A 500MHz NMR Spectrometer to Underpin Chemical Research at Bristol (invited resubmission)

Lead Research Organisation: University of Bristol
Department Name: Chemistry

Abstract

This proposal is concerned with the purchase and installation of scientific hardware that will be essential to the long term analysis of chemical problems at the University of Bristol. NMR spectroscopy is a technique that underpins nearly all apects of modern chemical analysis - from biological through materials to synthetic studies. It allows the elucidation of composition, structure and motion in chemical samples, leading to a fundamental understanding of molecular characteristics in these nano-scale systems. For example the School of Chemistry applies this technique to analysis of complex biologically active compounds isolated from natural sources, products of interest to the pharmaceutical and petrochemical industries, new materials relevant to nanoscience, biotechnology, monitoring complex chemical reactions, elucidation of novel structures produced in chemical synthesis and complex chemical catalysis. To these ends, NMR spectroscopy underpins the work of over 250 research workers, with national and international links to a range of academic and industrial applications. The NMR Facility within the School of Chemistry at Bristol University currently employs 5 instruments ranging from 7-23 years old with resolutions of 270-400MHz to conduct such chemical analysis. The increasing requirements of the high-level research undertaken in the School demand access to resolutions and sensitivity from fields >400MHz.The new instrument requested in the proposal will facilitate new and cutting edge developments in a number of areas as well as ensuring support for current levels of research in the School.The new 500 MHz machine will enable the study of of metabolic products, catalyst mechanisms, natural product structures, functional polymers, protein dynamics, ion-sensors and an array of other materials at down to microgram levels which hitherto have been inaccessible to the researchers in the School.

Publications

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Butts CP (2011) High precision NOEs as a probe for low level conformers--a second conformation of strychnine. in Chemical communications (Cambridge, England)

 
Description Significan new information on meechanisms of polyketide biosynthesis
Exploitation Route Ongoing area of wide international activity so our results will influence work of others
Sectors Chemicals,Pharmaceuticals and Medical Biotechnology

 
Title MOLECULAR STRUCTURE DETERMINATION FROM NMR SPECTROSCOPY 
Description  
IP Reference WO2010026418 
Protection Patent granted
Year Protection Granted
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