Nanometrology for Molecular Science, Medicine and Manufacture
Lead Research Organisation:
University of Strathclyde
Department Name: Physics
Abstract
The lack of capacity for advancing the emerging field of nanometrology can only be addressed through stra-tegic interdisciplinary collaborations that provide a stimulating and innovative research environment to catalyse and sustain a new dimension in UK research capability. In a major strategic initiative, Strathclyde University (SU) has founded a Centre for Molecular Nanometrology (2005 - to our knowledge, the first in the world) with facilities supported by the Wolfson Foundation and the Science Research Infrastructure Fund. This Centre has the ultimate goal of recording real-time images of dynamical interactions of single molecules in-situ. With the award of a Science and In-novation Award the Centre will facilitate the high quality, innovative, multidisciplinary research environment required to nurture and develop the extra capacity needed to make the UK a leader in nanometrology. A Science and Innovation Award will also bring together the Centre and medical collaborators at King's College London (KCL), bridging the molecular measurement gap to innovation in emerging areas of strategic impor-tance such as disease pathology, diagnostic tools in nanomedicine, the design of new drug treatments and new structural materials while facilitating knowledge transfer into the healthcare and chemical industries.
Organisations
- University of Strathclyde (Lead Research Organisation)
- HEFCE (Co-funder)
- Academy of Finland (Collaboration)
- Royal Society of Edinburgh (RSE) (Collaboration)
- National University of Ireland (Collaboration)
- The Scottish Universities Physics Alliance (SUPA) (Collaboration)
- Renishaw (United Kingdom) (Collaboration)
- Czech Technical University in Prague (Collaboration)
- International Society for Optics and Photonics (SPIE) (Collaboration)
- Horiba (Collaboration)
- Institute of Physics (IOP) (Collaboration)
- Engineering and Physical Sciences Research Council (EPSRC) (Collaboration)
- National Science Foundation of the United Arab Emirates (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
Publications
Alghamdi A
(2018)
Detecting beta-amyloid aggregation from time-resolved emission spectra.
in Methods and applications in fluorescence
Amaro M
(2011)
Beta-amyloid oligomerisation monitored by intrinsic tyrosine fluorescence.
in Physical chemistry chemical physics : PCCP
Apperson K
(2009)
Nanoparticle metrology standards based on the time-resolved fluorescence anisotropy of silica colloids
in Measurement Science and Technology
Bhaiji T
(2012)
Improving cellular function and immune protection via layer-by-layer nanocoating of pancreatic islet ß-cell spheroids cocultured with mesenchymal stem cells.
in Journal of biomedical materials research. Part A
Birch D
(2011)
Fluorescence detections and directions
in Measurement Science and Technology
Brown SD
(2010)
Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin.
in Journal of the American Chemical Society
Bruckbauer J
(2011)
High resolution cathodoluminescence hyperspectral imaging of surface features in InGaN/GaN multiple quantum well structures
in Applied Physics Letters
| Description | The Science and Innovation Award (SIA) succeeded in achieving its aim of building new capacity in the strategically important area of molecular nanometrology. The SIA not only built new capacity and bridged a critical molecular measurement gap, but also helped address important problems in disease pathology, diagnostic tools in nanomedicine and the design of new structural materials, while facilitating knowledge exchange with the research, healthcare and industry sectors. Amplification of the original SIA investment was been achieved through an additional £21.3M of competitively won funding during the course of the project. This represents over a fourfold return on the initial EPSRC/SFC investment of £4.9m. The original personnel capacity funded by the SIA totalled 25, comprising lecturers, post-doctoral fellows and research students. The additional investment provided double the original SIA capacity. Since the project began in 2006 up to the end of 2011, a total of 235 journal papers and 245 conference talks have been generated by the SIA team. The SIA team are continuing to build on the success of the SIA through new proposals and outputs. Their future research plans will continue to incorporate synergistic and multi-centre interdisciplinary collaboration such as that achieved in the SIA, for example through the new £89m Technology Innovation Centre presently under construction at Strathclyde. |
| Exploitation Route | The SIA research investment has led to new publications, new and expanded research directions and an enhanced skill base that continues to attract competitively won funding. Together these represent an increased research foundation for others to use, collaborate with and benefit from. |
| Sectors | Chemicals,Education,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| URL | https://www.strath.ac.uk/staff/birchdavidprof/ |
| Description | For decades, a simple and convenient way of enabling people with diabetes to monitor their own blood sugar levels has eluded medical science. But now advances in nanometrology - measuring at the nanoscale - are bringing the prospect within reach with 'smart' tattoos. With support from the Research Councils UK Nanoscience Programme, researchers at the University of Strathclyde and King's College London are developing 'smart' tattoos that can be injected just under the outer layer of skin. Once in place, they function like a tiny laboratory, constantly monitoring molecular-level changes in glucose concentrations within the body. Beneficiaries: Over four million people worldwide die from diabetes or diabetes-related conditions every year. By allowing people with the disease to manage it more effectively and with less discomfort, our technique could improve their health and quality of life, while |
| First Year Of Impact | 2012 |
| Sector | Healthcare,Pharmaceuticals and Medical Biotechnology |
| Impact Types | Societal |
| Description | MUX-TCSPC: Detection of cancer biomarkers |
| Amount | £27,570 (GBP) |
| Funding ID | EP/M01326x/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2014 |
| End | 09/2019 |
| Description | MUX-TCSPC: Detection of cancer biomarkers |
| Amount | £228,929 (GBP) |
| Funding ID | EP/M01326x/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2014 |
| End | 09/2019 |
| Description | Chaired review panel for the Physic Dep't at the National University of Ireland, Galway |
| Organisation | National University of Ireland |
| Country | Ireland |
| Sector | Academic/University |
| PI Contribution | Chair : Contribution to the work of national or international committees and working groups : Chaired review panel for the Physic Dep't at the National University of Ireland, Galway |
| Start Year | 2010 |
| Description | Committee Member for SPIE Photonics West/LASE |
| Organisation | International Society for Optics and Photonics (SPIE) |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Member : Contribution to the work of national or international committees and working groups : Committee Member for SPIE Photonics West/LASE |
| Start Year | 2010 |
| Description | External Committees: Masao Horiba Award |
| Organisation | Horiba |
| Department | Masao Horiba Award (HORIBA, Ltd) |
| Country | Japan |
| Sector | Public |
| PI Contribution | Member : Contribution to the work of national or international committees and working groups : External Committees: Masao Horiba Award |
| Start Year | 2011 |
| Description | External Committees: Physical Sciences Review Panel for the National Science Foundation of the United Arab Emirates, 2009. |
| Organisation | National Science Foundation of the United Arab Emirates |
| Country | United Arab Emirates |
| Sector | Public |
| PI Contribution | Member : Contribution to the work of national or international committees and working groups : External Committees: Physical Sciences Review Panel for the National Science Foundation of the United Arab Emirates, 2009. |
| Start Year | 2009 |
| Description | Industry: Director Horiba Jobin Yvon IBH Ltd. |
| Organisation | Horiba |
| Department | Horiba Jobin Yvon IBH Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Advisor : Consultancy (in kind) : Industry: Director Horiba Jobin Yvon IBH Ltd. |
| Start Year | 2007 |
| Description | Joint research with King's College |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | University of Strathclyde researchers worked on this project with researchers from King's College |
| Start Year | 2008 |
| Description | Member of Royal Society of Edinburgh Young Academy |
| Organisation | Royal Society of Edinburgh (RSE) |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Member : Membership of public/government advisory/policy group or panel |
| Start Year | 2011 |
| Description | Member of Strategic Advisory Committee for EPSRC ICT programme (2008 ? 2012) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Member : Work on advisory panel to industry or government or non-gov organisation : M.D. Dawson; member Strategic Advisory Committee for EPSRC ICT programme (2008 ? 2012) |
| Start Year | 2008 |
| Description | Panel member for the Academy of Finland in the area of Photonics and Modern Imaging Techniques |
| Organisation | Academy of Finland |
| Country | Finland |
| Sector | Public |
| PI Contribution | Member : Contribution to the work of national or international committees and working groups : Panel member for the Academy of Finland in the area of Photonics and Modern Imaging Techniques |
| Start Year | 2010 |
| Description | Renishaw Diagnostics Ltd |
| Organisation | Renishaw PLC |
| Department | Renishaw Diagnostics Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Advisor : Consultancy (in kind) : Renishaw Diagnostics Ltd |
| Start Year | 2008 |
| Description | Theme leader for SUPA Condensed Matter and Materials |
| Organisation | The Scottish Universities Physics Alliance (SUPA) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Chair : Membership of external research organisation : Theme leader for SUPA Condensed Matter and Materials |
| Start Year | 2008 |
| Description | Visiting Professorship: Applied Physics, Czech Technical University, Prague. |
| Organisation | Czech Technical University in Prague |
| Country | Czech Republic |
| Sector | Academic/University |
| PI Contribution | Visitor : Research and Teaching at External Organisation : Visiting Professorship: Applied Physics, Czech Technical University, Prague. |
| Start Year | 2007 |
| Description | Visiting Professorship: IoP lecture tour of Ireland |
| Organisation | Institute of Physics (IOP) |
| Country | United Kingdom |
| Sector | Learned Society |
| PI Contribution | Visitor : Research and Teaching at External Organisation : Visiting Professorship: IoP lecture tour of Ireland |
| Start Year | 2011 |
| Description | Academy of Finland (External organisation) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Panel member for the Academy of Finland in the area of Photonics and Modern Imaging Techniques |
| Year(s) Of Engagement Activity | 2010 |
| Description | Czech Technical University |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | Visiting Professorship: Applied Physics, Czech Technical University, Prague. |
| Year(s) Of Engagement Activity | Pre-2006 |
| Description | EPSRC (Engineering and Physical Sciences Research Council) (External organisation) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Member of Strategic Advisory Committee for EPSRC ICT programme (2008 - 2014) |
| Year(s) Of Engagement Activity | 2008,2009,2010,2011,2012,2013,2014 |
| Description | External Committees: Physical Sciences Review Panel for the National Science Foundation of the United Arab Emirates, 2009. |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Member : Contribution to the work of national or international committees and working groups : External Committees: Physical Sciences Review Panel for the National Science Foundation of the United Arab Emirates, 2009. Not recorded |
| Year(s) Of Engagement Activity | 2009 |
| Description | Institute of Physics |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Visiting Professorship: IoP lecture tour of Ireland |
| Year(s) Of Engagement Activity | 2011 |
| Description | International Society for Optics and Photonics (SPIE) (External organisation) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Committee Member for SPIE Photonics West/LASE |
| Year(s) Of Engagement Activity | 2010 |
| Description | Invited seminar, Laboratory for Biomolecular Dynamics, Katolieke Universiteit Leuven, Belgium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Visitor : Invited talk : Invited seminar, Laboratory for Biomolecular Dynamics, Katolieke Universiteit Leuven, Belgium. Not recorded |
| Year(s) Of Engagement Activity | 2009 |
| Description | Masao Horiba Award (External organisation) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | External Committees: Masao Horiba Award |
| Year(s) Of Engagement Activity | 2011 |
| Description | National Science Foundation of the United Arab Emirates (External organisation) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | External Committees: Physical Sciences Review Panel for the National Science Foundation of the United Arab Emirates, 2009. |
| Year(s) Of Engagement Activity | 2009 |
| Description | National University of Ireland (External organisation) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Chaired review panel for the Physic Dep't at the National University of Ireland, Galway |
| Year(s) Of Engagement Activity | 2010 |
| Description | New Technologies for Cancer Detection |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Contributor : Invited talk. Not recorded |
| Year(s) Of Engagement Activity | 2008 |
| Description | New Technologies for Cancer Detection |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Contributor : Invited talk. Not recorded |
| Year(s) Of Engagement Activity | 2008 |
| Description | New technologies for immunology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Contributor : Invited talk. Not recorded |
| Year(s) Of Engagement Activity | 2008 |
| Description | New technologies for immunology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Contributor : Invited talk. Not recorded |
| Year(s) Of Engagement Activity | 2008 |
| Description | Renishaw Diagnostics Ltd |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Renishaw Diagnostics Ltd |
| Year(s) Of Engagement Activity | 2008,2009,2010,2011,2012,2013 |
| Description | Royal Society of Edinburgh (External organisation) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Member of Royal Society of Edinburgh Young Academy |
| Year(s) Of Engagement Activity | 2011 |
| Description | SUPA (External organisation) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Theme leader for SUPA Condensed Matter and Materials |
| Year(s) Of Engagement Activity | 2008,2009,2010,2011,2012 |
| Description | Theme leader for SUPA Condensed Matter and Materials |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Chair : Membership of external research organisation : Theme leader for SUPA Condensed Matter and Materials. Not recorded |
| Year(s) Of Engagement Activity | 2008 |