Signal Amplification in MR achieved through novel inorganic templates

Lead Research Organisation: University of York
Department Name: Chemistry

Abstract

Nuclear magnetic resonance (NMR) is arguably one of the most important methods for characterising materials in solution. It relies on the fact that certain nuclei possess the property of magnetism. Consequently when they are placed in a uniform magnetic field a precise amount of energy is required to change their magnetic orientation and this is exploited to inform on their local physical and chemical environment. The most widely recognised use of this phenomenon is found the clinical application of Magnetic Resonance Imaging (MRI) which offers unparalleled non-invasive insights into the state and health of the body. In normal conditions the behaviour of nuclei in a magnetic field creates one of the major drawbacks of both NMR and MRI : poor sensitivity. This lack of sensitivity arises because the distribution of magnetic orientations in a sample is such that the effects of only a very few of the molecules can be observed as a signal. Hyperpolarisation, the subject of this proposal, is a method for altering the magnetic distribution so that the observed signal can be increased by several orders of magnitude. Until recently effective hyperpolarisation could be achieved either by a lengthy and small scale process of transferring magnetisation from electrons to nuclei, or by using a hydrogenation reaction to transfer magnetisation from hyperpolarised nuclei in parahydrogen. Parahydrogen constitutes one quarter of naturally occurring hydrogen at room temperature and is the fuel of the space shuttle. This proposal is concerned with a new technique that allows hyperpolarisation of a substance without the need for a chemical reaction. The proposal is specifically concerned with the optimisation of the process, in terms of the chemistry of catalysis, the range of molecules that can interact with the hyperpolarised catalysts and the physical basis of the phenomenon. The proposal seeks to create a flow cell for generic use for the continuous production of hyperpolarised substances in large quantities. It is predicted that the provision of this unprecedented new method for increasing signal strengths could have wide ranging applications within chemistry and also have important implications for methods that seek to improve MRI and therefore its power as a diagnostic tool.

Publications

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Ardenkjaer-Larsen JH (2015) Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy. in Angewandte Chemie (International ed. in English)

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Boutain M (2010) A parahydrogen based NMR study of Pt catalysed alkyne hydrogenation. in Dalton transactions (Cambridge, England : 2003)

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Burns MJ (2015) Improving the hyperpolarization of (31)P nuclei by synthetic design. in The journal of physical chemistry. B

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Duckett SB (2013) Improving NMR and MRI sensitivity with parahydrogen. in Topics in current chemistry

 
Description Scientists at the University of York have developed new technology which could dramatically cut scanning times for important health tests and increase the accuracy of the results.

They have discovered a way of making Magnetic Resonance Imaging (MRI) scanners, extensively used in hospitals, and Nuclear Magnetic Resonance (NMR) machines employed in chemistry research far more sensitive than was previously possible.

Research conducted at the York NMR Centre and the York Neuroimaging Centre has uncovered/produced/developed a new technique which allows molecules to be much more easily detected in a scanner without changing their chemical structure. This is achieved by manipulating a fundamental property of atoms termed 'spin'.

The key advantage over previous technologies is that this can be achieved without the use of a chemical reaction or having to cool the molecules down to very low temperatures. This will allow much easier and cheaper implementation in hospitals or in the laboratory.

We have shown that the gain in sensitivity is so great that data can be acquired in seconds rather than months.

This has very positive implications for faster diagnosis for patients in the future.

The technique could ultimately replace current clinical imaging technologies that depend on the use of radioactive substances or heavy metals."
Exploitation Route They have the potential to improve NMR or MRI
Sectors Chemicals,Healthcare,Manufacturing, including Industrial Biotechology

URL https://www.york.ac.uk/chym/
 
Description Our findings have been used by around 30 research groups worldwide. They have led to the production of a parahydrogen generator which is sold by Bruker BioSpin. Bruker have produced additional equipment which is now undergoing beta-test.
First Year Of Impact 2012
Sector Chemicals,Healthcare,Manufacturing, including Industrial Biotechology
Impact Types Societal,Economic

 
Description Clinical Research Capabilities and Technologies Initiative
Amount £3,105,879 (GBP)
Funding ID R16249 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2015 
End 06/2020
 
Description GlaxoSmithKline (GSK)
Amount £65,000 (GBP)
Funding ID STU029361 
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 10/2010 
End 09/2013
 
Description GlaxoSmithKline (GSK)
Amount £65,000 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 10/2013 
End 09/2017
 
Description Wellcome Trust Capital Awards Scheme
Amount £4,360,000 (GBP)
Funding ID 092506/B/10/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2011 
End 11/2016
 
Description Wellcome Trust Strategic Awards Scheme
Amount £3,500,000 (GBP)
Funding ID 098335/Z/12/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2012 
End 11/2017
 
Description Bruker BioSpin 
Organisation Bruker Corporation
Department Bruker BioSpin
Country Germany 
Sector Private 
PI Contribution We have worked with Bruker to produce a parahydrogen generator, a device for the preparation of hyperpolarised samples and a flow probe for the detection of hyperpolarised signals
Collaborator Contribution Bruker have provided access to equipment and engineering. They have provided legal support for patents
Impact Bruker now sell a parahydrogen generator. A beta test version of the polariser in on test with 5 international research groups.
Start Year 2009
 
Description Using SABRE to aid in the study of biologically relevant molecules 
Organisation AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution We have worked with AstraZeneca on the application of SABRE methods to aid in the characterisation and probing of small molecules of biological relevance
Collaborator Contribution Knowledge and materials
Impact Publications
Start Year 2009
 
Description Using SABRE to aid molecular characterisation 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution GlaxoSmithKline has supported two studentships to drive forward the SABRE research. They are interested in using it to probe pharamaceutical products
Collaborator Contribution They provide knowledge and materials.
Impact Publications
Start Year 2009
 
Description Using parahydrogen to probe small molecules 
Organisation Fera Science Limited
Country United Kingdom 
Sector Public 
PI Contribution We worked with FERA to develop methods to characterise trace amounts of organic materials that are relevant to food.
Collaborator Contribution Knowledge and Materials
Impact Publicatons
Start Year 2009
 
Title Field Cycling Method for Magnetic Resonance 
Description An NMR experiment on hyperpolarizable magnetic nuclei of substrate molecules in a living human or animal body, involves polarizing the substrate molecules by non-hydrogenating para-hydrogen induced polarization (=NH-PHIP) into a singlet/pseudo singlet state in low magnetic field and injecting the substrate molecules into the living body, the body or a part thereof being previously located inside a magnet at low magnetic field. The magnet is switched on to high magnetic field, and in at least part of the substrate molecules, the singlet state/pseudo singlet state is converted into observable magnetization. An MRI or MRS measurement is carried out with the living body or the part thereof, collecting data from the substrate molecules. The NMR experiment is well applicable on hyperpolarized nuclei within a patient, with reduced losses of magnetization due to relaxation processes. 
IP Reference US8825132 
Protection Patent granted
Year Protection Granted 2014
Licensed Yes
Impact We hope that this patent will be used by Bruker BioSpin.
 
Title Hyperpolaritzation of compounds for NMR, in particular by means of PHIP 
Description An NMR method is presented having enhanced sensitivity on a compound comprising hyperpolarizable nuclei, in particular applying enhanced PHIP. Polarization is thereby transferred from a prepared fluid, which is enriched with symmetric molecules of a particular spin state (e.g. para-hydrogen enriched), directly to the hyperpolarizable nuclei of a compound, without altering the chemical identity of the compound in this process. Spin transfer is achieved using a template having sites of ordered environment, and the fluid and the compound are brought together in the presence of the template. Polarization transfer to the hyperpolarizable nuclei of the compound is thereby easier to perform and can be applied to a broader scope of compounds. 
IP Reference US8154284 
Protection Patent granted
Year Protection Granted 2012
Licensed Yes
Impact This product has been licensed to Bruker BioSpin
 
Title NMR measurement apparatus with flow-through probehead 
Description The invention relates to a device (1, 21, 31, 41, 64) for the preparation and measurement of a nuclear spin resonance (NMR) measurement sample (10), including-a flow-through NMR probehead (2), with a first tube (3) and a second tube (14) each for the supply and removal of a liquid NMR measurement sample (10),-at least one chamber (4, 22, 32) which is connected to one of the tubes (3, 14),-a sample inlet (5) for introducing the liquid measurement sample (10) into the device (1, 21, 31, 41, 64), wherein at least one chamber (4, 22, 32) has at least one connection for increasing (9, 24, 25, 42, 43, 46, 47) and releasing (8, 23, 27, 48 a , 48 b) the gas pressure, and in which at least one chamber (4, 22, 32) comprises means for mixing the liquid measurement sample (10) contained in the chamber (4, 22, 32) with a gas With the inventive device it is possible to reduce the measurement sample consumption when doing an NMR spectroscopic measurement on liquid measurement samples to which spin order can be catalytically transferred. 
IP Reference US8766631 
Protection Patent granted
Year Protection Granted 2014
Licensed Yes
Impact This has been licensed to Bruker BioSpin
 
Title Pulse sequencing with hyperpolarisable nuclei 
Description There is described a method of selective observation of non-hydrogenative para- hydrogen induced polarisation (NH-PHIP) as enhanced magnetic resonance signals which comprises separating the thermal and longitudinal spin order states. There is also described a template comprising [Ir(COD)(NHC)(Py)]+, and analogues thereof, for use in a PHIP magnetic resonance technique and a method for its preparation. 
IP Reference WO2010067076 
Protection Patent application published
Year Protection Granted 2010
Licensed Yes
Impact We are working with Bruker BipSpin on the application.
 
Title Parahydrogen Generator 
Description We worked with Bruker BioSpin to produce a device to make parahydrogen 
Type Of Technology New/Improved Technique/Technology 
Year Produced 2013 
Impact The device is being used by a number of researchers to help support hyperpolarisation studies aligned to clinical MRI. 
URL http://www.bruker.com/products/mr/nmr/accessories/hyperpolarization/parahydrogen-generator/overview....
 
Company Name HYPERNETICS IMAGING LIMITED 
Description Currently company holds the patents associated with SABRE and seeks to develop their use. 
Year Established 2013 
Impact Currently seeking investment
 
Description 4th International Metabolic Imaging Workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact A presentation on parahydrogen based methods to improve NMR and MRI
Year(s) Of Engagement Activity 2016
 
Description 5th Australian Organometallics Meeting (Sydney) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact 70 academics, postdocs and research students attended a research presentation, which sparked questions and discssion afterwards

Subsequent joint ARC grant with B Messerle (Sydney)
Year(s) Of Engagement Activity 2010
 
Description 7th Conference on Field Cycling NMR Relaxometry 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact People attended a presentation which sparked questions and discussion afterwards

Other researchers now use our methods
Year(s) Of Engagement Activity 2011
URL http://www.ffcrelax.com/ffcrelax/ffc2011/mainpage.php?folder=program&page=index.php
 
Description Article in the daily mail 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Potential for hyperpolarisation to transform MRI
Year(s) Of Engagement Activity 2018
 
Description BBC the one show 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Presentation to celebrate the life of Sir Peter Mansfield; input into the future of MRI
Year(s) Of Engagement Activity 2018
 
Description BioNMR workshop Weizmann Institute. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Over 50 people attended a presentation which sparked questions and discussion afterwards

Over 15 research groups worldwide have adopted our methods
Year(s) Of Engagement Activity 2013
URL http://www.weizmann.ac.il/weizsites/bionmr/
 
Description CPACT Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Workshop detailing potential routes to use hyperpolarisation to aid in industrial production
Year(s) Of Engagement Activity 2016
 
Description Dalton Discussion Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact A research talk on the use of parahydrogen enhanced NMR methods for cataysis
Year(s) Of Engagement Activity 2016
 
Description Domino Printing Inks Visit 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact A presentation was given on the potential of SABRE as a tool to aid in the analysis of printing ink solutions
Year(s) Of Engagement Activity 2017
 
Description Euromar, Florence, Italy. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Over 100 people attended a presentation which sparked questions and discussion afterwards

Over 15 research groups worldwide have adopted our methods
Year(s) Of Engagement Activity 2010
URL http://www.euromar.org/about.html
 
Description Experimental Nuclear Magnetic Resonance Conference (ENC), Daytona Beach USA. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Over 100 people attended a presentation which sparked questions and discussion afterwards

Over 15 research groups worldwide have adopted our methods
Year(s) Of Engagement Activity 2010
URL http://www.enc-conference.org/
 
Description German-UK MR Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited key-note talk at international meeting.
Year(s) Of Engagement Activity 2015
URL http://www.chemie.tu-darmstadt.de/gdch-fgmr2015/fgmr_2015/index.en.jsp
 
Description Gordon Conference, In Vivo Magnetic Resonance 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Over 100 people attended a presentation which sparked questions and discussion afterwards

Over 15 research groups worldwide have adopted our methods
Year(s) Of Engagement Activity 2014
URL http://www.grc.org/programs.aspx?year=2014&program=invivo
 
Description Huddersfield Hyperpolarisation Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Series of presentations detailing aspects of hyperpolarisation
Year(s) Of Engagement Activity 2016
 
Description Imaging in 2020 VII, Bridging Molecular Imaging and Therapy, Jackson Hole USA. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact people attended a presentation which sparked questions and discussion afterwards

15 research groups worldwide have adopted our methods
Year(s) Of Engagement Activity 2011
 
Description Intermediary Metabolism in Cancer meeting, Dallas USA. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Over 100 people attended a presentation which sparked questions and discussion afterwards

Over 15 research groups worldwide have adopted our methods. This includes groups at Johns Hopkins, UT Southwestern Medical Centre, and the University Medical Center Freiburg
Year(s) Of Engagement Activity 2010
URL http://www.utsouthwestern.edu/edumedia/edufiles/departments_centers/airc/annual-symposium-202010.pdf
 
Description Invited Speaker, Euromar, Dublin, Eire. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Over 100 people attended a presentation which sparked questions and discussion afterwards

Over 15 research groups worldwide have adopted our methods
Year(s) Of Engagement Activity 2012
 
Description Local Workshop for EUROPOL (ITN) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact A workshop on hyperpolarisation methods based on parahydrogen.
Year(s) Of Engagement Activity 2016
 
Description MRC Hyperpolarised MRI workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Workshop to consider progress in hyperpolarisation that will lead to clinical use
Year(s) Of Engagement Activity 2015
 
Description NMR discussion group meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Local organiser and speaker at a meeting focussed on low field NMR
Year(s) Of Engagement Activity 2016
 
Description New national centre to transform medical imaging 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Detail new funding stream

A new £6.8 million research centre based across two Yorkshire universities will aim to transform diagnosis and treatment of patients suffering from cancer, heart disease and musculoskeletal diseases with the help of new medical imaging facilities to be created at Leeds Teaching Hospitals and the University of York.
Year(s) Of Engagement Activity 2014
URL http://www.york.ac.uk/news-and-events/news/2014/medical-imaging-centre/
 
Description New scanning technology aims to achieve quicker diagnosis of disease 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact New scanning technology aims to achieve quicker diagnosis of disease. Groundbreaking research taking place at the University of York could lead to Alzheimer's disease being diagnosed in minutes using a simple brain scan. Scientists are working on new technology that could revolutionise the way in which Magnetic Resonance Imaging (MRI) scans are used to view the molecular events behind diseases like Alzheimer's, without invasive procedure, by increasing the sensitivity of an average hospital scanner by 200,000 times.

The technology underpinning this project, SABRE (Signal Amplification by Reversible Exchange), has received a £3.6m Strategic Award from the Wellcome Trust to fund a team of seven post-doctoral researchers from this month.

on-going
Year(s) Of Engagement Activity 2012
URL http://www.york.ac.uk/chym/news/2012/scanning/
 
Description Opening National Centre of Hyperpolarised MRI 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Scientific talk on developments in SABRE hyperpolarisation.
Year(s) Of Engagement Activity 2016
 
Description Progress With Parahydrogen 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk to Pfizer
Year(s) Of Engagement Activity 2018
 
Description Rank Prize Symposium 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact I contributed to a workshop aimed at driving forward change in chemical detection

Over 15 research groups worldwide have adopted our methods
Year(s) Of Engagement Activity 2011
URL http://www.rankprize.org/index.php/symposia/general
 
Description Seminar Programme 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Series of seminars in Strasbourg related to hyperpolarisation
Year(s) Of Engagement Activity 2018
 
Description Series of talks based on award of RSC Tilden Prize 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Three talks were given to illustrate future opportunities for MRI and NMR based on our scientific developments at Aston, Durham and Southampton
Year(s) Of Engagement Activity 2019
 
Description Talk Cambridge Synthesis and Applications of Labelled Compounds 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk within international meeting
Year(s) Of Engagement Activity 2016
 
Description Talk Hyperpolarisation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Talk as part of a prize symposium
Year(s) Of Engagement Activity 2016
 
Description Talk on progress with parahydrogen 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk with GSK
Year(s) Of Engagement Activity 2018
 
Description Talk on progress with parahydrogen 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact talk with scientists at AstraZeneca
Year(s) Of Engagement Activity 2018
 
Description Talk, ISMAR, Rio de Janerio, Brazil 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact people attended a presentation which sparked questions and discussion afterwards

Over 15 research groups worldwide have adopted our methods
Year(s) Of Engagement Activity 2013
 
Description Using SABRE to improve NMR and MRI 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk given in Paris
Year(s) Of Engagement Activity 2016
 
Description Wellcome Trust Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact To inform on progress towards the clinical uptake of SABRE
Year(s) Of Engagement Activity 2016
 
Description Wellcome Trust, Next Generation Brain Imaging Technologies, London, UK. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact people attended a presentation which sparked questions and discussion afterwards

Funding awarded to take methods forward.
Year(s) Of Engagement Activity 2011
 
Description York Hyperpolarisation Symposium (2 Day) 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Series of 20 talks over 2 days
Year(s) Of Engagement Activity 2016
 
Description iMR CDT Research Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presentation at CDT workshop to inform on hyperpolarisation with parahydrogen
Year(s) Of Engagement Activity 2015
URL https://www2.warwick.ac.uk/fac/sci/physics/research/condensedmatt/imr_cdt/news_events/
 
Description press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Information shared with public

Research progresses towards clinical use
Year(s) Of Engagement Activity 2010
URL http://www.york.ac.uk/news-and-events/news/2010/research/hyperpolarisation/
 
Description press release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact A press release written to share a research success

Over 30 reports in the national and international media picked up this press release. Interviews resulted on local radio.
Year(s) Of Engagement Activity 2009
URL http://www.york.ac.uk/news-and-events/news/2009/medical-diagnosis/