint publications and grant applications; no tangible impacts yet.
Start Year 2017
 
Description Challenge of transgenic chickens with influenza viruses 
Organisation Imperial College London
Department Section of Virology
Country United Kingdom 
Sector Academic/University 
PI Contribution We have challenged transgenic chickens with recombinant avian influenza viruses to determine outcome; infectivity, transmission, pathogenicity, dissemination within host. We also processed the samples generated from these animal experiments at The Pirbright Institute.
Collaborator Contribution Imperial College (Wendy Barclay and Mike Skinner) generated recombinant avian influenza viruses for challenge.
Impact This collaboration has resulted in the successful award of a joint grant with imperial college aiming to carry out challenge experiments on novel transgenic chickens to facilitate control of avian influenza virus in the poultry population. BB/S007911/1 - Investigating the role of ANP32A in the replication of avian Influenza virus
Start Year 2018
 
Description Chicken Microbiome - Robert La Ragione - University of Surrey 
Organisation University of Surrey
Department School of Veterinary Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Providing sequencing data of gut microbiome from chickens infected with avian influenza viruses.
Collaborator Contribution Sharing expertise in the analysis of microbiome data
Impact Joint manuscripts and funding opportunities are being explored
Start Year 2019
 
Description Collaboration with Bauchi State Veterinary Services, Nigeria 
Organisation Bauchi State University
Country Nigeria 
Sector Academic/University 
PI Contribution We have provided expertise on sheeppox, goatpox and lumpy skin disease virus diagnosis and epidemiology
Collaborator Contribution Our collaborators in Bauchi State have provided virus samples and epidemiological data
Impact Preliminary data was used to support successful funding via a BBSRC Impact Accelerator Award, and a Pathways to Impact project in BBSRC project BB/R008833/1 "Development of rationally designed live-attenuated lumpy skin disease vaccines"
Start Year 2016
 
Description Collaboration with State Central Veterinary Laboratory, Mongolia 
Organisation State Central Veterinary Laboratory
Country Mongolia 
Sector Public 
PI Contribution We provided tools, techniques and expertise on sheeppox and goatpox
Collaborator Contribution Our colleagues provided data and field samples
Impact A workshop was held in Pirbright in March 2017, and a return workshop in Ulaanbaatar in July 2017. Preliminary data supported successful grant applications for an Impact Accelerator Award, and a Pathways to Impact project in BB/R008833/1 "Development of rationally designed live-attenuated lumpy skin disease vaccines".
Start Year 2016
 
Description Commonwealth Scholarship. Molecular determinants impacting avian influenza H9N2 virus evolution, replication fitness and virulence 
Organisation Royal Veterinary College (RVC)
Country United Kingdom 
Sector Academic/University 
PI Contribution I develop a research project proposal in which we are investigating how evolutionary changes in the H9N2 avian influenza virus modulate virus fitness and virulence in chickens. This PhD studentship project was funded by Commonwealth scholarship commission for 3 years.
Collaborator Contribution The collaborating Partner Dr Nicola Lewis at Royal Veterinary College is a co-supervisor of the PhD student Thusitha Karunarathna. she provide necessary guidance to achieve prescribed objectives of this project.
Impact The project is at its initial stage.
Start Year 2019
 
Description Distributed Bio - Gates foundation funding - universal influenza vaccine 
Organisation Distributed Bio.
Country United States 
Sector Private 
PI Contribution Pirbright has provided expert advice to the design of adjuvant and challenge studies in appropriate animal models for human influenza vaccine trials. Pirbright is facilitating these studies in line with UK home office requirements and good scientific practice.
Collaborator Contribution Distributed Bio have developed a novel vaccine that is hoped to be a candidate for a human universal influenza virus vaccine.
Impact Funding from Bill and Melinda Gates foundation as part of the Grand challenges - Universal vaccine for influenza for the animal studies involving Pirbright and Distributed Bio
Start Year 2019
 
Description Gene editing chickens with Roslin 
Organisation University of Edinburgh
Department Roslin Institute Transgenic Chicken Facility
Country United Kingdom 
Sector Academic/University 
PI Contribution We have provided infectious pathogen challenge and infectious pathogen sample processing facilities in this collaboration. We infected the transgenic chickens with avian influenza virus and processed the samples following challenge.
Collaborator Contribution Helen Sang and Mike McGrew at The Roslin Institute (University of Edinburgh) contributed by producing and providing transgenic chickens (Split GFP) for challenge. Expertise in genotype screening the transgenic birds was shared with us.
Impact We have now successfully received a BBSRC responsive mode grant to carry out more transgenic bird challenges with influenza viruses. BB/S007911/1 -Investigating the role of ANP32A in the replication of avian Influenza virus.
Start Year 2018
 
Description Identification of genetic markers in the haemagglutinin glycoprotein critical for antigenic activity of H9N2 avian influenza viruses. 
Organisation Francis Crick Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution d provision of reagents and virus samples.
Collaborator Contribution Technical training to PhD students and use of research facilities
Impact (1) Talk: Avian influenza virus evolution: immune escape, increase in zoonotic potential and fitness in poultry. Presented at "Prevention and Control Techniques for Infectious Diseases in Livestock and Poultry", 27th 29th August 2017, Beijing, China. (2) Impact of avian influenza virus evolution on antigenicity and zoonotic infection potential. Presented at University of Veterinary and Animal Sciences (UVAS) Lahore, Pakistan on 23rd August 2017. (3). Molecular determinants of H9N2 avian influenza virus influencing antigenicity and receptor binding. Presented at CERAD (Centre of Excellence for Research on Avian Diseases), 3rd Symposium Recent Advances in Avian Disease Research. 31st August - 1st September 2017 at the Harbour Hotel, Alexandra Terrace, Guildford, Surrey, UK. (4) Overview of ongoing research on Poultry diseases in United Kingdom. Presented as at International poultry Stakeholders work on poultry biosecurity in Sri Lanka from 26th February to 3rd March 2017. (5). Evolutionary fitness of avian influenza viruses and development of improved vaccines and diagnostics. Presented as invited seminar speaker at RVC (Hawkshead Campus), UK. 19th October 2016.
Start Year 2012
 
Description Identification of genetic markers in the haemagglutinin glycoprotein critical for antigenic activity of H9N2 avian influenza viruses. 
Organisation Imperial College London
Department Section of Virology
Country United Kingdom 
Sector Academic/University 
PI Contribution d provision of reagents and virus samples.
Collaborator Contribution Technical training to PhD students and use of research facilities
Impact (1) Talk: Avian influenza virus evolution: immune escape, increase in zoonotic potential and fitness in poultry. Presented at "Prevention and Control Techniques for Infectious Diseases in Livestock and Poultry", 27th 29th August 2017, Beijing, China. (2) Impact of avian influenza virus evolution on antigenicity and zoonotic infection potential. Presented at University of Veterinary and Animal Sciences (UVAS) Lahore, Pakistan on 23rd August 2017. (3). Molecular determinants of H9N2 avian influenza virus influencing antigenicity and receptor binding. Presented at CERAD (Centre of Excellence for Research on Avian Diseases), 3rd Symposium Recent Advances in Avian Disease Research. 31st August - 1st September 2017 at the Harbour Hotel, Alexandra Terrace, Guildford, Surrey, UK. (4) Overview of ongoing research on Poultry diseases in United Kingdom. Presented as at International poultry Stakeholders work on poultry biosecurity in Sri Lanka from 26th February to 3rd March 2017. (5). Evolutionary fitness of avian influenza viruses and development of improved vaccines and diagnostics. Presented as invited seminar speaker at RVC (Hawkshead Campus), UK. 19th October 2016.
Start Year 2012
 
Description Improving vaccines and diagnostics for avian influenza viruses 
Organisation Zagazig University
Country Egypt 
Sector Academic/University 
PI Contribution Provision of Research training, analysis of field samples
Collaborator Contribution Provision of Field data and samples
Impact Characterisation of Avian Influenza Virus Hemagglutinin from Egyptian Chicken Flocks during 2016 Outbreaks. Presented at Global Alliance for Research on Avian Diseases conference. Hanoi, VietNam17-19 January 2018.
Start Year 2017
 
Description Investigating antigenic determinants inducing stronger and broader cross-protective immunity among H5 avian influenza viruses 
Organisation Royal Veterinary College (RVC)
Department Veterinary Basic Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution The overarching aims of the proposed research are to improve controls against H5 subtype of avian influenza viruses infecting poultry by investigating underlying mechanisms that define how vaccines renders effectiveness and develop novel approaches enhancing the effectiveness of H5 avian influenza vaccines. We recently generated a panel of monoclonal antibodies (mAbs) that recognise a variety of different clades of H5 viruses. Propagation of AIV in eggs or cultured cells together with mAbs drives virus to escape from mAbs neutralisation activity. These classical virus neutralization assays (VN) followed by HA gene sequence analysis allowed us to defined the role of amino acid substitutions that are associated with evasion of antibody neutralization through emergence of antigenic variants and failure of vaccine efficacy.
Collaborator Contribution provided intellectual input for achieving prescribed objectives of this work.
Impact Talk entitled "Molecular determinants for antigenicity and vaccine efficacy of avian influenza viruses" was presented at Newton Agham Researcher Links Workshop " Novel Vaccines and Diagnostic Technologies against Emerging and re-emerging Veterinary Pathogens" at Rizal Park Hotel, Manila, Philippines, 4-7 February 2019.
Start Year 2019
 
Description Investigating antigenic determinants inducing stronger and broader cross-protective immunity among H5 avian influenza viruses. 
Organisation Royal Veterinary College (RVC)
Country United Kingdom 
Sector Academic/University 
PI Contribution We developed research programme to characterise diversity of antigenic epitopes induce protective immunity in chickens against H5 subtypes of avian influenza viruses.
Collaborator Contribution Collaborating partner Dr Nicola Lewis at Royal Veterinary College provide advise to on cartography programme to visualize the antigenic similarity or difference among different strains of influenza viruses.
Impact The work under this collaborative determined the antigenic differences among different clades of H5 avian influenza viruses circulating in birds. This project is multi-disciplinary. our laboratory mainly work on virology and immunology part of the project and we seek help on computer modeling part from the collaborating partner Dr Nicola Lewis.
Start Year 2019
 
Description Invitation to participate in the Vaccine Innovation Forum 2017 at Shanghai 26-27 April 2017 
Organisation Chinese Academy of Agricultural Sciences
Department Shanghai Veterinary Research Institute
Country China 
Sector Public 
PI Contribution Prof. Nair was invited to participate in the Vaccine Innovation Forum 2017 at Shanghai 26-27 April 2017 to present a talk on 'Novel Vaccine Development for Avian Virus Diseases'. He also participated in the round table discussions on the challenges and opportunities in the vaccines and vaccination sector
Collaborator Contribution Vaccine Innovation Forum will help in expanding the future collaborations and activities of the UK-China Centre of Excellence for Research on Avian Diseases (http://www.uk-china-cerad.org/).
Impact organised joint meeting in China and the UK to discuss on challenges and opportunities
Start Year 2017
 
Description Mapping ligand binding domain on African swine fever virus CD2v protein 
Organisation University of Oxford
Department Weatherall Institute of Molecular Medicine (WIMM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Testing of mutant versions of CD2v extracellular domain for ability to bind to red blood cells
Collaborator Contribution Produced predicted model of CD2v extracellular domain and selected mutations to be made
Impact Preliminary results for publication and future funding application
Start Year 2018
 
Description Molecular epidemiology of H9N2 avian influenza viruses in Vietnam and Pakistan. 
Organisation Royal Veterinary College (RVC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Exchange of technical ideas, reagents and samples.
Collaborator Contribution Provision of field samples and data on avian influenza infection in poultry. This diseases is endemic in poultry in Pakistan.
Impact (1) Increased receptor binding avidity of H9N2 avian influenza viruses is associated with escape from antibody based immunity and enhanced zoonotic potential. presented by Joshua Sealy at GARAD and ZELS conferences in Haneoi, Vietnam from 17-27 January 2018.
Start Year 2008
 
Description Molecular epidemiology of H9N2 avian influenza viruses in Vietnam and Pakistan. 
Organisation University of Veterinary & Animal Sciences
Department Department of Microbiology
Country Pakistan 
Sector Academic/University 
PI Contribution Exchange of technical ideas, reagents and samples.
Collaborator Contribution Provision of field samples and data on avian influenza infection in poultry. This diseases is endemic in poultry in Pakistan.
Impact (1) Increased receptor binding avidity of H9N2 avian influenza viruses is associated with escape from antibody based immunity and enhanced zoonotic potential. presented by Joshua Sealy at GARAD and ZELS conferences in Haneoi, Vietnam from 17-27 January 2018.
Start Year 2008
 
Description Morphological differences of Influenza A viruses 
Organisation University of Edinburgh
Department The Roslin Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Exchange of research methods and reagents
Collaborator Contribution (1) Exchange of reagents and Research methods.(2) training of PhD students and Postdoctoral Scientists (3) use of research facilities
Impact Research output were presented at Avian Influenza A virus budding morphology: spherical or filamentous? presented at The European Scientific Working group on Influenza (ESWI) Riga, Latvia. 10 to 13 September 2017 (2) .Budding morphology of avian influenza A viruses. Microbiology Society, annual Conference 2017, 306 April, EICC, Edinburggh, UK
Start Year 2016
 
Description NVRI Vom 
Organisation National Veterinary Research Institute, Nigeria
Country Nigeria 
Sector Academic/University 
PI Contribution The collaboration is investigating the epidemiology of capripoxvirus disease in Nigeria
Collaborator Contribution A serosurveillance study has been carried out and is currently being analysed
Impact None yet
Start Year 2019
 
Description Paul Digard & Reidun Twarock - Packaging signals 
Organisation University of Edinburgh
Department The Roslin Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Supply of reverse genetic avian influenza viruses for the successful award of a PhD studentship based at The Roslin Institute entitled "Identification of interaction sites between the genomic segments of influenza virus as putative novel anti-viral targets".
Collaborator Contribution University of York is providing mathematical modelling algorithms of viral packaging. Paul Digard- Roslin Institute is providing influenza virology expertise and hosting the student.
Impact Studentship commenced in October 2019
Start Year 2019
 
Description Paul Digard & Reidun Twarock - Packaging signals 
Organisation University of York
Country United Kingdom 
Sector Academic/University 
PI Contribution Supply of reverse genetic avian influenza viruses for the successful award of a PhD studentship based at The Roslin Institute entitled "Identification of interaction sites between the genomic segments of influenza virus as putative novel anti-viral targets".
Collaborator Contribution University of York is providing mathematical modelling algorithms of viral packaging. Paul Digard- Roslin Institute is providing influenza virology expertise and hosting the student.
Impact Studentship commenced in October 2019
Start Year 2019
 
Description Semiochemical-based detection of arboviral infection 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Preliminary data collection on the influence of arboviral infection on semiochemical output from sheep. These studies are being conducted as part of an unrelated animal experiment within the isolation units at Pirbright. We are carrying out the animal-based studies and collecting air entrainments from animals both pre- and post-infection. These are then decontaminated for movement to LSHTM.
Collaborator Contribution LSHTM are carrying out analysis of air entrainments using GC-MS. They will assess differences in profiles of infected vs uninfected animals and report their findings to us.
Impact Still ongoing.
Start Year 2018
 
Description Semliki Forest 
Organisation The Pirbright Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Generated and analysed RNA-sequencing samples with bespoke in-house methods
Collaborator Contribution Generated samples
Impact The purpose of the collaboration is to study how arboviruses interact with their host cells with modern high-throughput techniques. No outputs yet
Start Year 2017
 
Description Syngenta UK 
Organisation Syngenta International AG
Department Syngenta Ltd (Bracknell)
Country United Kingdom 
Sector Private 
PI Contribution This collaboration aims to identify functional relationships between insecticide resistances in mosquitoes and competence of vector mosquitoes for arboviruses. Further, this collaboration aims at the generation of transgenic mosquitoes overexpressing proteins involved in certain insecticide resistances as tools to study the mechanism for such resistances. We have selected candidate proteins and overexpressed them in cell culture and in mosquitoes for vector competence studies as well as functional studies (insecticide uptake bioassays).
Collaborator Contribution Syngenta UK has provided intellectual input into our study design and expertise in the field of insecticide resistance mechanisms.
Impact No outputs yet. Collaboration between The Pirbright Institute and agrochemical industry.
Start Year 2019
 
Description The GCRF One Health Poultry Hub 
Organisation Royal Veterinary College (RVC)
Country United Kingdom 
Sector Academic/University 
PI Contribution The focus of the research is to achieve sustainable global intensification of poultry meat and egg production whilst reducing risks to human and animal health and welfare. We are undertaking research to investigate the diversity of avian influenza viruses prevalent in poultry and wild birds in south east Asia.
Collaborator Contribution Royal Veterinary College, London is leading this GCRF One Health Poultry Hub. The project will address the need to meet rising demand for poultry meat and eggs in developing countries, while minimising risk to international public health. Population growth is driving global demand for poultry, meat and egg production; this unfortunately creates conditions in which animal diseases can spread to humans ('zoonoses'). These include bacterial food poisoning and strains with avian influenza with epidemic or pandemic potential. The GCRF One Health Poultry Hub will adopt a 'One Health' approach to the issue of combatting animal-to-human diseases by bringing together a team of laboratory, clinical, veterinary and social scientists. This team will test and evaluate novel interventions. The need for safe poultry production is most urgent in South and South East Asia, so the RVC and its partners will then use their local networks in these regions to put its positive research to immediate use.
Impact Development of international interdisciplinary partnership of 55 investigators from 13 countries to address the emerging global challenges of food security and public health associated with intensification of poultry production.
Start Year 2018
 
Description The Pirbright "Livestock Antibody Hub" funded by Bill & Melinda Gates Foundation 
Organisation The Pirbright Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Me and my team established collaboration in the "Livestock Antibody Hub" funded ($5.5 million) by the from Bill & Melinda Gates Foundation. Focus of our partnership is to develop techniques and capacity to analyse immune cells (B cells) of cattle, poultry and pigs that produce virus neutralizing antibodies. This research will support rational development of next generation of vaccines and to explore antibody-based passive immunization approaches for treatment and prophylaxis of infectious viral diseases affecting livestock and humans. Our initial focus is to target major animal viral pathogens that cause severe losses within Low and Middle-Income Countries (LMIC) animal production systems including avian influenza virus (AIV), Newcastle disease virus (NDV), infectious bursal disease virus (IBDV), infectious bronchitis virus (IBV) and foot-and-mouth disease virus (FMDV).
Collaborator Contribution This is a collaborative project and partners are providing help in provision of reagents and techniques for analysis of diversity of B cells repertoire that produce infleunza virus-specific antibodies, single cell sequencing and bioinformatic analysis. This project will further strengthen our on-going research collaborations with many research groups in academia as well as with animal health industry (Zoetis, Boehringer Ingelheim Animal Health, Merck, CEVA, Jovac, YeBio, ILRI, Galvmed, The Roslin Institute, HuMabs, AbCellera and Distributed Bio) to take the research outputs from laboratory to the field. The outputs of research will be improved vaccines and diagnostics enabling to reduce the impact of infectious diseases on farm animals, which offer substantial direct and indirect economic, public health, environmental and social benefits to the UK and rest of the world.
Impact Development of passive immunization approaches against avian influenza viruses affecting poultry (project incited in January 2020).
Start Year 2020
 
Description The role of segment 3 in H9N2 avian influenza virus pathogenicity 
Organisation University of Edinburgh
Department The Roslin Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution This is a Joint studentship project funded by The Pirbright Institute and The Roslin Institute. We identiifed molecular markers that are responsible for increase in virus pathogenicity and transmission.
Collaborator Contribution The Roslin Institute contributed both intellectually and by proving research training, samples and regents to achieve the prescribed objectives this project.
Impact 1. Oral Presentation Title: Identification of segment 3 sequence polymorphisms which alter shut off activity and pathogenicity of H9N2 avian influenza viruses in vivo. Anabel Clements, Saira Hussain, Holly Shelton, Paul Digard and Munir Iqbal. Global Alliance for Research Into Avian Diseases (GARAD). January 17th to 19th 2018. Fortuna Hotel, Lang Ha Street, Hanoi, VietNam 2. Poster title: What is the role of H9N2 avian influenza virus PA-X within an avian model?. Anabel Clements, Saira Hussain, Holly Shelton, Paul Digard & Munir Iqbal. UK- China CERAD (Centre of Excellence for Research on Avian Diseases), 3rd Symposium Recent Advances in Avian Disease Research. August 31st - 1st September 2017. The Harbour Hotel, Alexandra Terrace, Guildford, Surrey, UK. 3. Poster title: What is the role of H9N2 avian influenza virus PA-X within an avian model?. Anabel Clements, Saira Hussain, Holly Shelton, Paul Digard & Munir Iqbal. Microbiology Society Annual Conference. April 3rd-6th 2017. Edinburgh International Conference Centre (EICC), Edinburgh, UK. 4. Oral Presentation title: Identification of sequence polymorphisms in segment 3 of H9N2 avian influenza viruses that affect PA-X activity. Anabel Clements, Saira Hussain, Holly Shelton, Paul Digard & Munir Iqbal. Focused Meeting 2016: Molecular Biology and Pathogenesis of Avian Viruses. September 27th-29th 2016. Charles Darwin House, London, UK. 5. Oral Presentation title: The role of segment 3 in H9N2 avian influenza virus pathogenicity. Anabel Clements, Saira Hussain, Holly Shelton, Munir Iqbal & Paul Digard. UK -Taiwan BBSRC Partnering Award workshop: Improving Control of influenza viruses. 26th-27th April 2016. Taipei, Taiwan. 6. Oral Presentation title: Identification of sequence polymorphisms in segment 3 of H9N2 avian influenza viruses that affect PA-X activity. Anabel Clements, Saira Hussain, Holly Shelton, Munir Iqbal & Paul Digard. Microbiology Society Annual Conference 2016; virus Workshop: Negative strand RNA Viruses. 21st-24th March 2016. Arena and Convention Centre, Liverpool, UK. 7. Poster title: The role of segment 3 in H9N2 influenza virus pathogenicity. Anabel Clements, Saira Hussain, Holly Shelton, Munir Iqbal & Paul Digard. 7th Orthomyxovirus research conference. 16th-18th September 2015. Ecole Nationale Veterinaire de Toulouse, Toulouse, France. 8. Poster title: The role of segment 3 in H9N2 influenza virus pathogenicity. Anabel Clements, Saira Hussain, Holly Shelton, Munir Iqbal & Paul Digard. Edinburgh Infectious Diseases Annual Symposium. 20th May 2015. Royal College of Physicians, Edinburgh, UK.
Start Year 2014
 
Description Understanding antigenic diversity, zoonotic potential and immunological prevention of avian influenza viruses affecting poultry 
Organisation Beijing Academy of Agriculture and Forestry Sciences
Country China 
Sector Academic/University 
PI Contribution Undertake joint research work to investigate to identify the molecular determinants that are critical for enhancing potency and efficacy of vaccines, as well as those that are associated with heightened zoonotic risk.
Collaborator Contribution Provision of samples, reagents and research facilities
Impact Published joint paper (1)ian Xu, Xixi Zhang, Shuanghai Zhou, Junjun Shen,Dawei Yang, Jing Wu, Xiaoyang Li, Meiling Li, Xiufen Huang, Joshua E. Sealy, Munir Iqbal&Yongqing Li (2017). A DNA aptamer efficiently inhibits the infectivity of Bovine herpesvirus 1 by blocking viral entry. Scientific Reports. 7: 11796. doi:10.1038/s41598-017-10070-1. (2) Jian Xu, Jing Wu, Houjun He, Junjun Shena, Dawei Yang, Xixi Zhang, Xiaoyang Li, Meiling Li, Xiufen Huang, Joshua Sealy, Munir Iqbal & Yongqing Li (2017). Bovine single chain Fv antibody inhibits bovine herpesvirus-1 infectivity by targeting viral glycoprotein D. Applied Microbiology and Biotechnology. https://doi.org/10.1007/s00253-017-8566-0. (2)
Start Year 2017
 
Description Understanding antigenic diversity, zoonotic potential and immunological prevention of avian influenza viruses affecting poultry 
Organisation China Agricultural University (CAU)
Department College of Veterinary Medicine
Country China 
Sector Academic/University 
PI Contribution Undertake joint research work to investigate to identify the molecular determinants that are critical for enhancing potency and efficacy of vaccines, as well as those that are associated with heightened zoonotic risk.
Collaborator Contribution Provision of samples, reagents and research facilities
Impact Published joint paper (1)ian Xu, Xixi Zhang, Shuanghai Zhou, Junjun Shen,Dawei Yang, Jing Wu, Xiaoyang Li, Meiling Li, Xiufen Huang, Joshua E. Sealy, Munir Iqbal&Yongqing Li (2017). A DNA aptamer efficiently inhibits the infectivity of Bovine herpesvirus 1 by blocking viral entry. Scientific Reports. 7: 11796. doi:10.1038/s41598-017-10070-1. (2) Jian Xu, Jing Wu, Houjun He, Junjun Shena, Dawei Yang, Xixi Zhang, Xiaoyang Li, Meiling Li, Xiufen Huang, Joshua Sealy, Munir Iqbal & Yongqing Li (2017). Bovine single chain Fv antibody inhibits bovine herpesvirus-1 infectivity by targeting viral glycoprotein D. Applied Microbiology and Biotechnology. https://doi.org/10.1007/s00253-017-8566-0. (2)
Start Year 2017
 
Description Understanding antigenic diversity, zoonotic potential and immunological prevention of avian influenza viruses affecting poultry 
Organisation Chinese Center for Disease Control and Prevention (China CDC)
Country China 
Sector Public 
PI Contribution Undertake joint research work to investigate to identify the molecular determinants that are critical for enhancing potency and efficacy of vaccines, as well as those that are associated with heightened zoonotic risk.
Collaborator Contribution Provision of samples, reagents and research facilities
Impact Published joint paper (1)ian Xu, Xixi Zhang, Shuanghai Zhou, Junjun Shen,Dawei Yang, Jing Wu, Xiaoyang Li, Meiling Li, Xiufen Huang, Joshua E. Sealy, Munir Iqbal&Yongqing Li (2017). A DNA aptamer efficiently inhibits the infectivity of Bovine herpesvirus 1 by blocking viral entry. Scientific Reports. 7: 11796. doi:10.1038/s41598-017-10070-1. (2) Jian Xu, Jing Wu, Houjun He, Junjun Shena, Dawei Yang, Xixi Zhang, Xiaoyang Li, Meiling Li, Xiufen Huang, Joshua Sealy, Munir Iqbal & Yongqing Li (2017). Bovine single chain Fv antibody inhibits bovine herpesvirus-1 infectivity by targeting viral glycoprotein D. Applied Microbiology and Biotechnology. https://doi.org/10.1007/s00253-017-8566-0. (2)
Start Year 2017
 
Description Understanding antigenic diversity, zoonotic potential and immunological prevention of avian influenza viruses affecting poultry 
Organisation Francis Crick Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Undertake joint research work to investigate to identify the molecular determinants that are critical for enhancing potency and efficacy of vaccines, as well as those that are associated with heightened zoonotic risk.
Collaborator Contribution Provision of samples, reagents and research facilities
Impact Published joint paper (1)ian Xu, Xixi Zhang, Shuanghai Zhou, Junjun Shen,Dawei Yang, Jing Wu, Xiaoyang Li, Meiling Li, Xiufen Huang, Joshua E. Sealy, Munir Iqbal&Yongqing Li (2017). A DNA aptamer efficiently inhibits the infectivity of Bovine herpesvirus 1 by blocking viral entry. Scientific Reports. 7: 11796. doi:10.1038/s41598-017-10070-1. (2) Jian Xu, Jing Wu, Houjun He, Junjun Shena, Dawei Yang, Xixi Zhang, Xiaoyang Li, Meiling Li, Xiufen Huang, Joshua Sealy, Munir Iqbal & Yongqing Li (2017). Bovine single chain Fv antibody inhibits bovine herpesvirus-1 infectivity by targeting viral glycoprotein D. Applied Microbiology and Biotechnology. https://doi.org/10.1007/s00253-017-8566-0. (2)
Start Year 2017
 
Description Understanding antigenic diversity, zoonotic potential and immunological prevention of avian influenza viruses affecting poultry 
Organisation University of Glasgow
Department Institute of Biodiversity, Animal Health and Comparative Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Undertake joint research work to investigate to identify the molecular determinants that are critical for enhancing potency and efficacy of vaccines, as well as those that are associated with heightened zoonotic risk.
Collaborator Contribution Provision of samples, reagents and research facilities
Impact Published joint paper (1)ian Xu, Xixi Zhang, Shuanghai Zhou, Junjun Shen,Dawei Yang, Jing Wu, Xiaoyang Li, Meiling Li, Xiufen Huang, Joshua E. Sealy, Munir Iqbal&Yongqing Li (2017). A DNA aptamer efficiently inhibits the infectivity of Bovine herpesvirus 1 by blocking viral entry. Scientific Reports. 7: 11796. doi:10.1038/s41598-017-10070-1. (2) Jian Xu, Jing Wu, Houjun He, Junjun Shena, Dawei Yang, Xixi Zhang, Xiaoyang Li, Meiling Li, Xiufen Huang, Joshua Sealy, Munir Iqbal & Yongqing Li (2017). Bovine single chain Fv antibody inhibits bovine herpesvirus-1 infectivity by targeting viral glycoprotein D. Applied Microbiology and Biotechnology. https://doi.org/10.1007/s00253-017-8566-0. (2)
Start Year 2017
 
Description Understanding diversity of avian influenza viruses and improvement disease control in poultry and humans 
Organisation Agricultural Research Centre
Department Veterinary Serum and Vaccine Research Institute
Country Egypt 
Sector Public 
PI Contribution This project helped my research group to establish research collboration between the Pirbright Institute and the scientists at the collaborating laboratories listed above and an excellent opportunity for building a joint "ONE HEALTH" platfor. I am sharing knowledge, reagents and techniques to improve efficacious vaccines and diagnostic tools against avian influenza viruses. The easy availability of better control tools against avian influenza viruses will aid in the reduction of poultry production losses and thus be important for global food security and improved animal welfare whilst also reducing zoonotic transmission to humans.
Collaborator Contribution Each collaborating institute and team member has specific expertise and facilities in areas relevant to this research programme. Collaborators in different institutions have extensive experience collecting field samples and implementing vaccination and large scale surveillance programmes. Each partner institutions have unique experience in monitoring the endemic prevalence of many animal diseases including avian influenza in both domestic and wild birds from which UK is under constant threat. The partners are sharing knowledge, expertise and facilities to investigate fundamental biology of influenza viruses and predict their epidemiological relevance, to assess potential risks and to devise appropriate intervention strategies. The knowledge, reagents and field samples will be available through this partnership. which will be essential for development of informed control policies and tools(vaccines and diagnostics) that may contribute to reducing the ever increasing threat from endemic, emerging and re-emerging influenza virus variants posing risk to animals and humans. Also, All researchers involved will benefit through ongoing professional development and advanced training in new technologies and new systems-level approaches to disease management. Exchange visits of researchers from collaborating laboratories to undertake training in a number of disciplines including disease surveillance, molecular virology, epidemiology, immunology, vaccinology and diagnostics will have a tangible impact on capacity building and training of next generation researchers in control of infectious animal and zoonotic diseases.
Impact The ultimate aims of this collaboration are to reduce the impact of influenza virus on poultry production and reduce their zoonotic transmission to humans. The collaboration will improve resources and capacity for disease control systems. Achieving these specific goals will prove a step-change in AIV disease management and increase in poultry productivity directly drives economic prosperity of farmers and allied communities. The will directly impact on socio-economic well-being of partner countries.
Start Year 2017
 
Description Understanding diversity of avian influenza viruses and improvement disease control in poultry and humans 
Organisation Francis Crick Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution This project helped my research group to establish research collboration between the Pirbright Institute and the scientists at the collaborating laboratories listed above and an excellent opportunity for building a joint "ONE HEALTH" platfor. I am sharing knowledge, reagents and techniques to improve efficacious vaccines and diagnostic tools against avian influenza viruses. The easy availability of better control tools against avian influenza viruses will aid in the reduction of poultry production losses and thus be important for global food security and improved animal welfare whilst also reducing zoonotic transmission to humans.
Collaborator Contribution Each collaborating institute and team member has specific expertise and facilities in areas relevant to this research programme. Collaborators in different institutions have extensive experience collecting field samples and implementing vaccination and large scale surveillance programmes. Each partner institutions have unique experience in monitoring the endemic prevalence of many animal diseases including avian influenza in both domestic and wild birds from which UK is under constant threat. The partners are sharing knowledge, expertise and facilities to investigate fundamental biology of influenza viruses and predict their epidemiological relevance, to assess potential risks and to devise appropriate intervention strategies. The knowledge, reagents and field samples will be available through this partnership. which will be essential for development of informed control policies and tools(vaccines and diagnostics) that may contribute to reducing the ever increasing threat from endemic, emerging and re-emerging influenza virus variants posing risk to animals and humans. Also, All researchers involved will benefit through ongoing professional development and advanced training in new technologies and new systems-level approaches to disease management. Exchange visits of researchers from collaborating laboratories to undertake training in a number of disciplines including disease surveillance, molecular virology, epidemiology, immunology, vaccinology and diagnostics will have a tangible impact on capacity building and training of next generation researchers in control of infectious animal and zoonotic diseases.
Impact The ultimate aims of this collaboration are to reduce the impact of influenza virus on poultry production and reduce their zoonotic transmission to humans. The collaboration will improve resources and capacity for disease control systems. Achieving these specific goals will prove a step-change in AIV disease management and increase in poultry productivity directly drives economic prosperity of farmers and allied communities. The will directly impact on socio-economic well-being of partner countries.
Start Year 2017
 
Description Understanding diversity of avian influenza viruses and improvement disease control in poultry and humans 
Organisation Imperial College London
Department MSk Lab
Country United Kingdom 
Sector Academic/University 
PI Contribution This project helped my research group to establish research collboration between the Pirbright Institute and the scientists at the collaborating laboratories listed above and an excellent opportunity for building a joint "ONE HEALTH" platfor. I am sharing knowledge, reagents and techniques to improve efficacious vaccines and diagnostic tools against avian influenza viruses. The easy availability of better control tools against avian influenza viruses will aid in the reduction of poultry production losses and thus be important for global food security and improved animal welfare whilst also reducing zoonotic transmission to humans.
Collaborator Contribution Each collaborating institute and team member has specific expertise and facilities in areas relevant to this research programme. Collaborators in different institutions have extensive experience collecting field samples and implementing vaccination and large scale surveillance programmes. Each partner institutions have unique experience in monitoring the endemic prevalence of many animal diseases including avian influenza in both domestic and wild birds from which UK is under constant threat. The partners are sharing knowledge, expertise and facilities to investigate fundamental biology of influenza viruses and predict their epidemiological relevance, to assess potential risks and to devise appropriate intervention strategies. The knowledge, reagents and field samples will be available through this partnership. which will be essential for development of informed control policies and tools(vaccines and diagnostics) that may contribute to reducing the ever increasing threat from endemic, emerging and re-emerging influenza virus variants posing risk to animals and humans. Also, All researchers involved will benefit through ongoing professional development and advanced training in new technologies and new systems-level approaches to disease management. Exchange visits of researchers from collaborating laboratories to undertake training in a number of disciplines including disease surveillance, molecular virology, epidemiology, immunology, vaccinology and diagnostics will have a tangible impact on capacity building and training of next generation researchers in control of infectious animal and zoonotic diseases.
Impact The ultimate aims of this collaboration are to reduce the impact of influenza virus on poultry production and reduce their zoonotic transmission to humans. The collaboration will improve resources and capacity for disease control systems. Achieving these specific goals will prove a step-change in AIV disease management and increase in poultry productivity directly drives economic prosperity of farmers and allied communities. The will directly impact on socio-economic well-being of partner countries.
Start Year 2017
 
Description Understanding diversity of avian influenza viruses and improvement disease control in poultry and humans 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution This project helped my research group to establish research collboration between the Pirbright Institute and the scientists at the collaborating laboratories listed above and an excellent opportunity for building a joint "ONE HEALTH" platfor. I am sharing knowledge, reagents and techniques to improve efficacious vaccines and diagnostic tools against avian influenza viruses. The easy availability of better control tools against avian influenza viruses will aid in the reduction of poultry production losses and thus be important for global food security and improved animal welfare whilst also reducing zoonotic transmission to humans.
Collaborator Contribution Each collaborating institute and team member has specific expertise and facilities in areas relevant to this research programme. Collaborators in different institutions have extensive experience collecting field samples and implementing vaccination and large scale surveillance programmes. Each partner institutions have unique experience in monitoring the endemic prevalence of many animal diseases including avian influenza in both domestic and wild birds from which UK is under constant threat. The partners are sharing knowledge, expertise and facilities to investigate fundamental biology of influenza viruses and predict their epidemiological relevance, to assess potential risks and to devise appropriate intervention strategies. The knowledge, reagents and field samples will be available through this partnership. which will be essential for development of informed control policies and tools(vaccines and diagnostics) that may contribute to reducing the ever increasing threat from endemic, emerging and re-emerging influenza virus variants posing risk to animals and humans. Also, All researchers involved will benefit through ongoing professional development and advanced training in new technologies and new systems-level approaches to disease management. Exchange visits of researchers from collaborating laboratories to undertake training in a number of disciplines including disease surveillance, molecular virology, epidemiology, immunology, vaccinology and diagnostics will have a tangible impact on capacity building and training of next generation researchers in control of infectious animal and zoonotic diseases.
Impact The ultimate aims of this collaboration are to reduce the impact of influenza virus on poultry production and reduce their zoonotic transmission to humans. The collaboration will improve resources and capacity for disease control systems. Achieving these specific goals will prove a step-change in AIV disease management and increase in poultry productivity directly drives economic prosperity of farmers and allied communities. The will directly impact on socio-economic well-being of partner countries.
Start Year 2017
 
Description Understanding diversity of avian influenza viruses and improvement disease control in poultry and humans 
Organisation Suez Canal University
Country Egypt 
Sector Academic/University 
PI Contribution This project helped my research group to establish research collboration between the Pirbright Institute and the scientists at the collaborating laboratories listed above and an excellent opportunity for building a joint "ONE HEALTH" platfor. I am sharing knowledge, reagents and techniques to improve efficacious vaccines and diagnostic tools against avian influenza viruses. The easy availability of better control tools against avian influenza viruses will aid in the reduction of poultry production losses and thus be important for global food security and improved animal welfare whilst also reducing zoonotic transmission to humans.
Collaborator Contribution Each collaborating institute and team member has specific expertise and facilities in areas relevant to this research programme. Collaborators in different institutions have extensive experience collecting field samples and implementing vaccination and large scale surveillance programmes. Each partner institutions have unique experience in monitoring the endemic prevalence of many animal diseases including avian influenza in both domestic and wild birds from which UK is under constant threat. The partners are sharing knowledge, expertise and facilities to investigate fundamental biology of influenza viruses and predict their epidemiological relevance, to assess potential risks and to devise appropriate intervention strategies. The knowledge, reagents and field samples will be available through this partnership. which will be essential for development of informed control policies and tools(vaccines and diagnostics) that may contribute to reducing the ever increasing threat from endemic, emerging and re-emerging influenza virus variants posing risk to animals and humans. Also, All researchers involved will benefit through ongoing professional development and advanced training in new technologies and new systems-level approaches to disease management. Exchange visits of researchers from collaborating laboratories to undertake training in a number of disciplines including disease surveillance, molecular virology, epidemiology, immunology, vaccinology and diagnostics will have a tangible impact on capacity building and training of next generation researchers in control of infectious animal and zoonotic diseases.
Impact The ultimate aims of this collaboration are to reduce the impact of influenza virus on poultry production and reduce their zoonotic transmission to humans. The collaboration will improve resources and capacity for disease control systems. Achieving these specific goals will prove a step-change in AIV disease management and increase in poultry productivity directly drives economic prosperity of farmers and allied communities. The will directly impact on socio-economic well-being of partner countries.
Start Year 2017
 
Description Understanding diversity of avian influenza viruses and improvement disease control in poultry and humans 
Organisation University of Tokyo
Department International Research Center for Infectious Diseases
Country Japan 
Sector Hospitals 
PI Contribution This project helped my research group to establish research collboration between the Pirbright Institute and the scientists at the collaborating laboratories listed above and an excellent opportunity for building a joint "ONE HEALTH" platfor. I am sharing knowledge, reagents and techniques to improve efficacious vaccines and diagnostic tools against avian influenza viruses. The easy availability of better control tools against avian influenza viruses will aid in the reduction of poultry production losses and thus be important for global food security and improved animal welfare whilst also reducing zoonotic transmission to humans.
Collaborator Contribution Each collaborating institute and team member has specific expertise and facilities in areas relevant to this research programme. Collaborators in different institutions have extensive experience collecting field samples and implementing vaccination and large scale surveillance programmes. Each partner institutions have unique experience in monitoring the endemic prevalence of many animal diseases including avian influenza in both domestic and wild birds from which UK is under constant threat. The partners are sharing knowledge, expertise and facilities to investigate fundamental biology of influenza viruses and predict their epidemiological relevance, to assess potential risks and to devise appropriate intervention strategies. The knowledge, reagents and field samples will be available through this partnership. which will be essential for development of informed control policies and tools(vaccines and diagnostics) that may contribute to reducing the ever increasing threat from endemic, emerging and re-emerging influenza virus variants posing risk to animals and humans. Also, All researchers involved will benefit through ongoing professional development and advanced training in new technologies and new systems-level approaches to disease management. Exchange visits of researchers from collaborating laboratories to undertake training in a number of disciplines including disease surveillance, molecular virology, epidemiology, immunology, vaccinology and diagnostics will have a tangible impact on capacity building and training of next generation researchers in control of infectious animal and zoonotic diseases.
Impact The ultimate aims of this collaboration are to reduce the impact of influenza virus on poultry production and reduce their zoonotic transmission to humans. The collaboration will improve resources and capacity for disease control systems. Achieving these specific goals will prove a step-change in AIV disease management and increase in poultry productivity directly drives economic prosperity of farmers and allied communities. The will directly impact on socio-economic well-being of partner countries.
Start Year 2017
 
Description Understanding diversity of avian influenza viruses and improvement disease control in poultry and humans 
Organisation Zagazig University
Country Egypt 
Sector Academic/University 
PI Contribution This project helped my research group to establish research collboration between the Pirbright Institute and the scientists at the collaborating laboratories listed above and an excellent opportunity for building a joint "ONE HEALTH" platfor. I am sharing knowledge, reagents and techniques to improve efficacious vaccines and diagnostic tools against avian influenza viruses. The easy availability of better control tools against avian influenza viruses will aid in the reduction of poultry production losses and thus be important for global food security and improved animal welfare whilst also reducing zoonotic transmission to humans.
Collaborator Contribution Each collaborating institute and team member has specific expertise and facilities in areas relevant to this research programme. Collaborators in different institutions have extensive experience collecting field samples and implementing vaccination and large scale surveillance programmes. Each partner institutions have unique experience in monitoring the endemic prevalence of many animal diseases including avian influenza in both domestic and wild birds from which UK is under constant threat. The partners are sharing knowledge, expertise and facilities to investigate fundamental biology of influenza viruses and predict their epidemiological relevance, to assess potential risks and to devise appropriate intervention strategies. The knowledge, reagents and field samples will be available through this partnership. which will be essential for development of informed control policies and tools(vaccines and diagnostics) that may contribute to reducing the ever increasing threat from endemic, emerging and re-emerging influenza virus variants posing risk to animals and humans. Also, All researchers involved will benefit through ongoing professional development and advanced training in new technologies and new systems-level approaches to disease management. Exchange visits of researchers from collaborating laboratories to undertake training in a number of disciplines including disease surveillance, molecular virology, epidemiology, immunology, vaccinology and diagnostics will have a tangible impact on capacity building and training of next generation researchers in control of infectious animal and zoonotic diseases.
Impact The ultimate aims of this collaboration are to reduce the impact of influenza virus on poultry production and reduce their zoonotic transmission to humans. The collaboration will improve resources and capacity for disease control systems. Achieving these specific goals will prove a step-change in AIV disease management and increase in poultry productivity directly drives economic prosperity of farmers and allied communities. The will directly impact on socio-economic well-being of partner countries.
Start Year 2017
 
Description Vaccinia 
Organisation Defence Science & Technology Laboratory (DSTL)
Country United Kingdom 
Sector Public 
PI Contribution Generated and analysed DNA- and RNA-sequencing data from vaccinia samples with bespoke in-house pipelines
Collaborator Contribution Generated DNA and RNA vaccinia samples
Impact The collaboration aims to better understand the interaction between vaccina virus and its host(s), through the use of modern high-throughput techniques. No outputs yet
Start Year 2016
 
Description Virus and host community interaction and virus transmission 
Organisation Columbia University
Department Mailman School of Public Health
Country United States 
Sector Academic/University 
PI Contribution Expertise exchange between partners to cover disciplines of virology, immunology and veterinary medicine. Intellectual input into PhD studentship on viral diversity and transmission, student registered at the University of Surrey but practical work carried out at the University of Columbia. Visit to the University of Columbia in May 2018 to design collaborative project ideas and identify funding sources
Collaborator Contribution Collaborators contribute their expertise on virus ecology, bioinformatics and mathematical modelling as well as human health to enable a true one health approach to studying virus transmission and potential viral emergence. They also shared data and staff training to enable funding application
Impact Preliminary data for funding application
Start Year 2017
 
Description Virus and host community interaction and virus transmission 
Organisation University of Surrey
Department School of Veterinary Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise exchange between partners to cover disciplines of virology, immunology and veterinary medicine. Intellectual input into PhD studentship on viral diversity and transmission, student registered at the University of Surrey but practical work carried out at the University of Columbia. Visit to the University of Columbia in May 2018 to design collaborative project ideas and identify funding sources
Collaborator Contribution Collaborators contribute their expertise on virus ecology, bioinformatics and mathematical modelling as well as human health to enable a true one health approach to studying virus transmission and potential viral emergence. They also shared data and staff training to enable funding application
Impact Preliminary data for funding application
Start Year 2017
 
Description Talk Presented at 2nd International Congress of Veterinary Microbiology, 16th -19th October 2018. Sherwood Breezes Resort-Lara, Antalya, Turkey. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Conference discussed improving prevention and control of viral diseases of poultry.
Year(s) Of Engagement Activity 2018
 
Description "Challenges for Poultry Industry". Organised by Fakieh Poultry at the Ritz-Carlton Hotel in Jeddah, Saudi Arabia, 2nd -3rd December 2018, 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Conference discussed prevention and control of infectious diseases affecting poultry production.
Year(s) Of Engagement Activity 2018
 
Description "Interactive session with poultry stakeholders". Title: Overview of Avian Influenza group Research at The Pirbright Institute. Presented at University of Veterinary and Animal Sciences (UVAS) Lahore, Pakistan, 3rd August 2018. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The workshop discussed the economic impacts and prevention strategies against avian influenza viruses affecting poultry production and zoonotic infections.
Year(s) Of Engagement Activity 2018
 
Description 1st JSPS Core-to-Core Program Joint Seminar and the 7th CADIC International Symposium "Livestock Revolution in ASEAN for the Kitchen of the World" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Don King provided an invited Keynote presentation to 1st JSPS Core-to-Core Program Joint Seminar and the 7th CADIC International Symposium "Livestock Revolution in ASEAN for the Kitchen of the World", Bangkok, Thailand, October 2017 on work undertaken at Pirbright to monitor the evolution of FMDV and threats posed for transbounadary spread.
Year(s) Of Engagement Activity 2017
 
Description 2. Overview of Avian Influenza group Research at The Pirbright Institute. Presented at "Interactive session with poultry stakeholders" at University of Veterinary and Animal Sciences (UVAS) Lahore, Pakistan, 3rd August 2018. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dissemination of research Project outcomes These include presenting research data for vaccine seed strains with emergent field avian influenza variants; The zoonotic risk posed by emerging avian influenza viruses circulating in the wild birds and poultry. Impact of virus evolution on vaccine efficacy and persistence in poultry.
Year(s) Of Engagement Activity 2018
 
Description 33rd World Veterinary Congress, Incheon, South Korea, August 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Don King was an invited speaker at the 33rd World Veterinary Congress, Incheon, South Korea, August 2017. He presented a talk entitled: New tools for the detection and characterisation of transboundary diseases.
Year(s) Of Engagement Activity 2017
URL http://wvc2017korea.com/
 
Description 360 degree Lab Animal Tour (and film) of The Plowright Building, The Philip Mellor Insectary, and Animal Isolation Facilities 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The website provides unique access to the animal research facilities at The Pirbright Institute which support its world-leading scientific research into livestock viral diseases and helps save countless animal and potentially human lives, globally. Produced and filmed by Understanding Animal Research, the Lab Animal Tour was filmed at Pirbright, and at three other research centres, and provides the viewer with an interactive 360 virtual tour of the animal facilities.
Year(s) Of Engagement Activity 2017
URL http://www.labanimaltour.org/pirbright
 
Description Article in The Scientist Magazine following interview with Katya Zimmer (June 2019) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview with Journalist with The Scientist Magazine for a News Article concerning Race to Build ASFV vaccine in response to outbreaks in China/Asia
Year(s) Of Engagement Activity 2019
URL https://www.the-scientist.com/news-opinion/scientists-race-to-build-vaccine-for-african-swine-fever-...
 
Description Ash Manor Science Workshops; general science 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Ash Manor Science Workshops
Year(s) Of Engagement Activity 2019
 
Description BBSRC Partnering Seminar, University of Liverpool, Tamilnadu Veterinary and Animal Science University 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk presented entitled " Molecular determinants of antigenicity of H7 and H9 avian Influenza viruses". The research data shared with the colleagues working to reduce the impact of avian infectious diseases on poultry production. The discussion led to more collaboration and work together, acquiring reagents and protocols for further research and development activities.
Year(s) Of Engagement Activity 2019
 
Description BBSRC website article: Halloween 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Article on BBSRC website: Halloween Creepy Crawlies
Year(s) Of Engagement Activity 2017
URL http://www.bbsrc.ac.uk/news/fundamental-bioscience/2017/171031-f-uk-creepiest-creepy-crawlies/
 
Description Big Bang SE 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Stimulating increased interest in science and research
Year(s) Of Engagement Activity 2019
 
Description Blenheim High School Fair - DB 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Team members attended sessions at a local high school with secondary school children and those in the 6th form to talk about paths into scientific careers, sharing their experiences of working at The Pirbright Institute. Approximately 300 students attended and it stimulated increased interest in science and research.
Year(s) Of Engagement Activity 2019
 
Description Bluetongue and Wildlife (15 minute presentation on Epizootic Haemorhagic Disease Virus), (July/Pirbright, UK) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Policymakers reported greater interest in deer-associated diseases including EHDV and BTV
Year(s) Of Engagement Activity 2018
 
Description Bluetongue in wildlife workshop - presentation on "Bluetongue virus in deer (and other wildlife) - pathogenesis and immune responses" July 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact This workshop brought together policy makers, veterinary advisers and scientist to share information and discuss the role of wildlife for important Culicoides-borne viruses of ruminants. Gave 15 minutes presentation on "Bluetongue virus in deer (and other wildlife) - pathogenesis and immune responses"
Year(s) Of Engagement Activity 2018
 
Description Broadcast on African swine fever on BBC wolrd service "The Food Chain" 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview with BBC World Service "The Food Chain" on African swine fever virus.
Year(s) Of Engagement Activity 2018
URL https://www.bbc.co.uk/programmes/p05xhflj
 
Description Cafe Scientifique, Bradfield School, West Berkshire: "How insects spread viruses" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Cafe Scientifique is a public forum for exploring the latest ideas in science and technology. Meetings take place in cafes, bars, restaurants and even theatres, but always outside a traditional academic context. I presented to an audience of the general public and answered questions.
Year(s) Of Engagement Activity 2017
 
Description Cafe Scientifique, Reading: "How insects spread viruses" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Cafe Scientifique is a public forum for exploring the latest ideas in science and technology. Meetings take place in cafes, bars, restaurants and even theatres, but always outside a traditional academic context. I presented to an audience of the general public and answered questions.
Year(s) Of Engagement Activity 2007,2017
 
Description Chair - Royal Entomological Society Session on Insect Vectors 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Chaired session on Insect Vectors including selecting speakers and managing session.
Year(s) Of Engagement Activity 2019
URL https://www.royensoc.co.uk/sites/default/files/RES%20Ento%20'19%20Reg.%20Leaflet_web.pdf
 
Description Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Institute stand at the festival covering the Institute science in general, and transmission and gene editing to control disease, in particular.
Year(s) Of Engagement Activity 2018
 
Description Cheltenham Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Panel discussion at the Cheltenham Science Festival in 2018
One of the biggest threats to our food security is disease of our livestock and crops. Disease affects our economy and the availability of food in our shops. Don King, Head of the World Reference Lab for Foot-and-Mouth Disease, chemical ecologist John Pickett and food systems researcher John Ingram join climate scientist Tamsin Edwards to explore the risks to the UK's food supply and how preventing and controlling these diseases keeps our store cupboards well-stocked.
Year(s) Of Engagement Activity 2018
URL https://www.cheltenhamfestivals.com/science/whats-on/2018/how-safe-is-our-food-supply/
 
Description Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Stimulating increased interest in science and research
Year(s) Of Engagement Activity 2019
 
Description Cheltenham Science Festival 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Attended the Cheltenham Science Festival and presented "Pandemic Live" an interactive debate on the spread of viruses in livestock. The audience were guided through the decision making processes that accompany an outbreak of an exotic livestock disease outbreak.
Year(s) Of Engagement Activity 2018
 
Description Cheltenham Science festival - LB 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact National science festival which Team members attended to demonstrate to the public how scientists at The Pirbright Institute can work to contain and control viral outbreaks. Over 500 people accessed the information and this stimulated increased interest in science and research.
Year(s) Of Engagement Activity 2019
 
Description Combating avian influenza through systematic analysis of antigenic drift, genetic variation, and development of novel diagnostic tools and vaccines. Presented at as PI of the ZELS project at ZELS grant holders and Stakeholders meeting in Hanoi, Vietnam 23th-24th January 2017. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Engagement and dissemination of research outcome to representatives of research funding bodies such as Department for International Development (DFID), Medical Research Council (MRC) and the researchers working on different research projects funded by BBSRC under Zoonoses and Emerging Livestock Systems (ZELS).
Year(s) Of Engagement Activity 2018
 
Description Conor Haydon participated in the STEM Day - Speed interviews and Careers Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact STEM day engagement and careers
Year(s) Of Engagement Activity 2018
 
Description Deimante Lukosaityte: Microbiology Society conference 2019. Poster presentation: Chicken protection against H9N2 virus by passive immunization 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Described techniques for development of next generation of vaccines against viral diseases affecting animals and humans.
Year(s) Of Engagement Activity 2019
 
Description Demonstrating Mathematics (Angita Shrestha) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Angita Shrestha (PhD student within Avian Influenza group) provided help in a Maths session to the new Oxford Doctoral Training Porgramme (DTP) cohort.
Year(s) Of Engagement Activity 2018
 
Description Determinants of antigenicity of H9 Avian Influenza Viruses. UK-China Swine and Poultry Workshop.17-18 June 2019, The Pirbright Institute, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description EUFMD 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact During the EuFMDV conference taking place from 26 to 28 October 2016, Paolo Ribeca gave a talk on "VIBAsys and FMDV-Tools: Practical resources for FMDV sequence analysis". The conference, organised by the EU, gathers most of the important actors in FMD control. The talk explained how the new resources being developed by the Integrative Biology and Bioinformatics on behalf of the FMDV World Reference Lab can be useful to the community
Year(s) Of Engagement Activity 2016
 
Description EpiRisk Workshop, IZS Teramo, Italy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on work done as part of EFSA lumpy skin disease working groups to inform risk modellers/epidemiologists about possible approaches
Year(s) Of Engagement Activity 2019
 
Description European Society Vector Ecology (Invited Chair for two sessions and speaker for 15min talk); (October/Palermo, Sicily) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chaired two sessions, one on vector-borne diseases, one on scientific networks. Latter included a discussion with early career researchers. Main outcome was coordination between active networks including The Gnatwork.
Year(s) Of Engagement Activity 2018
URL http://www.sove.org/European%20SOVE%20folder/greecescientificprogram/palermo_Scientific_program_revi...
 
Description Evolution of H9N2 avian influenza virus under immune pressure. Presented at 10th International Symposium on Avian Influenza, 15th - 18th April 2018, The Grand Hotel, Brighton, UK. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The primary aim of the workshop was to forge long-term research partnerships between early-career researchers, livestock industry and national disease control authorities in the UK and the Philippines. In addition, the activity hopes provide information about the emerging and next generation diagnostic and vaccine strategies and their utilization to reduce the impact of viral diseases on livestock and poultry.
Year(s) Of Engagement Activity 2019
URL https://www.slideshare.net/zerep_cire/2019-newton-agham-researcher-links-workshop-vaccines-and-diagn...
 
Description Expert group meeting for PPR eradication at head quarters of WHO, Vienna, Austria, 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact In the FAO/PPR eradication meeting satya has presented work on PPR epidemiology and diagnosis. The talk was designed for the stakeholders and policy make to make aware on important points that are required for eradication of PPR
Year(s) Of Engagement Activity 2018
 
Description FMD vaccine evaluation and reasons for failures 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Presentation given to Gulf countries in collaboration with Boehringer Ingelheim Animal Health
Year(s) Of Engagement Activity 2017
 
Description Facebook Live: Infectious Disease Portrayals in Pop Culture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Infectious diseases are a frequent topic in movies. The CDC has used zombies to talk about infectious disease and disaster preparedness, and infotainment has flamed fears of Ebola. I took part in a Facebook Live chat organised by the AAAS Public Engagement team about why infectious diseases are so often the topic of pop culture discussions; what movies, books, and other pop culture gets right and wrong about infectious disease; and how scientists can use pop culture as a jumping-off point for public engagement. The chat was broadcast live on the AAAS Facebook page.
Year(s) Of Engagement Activity 2017
URL https://www.aaas.org/event/facebook-live-infectious-disease-portrayals-pop-culture
 
Description H9N2 avian influenza viruses: impact of evolutionary changes on virus antigenicity, receptor binding and zoonotic potential. Presented at "Conference on Animal Infectious Diseases and Human Health" held at The Veterinary Biotechnology Branch of Chinese Association of Animal Science and Veterinary Medicine & the Veterinary Immunology Branch of Chinese Society for Immunology. August 7th-10th, 2018 Harbin, China. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Focus of the conference was to improve control against infectious diseases affecting poultry and livestock.
Year(s) Of Engagement Activity 2018
 
Description H9N2 avian influenza viruses: impact of evolutionary changes on virus antigenicity, receptor binding and zoonotic potential. Presented at "Conference on Animal Infectious Diseases and Human Health" held at The Veterinary Biotechnology Branch of Chinese Association of Animal Science and Veterinary Medicine & the Veterinary Immunology Branch of Chinese Society for Immunology. August 7th-10th, 2018 Harbin, China. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Dissemination of research outcomes to prevent and control of infectious diseases of animals and humans.
- Avian influenza virus evolution and efficacy.
-
Year(s) Of Engagement Activity 2018
 
Description Identification of antigenic epitopes to broaden and enhance the efficacy of avian influenza vaccines. Presented at 6th Animal Vaccines and immune Adjuvant Technologies Salon & Advanced seminar, Shandong-Binzhou Animal Science and Veterinary Medicine Academy, China, 18-20 October 2019. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion was the best practices to improve control systems (vaccines and diagnostics) for prevention of avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description Immuno-pathobiology of H9N2 avian influenza viruses: looking at how the viruses evolve and persist in poultry. Presented at "Techniques for Healthy Farming and Diseases Prevention & Control of Livestock and Poultry. Beijing, August 13th-15th, 2018. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Dissemination of research outputs. Improvement of vaccines and diagnostics.
Year(s) Of Engagement Activity 2018
 
Description Influenza update 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Approx. 70 scientists attended a Influenza update meeting at which our group presented an oral presentation and poster presentation on our work. These actions resulted in establishment of new collaborations for ongoing work and the initiation of a joint grant writing exercise.
Year(s) Of Engagement Activity 2018
 
Description Influenza update meeting (Pengxiang Chang) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact presented work entitled: Antigenic characterization of avian influenza H7N9 virus by in vitro immune escape mutant selection method.
Year(s) Of Engagement Activity 2018
 
Description Initiation of a mass vaccination campain ( 2018) in TamilNadu, India 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Scientists from The Pirbright Institute's Vaccine Differentiation group have recently returned from Chennai in India, where they conducted a mass peste des petits ruminants (PPR) vaccination campaign and awareness programme. They joined scientists from four specialist organisations; Tamil Nadu Veterinary and Animal Sciences University (TANUVAS), Indian Veterinary Research Institute (IVRI), National Institute of Animal Biotechnology (NIAB) and National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI).
Peste des petits ruminants (PPR), also known as goat plague, is highly contagious and infects small ruminants such as sheep and goats, causing up to 90% mortality. The disease is prevalent across large parts of Africa, the Middle East, India and China and is estimated to cost between US$1.4 billion and US$2.1 billion globally each year. In 2017, the Food and Agricultural Organization (FAO) and the World Organisation for Animal Health (OIE) introduced a global eradication programme to reduce the devastating impact PPR has on the economy and food security of affected countries.
"Over 40 vets joined our vaccination campaign in the Tanir Kulum village of Tiruvallur District, TaminNadu (close to Chennai), where we administered vaccines to over 400 sheep and goats in a single day. We also ran an awareness camp where we provided farmers and vets alike with expert guidance on diagnosing clinical signs of PPR and what measures they could take to reduce its spread", said Professor Satya Parida from Pirbright, who led the collaborative effort with Dr Dhinakar Raj from TANUVAS.
Year(s) Of Engagement Activity 2018
URL https://www.pirbright.ac.uk/news/2018/09/pirbright-scientists-run-vaccination-campaign-eradicate-pes...
 
Description InnovSur : Conference in IRD Montpellier on Insect Vector Surveillance 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Working group on standardisation of techniques for surveillance of insect vectors. Included break out group brainstorming and subsequent commentaries. Total audience approximately 110 people for main lectures.
Year(s) Of Engagement Activity 2018
URL https://www.alphavisa.com/isessah-innovsur/2018/
 
Description Innovate Guildford (Angita Shrestha): 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact GENERAL SCIENCE
Year(s) Of Engagement Activity 2019
 
Description Innovate Guildford - DB & KC 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Public science event where team members participated on a Pirbright Institute stand which contained activities to help the public understand how scientists can help to contain and control viral outbreaks. Over 500 members of the general public attended which stimulated increased interest in science and research and led to requests for more information.
Year(s) Of Engagement Activity 2019
 
Description Innovate Guildford 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Institute stand at the Innovate Guildford event, covering the work of the Institute in general and genetic modification through gene editing specifically.
Year(s) Of Engagement Activity 2018
URL https://www.guildford.gov.uk/IG18
 
Description Inreview with Daily Telegraph about African swine fever 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Interview with reporter from Daily Telegraph about African swine fever virus and risks to UK farmers
Year(s) Of Engagement Activity 2018
URL https://www.telegraph.co.uk/news/2018/12/12/uk-farmers-warned-alert-african-swine-fever-virus-hits-e...
 
Description Insect Festival 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Ran a stand on blood-sucking arthropods and their role in the transmission of disease at the Royal Entomological Society's Insect Festival. Talked to public, answered questions. Lots of enquiries about ticks, midges, mosquitoes and large biting flies (particularly horseflies).
Year(s) Of Engagement Activity 2017
URL https://www.yorkmuseumstrust.org.uk/whats-on/events/insect-festival-2017/
 
Description Institute stand at Surrey Vet School open day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Stimulating increased interest in science and research
Year(s) Of Engagement Activity 2019
 
Description International Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Global Alliance for Research on Avian Diseases conference health in Hanoi 17-19 January 2018. Purpose of the conference was to establish global partnerships and links between academic researchers and the poultry industry to improve joined up work in regards to preventing, controlling and
combating avian diseases. The conferences provided a forum for discussion and exchange of ideas around the single theme of exploiting available opportunities to deal with emerging and existing infectious avian diseases in poultry production systems and to safeguard food supplies and human health.
Conference speakers discuused basic, applied and commercial aspects of research on avian diseases including:
• Evolution and Epidemiology of Avian Pathogens
• Host-Pathogen Interactions - Virulence and Pathogenicity
• Pathogen Mechanisms of Immune Evasion
• Next Generation Disease Control Strategies
• Vaccines
• Immunity
• Diagnostics
• Zoonoses and Socio-economic impacts of avian diseases
• Global Research Opportunities and Threats
Year(s) Of Engagement Activity 2018
URL http://www.theeventsportal.com/GARAD-2018/3/Home
 
Description Interview with Associated Press on ASFV vaccines 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview with Associated Press
Year(s) Of Engagement Activity 2019
URL https://apnews.com/32f84f66ce77415b96c4e90915cce6ee
 
Description Interview with Australian Broadcasting Corporation on African swine fever virus impact and vaccine development 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview with Australian Broadcasting Corporation about ASFV impact and vaccines
Year(s) Of Engagement Activity 2019
URL https://www.abc.net.au/news/rural/2019-11-01/african-swine-fever-vaccine-development/11645366
 
Description Interview with CNN on African swine fever virus 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview with Nina Avramova from CNN International about African swine fever virus generally including transmission mechanisms and control strategies
Year(s) Of Engagement Activity 2018
URL https://edition.cnn.com/2018/10/02/health/african-swine-fever-europe-china-spread-intl/index.html
 
Description Interview with Health for Animals about African swine fever vrius vaccine development and current situation 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Interview with journalists from Health for Animals about African swine fever vaccine research published in a newsletter sent to 200 people.
Year(s) Of Engagement Activity 2018
URL https://healthforanimals.org/resources-and-events/newsletter-repository/17-disease-outbreaks.html?q=...
 
Description Interview with IEG Policay about ASFV vaccines 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Interview with Peter Rixon of IEG policy about the prospects for development of vaccines for African swine fever vrius
Year(s) Of Engagement Activity 2018
URL https://iegvu.agribusinessintelligence.informa.com/CO221819/ASF-outbreak-in-Belgium-highlights-lack-...
 
Description Interview with Journalist with The Scientist Magazine concerning ASFV vaccines and our research 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview with Katya Zimmer Science Journalist with The Scientist Magazine published in July. This lead to follow up interviews for an in depth article on ASFV vaccines for the Scientist Magazine. In addition The Scientist published 4 Infographics images associated with the article
Year(s) Of Engagement Activity 2019
URL https://www.the-scientist.com/features/can-a-vaccine-save-the-worlds-pigs-from-african-swine-fever
 
Description Interview with New Scientist Magazine about African swine fever virus spread and vaccines 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview for an article in New Scientist about impact of African swine fever in Asia
Year(s) Of Engagement Activity 2019
URL https://www.newscientist.com/article/2222501-a-quarter-of-all-pigs-have-died-this-year-due-to-africa...
 
Description Interview with United Press about ASFV vaccine development 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview with United Press International on Development of ASFV vaccines
Year(s) Of Engagement Activity 2019
URL https://www.upi.com/Top_News/US/2019/07/12/World-races-to-develop-African-swine-fever-vaccine/671156...
 
Description Interview with journalist and provided input to article on African swine fever vaccine development 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interviews with Katya Zimmer journalist with the Scientist Magazine and help with preparation of figures
Year(s) Of Engagement Activity 2019
URL https://www.the-scientist.com/features/can-a-vaccine-save-the-worlds-pigs-from-african-swine-fever--...
 
Description Invitation to give keynote talk on 'Control of avian diseases: Challenges and opportunities' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Gave the Keynote talk on 'Control of avian diseases: Challenges and opportunities' at this International Symposium organized with an aim to gather international virology experts from both human and veterinary fields to share research experience, update findings and contribute their expertise through presentation and interactive discussion. The topics will cover a wide range of virology research common in both human and animal aspects. In addition, technological platforms such as vaccine development, and novel assays will be emphasized and addressed.
Year(s) Of Engagement Activity 2018
URL http://www.biotec.or.th/virus-symposium2018/index.php
 
Description Invited Chair at European Congress of Entomology (Naples,July) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chaired session on vector-borne diseases at meeting and subsequent question sessions with 15 minute presentation on Culicoides biting midges.
Year(s) Of Engagement Activity 2018
URL http://www.ece2018.com/scientific-programme/day-1-monday-2-july/
 
Description Invited Keynote Speaker International Society of Veterinary Epidemiology and Ecology, China Mai Thailand 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote talk on progress towards African swin efever virus vaccine development at ISVEE meeting Thailand
Year(s) Of Engagement Activity 2018
 
Description Invited Lecture - Antivec Network 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation give on 'The Gnatwork'. 21/06/19.
Year(s) Of Engagement Activity 2019
URL https://www.gla.ac.uk/research/az/antivec/
 
Description Invited Lecture - Public Health Interest Group (London School Hygiene and Tropical Medicine) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited talk presented and discussion session particiation (09/04/19)
Year(s) Of Engagement Activity 2019
 
Description Invited Lecture - Wageningen University and Research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk title: Culicoides-borne arboviruses in Europe - Invited lecture
Year(s) Of Engagement Activity 2019
 
Description Invited Speaker: 33rd World Veterinary Congress, South Korea 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Provided two invited keynote presentations at the 33rd World Veterinary Congress, Incheon, South Korea, August 2017:
[1] Foot-and-mouth disease: recent outbreaks and patterns of virus spread
[2] New tools for the detection and characterisation of transboundary diseases
Year(s) Of Engagement Activity 2017
URL http://www.worldvet.org/congress.php?year=2017
 
Description Invited Talk: 8th International Veterinary Congress, Moscow, Russia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact DK was invited to give a talk entitled "Global surveillance for foot-and-mouth disease: new tools and approaches to predict risks and help control outbreaks" at the 8th International Veterinary Congress, in Moscow, Russia, April 2018.
Year(s) Of Engagement Activity 2018
 
Description Invited expert to the International gnatwork training workshop in Bangladesh 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact One of the invited disease experts to deliver an international training workshop in Bangladesh on the biology and vectorial roles of blackflies, sandflies and Culicoides biting midges. Initially this involved a presentation on "Of creatures big and very small - veterinary aspects of veterinary vector-borne pathogen research" at the start-up conference in Dhaka followed by a 4 day practical workshop at the BRAC learning centre (Mymensingh) where I was part of the training team on study design, data analysis and genetic identification of vector insects using molecular diagnostics.
Year(s) Of Engagement Activity 2018
URL https://www.gnatwork.ac.uk/bangladesh-18
 
Description Invited participant, Improving the Use of Evidence in Policymaking in the UK Government (Parliamentary Office of Science and Technology) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Invited to attend meeting to launch POST report "Improving the Use of Evidence in Policymaking in the UK Government" as a result of previous collaboration.
Year(s) Of Engagement Activity 2017
URL http://www.sciencecampaign.org.uk/resource/casereportimprovingtheuseofevidence2017.html
 
Description Invited presentation at the Friedrich Loeffler Institute (January; Riems) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Formal presentation on biting midges and bluetongue to professional audience with question session and collaborative meetings
Year(s) Of Engagement Activity 2019
 
Description Invited speaker British Society of Veterinary Pathology Annual Meeting 2018, Applied Ruminant Pathology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker on "Bluetongue virus and Schmallenberg virus - recognising the continued threat of Culicoides-borne viruses of ruminants" British Society of Veterinary Pathology Annual Meeting 2018, Applied Ruminant Pathology
School of Veterinary Medicine, University of Surrey, 29th of September 2018,
Year(s) Of Engagement Activity 2018
URL https://www.bsvp.org/event/applied-ruminant-pathology-disease-investigation-diagnosis-and-surveillan...
 
Description Invited speaker VECTOR-BORNE DISEASES (VBD) IN THE UK - BIENNIAL MEETING 2018 John Innes Centre Norwich 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker on "The Host-vector-pathogen Interface of Culicoides-borne Bluetongue Virus" at the VECTOR-BORNE DISEASES (VBD) IN THE UK - BIENNIAL MEETING 2018 John Innes Centre Norwich 4th-5th December 2018
Year(s) Of Engagement Activity 2018
 
Description Invited speaker at APHA surveillance meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker on insect surveillance at Animal and Plant Health Agency meeting with discussion around current studies.
Year(s) Of Engagement Activity 2018
 
Description Invited speaker, Vienna Veterinary School 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Gave a guest lecture at the Veterinary school in Vienna. There were a lot of questions and discussion after the talk. As a result established collaboration with Gerner Wilhelm's group.
Year(s) Of Engagement Activity 2019
URL https://www.vetmeduni.ac.at/de/graduate-school-pig-and-poultry-medicine/
 
Description Invited talk at Agricultural Science congress at New Delhi, India, February-2019- Use of reverse genetics to study the early pathogenesis and to develop marker vaccines for PPR 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact 1. In a DBT-BBSRC FADH grant, The Pirbright Institute in collaboration with four Indian partners (TANUVAS, IVRI, NIAB and NIVEDI) has developed a PPR vaccine, which will be the first to differentiate between infected and vaccinated animals (DIVA), for which a patent application has been filed. Scientists have manipulated in the genome of PPR full length cDNA and rescued the DIVA vaccine virus using reverse genetic technique. Further this vaccine has been tested in goats providing full safety and potency upon virulent virus challenge. In contrast to current vaccine, this new DIVA vaccine can differentiate between naturally infected and vaccinated animals, therefore will help in meaningful assessment of vaccine coverage and epidemiological surveillance based on serology, in turn increasing the efficiency of control programmes.
2. Little is known about the early events in the development of peste des petits ruminants (PPR) virus (PPRV) infection. The current dogma is that similar to RPV, PPRV replicates primarily in the epithelium of the respiratory tract before disseminating throughout the host. However, our investigations, using intranasal inoculation of PPRV containing GFP (Green Fluorescent Protein) to mimic natural infection, indicate this is not the case and that immune cells in the pharyngeal tonsil is the primary target. This is a ground breaking discovery which changes the PPR pathogenesis. This infectious GFP virus is made from a synthetic cDNA of field virus (PPRV/Mor-08) using reverse genetics technique under FADH grant.
The presentation sparked questions and discussions after the talk. Two PPR DIVA vaccines developed and the mechanism of PPR virus pathogenesis explained.
Year(s) Of Engagement Activity 2019
 
Description Invited to talk at the International Conference on Building Human and Animal Health Capacities organised by the Jordan University of Science and Technology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Participated in the discussion and talked on 'The recent advances in vaccination-based control of poultry diseases'. The need for increased awareness of the pathogen diversity in the design of vaccines and the opportunities from advances in vaccine technologies were discussed
Year(s) Of Engagement Activity 2017
URL http://www.just.edu.jo/conferences/bhahc/Pages/default.aspx
 
Description Isabelle Dietrich - Bishop David Brown School Careers Fair 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact >100 students attended careers fair. Informed students about The Pirbright Institute's work and career opportunities.
Year(s) Of Engagement Activity 2019
 
Description Isabelle Dietrich - Collingwood College Careers Fair 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact >100 students attended careers fair. Informed students about The Pirbright Institute's work and career opportunities.
Year(s) Of Engagement Activity 2019
 
Description Isabelle Dietrich - Poster at IMAV 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Conference presentation, followed by questions and discussions and establishment of new collaborations.
Year(s) Of Engagement Activity 2019
 
Description Isabelle Dietrich - Talk at "Symposium on New Emerging Mosquito-Borne Diseases and Vectors", Taiwan 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Conference presentation, followed by questions and discussions and establishment of new collaborations.
Judged poster competition. Visited collaborators' institutes to introduce The Pirbright Institute's work in general and our group's work in particular.
Year(s) Of Engagement Activity 2019
 
Description Isabelle Dietrich - Talk at RIVR 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Conference presentation, followed by questions and discussions.
Year(s) Of Engagement Activity 2020
 
Description Keynote Presentation: 6ème Journée Scientifique sur les Maladies Animales Transfrontalières, Tunisia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Provided invited keynote presentation entitled "Épidémiologie de la Fièvre Aphteuse en Afrique du Nord" at the 6ème Journée Scientifique sur les Maladies Animales Transfrontalières, Gammarth, Tunisia, November 2018.
Year(s) Of Engagement Activity 2018
 
Description Keynote Presentation: EuFMD Open session 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote Presentation entitled "Global status report for foot-and-mouth disease: tracking the emergence and spread of new viral lineages" at the Open Session of the Standing Technical and Research Committee of the European Commission for the control of Foot-and-Mouth Disease, Borgo Egnazia, Puglia, Italy, October 2018.
Year(s) Of Engagement Activity 2018
URL https://intvetvaccnet.wordpress.com/2018/12/18/eufmd-open-session-2018-global-vaccine-security-borgo...
 
Description Keynote talk at the World Veterinary Poultry Association meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited to give the keynote talk on 'Avian tumour viruses: their contribution to our understanding of cancer' at the World Veterinary Poultry Association XXth Congress in Edinburgh
Year(s) Of Engagement Activity 2017
URL http://www.wvpac2017.com/
 
Description Lecture given to University of Surrey MSc Veterinary Microbiology students 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact A 2-hour teaching lecture given to 10 MSc Veterinary Microbiology students at the University of Surrey on 8th December (Lara Harrup)
Year(s) Of Engagement Activity 2017
 
Description Lecture of dynamics of vector-borne diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Lecture on the dynamics of vector-borne diseases as part of Part II Pathology: Dynamics of Infectious Diseases course at Univerity of Cambridge
Year(s) Of Engagement Activity 2008,2009,2010,2011,2012,2013,2014,2015,2016,2017,2018,2019,2020
 
Description Lecture on dynamics of infectious diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Lecture as part of MSc in Veterinary Microbiology at University of Surrey
Year(s) Of Engagement Activity 2012,2013,2014,2015,2016,2017
 
Description Lecture to MSc studnets University of Surrey 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Lecture on African swine fever virus to MSc students University of Surrey Veterinary faculty
Year(s) Of Engagement Activity 2018
 
Description Lorin Adams (Gordon's School Careers Fair) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Describe the research that lead to improve control systems against infectious viral diseases of animals and from animals to humans.
Year(s) Of Engagement Activity 2019
 
Description Lumpy Skin Disease D2R2 profile 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Provided expert opinion to the assessment (D2R2) of the risk of lumpy skin disease virus (LSDV) to the UK.
Year(s) Of Engagement Activity 2017,2018
 
Description Mapping antigenic determinants of H9N2 avian influenza viruses and improving vaccines and diagnostics" presented at Foreign Talent Lecture: New strategies and new techniques for the prevention and control of major avian diseases. Shandong Binzhou Animal Science & Veterinary Medicine Academy, Binzhou, China. 6th August 2018. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The focus of the meeting was to improve the control systems against poultry diseases including development of improved vaccines and diagnostics
Year(s) Of Engagement Activity 2018
 
Description Molecular Determinants for Antigenicity and Vaccine Efficacy of H9 and H7 Avian Influenza Viruses. Newton Agham Researcher Links Workshop: Novel vaccines and diagnostics technologies against Emerging and re-emerging veterinary Pathogens. 4-7 February 2019 at Rizal Pak Hotel, Manila, Philippines. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description Molecular determinants of antigenicity of H7 and H9 avian Influenza viruses. Presented as invited speaker at BBSRC UK-India Partnering Award seminar: University of Liverpool. 2 May 2019. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description Munir Iqbal: Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Describe the research that lead to improve control systems against infectious viral diseases of animals and from animals to humans.
Year(s) Of Engagement Activity 2019
 
Description Newton Agham Researcher Links Workshop on "Novel Vaccines and Diagnostic Technologies Against Emerging and Re-emerging Veterinary Pathogens, Rizal Park Hotel, Manila, Philippines 4-7 February 2019 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The primary aim of this workshop was to forge long-term research partnerships between early-career researchers, livestock industry and national disease control authorities in the UK and the Philippines. The workshop provided information on emerging and next generation diagnostic and vaccine strategies and their utilization to reduce the impact of viral diseases on livestock and poultry.
Year(s) Of Engagement Activity 2019
URL https://www.slideshare.net/zerep_cire/2019-newton-agham-researcher-links-workshop-vaccines-and-diagn...
 
Description Oral and poster presentation at European Society of veterinary Virology and EPIZONE (ESVV/EPIZONE) at Vienna, Austria 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Presentation has been made on early events of PPR virus pathogenesis. The presentation reveled that PPR virus first taken up by the immune cells to the Pharyngeal tonsil and then to other lymph nodes before generalisation of the disease. Secondary replication happens in epithelial cells. This alters the existing believe that virus primarily replicate in the epithelial cells.
Similarly a poster presentation has been done to show the detection of nucleic acid of PPR virus during PPR eradication programme, nasal sample has been shown as the best sample for viral genome detection.
Year(s) Of Engagement Activity 2018
 
Description Oral presentation at the Global Alliance for Research on Avian Disease meeting in Hanoi, Vietnam 15th -19th Jan 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact A talk was given on the PB1-F2 function in avian influenza infection of avian hosts at the GARAD meeting. This meeting was attended by approximately 120 researchers and poultry industry members from a wide international geographic region.
Year(s) Of Engagement Activity 2018
 
Description Oral presentation to Large Animal Research Network 24th May 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Talk about work understanding PB1-F2 function in avian hosts highlighting how the animal work carried out was undertaken and monitored. this was delivered to an audience of researchers, funders and industry interested in animal model systems for research and the 3Rs commitment surrounding this work. Discussions with interested parties about our chicken work at the Institute and the diverse way that the birds are entertained whilst being housed (e.g. live food, vegetables, perches, dust baths etc).
Year(s) Of Engagement Activity 2017
 
Description Organisation of Influenza meeting at Roslin Institute 21st-22nd November 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Along with Paul Digard (Edinburgh) and Edward Hutchinson (Glasgow) I helped to organize, plan and run a Influenza update meeting which ran for 2 days at The Roslin Institute in November 2017. The symposium was attended by approximately 60 influenza researchers from the UK. Talks were given by a range of people with student talks and posters being awarded prizes. This was supported by Medimmune and the Microbiology Society.
Year(s) Of Engagement Activity 2017
 
Description Organisation of UK-India Bioinformatics Workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The meeting discussed the challenges and opportunities and have decided to come up with a strategy document on working together between UK and India on data-driven biology
Year(s) Of Engagement Activity 2018
 
Description Organised the 3rd UK-China CERAD meeting in Guildford, UK in July 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The 3rd UK-China CERAD meeting helped to bring together professional from both countries to identify challenges and exploit the opportunities for improved control of poultry diseases and increasing food security.
Year(s) Of Engagement Activity 2017
URL http://www.uk-china-cerad.org/
 
Description Organising and giving Keynote talk at the GARAD meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Global Alliance of Poultry industry professional and academia to discuss about the advances in control strategies of diseases
Year(s) Of Engagement Activity 2018
URL http://Garad.org
 
Description Oxford DTP students 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact High level overview of diseases studied [at Pirbright], and the importance of our work, provided to a group of over 30 Oxford DTP students, followed by a networking lunch (29th September 2017).
Year(s) Of Engagement Activity 2017
 
Description PPR eradication meeting organised by FAO and OIE at Rome and talk has been delived on Development of DIVA vaccines 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Satya Parida is working as an expert to PPR eradication and he is being invited for few of FAO/OIE meetings. The meetings discussed about roadmap, vaccine production capacity and eradication policy.
Satya also presented work on PPR DIVA vaccine and DIVA tests developments and their evaluation in goats.
Year(s) Of Engagement Activity 2018
 
Description PPR vaccine producers meeting at MCI, Morocco organised by FAO/OIE 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact PPR vaccine producers meeting at MCI, Morocco organised by FAO/OIE. Almost all PPR vaccine producers through out world joined this meeting. Satya Parida has presented a talk on vaccine development and transmission of PPR virus in North Africa. There was hues interest on the talk particularly the spread of PPR in North Africa and new vaccine development.
Year(s) Of Engagement Activity 2017
 
Description Pandemic Live (Cheltenham Science Festival) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Approximately 250 attendees at a 1 hour discussion around a simulated virus outbreak scenario (Speakers Fry; Carpenter; Beard; Hatchett). Followed by question and answer session.
Year(s) Of Engagement Activity 2018
URL https://www.cheltenhamfestivals.com/science/whats-on/2018/pandemic-live/
 
Description Paolo's talk on FMDV vaccine matching 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Paolo Ribeca gave a talk at the 2018 Open Session of EuFMD (European commission for the control of foot-and-mouth disease ) on "Effective in-silico sequence-based prediction of FMDV vaccine matching" on behalf of Yasaman Kalantar-Motamedi, Mana Mahapatra, Luca Ferretti, Sophie Mahendran, Satya Parida, and himself.
Year(s) Of Engagement Activity 2018
 
Description Participant in IDEAS arboviruses workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Participated in discussions and breakout groups, formed contacts. Planned future meetings on minimum reporting standards in insect infection studies (now funded and scheduled for 2018).
Year(s) Of Engagement Activity 2017
URL http://ideas.princeton.edu/workshop-for-2017/
 
Description Pengxiang Chang: Talk presentation:The application of CRISPR/Cas9 system in the generation of viral vectored avian influenza vaccines at Microbiology Society conference, UK. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion on the improvement of vaccines to prevent avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
URL https://microbiologysociety.org/event/annual-conference/annual-conference.html
 
Description Pengxiang Chang: UK-China Newton Fund (Poultry and swine) workshop at The Pirbright Institute.Oral presentation:Avian Influenza H7N9 Antigenic markers 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion on the improvement of disease control systems (vaccines) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description Pengxiang Chang:Influenza update meeting. The application of CRISPR/Cas9 in the development of vaccines against avian influenza virus 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Described techniques to improve and produce new effective vaccines against viral diseases of animals and humans.
Year(s) Of Engagement Activity 2019
 
Description Pirbright Dragon Fair - MZ 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Team members attended the locally held Dragon fair where the Pirbright Institute had a stand explaining the types of research that are conducted at the Institute, making our high containment science activities transparent to the local community. Approximately 60 people engaged with the stall to learn about the science happening on their doorstep. This stimulated interest in science and research.
Year(s) Of Engagement Activity 2019
 
Description Population Biology of Vector-Borne Diseases Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation on "Population biology of Culicoides-borne viruses in Europe" at symposium held at University of Georgia Athens on 24 February 2018
Year(s) Of Engagement Activity 2018
 
Description Poster by Nick on the sequencing of Zimbabwe FMDV 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Nick Knowles presented a poster at the 2018 Europic (the meeting of the European Study Group on the Molecular Biology of Picornaviruses) on "Complete Genome Sequence Analysis of Over 140 Foot-and-mouth Disease Viruses Isolated From Free-living African Buffalo (Syncerus Caffer) in Zimbabwe" on behalf of Jemma Wadsworth, Bruce Bolt, Luca Ferretti, Euan C. Anderson, Ashley Gray, Paolo Ribeca, and himself. The sequencing was funded by the Transboundary Pathogens portal project awarded to Pirbright.
Year(s) Of Engagement Activity 2018
 
Description Poultry Health course 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Poultry Health Course is run as a residential and online course to transfer recent advances in avian disease research from the laboratory to the field.
Year(s) Of Engagement Activity Pre-2006
URL http://www.poultryhealthcourse.com/
 
Description Practical training given to LSHTM MSc students 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Two-hour practical teaching session given to 12 MSc students at the London School of Hygiene and Tropical Medicine (LSHTM) on 17th November 2017 (Lara Harrup).
Year(s) Of Engagement Activity 2017
 
Description Predicting Pandemics (Panel discussion at Cheltenham Science Festival) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Stimulating increased interest in science and research
Year(s) Of Engagement Activity 2019
 
Description Preparation of presentation on African swine fever clinical signs and pathogenesis 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Prepared a presentation on African swine fever clinical signs and pathogenesis aimed at making farmers and veterinary practitioners aware. Presentation made available publically on the APHA, DEFRA and Pirbright websites. A follow up video was made by APHA and training for APHA veterinary services is planned
Year(s) Of Engagement Activity 2018
URL http://apha.defra.gov.uk/documents/surveillance/diseases/african-swine-fever-images.pdf
 
Description Presentation and sicussion with members of the CLA group visiting Pirbright Institute 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The CLA is the membership organisation for owners of land, property and businesses in rural England and Wales. The CLA came for a visit to the Pirbrigtht Institute and I presented on Bluetongue virus epidemiology, transmission and risk to the UK agriculture followed by a general discussion
Year(s) Of Engagement Activity 2017
 
Description Presentation to Jordan University of Science and Technology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Presentation on epidemiological approaches to vaccine evaluation focussing on foot-and-mouth disease. Generated a lot of interest on evaluating the impact of vaccination policy which has led to follow-up communication regarding future projects.
Year(s) Of Engagement Activity 2017
 
Description Project close meeting at TANUVAS, Chennai July 2018- Delivering talk on outcome of the project 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The project team held their final workshop at TANUVAS, which concluded a four year Farmed Animal Disease and Health (FADH) grant joint funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and the Indian Government's Department of Biotechnology (DBT). "This grant has enabled us to collaborate with four organisations across India, and ensured that our research can be applied in the field to aid the campaign for PPR global eradication", said Professor Parida.The project covered many areas of research which are essential for understanding PPR and creating tools to help control and prevent the disease. The team have now filed a patent application for their newly developed PPR vaccine, which is the first to differentiate between vaccinated and infected animals (DIVA) - a quality that enables livestock owners to protect their animals whilst continuing to trade.
The team have also investigated how the PPR virus (PPRV) infects sheep and goats and how their immune systems respond. By inserting green fluorescent protein into virulent PPRV and administering the modified virus to goats, they demonstrated that PPRV primarily infects the tonsils, challenging the earlier belief that the virus first replicates in the respiratory tract epithelial cells. The collaborative project has also generated better diagnostic tests for use in the field and laboratory, and preliminary research has identified why some Indian breeds of goats and sheep are resistant to the disease, which could help scientists to create PPRV resistant breeds in the future.
Project partners, scientists from the University and 40 field veterinarians have joined the meeting. An awareness training has been conducted on PPR disease and eradication for these field veterinarians.
Year(s) Of Engagement Activity 2018
URL https://www.pirbright.ac.uk/news/2018/09/pirbright-scientists-run-vaccination-campaign-eradicate-pes...
 
Description Protecting poultry from avian influenza through passive immunisation. Presented at Foreign Experts Seminar "New strategies and new tools for the prevention and control of major poultry diseases. Shandong-Binzhou Animal Science and Veterinary Medicine Academy, China, 20-22 September 2019. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion was the best practices to improve control systems (vaccines and diagnostics) for prevention of avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description Provided information to Podcast This week in Virology about African swine fever virus spread in wild boar 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact E-mail correspondence providing advice to presenters of TWIV This week in Virology Podcast.
Year(s) Of Engagement Activity 2019
URL http://www.microbe.tv/twiv/twiv-532/
 
Description Public Health Entomology Group (LSHTM) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited lecture on 4th April 2017.
Year(s) Of Engagement Activity 2017
 
Description Public event - TK - Innovate Guildford (17 Mar 18) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Showcase of science and engineering in South East held in Guildford. Pirbright Institute has a stand which allows talk with the general public about our science, including the control of avian influenza
Year(s) Of Engagement Activity 2018
 
Description Rebecca Daines: Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Described the research undertaken at the Pirbright Institute that lead to improve control systems against infectious viral diseases of animals and from animals to humans.
Year(s) Of Engagement Activity 2019
 
Description Reddit AMA (Ask Me Anything) on vector-borne diseases 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Took part in a Reddit Ask Me Anything (AMA) on vector-borne diseases. AMAs are a question-and-answer format activity where an individual expert or panel of experts answers questions from the public for a specified duration. We received a large number of questions and the parent post received 493 upvotes, indicating an absolute minimum of 493 participants (and very probably more), so I have given the estimated audience as 500+.
Year(s) Of Engagement Activity 2017
URL https://www.reddit.com/r/science/comments/6he8go/aaas_ama_hi_were_maria_elena_bottazzi_marcia/
 
Description SATRO Mentoring Scheme Ash Manor School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Fortnightly mentoring activity for student's soft skill and career development.
Year(s) Of Engagement Activity 2019,2020
 
Description STEAMfest - HS 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Team members attended the event where a flu fighters stand was displayed demonstrating how scientists are working to rapidly detect and control avian influenza in the filed to protect food security, animal welfare and human health. Approximately 200 secondary school students engaged with the stall and this stimulated increased interest in science and research,
Year(s) Of Engagement Activity 2019
 
Description Scheduled Twitter session with University of Nottingham students on professional skills for biosciences 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact Hour-long Twitter chat on Friday 12th May with biotechnology students, microbiology students, animal science students interested in animal diseases and animal welfare and behaviours and agriculture students interested in livestock.
Year(s) Of Engagement Activity 2017
URL https://twitter.com/search?q=%23biosciprofskills
 
Description Scientific Presentation: SOVE lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Society of Vector Ecology Presentation 'The Gnatwork'. 6th October 2017 over 150 attendance.
Year(s) Of Engagement Activity 2017
URL http://www.uibcongres.org/sove2017/
 
Description Seminar given at The Roslin Institute - 19th October 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other audiences
Results and Impact Invited to give a Seminar on PB1-F2 programme of work at The Roslin Institute in Edinburgh to researchers.
Year(s) Of Engagement Activity 2017
 
Description Seminar on African swine fever virus 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Seminar at Beijing Institute of Animal Sciences, Chinese Academy of Agricultural Sciences 12 Zhongguanchan South Stree, Haifing District Beijing
Year(s) Of Engagement Activity 2018
 
Description Seminar on African swine fever virus 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Presentation on African swine fever virus vaccine development to Yebio Bioengineering and China Animal Health and Epidemiology Centre, Qingdao, PR China
Year(s) Of Engagement Activity 2018
 
Description Seminar on African swine fever virus 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Seminar on African swine fever virus host interactions and vaccine development. Yangzhou University Veterinary Faculty PR China
Year(s) Of Engagement Activity 2018
 
Description Seminar on African swine fever virus virus host interaction and vaccine development 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Seminar Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences PR China
Year(s) Of Engagement Activity 2018
 
Description Seminar on African swine fever virus virus host interaction and vaccine development 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Seminar on African swine fever virus evasion of host defences and vaccine development Institute of Molecular and Cellular Biology, UCL London
Year(s) Of Engagement Activity 2018
 
Description Seminar on prospects for African swine fever virus vaccine development 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Seminar at Harbin Institute for Veterinary Research, PR China
Year(s) Of Engagement Activity 2018
 
Description Seminar on virus host interactions and prospects for African swine fever virus vaccine development 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Seminar on African swine fever virus host interactions and vaccine development
Year(s) Of Engagement Activity 2018
 
Description Site tour with Department of Trade and Industry 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Tour/site visit with Department of Trade and Industry (25 people attending)
Year(s) Of Engagement Activity 2017
 
Description Site tour with UK Science Partnership for Animal and Plant Health, BBSRC (Chris Jacobs, Julie Fitzpatrick) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact 'Fact-finding' visit from Chris Jacobs (Head of Secretariat, UK Science Partnership for Animal and Plant Health) & Julie Fitzpatrick (Chair of the Partnership) to organisations involved in the areas of animal and plant health science capabilities, to gain a better understanding of who the key players are, what they're working on, and any particular issues the Partnership may be able to address.
Year(s) Of Engagement Activity 2017
 
Description Socioeconomic impact of FMD in Mongolia workshops 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact In March 2019 two workshops were held in Mongolia to present and discuss the results of a project investigating the socio-economic impact of FMD outbreaks and control measures in Mongolia. The project had been carried out as a collaboration between The Pirbright Institute and the State Central Veterinary Laboratory of Mongolia. The first workshop was held in a rural location (Khenti province) and focused on knowledge exchange with herders and private vets. Nine private vets and 17 herders affected by FMD during the 2017 epidemic attended the workshop, representing 8 provinces.
The second workshop was held in the capital Ulaanbaatar and focused on knowledge exchange with government ministries and veterinarians. During the workshop results from the socio-economic study and a summary of outputs from the herders' workshop were presented and discussed. In total 20 people attended this workshop including representatives from the State Central Veterinary Laboratory (SCVL), National Emergency Management (NEMA) and General Agency Veterinary Service (GAVS), as well as government vets from provinces affected during the last FMD outbreak and representatives from FAO in Mongolia.
Presentations for both workshops were translated in Mongolian ahead of the workshops, and a translator was present to facilitate the discussions.
Year(s) Of Engagement Activity 2019
 
Description Sushant Bhat:Pirbright Dragon Fair 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Described the research undertaken at the Pirbright Institute that lead to improve control systems against infectious viral diseases of animals and from animals to humans.
Year(s) Of Engagement Activity 2019
 
Description Sutton College Lecture (Enjoy your retirement) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Talk to group on virus outbreaks (Enjoy your retirement) - 16 people & class coordinator. Included simulation of a virus outbreak.
Year(s) Of Engagement Activity 2019
 
Description Symposium for WRLFMD 60th Anniversary 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact During November, the Pirbright Institute hosted a two-day symposium attended by over 100 FMD scientists to celebrate the 60-year anniversary of the establishment of the World Reference Laboratory for Foot-and-Mouth Disease (WRLFMD).

The meeting was opened by Christine Middlemiss (UK, Chief Veterinary Officer), Matthew Stone (Deputy Director General of the OIE) and Keith Sumption (from FAO/EuFMD). Subsequent scientific sessions reviewed the current activities of the WRLFMD (and OIE/FAO FMD Laboratory Network: https://www.foot-and-mouth.org), and discussed new opportunities to monitor, diagnose and control FMD by applying knowledge from fundamental research projects that aim to understand the pathogenesis, host responses and epidemiology of the disease.

Talks from invited speakers and WRLFMD staff were within four themes of (i) Risks & Threats, (ii) Diagnostic Innovation, (iii) Pathogenesis & Immunity and (iv) FMD Control with a Focus on Vaccination. These presentations showcased the synergy between fundamental/basic science and the on-going global surveillance activities undertaken by FMD Reference Laboratories.

In the evening, the meeting delegates (including past and present members of the WRLFMD) were royally entertained at a local hotel by after-dinner "trips down memory lane" talks from Nick Knowles and Dave Rowlands that highlighted key events and personalities that have shaped the history of work at Pirbright.
Year(s) Of Engagement Activity 2018
URL https://www.wrlfmd.org/60th-anniversary
 
Description TAIEX Multi Country Workshop on Animal Health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Donald King was an invited speaker (and expert panel member) at a TAIEX Multi Country Workshop on Animal Health, Malta, June 2017. He gave a talk entitled: foot-and mouth disease: epidemiological situation in the Mediterranean area and new threats to North Africa, Near East and Europe
Year(s) Of Engagement Activity Pre-2006,2017
URL https://www.eu2017.mt/en/Events/Pages/TAIEX-multi-country-seminar-on-animal-health.aspx
 
Description Talk (Christopher Sanders): Lancaster University (Culicoides and their role as vectors) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Talk give to academic audience through invited lecture.
Year(s) Of Engagement Activity 2019
 
Description Talk (Christopher Sanders): Virus Transmission and Vector Competence of Culiocides (Royal Entomological Society Annual Meeting) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Annual Meeting of the ROyal Entomological Society presentation. Held at LSHTM on 21st August 2019.
Year(s) Of Engagement Activity 2019
 
Description Talk by Nick on the sequencing of Zimbabwe FMDV 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Nick Knowles gave a talk at the 2018 Open Session of EuFMD (European commission for the control of foot-and-mouth disease ) on "Complete Genome Sequence Analysis of Over 140 Foot-and-mouth Disease Viruses Isolated From Free-living African Buffalo (Syncerus Caffer) in Zimbabwe" on behalf of Jemma Wadsworth, Bruce Bolt, Luca Ferretti, Euan C. Anderson, Ashley Gray, Paolo Ribeca, and himself. The sequencing was funded by the Transboundary Pathogens portal project awarded to Pirbright.
Year(s) Of Engagement Activity 2018
 
Description Talk on "Emerging Diseases" at BBSRC Cross-Institute workshop, Roslin Institute 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Talk on Emerging Diseases in the context of a workshop on Future of Livestock in Food Production
Year(s) Of Engagement Activity 2019
URL https://www.ed.ac.uk/roslin/news-events/latest-news/future-of-livestock-production-in-the-spotlight
 
Description Talk to clinicians at Hospital for Tropical Diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Talk to clinicians at Hospital for Tropical Diseases, London, regardingcurrent and future methods for controlling mosquito-borne disease based on mosquito genetics
Year(s) Of Engagement Activity 2020
 
Description Television interview Ulaanbaatar 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact I was interviewed by UB television while on a collaborative visit to the State Central Veterinary Laboratory in Mongolia. I spoke about the collaboration between The Pirbright Institute and the SCVL, and how this benefits the Mongolian agricultural sector.
Year(s) Of Engagement Activity 2017
 
Description The Pirbright Village Duck Fair held on 16 June 2018 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Local Village Fair, interaction with local residence to expanse research aims and activities of The Pirbright Institute and benefits to UK and around the globe to prevent and control infectious diseases of animals and humans.
Year(s) Of Engagement Activity 2018
 
Description The co-Circulation of Low and High-path-AIV in the same country with sub-optimal bio-security: Virus evolution and impact on vaccine efficacy. Presented at the 11th Scientific conference of Egyptian Veterinary Poultry Association, Conference "Towards a National strategy to control poultry industry problems in Egypt". 20-23 April 2019. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description The global Situation and pathobiology of Avian Influenza in different Avian Species. Presented at the 11th Scientific conference of Egyptian Veterinary Poultry Association, Conference "Towards a National strategy to control poultry industry problems in Egypt". 20-23 April 2019.. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The talk and the discussion on the improvement of disease control systems (vaccines and diagnostics) to prevent avian influenza viruses infection in poultry and zoonotic infections in humans.
Year(s) Of Engagement Activity 2019
 
Description Tillingbourne Bug Hunt (Christopher Sanders) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Insect identification event with general public (primarily schools).
Year(s) Of Engagement Activity 2018
 
Description Tour of Philip Mellor Insectary (Country Land and Business Association) 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Third sector organisations
Results and Impact Tour of Philip Mellor Insectary with Country Land and Business Association (20 people)
Year(s) Of Engagement Activity 2017
 
Description Tour of Pirbright Research facilities for CLA group 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The CLA is the membership organisation for owners of land, property and businesses in rural England and Wales. The CLA came for a tour of the Jenner building facilities at The Pirbright Institute. I led a tour of our building for the group and described the work undertaken by the avian research programme here.
Year(s) Of Engagement Activity 2017
 
Description U3A talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Presentation on influenza virus research at The Pirbright Institute for the local University of the Third Age group, approx. 50 people aged 65 years + all with an interest in science.
Year(s) Of Engagement Activity 2018
URL https://cu3asandt.wordpress.com/2018/09/23/meeting-2nd-october/
 
Description UK vector meeting 2018 (Organising committee; Chair) (December; John Innes Centre, UK) 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Chaired and helped organise meeting on UK Vector-borne Diseases as part of committee. Included reviewing talks and inviting speakers.
Year(s) Of Engagement Activity 2018
URL http://www.hpruezi.nihr.ac.uk/media/29013/master-draft-vbd-programme-with-titles-oct18_.pdf
 
Description UK-China Philippines-Thailand Swine and Poultry Research Initiative project kick-off workshop" at China Agriculture University, Beijing, 26th-28th September 2018. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Emerging new approaches were discussed for prevention and control of infectious diseases affecting swines and poultry.
Year(s) Of Engagement Activity 2018
 
Description UK-India bioinformatics workshop 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact On February 9 2018 Pirbright organised a "UK-India bioinformatics workshop" in order to foster ties between Indian and UK bioinformaticians working in the field of livestock and crop research. Paolo Ribeca gave a talk on "Bioinformatics and sequencing at Pirbright".
Year(s) Of Engagement Activity 2018
 
Description Understanding Antigenic Diversity, Zoonotic potential and immunological prevention of avian influenza viruses affecting poultry. Presented at "UK-China Philippines-Thailand Swine and Poultry Research Initiative project kick-off workshop" at China Agriculture University, Beijing, 26th-28th September 2018. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Meeting focus was to share research plans funded under "UK-China-Philippines-Thailand Swine and Poultry Research Initiative". Research projects investigate pathogens, zoonotic pathogens or "commensals" associated with food safety issues affecting poultry and swine.
Year(s) Of Engagement Activity 2018
URL https://bbsrc.ukri.org/funding/filter/joint-swine-poultry-initiative/
 
Description Understanding antigenic diversity, zoonotic potential and immunological prevention of avian influenza viruses affecting poultry. Presented at UK-China-Philippines-Thailand Swine and Poultry Research Initiative: Interim Project Workshop 13th-15th January 2020 Hilton Hotel, Bracknell, UK 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Outcomes of the research project entitled "Understanding antigenic diversity, zoonotic potential and immunological prevention of avian influenza viruses affecting poultry" were presented to colleagues working on prevention and control of infectious diseases affecting animals and humans. the work led to incite further research collaborations with different groups from UK, China, Thailand and Philippine.
Year(s) Of Engagement Activity 2020
 
Description Understanding avian influenza virus evolution and development of next generation vaccines. Presented at 459th Scientific Meeting of The Veterinary Research Club at The Farmers Club, 3 Whitehall Court London Friday 14th February 2020. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A talk presented entitled"Understanding avian influenza virus evolution and development of next generation vaccines". The discussion with senior staff from DEFRA and UKRI- BBSRC, researchers and veterinary professional like with control and prevention of animal diseases in United kingdom
Year(s) Of Engagement Activity 2020
 
Description University of Surrey Vet School Open Day 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Institute stand at Surrey Vet School - introducing the institute to prospective vet students
Year(s) Of Engagement Activity 2018
 
Description V Nair invited to talk on 'Cell type- and disease stage-specific interactions of Marek's disease virus & the host' at the International Symposium on Marek's disease and avain herpesiviruses at Yangzhou, China during 29th July to 2nd Aug 2018 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Most recent updates in the field of avian herpesvirus research was discussed and active engagements for future collaborations discussed
Year(s) Of Engagement Activity 2018
 
Description Video on African swine fever clinical signs for APHA 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Video prepared to inform farmers and vets about African swine fever virus clinical signs
Year(s) Of Engagement Activity 2018
URL https://www.youtube.com/watch?v=z4kSR-wMO4M&feature=youtu.be
 
Description Visit to Cairo Poultry Company (CPC) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Industry/Business
Results and Impact Discussion and talk on prevention and control of poultry diseases (avian influenza and Newcastle Disease) and molecular factors affecting vaccine efficacy. The discussion and talk to present data, describing factors the directly influence protective efficacy of in use vaccines, and how they evaluate/ test vaccine failure.
Year(s) Of Engagement Activity 2019
 
Description Visit to Dakahlia Poultry Egypt 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Industry/Business
Results and Impact Discussion and talk presented at Dakahlia Poultry Egypt head office to workers involved in poultry production. The talk amis were to provide update on the impact of evolutionary genetic changes in the avian influenza and Newcastle disease viruses on the efficacy of vaccines and diagnostics. The molecular changes in virus genetic makeup allow virus to escape from vaccine induced immunity results vaccine and diagnostics failure. Consequently the avian influenza viruses continue to circulates in vaccinated flocks.
Year(s) Of Engagement Activity 2019
 
Description Workshop 1: Minimum Information for Reporting Arthropod Infection Studies 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A workshop was held as part of the VectorBiTE RCN annual meeting at Asilomar in CA. Attendance was roughly 60 people, mostly users of data resulting from experimental arthropod infection studies or arthropod ecological datasets. AW gave a presentation describing the objectives of the grant and then we formed breakout groups to discuss potential factors to report and their importance for different categories of users. The feedback was used to review and update the draft standards document before the second workshop as ASTMH's Trop Med meeting in New Orleans in October.
Year(s) Of Engagement Activity 2018
 
Description Workshop 2: Minimum Information for Reporting Arthropod Infection Studies 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A workshop was organised in collaboration with members of the ASTMH's Advisory Committee on Arthropod-borne Viruses (ACAV) at the start of the 2018 Trop Med annual meeting and was advertised via social media and society and project mailing lists. Around 30 people attended, mostly from the US but with representation from Asia, Europe and South America, and a mixture of senior academics, junior faculty and students. AW gave a brief introduction to the objectives of the workshop and AW, assisted by LH (a postdoc at Pirbright), helped participants pilot the questionnaire before its formal launch. Feedback was positive and used to refine the questionnaire before it was launched in November. As a result of specific points raised in the feedback, the survey was translated into French and Spanish and these versions were launched simultaneously to support involvement by a broader audience.
Year(s) Of Engagement Activity 2018
 
Description Workshop 3: Minimum Information for Reporting Arthropod Infection Studies 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact A workshop was organised during the biennial UK VBD meeting in Norwich to improve awareness of the survey and increase completion. A short presentation was given by LH, a postdoc at Pirbright who has been assisting with the development of the questionnaire and standards documentation (as AW is leaving Pirbright in December) and then breakout groups formed to discuss particular challenges and any suggested changes as well as pathways to increasing the chances of uptake of the resulting guidelines. The feedback was recorded and will influence the resulting report/manuscript.
Year(s) Of Engagement Activity 2018
 
Description careers 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Stimulating increased interest in science and research
Year(s) Of Engagement Activity 2019