Physical Organic Chemistry: Opportunities in Synthesis, Materials and Pharmaceuticals

Lead Research Organisation: University of Strathclyde
Department Name: Pure and Applied Chemistry

Abstract

This application aims to catalyse and sustain a new dimension in UK research capability in physical organic chemistry. Our strategic alliance in physical organic chemistry will provide a unique continuum of expertise to tackle research opportunities in areas as diverse as materials chemistry, synthesis methodologies and pharmaceutical discovery and development. It will have the capability to address issues from solid-state to solution and gas-phase, from small molecules to biopolymers, and from nanoscale to pilot plant. We focus on topics of international significance to industry worldwide as well as to academic chemistry, that will help to (i) drive the creation of 21st-century electronic materials, devices and technologies (ii) understand and exploit methodologies for assisting chemical reactions with the potential to revolutionise energy use in chemicals and pharmaceuticals industries (iii) provide new and more effective medicines through understanding molecular recognition in pharmaceutical systems including drug-receptor, drug-drug and drug-carrier complexes. Its importance is underlined by the initial substantial support from diverse sectors of the chemicals and pharmaceuticals industry that we have so far put in place. It will initially lead to 26 new appointments, and we look forward to even more dynamic growth as the program unfolds.

Publications

10 25 50

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Afonina I (2007) 10,11-Dihydro-diindeno[1,2-b:2',1'-d]thio-phene. in Acta crystallographica. Section E, Structure reports online

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Akkurt M (2012) 4-Bromo-2-[(E)-{[4-nitro-2-(trifluoro-meth-yl)phen-yl]imino}-meth-yl]phenol. in Acta crystallographica. Section E, Structure reports online

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Akkurt M (2012) Diethyl 3,4-dimethyl-thieno[2,3-b]thio-phene-2,5-dicarboxyl-ate. in Acta crystallographica. Section E, Structure reports online

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Alissandratos A (2012) Enzymatic acylation of starch. in Bioresource technology

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Allan DR (2010) The crystal structures of the low-temperature and high-pressure polymorphs of nitric acid. in Dalton transactions (Cambridge, England : 2003)

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Apweiler R (2010) A large-scale protein-function database. in Nature chemical biology

 
Description This grant has provided a framework for development of many facets of physical organic chemistry, from advanced materials to reactions mechanisms to breakthroughs in crystallisation and manufacture.
The award (EP/E036244/1, Physical Organic Chemistry: Opportunities in Synthesis, Materials and Pharmaceuticals) has contributed to a number of substantial follow on activities. The strong focus on crystallisation and investments in single crystal diffraction contributed to the strengths that underpinned the development of CMAC as a collaborative manufacturing research centre for continuous crystallisation and processing of pharmaceuticals, co-created with GSK, AZ and Novartis. Glasgow University have been collaborators on the subsequent critical mass awards that include: EP/I033459/1, EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation; EP/K503289/1, Doctoral Training Centre in Continuous Manufacturing and Crystallisation and EP/P006965/1, Future Continuous Manufacturing and Advanced Crystallisation Research Hub. Moreover, the early career researchers appointed into SIPBS have been able to utilise the equipment base to accelerate their career, for example, Dr Iain Oswald secured an EPSRC early career manufacturing fellowship EP/N015401/1, Pressure-Induced Nucleation for the Continuous Manufacture of supramolecular assemblies. In addition we have secured additional investments to augment our capabilities in surface analysis of pharmaceutical systems via EPSRC and Wolfson Foundation awards for fast-scan AFM and ToF-SIMS.
It also led to the Prosperity Partnership with GSK and the University of Nottingham that starts in 2019.

It provided training for many early career researchers and particularly to the appointment of at least one additional academic, Dr. David Nelson, recently promoted to Senior Lecturer, and more than 26 PhD students at the University of Strathclyde, notably co-funded by GSK and the University of Strathclyde, engaged in physical organic chemistry. A key example of international success in this follow-up is Joshua Barham, who won the world championship of chemistry PhDs, namely the Reaxys Prize, in 2017 for his studies on site-selective late-stage functionalisation of complex moleculs of biological interest. Joshua is the first such winner to be associated with a Scottish University.[https://www.elsevier.com/solutions/reaxys/reaxys-phd-prize]. It is clear that this award has been the springboard for a number of important interactions between UK chemistry and pharmacy and the pharmaceutical industry. Through it, we compete at a higher international level.
Exploitation Route The findings are being taken forward in collaborations with pharmaceutical companies for clean manufacturing processes.
Sectors Chemicals,Pharmaceuticals and Medical Biotechnology

URL http://www.johnmurphygroup.com/research-interests.html
 
Description Advisor : Joint or sponsored appointments or secondments with industry or commerce : One of my research group, Phillip Jolly, undertook a placement in GSK followed by a period back in U Strathclyde to facilitate interchange of our expertise with GSK. For more extensive text and indications of the impact, see also the 'key findings' section of this report, for the impetus that this grant provided for overlap between UK academics and the pharmaceutical industry.
First Year Of Impact 2008
Sector Chemicals,Healthcare
 
Description Accelerated Discovery and Development of New Medicines: Prosperity Partnership for a Healthier Nation
Amount £5,495,023 (GBP)
Funding ID EP/S035990/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 01/2019 
End 12/2023
 
Description Doctoral Training Centre in Continuous Manufacturing and Crystallisation
Amount £4,348,959 (GBP)
Funding ID EP/K503289/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 06/2012 
End 06/2019
 
Description EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation
Amount £6,060,701 (GBP)
Funding ID EP/H024107/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 10/2011 
End 12/2016
 
Description Future Continuous Manufacturing and Advanced Crystallisation Research Hub
Amount £10,330,544 (GBP)
Funding ID EP/P006965/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 01/2017 
End 12/2023
 
Description Molecular-Metal-Oxide-nanoelectronicS (M-MOS): Achieving the Molecular Limit
Amount £3,567,075 (GBP)
Funding ID EP/H024107/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 02/2010 
End 07/2014
 
Description Pressure-Induced Nucleation for the Continuous Manufacture of supramolecular assemblies
Amount £966,179 (GBP)
Funding ID EP/N015401/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 06/2016 
End 05/2021
 
Description Accelerated Discovery and Development of New Medicines: Prosperity Partnership for a Healthier Nation 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution I am leader for one of 5 themes; and am a member of a second theme. I represented University of Strathclyde as party of the panel of 3 who were interviewed at EPSRC for this grant
Collaborator Contribution GSK are the lead industrial partners who are collaborating with the University of Strathclyde and theUniversity of Nottingham in this Prosperity Partnership, which addresses accelerated discovery and development of new medicines.
Impact The collaboration has just started, so,as yet, there are no outputs, but they will be reported under that collaborative grant to RCUK.
Start Year 2019
 
Description Invited Table Rond Presentations and Discussions 
Organisation Novartis
Country Global 
Sector Private 
PI Contribution Participant : Participation in workshop/networks with non-academic organisation : Invited by Novartis in Basel to present a lecture on my recent chemistry and to engage in discussions about their potential interest in our chemistry
Collaborator Contribution The Partners set up the meeting in Basel which I attended. The discussions that followed di not progress to a more substantive collaboration
Impact These discussions did not lead to longer term collaboration
Start Year 2012
 
Description Joint research with UNIVERSITY OF GLASGOW 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution University of Strathclyde researchers worked on this project with researchers from UNIVERSITY OF GLASGOW
Start Year 2007
 
Description Knowledge Transfer secondment 
Organisation GlaxoSmithKline (GSK)
Department Research and Development GSK
Country United Kingdom 
Sector Private 
PI Contribution Advisor : Joint or sponsored appointments or secondments with industry or commerce : One of my research group, Phillip Jolly, undertook a placement in GSK followed by a period back in U Strathclyde to facilitate interchange of our expertise with GSK
Collaborator Contribution The collaborators hosted my team member Dr Phillip Jolly for a placement in 2011
Impact This collaboration strengthened the c.v. of Dr Phillip Jolly, who has pursued his career in chemical research and is now in Canada
Start Year 2011
 
Description Project partnership with Astra Zeneca 
Organisation AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution Astra Zeneca worked with the research team and assisted/contributed to the project outcomes
Collaborator Contribution AstraZeneca contributed studentship funding
Impact Hybrid super electron donors - preparation and reactivity By: Garnier, Jean; Thomson, Douglas W.; Zhou, Shengze; et al. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY Volume: 8 Published: JUL 3 2012 Imidazole-derived carbenes and their elusive tetraazafulvalene dimers By: Jolly, Phillip I.; Zhou, Shengze; Thomson, Douglas W.; et al. CHEMICAL SCIENCE Volume: 3 Issue: 5 Pages: 1675-1679 Published: 2012 Structure and reactivity in neutral organic electron donors derived from 4-dimethylaminopyridine By: Garnier, Jean; Kennedy, Alan R.; Berlouis, Leonard E. A.; et al. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY Volume: 6 Article Number: 73 Published: JUL 5 2010 Electron transfer activity of a cobalt crown carbene complex By: Park, Stuart R.; Findlay, Neil J.; Garnier, Jean; et al. TETRAHEDRON Volume: 65 Issue: 52 Pages: 10756-10761 Published: DEC 26 2009 One-Carbon Extrusion from a Tetraazafulvalene. Isolation of Aldehydes and a Study of Their Origin By: Murphy, John A.; Schoenebeck, Franziska; Findlay, Neil J.; et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Volume: 131 Issue: 18 Pages: 6475-6479 Published: MAY 13 2009 One-pot reduction of aryl iodides using 4-DMAP methiodide salt By: Garnier, Jean; Murphy, John A.; Zhou, Sheng-Ze; et al. SYNLETT Issue: 14 Pages: 2127-2131 Published: AUG 22 2008 Super-electron donors: Bis-pyridinylidene formation by base treatment of pyridinium salts By: Murphy, John A.; Garnier, Jean; Park, Stuart R.; et al. ORGANIC LETTERS Volume: 10 Issue: 6 Pages: 1227-1230 Published: MAR 20 2008
Start Year 2007
 
Description Project partnership with CEM Microwave Technology Ltd 
Organisation CEM Corporation
Country United States 
Sector Private 
PI Contribution CEM Microwave Technology Ltd worked with the research team and assisted/contributed to the project outcomes
Collaborator Contribution CEM contributed sompetitive servicing of microwave equipment
Impact n/a
Start Year 2007
 
Description Project partnership with Glaxo Smithkline (UK) 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Glaxo Smithkline (UK) worked with the research team and assisted/contributed to the project outcomes
Collaborator Contribution GSK contributed to funding of PhD studentships
Impact Contra-thermodynamic Hydrogen Atom Abstraction in the Selective C-H Functionalization of Trialkylamine N-CH3 Groups By: Barham, Joshua P.; John, Matthew P.; Murphy, John A. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Volume: 138 Issue: 47 Pages: 15482-15487 Published: NOV 30 2016 Mechanistic investigations of the Chan-Evans-Lam reaction: Overcoming the BPin problem By: Vantourout, Julien; Sproules, Stephen; Isidro-Llobet, Albert; et al. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 252 Meeting Abstract: 389 Published: AUG 20 2016 Clinical progress and pharmacology of small molecule bromodomain inhibitors By: Theodoulou, Natalie H.; Tomkinson, Nicholas C. O.; Prinjha, Rab K.; et al. CURRENT OPINION IN CHEMICAL BIOLOGY Volume: 33 Pages: 58-66 Published: AUG 2016 KOtBu: A Privileged Reagent for Electron Transfer Reactions? By: Barham, Joshua P.; Coulthard, Graeme; Emery, Katie J.; et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Volume: 138 Issue: 23 Pages: 7402-7410 Published: JUN 15 2016 Double Deprotonation of Pyridinols Generates Potent Organic Electron-Donor Initiators for Haloarene-Arene Coupling By: Barham, Joshua P.; Coulthard, Graeme; Kane, Ryan G.; et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Volume: 55 Issue: 14 Pages: 4492-4496 Published: MAR 24 2016 Context Sensitive Links Future Supply Chains Enabled by Continuous Processing-Opportunities Challenges May 20-21 2014 Continuous Manufacturing Symposium. By: Srai, Jagjit Singh; Badman, Clive; Krumme, Markus; et al. Journal of pharmaceutical sciences Volume: 104 Issue: 3 Pages: 840-849 Published: 2015-Mar (Epub 2016 Jan 08) One-pot functionalisation of N-substituted tetrahydro-isoquinolines by photooxidation and tunable organometallic trapping of iminium intermediates By: Barham, Joshua P.; John, Matthew P.; Murphy, John A. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY Volume: 10 Pages: 2981-2988 Published: DEC 12 2014 Lead identification of benzimidazolone and, azabenzimidazolone arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists By: Miah, Afjal H.; Abas, Hossay; Begg, Malcolm; et al. BIOORGANIC & MEDICINAL CHEMISTRY Volume: 22 Issue: 15 Pages: 4298-4311 Published: AUG 1 2014
Start Year 2007
 
Description Project partnership with Merck Chemicals Ltd 
Organisation Merck
Department Merck UK
Country United Kingdom 
Sector Private 
PI Contribution Merck Chemicals Ltd worked with the research team and assisted/contributed to the project outcomes
Collaborator Contribution Merck Chemicals Ltd contriobuted to funding of equipment
Impact n/a
Start Year 2007
 
Description Project partnership with Organon Laboratories Ltd 
Organisation Organon Laboratories Ltd
Country United Kingdom 
Sector Private 
PI Contribution Organon Laboratories Ltd worked with the research team and assisted/contributed to the project outcomes
Collaborator Contribution Organon contributed funding for a PhD studentship
Impact Development of chiral heteroleptic magnesium amides; asymmetric deprotonations mediated by six-membered metallocyclic amidomagnesium naphtholates By: Carswell, Emma L.; Kerr, William J.; McArthur, Duncan; et al. TETRAHEDRON Volume: 70 Issue: 40 Special Issue: SI Pages: 7344-7349 Published: OCT 7 2014 Recyclable supported chiral amines for use within highly efficient asymmetric Mg-amide base processes By: Kerr, William J.; Pazicky, Marek; McArthur, Duncan Conference: 236th National Meeting of the American-Chemical-Society Location: Philadelphia, PA Date: AUG 17-21, 2008 Sponsor(s): Amer Chem Soc ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 236 Meeting Abstract: 45-ORGN Published: AUG 17 2008
Start Year 2007
 
Description Project partnership with Rigaku 
Organisation Rigaku
Country Japan 
Sector Private 
PI Contribution Rigaku worked with the research team and assisted/contributed to the project outcomes
Collaborator Contribution Rigaku contributed to the equipment used in this programme
Impact n/a
Start Year 2007
 
Description Project partnership with University of Glasgow 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution University of Glasgow worked with the research team as part of the WestCHEM collaboration
Collaborator Contribution hosting of joint meetings, exchange of reseachers and joint use of equipment
Impact N/A
Start Year 2007
 
Description Project partnership with Xstalbio Limited 
Organisation Xstalbio Limited
Country United Kingdom 
Sector Private 
PI Contribution Xstalbio Limited worked with the research team and assisted/contributed to the project outcomes
Collaborator Contribution Xstalbio Limited contributed to PhD studentship funding
Impact N/A
Start Year 2007
 
Description 2 Lectures at Univrsite de Bordeaux 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact 2 Lectures at Universite de Bordeaux, principally to a postgraduate audience, on the discoveries arising from our research
Year(s) Of Engagement Activity 2017
 
Description 2 Research Colloquia at U Regensburg 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Graduate Research Training Group in Photocatalysis, U Regensburg, Germany
Year(s) Of Engagement Activity 2016
 
Description Invited Table Rond Presentations and Discussions 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited by Novartis in Basel to present a lecture on my recent chemistry and to engage in discussions about their potential interest in our chemistry.

Not recorded
Year(s) Of Engagement Activity 2012
 
Description Lecture at Ecole Polytechnique 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Lecture at Ecole polytechnique, principally to a postgraduate audience, on the discoveries arising from our research
Year(s) Of Engagement Activity 2017
 
Description Lecture at U de Grenoble 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Lecture at Universite de Grenoble, principally to a postgraduate audience, on the discoveries arising from our research
Year(s) Of Engagement Activity 2017
 
Description Lecture at U. Paris 6 (Diderot) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Lecture at Universite Paris 6 (Diderot), principally to a postgraduate audience, on the discoveries arising from our research
Year(s) Of Engagement Activity 2017
 
Description Lecture at Univeriste Pierre et Marie Curie, Paris 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Lecture to postgraduate students, other researchers and prfoessional chemists on our research in electron transfer
Year(s) Of Engagement Activity 2017
 
Description Lecture at Universite de Montpellier 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Lecture at Universite de Montpellier, principally to a postgraduate audience, on the discoveries arising from our research
Year(s) Of Engagement Activity 2017
 
Description Lecture at Universite de Mulhouse 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Lecture at Universite de Mulhouse, principally to a postgraduate audience, on the discoveries arising from our research
Year(s) Of Engagement Activity 2017
 
Description Lecture at Universitet Uppsala 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Lecture at Universitet Uppsala, Sweden, principally to a postgraduate audience, on the discoveries arising from our research
Year(s) Of Engagement Activity 2017
 
Description Research Colloquium Imperial College, London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact 'Lecture to young chemists', Imperial College London
Year(s) Of Engagement Activity 2017
 
Description Research Colloquium University of Poitiers 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Visitor : Invited talk : Departmental Research colloquium.
University of Poitiers
this visit and lecture led to application for joint funding at Royal Society with Prof Sebastien Thibaudeau
Year(s) Of Engagement Activity 2017
 
Description Research Colloquium University of Sussex 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Visitor : Invited talk : Departmental Research colloquium.
Year(s) Of Engagement Activity 2013
 
Description Research Colloquium at U Southampton 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Contributor : Invited talk : U Spouthampton
Year(s) Of Engagement Activity 2013