EPSRC IRC in Early-Warning Sensing Systems for Infectious Diseases

Lead Research Organisation: University College London
Department Name: London Centre for Nanotechnology

Abstract

The emergence and re-emergence of infectious diseases is one of the greatest threats to human health. By their very nature, outbreaks of infectious disease can spread rapidly, causing enormous losses to health and livelihood. For example, an estimated 35-million people are HIV-infected, antibiotic resistant pathogens such as MRSA are a major global public health problem and pandemic influenza is rated as the greatest national risk on the UK government risk register (Cabinet Office 'National Risk Register for Civil Emergencies 2012 Edition'). Early diagnosis plays a vital role in the treatment, care and prevention of infectious diseases. However worldwide, many infections remain undiagnosed and untreated or are diagnosed at the late stage due to poor diagnostic tools, resulting in on-going transmission of serious infections or delay in the identification of emerging threats, leading to major human and economic consequences for millions of people.

Our vision is to establish an EPSRC Interdisciplinary Research Centre to create a new generation of early-warning sensing systems to diagnose, monitor & prevent the spread of infectious diseases. This large scale collaboration will bring together scientists, engineers and computer scientists from University College London, Imperial College, London School of Hygiene and Tropical Medicine and the University of Newcastle together with NHS stakeholders, the Health Protection Agency and industry partners. Working across and beyond traditional research boundaries, the IRC will pioneer innovative nano-enabled mobile diagnostic tests which can be used in GP surgeries, community settings and developing countries, linked to smart digital-surveillance systems which search for information on the web to detect early indicators of diseases.

The tremendous expansion in mobile phone technology with an estimated 6 billion users worldwide, provides new opportunities for point-of-care diagnostics with inbuilt capacity to securely transmit results to public healthcare systems. The challenge is to create robust multimarker sensor platforms that can diagnose early infections with high sensitivity and specificity. Our strategy will seamlessly integrate the scientific excellence underpinning recent breakthroughs by our team in diverse areas of biomarker discovery, capture coatings, nanoparticles, nanopatterning, sensor systems, wireless connectivity, data mining and health economic analysis of diagnostics. Moreover we will explore innovative new strategies to search for early indicators of infection (herein we coin the phrase "e-markers") by searching through millions of web-accessible information sources including Google, Facebook and Twitter to identify outbreaks even from people who do not attend clinics or from geographical regions that are invisible to traditional public health efforts. By providing doctors, community workers and public health organisations with real-time, geographically-linked information about emerging infections which will be visualised on a "dashboard" display, we will support more rapid, stratified, integrated evidence-based interventions, benefitting individuals and populations.

Our disruptive early warning sensing capabilities will bring major human and economic benefits to the NHS and global healthcare systems. The ultimate beneficiaries will be patients since early diagnosis will empower them to gain faster access to better treatments, helping to reduce suffering and risk of death. Society will benefit by preventing the onwards spread of infection by people who are unaware of their infection and preserve the effectiveness of precious antimicrobial medicines for future generations. The NHS and healthcare systems will benefit by simplifying patient pathways allowing tests and results to be given in a single visit and so provide a more cost-effective solution of community based care. Our technologies will also provide new commercial opportunities for British industry.

Planned Impact

This exciting IRC proposal will combine cutting-edge UK research with leading commercial partners to bring significant benefits to patients, the public, the NHS and industry. The outcomes of the Centre will bring major impact in the following areas:

1. Patient benefit - The major beneficiaries will of course be the patients who will benefit from rapid and reliable diagnoses of their illnesses with reduced morbidity or mortality, and improvements in quality of life.

2. Public good - The public will benefit since early diagnosis tends to curb the spread of infectious diseases, preserving the effectiveness of antibiotics for future generation and will inform public health intervention programmes.

3. NHS and global healthcare systems - will benefit from improved service delivery:

i. Widening access to testing for infectious diseases in community settings will enable more patients be tested and increase the likelihood of identifying patients at early acute stage where the risk of onwards transmission is high. Currently unacceptably high numbers of patients are diagnosed at an advanced stage of infection. For example, 50% of patients are diagnosed at the late stage of HIV/AIDS.

ii. Simplify patient pathways within the NHS as patients can be tested and receive results within the same visit, overcoming the complexity and inherent delays associated with multiple visits and follow-up appointments to receive results.

iii. Informing public-health intervention programmes - the combination of point of care diagnostics and electronic surveillance systems has the potential to transform the "active" real-time surveillance of infectious diseases, even for patients who do not attend clinics or from geographical regions outside the remit of conventional surveillance systems. The UK Health Protection Agency and global public health bodies, will benefit from the proposed early-warning sensing systems, enabling them to make more rapid, evidence-based clinical interventions and monitor the effect of these strategies in real-time.

iv. Early diagnosis and monitoring will ultimately reduce the increasing economic cost of infectious diseases on the NHS and global healthcare systems.

v. Wireless connectivity will allow results to be rapidly and securely transmitted into NHS electronic systems, reducing the administrative burden on staff and ensuring that high-risk patients receive follow up care.

vi. The UK National Institute for Clinical Excellence (NICE) has published the health economic benefits for widening access to certain diagnostic tests in non-hospital settings including GP surgeries and community settings and will result in major cost savings for the NHS.

4. Commercial return - Our technologies will enable networked POC diagnostics, with attendant opportunities for epidemiology. Beyond trained manpower, the benefits to the UK will accrue through better patient care and monitoring, first adopter advantage to the medical research community, and employment in the emerging telemedicine sector. The dissemination plans are very well-defined and follow standard procedures. Key to both scientific and commercial success in cutting-edge medicine and technology are papers in high-profile journals (e.g. Science and Nature), patents and commercialisation through licensing deals and potentially spinouts. Further, the proposal will leverage from major grant funding, including EPSRC (4 out of 10 Grand Challenge in Nanotechnology for Healthcare awards), Gates Foundation ($25m), EC (£11m), & >£31m investment in infrastructure and facilities at the institutes involved.

Organisations

Publications

10 25 50
 
Title EPSRC IRCs interdisciplinary video 
Description The three EPSRC IRCs came together to create a video about the importance of interdisciplinarity, particularly in science. This was featured on all IRC's channels as well as EPSRC channels. 
Type Of Art Film/Video/Animation 
Year Produced 2017 
Impact Greater visibility for the three EPSRCs and an opportunity to work together. 
URL https://www.i-sense.org.uk/videos/why-collaboration-particularly-science-so-important
 
Title Education Alliance: Presentation skills workshop video 
Description To demonstrate some of the benefits of the i-sense Education Alliance events, we created a video of feedback from those who attended the Communications and Presentation Skills workshop run by Northern Stage in Newcastle. 
Type Of Art Film/Video/Animation 
Year Produced 2017 
Impact Ability to share and demonstrate the impacts of the Education Alliance to our stakeholders 
URL https://www.i-sense.org.uk/videos/communication-and-presentation-skills-workshop
 
Title Einsteins Garden Llama Outbreak! video 
Description As part of the Greenman Einstein's Garden Llama Outbreak! exhibition held by i-sense, Einstein's garden created a video and shared it across their channels and dedicated Llama Outbreak website. 
Type Of Art Film/Video/Animation 
Year Produced 2017 
Impact Greater visibility for i-sense research 
URL https://www.i-sense.org.uk/videos/llama-outbreak-einsteins-garden-greenman-festival
 
Title Prof McKendry led the Rosalind Franklin National Appathon 
Description This national app competition launched in 2015/16 was funded by the Royal Society Rosalind Franklin Award, won by UCL Professor Rachel McKendry. The Award, supported by the Department for Business, Innovation and Skills (BIS), is made to support the promotion of women in STEM and is in memory of the British biophysicist Rosalind Franklin who pioneered research into DNA, viruses, coal and graphite. Empowering women to become leaders in STEMM (Science, Technology, Engineering, Maths and Medicine) is not just the right thing to do, it's the smart thing to do and will make the UK more creative, competitive and prosperous. But cultural and institutional barriers mean women are all too often under-represented at the highest levels despite no apparent shortage of talent. The appathon invited teams and individuals from all backgrounds to take advantage of the telecommunications revolution to reach out to a global audience through apps, empower and recognise a new generation of women leaders, and change public perceptions of women in the digital space. More than 160 applications were received from groups across the UK including school children, researchers not for profit organisation, and industry. Short films were made of al the finalists an posted on youtube http://www.rfappathon.org Our competition was split into two challenges: Challenge 1: To develop new mobile phone apps to empower women in STEMM. The competition was open to both women and men, from complete novices with a good idea, established women in STEM groups looking to improve networking among their members and seasoned app developers. We welcomed early stage ideas and finalists worked with mentors at IDEALondon to help develop their ideas into apps that make a difference. The winner in this category was eSexual Health app - http://www.rfappathon.org/about_entries Challenge 2: To recognise leading women in STEMM who have pioneered new apps for research, societal good and enterprise. We had lots of nominations for apps that address a range of social, cultural and economic challenges, helping us identify and support the female role models who are making a difference through digital innovation. The winner in this category was : AMazing STEMM Trailblazers Finalists and delegates joined us for our Prize and Tech Day on 23rd February 2016 at Wayra, London. This free event included some short talks from our judges, UCL Provost Professor Michael Arthur and a very special guest talk from Rosalind Franklin's sister, author and historian Jenifer Glynn. We then heard pitches from the app finalists and winners were announced by a fantastic panel of judges, including Baroness Martha Lane Fox (Founder of Lastminute.com), Andrew Eland (Director of Social Impact Engineering, Google) and Professor Dame Athene Donald (Professor of Experimental Physics at the University of Cambridge). 
Type Of Art Film/Video/Animation 
Year Produced 2016 
Impact Featured in the Financial Times on International Women's Day Prof Rachel McKendry was invited to a reception from International Women's Day by the Prime Minister at Number 10 Downing Street. 
URL http://www.rfappathon.org
 
Title i-sense Bug Hunters stall at Spark Festival London 2015 
Description i-sense featured in the 2015 Spark Festival London event with our interactive stall 'Bug Hunters', at the Queen Elizabeth Olympic Park on 30th and 31st August 2015. The Bug Hunters stall aimed to engage members of the public with i-sense research and the challenge of infectious diseases. The stall was an interactive journey through our hunt for bugs- to identify disease outbreaks much earlier than ever before. We showed members of the public how technologies they use everyday - mobile phones, apps, search engines, social media- can be used to rapidly test and track infectious diseases. Visitors had the chance to use our mobile tests and read out your "diagnosis" in minutes. There was plenty of fun, hands-on activities, from art projects and puzzle competitions to helping us spread a "disease" around the festival. 
Type Of Art Artistic/Creative Exhibition 
Year Produced 2015 
Impact approximately 900 visitors to the stall An special invitation to a follow on meeting with policy makers including the Major of London 
URL https://www.i-sense.org.uk/events/all/i-sense-presents-bug-hunters
 
Title i-sense Llama Outbreak Exhibition at Einsteins Garden Greenman Festival 2016 
Description In August 2016, i-sense researchers asked festival goers at Greenman Festival to help us contain a mysterious outbreak that is turning people into Llamas! As thousands of people gathered at Einstein's Garden, a unique area of Greenman Festival that brings science to life through art, nature and interactive experiences, they came across a rather unique stall. The Llama Outbreak Control Clinic was set up in response to a public health emergency that had descended upon the festival- a strange virus that was turning people into Llamas! Starting off with one lifesize Llama in the centre of the site ("Llama 0" and the first victim of the virus), the llamas started to multiply throughout the festival and we were able to demonstrate how quickly and unpredictably an infectious disease could spread, particularly in a mass gathering. The virus was further spread through the sudden appearance of "llama tails" and quickly more and more potentially infected people came to our clinic to seek diagnosis! Once people reached the clinic, they were directed to the testing area to confirm their diagnosis. People of all ages gathered to try out our paper-based strip tests and read out their diagnosis using the i-sense app. Through a giant, wooden model, i-sense researchers explained the nanotechnology behind a simple lateral flow test; what exactly was happening with a person's sample as it flowed through the strip and how it might work for other infections like flu and HIV. If the test was positive, vistors helped us track the outbreak by pinpointing where they may have come into contact with the virus so we could predict where it might spread. People were also keen to communicate their opinions and concerns around health data; on the whole people were very positive about sharing data in the context of preventing a pandemic, but there were also concerns around data privacy and security. i-sense researchers were able to have some very useful conversations that will help us shape our research, and how we communicate it in future. There were also plenty of crafts and facepaints to keep people engaged! By the end of the festival, thanks to an increasing amount of people testing and sharing their data, we were successful in quarantining the sources of infection (5 lifesize llamas!) and containing the virus at Greenman Festival. Through this interactive game experience, i-sense was able to simulate a public health emergency and how the research and clinical community might react to an emerging disease outbreak. We were also able to show the public how the technologies they use everyday could help us detect an infectious disease outbreak earlier than is currently possible, as well as the benefits of home-based and community testing, and sharing data in rapidly preventing the spread of disease. Fun was had all round and it was great to see so many people interested in learning more about our research, and eager to contribute. Overall, public feedback was very positive, but the stall was also a great chance to hear people's concerns and start a dialogue that ultimately benefits our research. It is only with public feedback that we can realise our research vision, to develop usable and responsible technologies for the benefit of patients and populations. The Llama Outbreak experience was funded by a UCL Wellcome Trust Society Award. 
Type Of Art Artistic/Creative Exhibition 
Year Produced 2016 
Impact The Llama Outbreak experience was funded by a UCL Wellcome Trust Society Award. Kailey Nolan, i-sense comms and admin officer won the UCL Provost's Public Engagement Award for Professional Services 2017. 
URL https://www.i-sense.org.uk/news/i-sense-contain-llama-outbreak-greenman-festival-2016
 
Title i-sense exhibits at the Science Museum, South Kensington London 
Description i-sense flu research featured in the Science Museum's 'Too much information: Health tests today' exhibit from 29th June-29th September 2015. i-sense was chosen as a key example of cutting-edge research in the evolution of health diagnostics, as people increasingly search for ways to manage their own health away from the clinic or hospital. Featured in the exhibit, are our 'biobarcode' strips (top right-hand image) and our work with Flusurvey. 
Type Of Art Artistic/Creative Exhibition 
Year Produced 2015 
Impact Increased visibility of i-sense to a wider audience. Invitation for a follow up exhibition at the Science Museum. 
URL https://www.i-sense.org.uk/news/visit-i-sense-science-museum
 
Title i-sense features in EPSRC Healthy Nations Film 
Description innovative engineering and physical sciences research, which will improve future mental and physical health 
Type Of Art Film/Video/Animation 
Year Produced 2016 
Impact Increased the visibility of i-sense EPSRC IRC to a wider audience. 
URL https://www.i-sense.org.uk/videos/i-sense-director-epsrc-healthy-nation-film
 
Title i-sense features in Royal Society of Medicine and ITN Productions: EPSRC Cross Discipline Collaboration 
Description i-sense Deputy Director Professor Calum McNeil discusses i-sense as part of a film on innovative, interdisciplinary healthcare research, funded by the Engineering and Physical Sciences Research Council (EPSRC). 
Type Of Art Film/Video/Animation 
Year Produced 2016 
Impact Increased visibility of i-sense EPSRC IRC and for the researchers involved. The youtube film has been viewed over 1700 times, 
URL https://www.youtube.com/watch?v=naNp9Hk9l8c&list=PLmg59M9tRvlfhsszTwwqepKmGSiTMMD64
 
Description Since we began in October 2013, i-sense EPSRC researchers have built the research foundations of a new generation of digital sensing systems that aim to detect outbreaks of serious infectious diseases - including pandemic influenza, MRSA, HIV and Ebola - much earlier than ever before. We are linking traditional public health efforts with the millions of symptoms reported on the web each day, often before people visit their doctors. We are also engineering new mobile phone-connected diagnostics devices to help widen access to testing in the home, including self-tests and devices to support front-line health workers in care homes, and remote African villages. Strong partnerships with end users are central to our vision. From the very outset we have been working closely with Public Health England, clinicians, industry, patients, policy makers and the public to ensure we build technologies that meet their needs. The i-sense team has grown to more than 180 members of biochemists, chemists, physicists, engineers, computer scientists, microbiologists, statisticians, bioinformaticians, architects, philosophers, clinicians, and epidemiologists. Our team have published more than 100 papers on our research, appearing in publication such as Nature, ACS Nano, Scientific Reposts, Science, and Nature Nanotechnology. Our members are supported to produce quality research papers. Research highlights include, a new review on mHealth and connected diagnostic in Nature, advanced models of social media and search data to estimate the prevalence of flu, a self-swabbing pilot study with Flusurvey, the IDRIS biomarker discovery platform for bacterial infections, a pilot study of mobile devices for HIV, advanced nanomaterials for early infant diagnosis of HIV and a growingpartnership with the Africa Health Research Institute to link newly diagnosed individuals to HIV care in South Africa. Our platform diagnostic technologies were also piloted for an Ebola study in Uganda, and our research into the area of diagnostics for Ebola continues to develop. More recent highlights also include ultra-sensitive advanced nanomaterials, ultra-rapid diagnostic device prototypes, four patent applications, strategic clinical and industry partnerships including those with Africa Health Research Institute, Uganda Virus Research Institute, Africa CDC, and Foundation for Innovative New Diagnostics, and evaluation of our deep learning algorithms of Google searches for national influenza surveillance by Public Health England. Through our Education Alliance and communications outcomes, we have held 48 events and engagement activities throughout the lifetime of i-sense . These include the i-sense York retreat, the all IRC meeting in Bath, skills workshops (communication/presentation skills, data visualisation, and statistics), the Llama Outbreak at Greenman Festival, and a booth at New Scientist Live, and engagement activities at the Science Museum Lates. Our work has also featured in the likes of Reuters, The Evening Standard and a BBC One documentary. i-sense members have also given more than 195 talks and poster presentations throughout the years, at both internal and external events in the UK and internationally. Highlights include the World Wide Web Conference in Perth, Australia (Cox group, 2017), International Conference on Re-emerging Infectious Diseases in Addis, Ethiopia (Dr Noah Fongwen, 2017), the Chief Scientific Officer's Annual Conference in London, UK (Professor Rosanna Peeling, 2018), and the International Conference on Molecular Diagnostics & Biomarker Discovery in Penang, Malaysia (Newcastle group, 2017), Scripps Research Future of Individualized Medicine, America (Professor Rachel McKendry, 2019), and Science and Research Summit, UK (Professor Molly Stevens, 2019). We have leveraged over £20M in funding from a portfolio of sources, including two new awards this year; the £600K m-Africa MRC GCRF Foundation Award and the £3.8M EPSRC IRC Next Steps Award to secure our transition to a sustainable National Centre of Excellence. Our team have also won more than 58 awards, including Marie Curie fellowships, the Royal Society Rosalind Franklin Award (Professor Rachel McKendry, 2014), IEEE Signal Processing Society Sustained Impact Award (Professor Ingemar Cox, 2015), the Harrison Award from the Royal Pharmaceutical Society (Professor Molly Stevens, 2017), Elected Foreign Member of the National Academy of Engineering (Professor Molly Stevens, 2019), as well as a number of speaker and poster prizes for our PhD students and Postdocs, including at the MRC DTP Colloquium (Dr Harriet Gliddon, 2014), Biosensors Australia Conference (Dr Valérian Turbé, 2014), UCL EEE Cisco Poster Prize (Evdokia Pilavaki, 2016), UCL Population and Lifelong Health Domain Symposium (Dr Polina Brangel, 2017), and Best oral presentation at the ICM Directors Day (Matthew Setterfield, 2019). In addition to our Education Alliance's training programmes developing the skills of our bright young researchers to become future leaders, our Partnership Resource Fund and Exploratory Projects have supported 39 smaller projects to encourage knowledge sharing and to test our technologies. This includes 15 Mobility Fellowships, 12 Knowledge Transfer grants, and 12 Exploratory Projects. These projects have created international networks of excellence and a new spirit of engagement with the public. These key performance indicators reflect a collective research excellence and commitment to impact across the five partner universities and Public Health England.
Exploitation Route We will make our research findings available on open access journals. The programme's outcomes will carry on to i-sense Next Steps grant i-sense: EPSRC IRC in Agile Early Warning Sensing Systems for Infectious Diseases and Antimicrobial Resistance (EP/R00529X/1).
Sectors Digital/Communication/Information Technologies (including Software),Healthcare,Other

URL http://www.i-sense.org.uk
 
Description Our Twitter data analytics are being evaluated by Public Health England for national flu surveillance and our deep learning algorithms of Google searches for national influenza surveillance are being evaluated by Public Health England. Our 'i-sense flu' results were reported in Public Health England's Annual Flu Report for 2017/18. We have also initiated major new strategic collaborations with the Africa Health Research Institute (KwaZulu Natal, South Africa) and the Uganda Viral Research Institute to pilot our technologies within low and middle income settings. At the Africa Health Research Institute, our i-sense data dashboards are being used as part of the population implementation platform, and our tablet image capture of HIV test results is now being used routinely for quality control.
Sector Digital/Communication/Information Technologies (including Software),Healthcare,Other
Impact Types Societal

 
Description Dr Polina Brangel WHO policy placement
Geographic Reach National 
Policy Influence Type Citation in other policy documents
Impact Producing a landscape review for existing diagnostic tests for Ebola virus and outlining the key challenges and limitations for these. Producing target product profiles for a Ebola diagnostic test post outbreak period.
 
Description Dr Steve Hilton serves on SCI Fine Chemicals Group Committee
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
URL https://www.soci.org/interest-groups/technical-groups/fine-chemicals-group
 
Description Harriet Gliddon as a temporary Advisor to the WHO STI Guideline Development Group in 2017.
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
Impact This meeting took place so that experts could discuss the scope of the guidelines for the use of dual HIV/syphilis tests.
URL http://www.who.int/reproductivehealth/publications/rtis/dual-hiv-syphilis-diagnostic-tests/en/
 
Description James Wilson is a Member of the Public Health Ethics Committee of Faculty of Public Health
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
Impact Provision of policy advice as part of an ethics committee.
 
Description James Wilson is a member of the National Data Guardian's Panel
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a national consultation
Impact Provision advice to the National Data Guardian on complex and politically sensitive issues as DeepMind's use of patients' data, and the ethical issues posed by machine learning in the domain of health. The National Data Guardian's (NDG) role is to provide advice and challenge to the health and social care system, to ensure that patient data is being handled in a way that is conducive to public trust. NDG provides advice, often on a confidential basis to the Secretary of State for Health and Social Care. By the nature of the case much of her work occurs behind the scenes, and by the same token, the advice Wilson provides to her is given on a confidential basis. Like other members of the NDG panel, he often represents the NDG at external meetings, for example at the NHS Digital Research Advisory Group, and in workshops with the British Academy and Royal Society, and government officials. He has specialised in providing advice on the governance of AI in health, and patients' reasonable expectations about sharing of confidential information.
 
Description James Wilson is a member of the National Data Guardian's Steering Group
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
Impact Provision advice to the National Data Guardian. The National Data Guardian's (NDG) role is to provide advice and challenge to the health and social care system, to ensure that patient data is being handled in a way that is conducive to public trust. NDG provides advice, often on a confidential basis to the Secretary of State for Health and Social Care. By the nature of the case much of her work occurs behind the scenes, and by the same token, the advice Wilson provides to her is given on a confidential basis. Like other members of the NDG's Steering Group, he often represents the NDG at external meetings, for example at the NHS Digital Research Advisory Group, and in workshops with the British Academy and Royal Society, and government officials. He has specialised in providing advice on the governance of AI in health, and patients' reasonable expectations about sharing of confidential information.
 
Description James Wilson is a member, NHS Digital Data Access Advisory Group
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
Impact Provision of advice to NHS Digital about when confidential patient data can be disseminated.
 
Description James Wilson is providing policy advice on dissemination of confidential NHS Digital Data (successor body to DAAG)
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a national consultation
Impact Provision of advice to NHS Digital about when confidential patient data can be disseminated.
 
Description James Wilson was a specialist member (ethicist) of General Practice Extraction Service Independent Advisory Group
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
Impact Provision of advice to GPES as a member of an Independent Advisory Group. This involved advising on major and controversial projects such as care.data.
 
Description James Wilson was involved in the Discover society website - care.data and the future of the NHS
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Gave evidence to a government review
Impact This policy briefing summed up the state of the debated on the care.data project at a crucial moment in its evolution, explaining why the project needed to be paused.
 
Description McKendry participated in the closed EPSRC panel addressing the importance of long term investment in engineering and physical sciences in the UK
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description McKendry was invited to be in NIHR i4i panel
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Policy briefing by Dr James Wilson
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact A policy briefing on 'Care data and the Future of the NHS' written by NHS researcher and UCL Philosophy Lecturer James Wilson
URL https://discoversociety.org/
 
Description Policy consultation on AMR surveillance and barriers in POC
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
Impact The impetus to Africa CDC's mandate in curbing the rising trend of Antimicrobial Resistance (AMR) in Africa
URL http://www.panafrican-med-journal.com/content/article/28/271/full/
 
Description Prof Calum McNeil on panel for Cross Council Innovation and Collaboration Grants on Antimicrobial Resistance
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Membership of a guideline committee
 
Description Prof Emery Roundtable Discussion on Ebola
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Vince Emery participated in a roundtable discussion on Ebola
 
Description Prof McKendry Cross Council Antimicrobial Resistance Steering Committee
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact Shaping policy on AMR
 
Description Prof McKendry Invited to Blackett Review Panel on Biodetection
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Prof McKendry invited to attended the Prime Ministers Council for Science and Technology
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Prof McKendry serves on the Steering Group Cross Council Committee on AMR - Influencing national policy relating to health and research
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact Influencing national policy relating to health and research
URL https://www.mrc.ac.uk/research/initiatives/antimicrobial-resistance/tackling-amr-a-cross-council-ini...
 
Description Prof McKendry show-case of i-sense EPSRC for European Commissioner
Geographic Reach Europe 
Policy Influence Type Participation in a national consultation
Impact Rachel McKendry met with Carlos Moedas, the European Commissioner for Research, Innovation & Science. I-sense was chosen for this showcase event during Commissioner Moedas first visit to the UK, since appointed.
URL https://www.i-sense.org.uk/news/eu-science-commissioner-visits-i-sense-ucl
 
Description Prof McKendry, Cox and Johnson Invited to Wellcome Trust Digital Phenotypes Frontiers Meeting
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Prof Molly Stevens on Advisory Board which steered Royal Society Review of UK Research Councils
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Prof Rachel McKendry - Co-chair Digital Medicine Panel of the Topol Review
Geographic Reach Europe 
Policy Influence Type Membership of a guideline committee
URL https://www.hee.nhs.uk/our-work/topol-review
 
Description Prof Rosanna Peeling to act as judge for Longitude Prize on Antibiotics
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a national consultation
Impact Professor Rosanna Peeling was selected as judge to advise on prestigious £10m Longitude Prize on antibiotics, which aims to inspire the development of a rapid, point of care test kit for bacterial infections.
URL https://longitudeprize.org
 
Description Prof. McKendry invited to Co-Chair of Digital Medicine stream of Topol Technology Review commissioned by Jeremy Hunt, the Secretary of State for Health and Social Care
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
 
Description Rachel McKendry at Parliamentary Office of Science and Technology (POST)
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description Report on global sexually transmitted infection surveillanc
Geographic Reach Europe 
Policy Influence Type Gave evidence to a government review
Impact Clinical impacts
URL https://apps.who.int/iris/bitstream/handle/10665/277258/9789241565691-eng.pdf
 
Description Rosanna Peeling Advising Chief Medical Officer, UK
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a national consultation
Impact Working with Chief Medical Officer, Sally Davies, to develop a new model to accelerate the evaluation, regulatory approval and policy development of novel diagnostic technologies and potential winners of the Longitude Prize. The new model is to be piloted in the UK and a few countries in the developing world. Sally Davies was appointed Chief Medical Officer (CMO) for England and Chief Medical Advisor to the UK government in March 2011, having held the post on an interim basis since June 2010. She is an independent adviser to the government on medical matters, with particular responsibilities regarding public health.
 
Description Rosanna Peeling advising forums and panels in Latin America
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guideline committee
Impact Working with the WHO, International Medical Devices Regulatory Forum (IMDRF), the Pan-African Harmonization Working Party, the Latin America Alliance for in-vitro diagnostics (ALADDIV) and the Asian Harmonization Working Party to streamline and harmonize regulatory review of clinical performance studies for in-vitro diagnostics to detect infectious diseases.
 
Description Rosanna Peeling advising the Chief Scientific Officer and her Deputy, Fiona Caragher
Geographic Reach National 
Policy Influence Type Participation in a national consultation
Impact Working with the Chief Scientific Officer and her deputy, Fiona Caragher on identifying the barriers to adoption of technological innovation in the UK and what policy need to be in place to accelerate the uptake of innovation.
 
Description Rosanna Peeling member of European Commission Horizon 2020 Prize for AMR
Geographic Reach Europe 
Policy Influence Type Participation in a advisory committee
 
Description Rosanna Peeling on WHO consultation on Zika Outbreaks and member of the Advisory Group to develop target product profile for Zika diagnostics
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
Impact target product profile for zaikai diagnostics global security
 
Description Rosanna Peeling was Co-Chair of WHO Platform Technologies Initiative
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description Syphilis screening and treatment: integration with HIV services
Geographic Reach Europe 
Policy Influence Type Gave evidence to a government review
Impact Clincal impacts
URL https://www.who.int/bulletin/volumes/95/9/17-200923.pdf
 
Description WHO Guideline Development Group on the use of dual tests for HIV and syphilis
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in a advisory committee
 
Description WHO Information Note on the Use of Dual HIV/Syphilis Rapid Diagnostic Tests (RDT). Geneva: World Health Organization
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
Impact The document provides interim guidance for the use of dual HIV/syphilis diagnostic tests. It will be used by programme managers and healthcare workers, as well as ministries of health, Geneva: World Health Organization
 
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Description Pilot WP2 smartphone connected tests and WP3 data dashboards within the AHRI PIP (uMkhanyakude district in northern KwaZulu-Nata)
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Amount £320 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
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Start 11/2015 
 
Description Support research activity that addresses the challenges faced by developing countries, in accordance with ODA guidelines
Amount £50,000 (GBP)
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Sector Public
Country United Kingdom
Start 08/2016 
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Amount £642 (GBP)
Funding ID n/a 
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Amount £400 (GBP)
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Sector Charity/Non Profit
Country United Kingdom
Start 01/2015 
 
Description Travel grant
Amount £800 (GBP)
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Sector Charity/Non Profit
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Amount £1,530 (GBP)
Organisation University College London 
Department UCL Global Engagement Office
Sector Academic/University
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Amount £250 (GBP)
Funding ID n/a 
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Amount £6,684,742 (GBP)
Funding ID EP/S021612/1 
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Sector Public
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Start 03/2019 
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Amount £290,658 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
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Start 11/2017 
End 11/2020
 
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Amount £40,000 (GBP)
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Amount £50,000 (GBP)
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Amount £10,000 (GBP)
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Amount € 11,500,000 (EUR)
Funding ID 734584 
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Department Horizon 2020
Sector Public
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Start 10/2016 
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Description i-sense EPSRC IRC Next Steps Plus: A Smartphone Powered mRNA Sequence Detector
Amount £1,027,001 (GBP)
Funding ID EP/R018707/1 
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Sector Public
Country United Kingdom
Start 10/2018 
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Amount £11,057,949 (GBP)
Funding ID EP/K031953/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 10/2013 
End 09/2019
 
Description i-sense Next Steps Award: EPSRC IRC in Agile Early Warning Sensing Systems for Infectious Diseases and Antimicrobial Resistance
Amount £3,900,620 (GBP)
Funding ID EP/R00529X/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 10/2018 
End 09/2022
 
Description m-Africa: Building mobile phone-connected diagnostics and online care pathways for optimal delivery of population HIV testing, prevention and care in decentralised settings
Amount £599,115 (GBP)
Funding ID MR/P024378/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2017 
End 03/2019
 
Description studentship for student 21
Amount £85,000 (GBP)
Organisation University College London 
Sector Academic/University
Country United Kingdom
Start 10/2013 
End 09/2016
 
Title Advanced nanomaterials for infectious disease diagnosis 
Description i-sense is developing a range of advanced nanomaterials for ultra-sensitive disease diagnosis 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact Invention disclosure submitted to UCLB 
URL https://www.i-sense.org.uk/news/collaborative-research-explores-why-llamas-could-change-future-hiv-d...
 
Title Cantilever nanosensors for infectious diseases and antimicrobial resistance 
Description Cantilever nanosensors for infectious diseases and antimicrobial resistance 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact Patil, S.B., Manuel V., Webb, B., Mazza, G., Pinzani, M., Soh, Y., McKendry, R.A. & Ndieyira, J.W. 'Decoupling competing surface binding kinetics and reconfiguration of receptor footprint for ultrasensitive stress assays' Nature Nanotechnology 10, 899-907 (2015); DOI: 10.1038/nnano.2015.174. Kappeler, N. 'Cantilevers for biological monitoring: opportunities for classical and quantum physics' Contemporary Physics, (2014); DOI: 10.1080/00107514.2014.966615 Ndieyira, J. W., Kappeler, N., Logan, S., Cooper M.A., Abell, C., McKendry R.A. & Aeppli, G. 'Surface-stress sensors for rapid and ultrasensitive detection of active free drugs in human serum' Nature Nanotechnology 9, 225-232 (2014); DOI: 10.1038/nnano.2014.33. Kappeler N. 'Thoughts on an education' Nature Nanotechnology 8, 794-796 (2013); DOI: 10.1038/nnano.2013.239. McKendry R.A. & Kappeler N. 'Sensors: Good vibrations for bad bacteria' Nature Nanotechnology 8, 483-484 (2013); DOI: 10.1038/nnano.2013.127. 
URL https://www.ucl.ac.uk/mathematical-physical-sciences/maps-news-publication/maps1544/
 
Title Llama antibodies against HIV 
Description Llama antibodies have been developed against HIV and influenza biomarkers. Benchmarking studies to leading commercial antibodies show improved sensitivity and on rates. 
Type Of Material Antibody 
Year Produced 2017 
Provided To Others? Yes  
Impact Gray, E.R., Brookes, J.C., Caillat, C., Turbe, V., Webb, B.L., Granger, L.A., Miller, B.S., McCoy, L.E., El Khattabi, M., Verrips, C.T., Weiss, R.A., Duffy, D.M., Weissenhorn, W., McKendry, R.A. 'Unravelling the molecular basis of high affinity nanobodies against HIV p24: in vitro functional, structural and in silico insights.' ACS Infectious Diseases (2017); DOI: 10.1021/acsinfecdis.6b00189 ; Turbé, V., Gray, E. R., Lawson, V. E., Nastouli, E., Brookes, J. C., Weiss, R. A., Pillay, D., Emery, V. C., Verrips, C. T., Yatsuda, H., Athey, D., McKendry, R. A. 'Towards an ultra-rapid smartphone- connected test for infectious diseases' Scientific Reports 7, Article number: 11971 (2017); DOI:10.1038/s41598-017-11887-6 
URL https://www.i-sense.org.uk/news/collaborative-research-explores-why-llamas-could-change-future-hiv-d...
 
Title Machine learning algorithms to interpret rapid tests 
Description Machine Learning algorithms to interpret rapid tests. Models developed using library of images acquired in the field. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact Early stage development. Publications in preparation. 
 
Title Orion He/Ne EM 
Description SEM/FIB system which good for imgaging metal particles and biomaterials conjugations 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? Yes  
Impact Easy access, and good for out nanoparticals-antibody conjugation characterisation 
 
Title Orion He/Ne EM 
Description TEM facility accessable within UCL. 
Type Of Material Technology assay or reagent 
Year Produced 2018 
Provided To Others? Yes  
Impact Easy access, and good for out nanoparticals characterisation 
 
Title Quantification of active binding sites on a nanoparticle using qPCR 
Description Quantification of active binding sites on a nanoparticle using qPCR. Antigen of interest is bound to a short sequence of DNA. After binding to nanoparticles, and purified, the amount of bound DNA-modified antigen is quantified by qPCR. 
Type Of Material Technology assay or reagent 
Year Produced 2019 
Provided To Others? No  
Impact Further work planned using the method for a fundamental study of the factors affecting antibody conjugation. 
 
Title Smartphone app online care pathway for HIV self testing 
Description A smartphone app online care pathway for HIV self testing, was co-created with end users in KwaZulu-Natal Natal South Africa, and successfully pilots in a rural clinic with 30 participants. 
Type Of Material Technology assay or reagent 
Year Produced 2019 
Provided To Others? No  
Impact Publication in progress 
 
Title Smartphone connected paper microfluidic tests for infectious diseases 
Description Smartphone connected paper microfluidic lateral tests for infectious diseases, including influenza, C Difficiie, HIV and eBOLA. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact Publications in Progress 
URL https://www.i-sense.org.uk/research/core-research
 
Title Surface Acoustic Wave Mobile phone connected test for infectious disease and AMR 
Description Mobile phone connected test for infectious disease and AMR based on SAW biochips. 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? No  
Impact Brookes, J.C., Bufacchi, R., Kondoh, J., Duffy, D.M., McKendry, R.A. 'Determining biosensing modes in SH-SAW device using 3D finite element analysis' Sensors & Actuators: B. Chemical 234, 412-419 (2016); DOI: 10.1016/j.snb.2016.03.103; Turbé, V., Gray, E. R., Lawson, V. E., Nastouli, E., Brookes, J. C., Weiss, R. A., Pillay, D., Emery, V. C., Verrips, C. T., Yatsuda, H., Athey, D., McKendry, R. A. 'Towards an ultra-rapid smartphone- connected test for infectious diseases' Scientific Reports 7, Article number: 11971 (2017); DOI:10.1038/s41598-017-11887-6 Publications in progress 
URL https://www.i-sense.org.uk/i-sense-and-ucl-researchers-meet-japans-saw-experts
 
Title novel monoclonal antibodies against MRSA and C. difficile. 
Description The IDRIS Biomarker Discovery platform has identified novel surface active proteins on the surface of MRSA and C dfficle 
Type Of Material Antibody 
Provided To Others? No  
Impact Two patent applications to be submitted imminently by Newcastle University Tech Transfer Office 
URL https://www.i-sense.org.uk/research/core-research
 
Title prototype smartphone connected test for early HIV infections using ultra-sensitive nanozyme technology 
Description Prototypes tests under development based on ultra-sensitive nanozymes. Pilot study with clinical patient samples and benchmarking to gold-standard commercial tests. - Loynachan, C.N., Thomas, M.R., Gray, E.R., Richards, D.A., Kim, J., Miller, B.S., Brookes, J.C., Agarwal, S., Chudasama, V., McKendry, R.A., Stevens, M.M. 'Platinum Nanocatalyst Amplification: Redefining the Gold Standard for Lateral Flow Immunoassays with Ultrabroad Dynamic Range' ACS Nano (2017); DOI: 10.1021/acsnano.7b06229 
Type Of Material Technology assay or reagent 
Year Produced 2017 
Provided To Others? Yes  
Impact High impact publication ACS Nano; interest from commercial party; 
 
Title COMSOL modelling of SAWS 
Description 3D Model of SAWs for biosensing applications 
Type Of Material Data analysis technique 
Provided To Others? No  
Impact Brookes, J.C., Bufacchi, R., Kondoh, J., Duffy, D.M., McKendry, R.A. 'Determining biosensing modes in SH-SAW device using 3D finite element analysis' Sensors & Actuators: B. Chemical 234, 412-419 (2016); DOI: 10.1016/j.snb.2016.03.103. Collaboration with OJ-Bio and Japan Radio Company 
 
Title Flu detector 
Description Machine learning model to nowcast influenza activity in the UK. The database include Twitter, unique Google API and symptoms reported to the RCGP. 
Type Of Material Computer model/algorithm 
Provided To Others? No  
Impact Zou, B., Lampos, V., Gorton, R. & Cox, I.J. 'On Infectious Intestinal Disease Surveillance using Social Media Content' Proceedings of the 6th International Conference on Digital Health (2016); PDF. Preotiuc-Pietro, D., Lampos, V. & Aletras, N. 'An analysis of the user occupational class through Twitter content' Proceedings of the 53rd annual meeting of the Association for Computational Linguistics, ACL (2015); PDF Lampos, V., Miller, A.C., Crossan, S. & Stefansen, C. 'Advances in nowcasting influenza-like influenza rates using search query logs' Scientific Reports 5, 12760 (2015); DOI: 10.1038/srep12760. Preotiuc-Pietro D., Volkova S., Lampos V., Bachrach Y. & Aletras N. 'Studying User Income through Language, Behaviour and Affect in Social Media' PLoS ONE 10(9): e0138717; DOI: 10.1371/journal.pone.0138717. Lampos, V., Yom-Tov, E., Pebody, R. & Cox, I.J. 'Assessing the impact of a health intervention via user-generated Internet content' Data Mining and Knowledge Discovery 5, 1434-1457 (2015); DOI: 10.1007/s10618-015-0427-9. Yom-Tov, E., Cox, I.J., Lampos, V. & Hayward, A.C. 'Estimating the secondary attack rate and serial interval of influenza-like illnesses using social media' Influenza and other respiratory viruses 9, 191-199 (2015); DOI: 10.1111/irv.12321. Zhang, C., Zhou, S., Miller, J.C., Cox, I.J. & Chain, B.M. 'Optimizing Hybrid Spreading in Metapopulations' Scientific Reports 5, 9924 (2015); DOI: 10.1038/srep09924. Yom-Tov, E., Borsa, D., Hayward, A.C., McKendry, R.A. & Cox, I.J. 'Automatic Identification of Web-Based Risk Markers for Health Events' Journal of Medical Internet Research 17(1):e29, (2015); DOI: 10.2196/jmir.4082 Yom-Tov, E., Borsa, D., Cox, I.J. & McKendry, R.A. 'Detecting Disease Outbreaks in Mass Gatherings Using Internet Data' J. Med. Internet Res. 16(6):e154, (2014); DOI: 10.2196/jmir.3156. Hayward, A.C. et al, 'Comparitive Community burden and severity of seasonal and pandemic influenza: results of Flu watch cohort study' The Lancet Respiratory Medicine 2, 445-454 (2014); DOI: 10.1016/S2213-2600(14)70034-7. 
URL http://fludetector.cs.ucl.ac.uk
 
Title IDRIS 
Description Biomarker discovery software platform- Version 1.0 of the IDRIS Web interface has been completed, together with a dataset generated from a recent NCBI Genbank snapshot. The system will soon be hosted on dedicated hardware, allowing for expansion for the increasing number of new genome sequence. Development work has started on v2.0. 
Type Of Material Computer model/algorithm 
Provided To Others? No  
Impact By harnessing the revolution in genomic sequencing we will continue to develop cloud computing-based bioinformatics work-flows to identify novel markers or groups of biomarkers - pathogen-specific "finger prints".Currently we have established workflows to detect unique "tokens" (short peptide sequences) for any group of organisms of interest. 
 
Title Library of rapid HIV test images under development in partnership with AHRI 
Description A library of photographs of HIV tests has been acquired in rural KwaZulu Natal in South Africa. Images acquired by m-africa and i-sense researchers and AHRI health workers. 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? No  
Impact The library images are being used to support early stage machine learning models to interpret HIV test results. 
 
Title Molecular Dynamics Simulations of antibody-antigen interactions 
Description Modelling of novel capture HIV and influenza capture antibodies based on llama VHH 
Type Of Material Computer model/algorithm 
Provided To Others? No  
Impact Publication if progress Crystal structure 
 
Title Research Data Supporting "A Robust Liposomal Platform For Direct Colorimetric Detection Of Sphingomyelinase Enzyme And Inhibitors" 
Description Raw research data supporting the publication: Holme, M. N. et al., ACS Nano, 2018, DOI: 10.1021/acsnano.8b03308. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
 
Title Research Data Supporting "Duplex-Specific Nuclease-Amplified Detection Of Microrna Using 2 Compact Quantum Dot-Dna Conjugates" 
Description Raw research data supporting the publication: Wang, Y. et al., 2018, ACS Applied Materials & Interfaces, "Duplex-Specific Nuclease-Amplified Detection of MicroRNA Using 2 Compact Quantum Dot-DNA Conjugates", DOI: 10.1021/acsami.8b07250. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
 
Title Research Data Supporting "Fate Of Liposomes In Presence Of Phospholipase C And D: From Atomic To Supramolecular Lipid Arrangement" 
Description Raw research data for experimental work supporting the publication above. Raw data for MD simulation is available upon reasonable request from Irene Yarovsky (irene.yarovsky@rmit.edu.au). 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
 
Title Research Data Supporting "Single Particle Automated Raman Trapping Analysis" 
Description Research raw data supporting the publication: Penders J., et al., Nature Communications. (2018) 9:4256 | DOI: 10.1038/s41467-018-06397 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
 
Title Research data supporting "Bioinspired fabrication of DNA-inorganic hybrid composites using synthetic DNA" 
Description Raw data supporting the publication: Kim E., et al., "Bio-inspired fabrication of DNA-inorganic hybrid composites using synthetic DNA.", ACS Nano, 2019, DOI: 10.1020/acsnano.8b06492. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
 
Title Research data supporting "Detection of microRNA biomarkers via inhibition of DNA-mediated liposome fusion" 
Description Raw research data supporting Jumeaux, C. et al., Nanoscale (2018), DOI: 10.1039/C8NA00331A . 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
 
Title Research data supporting "Effect of Formulation Method, Lipid Composition and PEGylation on Vesicle Lamellarity: A Small-Angle Neutron Scattering Study" 
Description Research data supporting the paper: Nele V. et al., Langmuir (2019), DOI: 10.1021/acs.langmuir.8b04256 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
 
Title Research data supporting "Residue-Specific Solvation Directed Thermodynamic and Kinetic Control over Peptide Self-Assembly with 1D/2D Structure Selection" 
Description Experimental research raw data supporting the publication by Lin, Y. et al, 2019, "Residue-Specific Solvation Directed Thermodynamic and Kinetic Control over Peptide Self-Assembly with 1D/2D Structure Selection", ACS Nano. DOI: 10.1021/acsnano.8b08117. Molecular simulation data is available upon reasonable request from irene.yarovsky@rmit.edu.au. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
 
Title Research data supporting "Surface dynamics and ligand-core interactions of quantum size photoluminescent gold nanoclusters" 
Description Experimental research raw data supporting the publication by Lin, Y. et al, 2018, Surface dynamics and ligand-core interactions of quantum sized photoluminescent gold nanoclusters, Journal of the American Chemical Society. DOI: 10.1021/jacs.8b04436 Molecular simulation data is available upon reasonable request from irene.yarovsky@rmit.edu.au. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
 
Title Research raw data supporting "Activatable cell-biomaterial interfacing with photo-caged peptides" 
Description Raw data supporting the publication; Lin Y. et al., Activatable cell-biomaterial interfacing with photo-caged peptides, 2018, Chemical Science, DOI: 10.1039/c8sc04725a. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
 
Description Africa Health Research Institute 
Organisation Africa Health Research Institute
Country South Africa 
Sector Charity/Non Profit 
PI Contribution current close working relationship between AHRI and UCL and represents a key strategic initiative to extend collaborations in education, research, business and healthcare, within the global health sector. AHRI will provide the necessary resources to facilitate this project in order to accomplish its objectives. As AHRI Chief Scientific Officer I am highly supportive of the goals outlined in this proposal and the opportunity to enable the highest calibre science to be brought to bear on a population with the most significant burden of need.
Collaborator Contribution The ability to link clinical and laboratory-based studies with social science, health systems research and population health data maximizes the potential to undertake biological, causal and interventional research at AHRI. The laboratory base in Durban is currently expanding, in collaboration with other partners, to facilitate human and pathogen genomics underpinned by high-level bioinformatics, biomarker screening, and pathogenesis research. Data, including extensive Department of Health patient records, is singly managed within a health informatics data repository. This maximises the opportunity for understanding the health of the surveillance population, and in conducting intervention studies to mitigate the adverse impact of the HIV/TB epidemics through improved treatment and care of affected individuals. It is this setting which provides a major opportunity to explore the best approach to visualisation of such complex data with impact of using innovative technology to support HIV prevention in South Africa. Basing this research within our setting ensures a rapid route to impact, as well as policy change.
Impact On-going
Start Year 2014
 
Description Cambridge Life Sciences 
Organisation Cambridge Life Sciences Ltd
Country United Kingdom 
Sector Private 
PI Contribution Collaborated with Newcastle University on Biosensors and immunosensor projects
Collaborator Contribution Technical Director will act in an advisory capacity on senior design and manufacture and also conducting market research for relevant applications including technology being developed into key commercial target areas
Impact None as of yet
Start Year 2017
 
Description Collaboration with Imperial College 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Prof. Stevens is currently Professor of Biomedical Materials and Regenerative Medicine at Imperial College London in the Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering. She has excellent support on the Departmental level that provides access to state-of-the-art equipment and instrumentation, such as the Harvey Flowers Characterisation suite. Her research programme is housed within 500m2 of space on most of the 6th floor within the Institute of Biomedical Engineering, which includes dedicated space for synthetic as well as biological studies. She also has a room dedicated to Raman spectroscopic studies, along with access to facilities and core support such as histological analyses, FACS, cleanroom facilities and confocal microscopy. In addition, she has a satellite group in the Francis Crick Institute, a £700M newly constructed world-class biomedical institute located in the heart of central London.
Collaborator Contribution Imperial are completing the construction of the Michael Uren Biomedical Engineering Research Hub, a 13-storey building comprising state-of-the-art laboratory and office facilities for the next generation of biomedical engineering research. i-sense2 activities will be offered half a floor within the Hub, where research towards the developing biosensing technologies can be executed. This is equivalent to an in-kind building infrastructure contribution of £5M. Imperial can confirm that the Department of Bioengineering will prioritise the recruitment of an external candidate to a lectureship in biosensing/diagnostics. This is an in-kind contribution of £400,000 over 5 years, including start-up funds. Imperial's Department of Bioengineering will underwrite a minimum of four 3.5-year PhD studentships in the area of nanomaterial-based research for diagnostics (value £300,000).
Impact he nanomaterials-based designs from the Stevens programme developed in this consortium are high impact. Further investment would greatly support their validation in the field and contribute towards their optimal use as biosensors at the point-of-care. Publications from the programme based on these technologies have been published in Science, ACS Sensors and Nanoscale, while several others are being completed. Their demonstrated capability of a point-of-care technology in Uganda in 2015 is extraordinary and shows the potential for these approaches as viable tools for the biosensing and healthcare communities. Overall the "i-sense" consortium performed exceptionally well and is prepared to continue to research innovative biosensing and mobile network-based approaches to combating infectious diseases. Imperial College fully supports this i-sense2 proposal as the next step to continue pushing the forefront of the field to deliver technologies with real impact.
Start Year 2013
 
Description Collaboration with Professor Michael Marber on heart markers 
Organisation Guy's Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Development of lateral flow test based on the marker and antibodies produced by Prof Marber.
Collaborator Contribution Provided antibodies, antigen and sensitivity target.
Impact Preliminary work with 50nm gold nanoparticles shows low ng/mL sensitivity. Future work will be in collaboration with Dr Michael Thomas to produce more sensitive nanoparticle clusters.
Start Year 2019
 
Description Dr Pyne and Bruker 
Organisation Bruker Corporation
Country United States 
Sector Private 
PI Contribution PI on grant. Research collaboration to develop new probes for high resolution imaging of biomolecules by AFM - testing of probes
Collaborator Contribution Research collaboration to develop new probes for high resolution imaging of biomolecules by AFM - development of probes
Impact New probe launched for high reoslution imaging (https://www.brukerafmprobes.com/p-3958-peakforce-hirs-f-b.aspx). More being developed.
Start Year 2017
 
Description Dr Pyne and John Innes Centre Collaboration 
Organisation John Innes Centre
Country United Kingdom 
Sector Academic/University 
PI Contribution Alice Pyne is PI on grant. Research collaboration to determine how supercoiling affects topoisomerase activity. UCL to characterise sunbstrates and determine binding kinetics by AFM
Collaborator Contribution Research collaboration to determine how supercoiling affects topoisomerase activity - PI on grant is Alice Pyne. JIC to provide DNA and protein samples and biochemistry training
Impact Paper being written for submission to NAR
Start Year 2017
 
Description Francis Crick Institute 
Organisation Francis Crick Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution The Crick Institute has worked with this IRC since it began in 2013 . Since then we have added i-sense Flu meeting at the Institute of Materials in London and also at the i-sense seminar series. Also provided strategic advise.
Collaborator Contribution The Crick Institute is also interested to compare how their Google models compare to impact assessments that we measure at the World Influenza Centre e.g. from winter deaths and flu cases in ICU and in wards and would be happy to support Rachel in any new types of assessment. The value of this in-kind contribution - strategic advice, samples, to host students and data - which will not be charged to i-sense2, is estimated to be £5k.
Impact Crick closely believe the vision for the IRC to create a UK platform supporting the effective translation from lab to clinic of potentially game-changing early sensing systems for infections, with broad applicability to non-communicable diseases.
Start Year 2017
 
Description Google UK 
Organisation Google
Department Google UK
Country United Kingdom 
Sector Private 
PI Contribution i-sense work on data collection both at an individual level through novel nanomaterials for diagnosis, and at a national level though nowcasting via aggregate data analysis - including data contributed by Google. At the end of the pathway, they conduct user research into the end-user needs of early warning systems.
Collaborator Contribution ? Provided access to aggregate, anonymised search trend data. i-Sense have used this data to build predictive model. This level of access to data isn't generally available, even for research purposes. Our specific collaboration with i-Sense allows us to explore approaches for future, wider, access. While this is not a commercial arrangement, commercial access to aggregate data with similar predictive properties, for example content posted on Twitter, would have cost in the region of £50,000. Google UK intend to maintain this level of access, and include any data quality improvements we develop. ? Hosted a researcher, Bill Lampos, from i-Sense within Google as part of our Visiting Faculty programme. This programme allows external researchers to continue their research within Google for the duration of a placement, during which time they benefit from access to Google's technology, and consultation with Google's engineers and research scientists. The are also paid a salary - often around £40,000. Should project goals align, we would consider repeating such a placement in future. ? Advisory capacity provided as an active member of i-Sense's advisory board, and by speaking at a number of the events organised by the group.
Impact Twitter data is fed into PHE flu reports for the UK
Start Year 2017
 
Description Imperial Stevens group and KTH Nygren group collaboration 
Organisation Royal Institute of Technology
Country Sweden 
Sector Academic/University 
PI Contribution Expertise in protein engineering.
Collaborator Contribution Expertise in nanomaterials for biosensing.
Impact No outcomes to date.
Start Year 2019
 
Description Imperial Stevens group and MIT Bhatia group collaboration 
Organisation Massachusetts Institute of Technology
Country United States 
Sector Academic/University 
PI Contribution Design of catalytic nanomaterials for sensing platform
Collaborator Contribution in vivo mouse studies of nanosensor platform
Impact This collaboration led to a publication in Nature Nanotechnology (Loynachan et al., 2019)
Start Year 2017
 
Description Imperial Stevens group and MIT Collins group collaboration 
Organisation Massachusetts Institute of Technology
Country United States 
Sector Academic/University 
PI Contribution Development of LFIA for disease diagnostics.
Collaborator Contribution Expertise on Cas13a diagnostics.
Impact Knowledge transfer collaboration to develop CRISPR diagnostics. Publication under preparation.
Start Year 2019
 
Description Mologic 
Organisation Mologic
Country United Kingdom 
Sector Private 
PI Contribution To research and identify advancements of diagnosing and online pathways for sexually transmitted diseases
Collaborator Contribution Materials (substrates, lateral flow based components)
Impact None as of yet
Start Year 2017
 
Description New SERS platform technology for infectious disease detection and antimicrobial resistance detection devised by collaborating team and submitted as grant application. Strathclyde, Newcastle, Imperial 
Organisation University of Strathclyde
Country United Kingdom 
Sector Academic/University 
PI Contribution The collaboration started off with Newcastle (Keegan) engaging with a Strathclyde PhD student Danny Macdonald. It culminated in the award of the £1.39 M grant, IRC Next Steps Plus: Ultra-Sensitive Enhanced NanoSensing of Anti-Microbial Resistance (u-Sense) EP/R018391/1
Collaborator Contribution in kind time commitment to writing grant at Newcastle, Strathclyde and Imperial
Impact Successful grant u-Sense EP/R018391/1
Start Year 2017
 
Description Newcastle University 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution Newcastle are collaborators led by Neil Keegan
Collaborator Contribution i) Newcastle University has created a cohort of Newcastle University Research Fellowships (NURFs). These are five year, tenure-track positions designed to convert promising early career independent scientists into full academic members, with more experienced academics providing support and guidance to aid our NURFs in establishing thriving research groups, writing successful grants and producing high quality publications. They are given a generous start-up package and we are prepared to support them financially for up to 5 years until they can bring in their own funding. They are set clear publication and grant funding targets for these 5 years and if these are met (externally validated) they will subsequently be given an open-ended appointment at the end of this term. Recruitment is dependent on evidence of existing 'star quality' respective to their peer group. As part of the NURF process, a salary line within their host research Institute has to be identified before the position can be advertised. For i-sense follow-on, a suitable salary line has been identified and agreed with the Director of the Institute of Cellular Medicine (ICM). This provides the opportunity to recruit a NURF within ICM in the area of molecular diagnostic technologies (value ~£300,000). The NURF would join the group as an independent researcher but would add to the critical mass of the group. ii) As part of capacity building in this area we can confirm that the University has recruited an external candidate to a lectureship in molecular diagnostic technologies who will start in Newcastle on 1st August 2017. iii) The Institute of Cellular Medicine will underwrite a 3 year PhD studentship in the area of Diagnostic and Therapeutic Technologies (value £70,000).
Impact The team has developed a bioinformatics pipeline (IDRIS) which, has targeted the rapid, specific detection of Clostridium difficile as well as, excitingly, providing proof of concept for the detection of other specific bacterial organisms, both Gram positive and Gram negative. Patent applications have been lodged for IDRIS system itself and antibodies against aF protein which is specific to all strains of C. difficile and which does not occur in closely related organisms. Publications are being held to be submitted as soon as a priority date for the patent applications has been secured. A spin-out company is a real possibility and the team are working closely with our Research and Enterprise team on an independent market analysis. The detection and diagnosis of specific bacterial infections facilitated by IDRIS is a major breakthrough in terms of rapid diagnostics but the next vital step in dealing with, or controlling, infection is effective treatment with antibiotics. Therefore the Newcastle team will investigate the adaptation of the IDRIS approach to target rapid systems for identification of antimicrobial resistance. We are committed to building upon our success by supporting the growth of Diagnostic Technologies for Healthcare and by retaining and further developing key research staff, - thus providing an impetus to i-sense which will contribute significantly towards sustainability.
Start Year 2013
 
Description OJ-Bio on the development of smartphone connected SAW diagnostic tests 
Organisation Oj-Bio Ltd
Country United Kingdom 
Sector Private 
PI Contribution Development of capture coatings and signal enhancement steps for HIV SAW sensors. Modelling the physics of SAWS.
Collaborator Contribution OJ-Bio provided 4 SAW devices and hundreds of biochips. Our collaboration also benefitted from their experience and knowhow.
Impact Multidisciplinary collaboration involving chemists, virologists, physicists, engineers, clinicians from UCLH NIHR BRC, Training: visit to Japan Radio Company to see manufacture of SAWs; 3 publications: 1) Brookes, J.C., Bufacchi, R., Kondoh, J., Duffy, D.M., McKendry, R.A. 'Determining biosensing modes in SH-SAW device using 3D finite element analysis' Sensors & Actuators: B. Chemical 234, 412-419 (2016); DOI: 10.1016/j.snb.2016.03.103; 2) Gray, E.R., Brookes, J.C., Caillat, C., Turbe, V., Webb, B.L., Granger, L.A., Miller, B.S., McCoy, L.E., El Khattabi, M., Verrips, C.T., Weiss, R.A., Duffy, D.M., Weissenhorn, W., McKendry, R.A. 'Unravelling the molecular basis of high affinity nanobodies against HIV p24: in vitro functional, structural and in silico insights.' ACS Infectious Diseases (2017); DOI: 10.1021/acsinfecdis.6b00189; 3) Turbé, V., Gray, E. R., Lawson, V. E., Nastouli, E., Brookes, J. C., Weiss, R. A., Pillay, D., Emery, V. C., Verrips, C. T., Yatsuda, H., Athey, D., McKendry, R. A. 'Towards an ultra-rapid smartphone- connected test for infectious diseases' Scientific Reports 7, Article number: 11971 (2017); DOI:10.1038/s41598-017-11887-6
Start Year 2012
 
Description Oxford Nanopore Technologies 
Organisation Oxford Nanopore Technologies
Country United Kingdom 
Sector Private 
PI Contribution Collaboration opportunities are around upstream protocol development and engineering of sample presentation, in the areas of TB and HIV, feasibility studies in collaboration with AHRI plus downstream analysis ie using machine learning techniques which are being developed by i-sense researchers.
Collaborator Contribution MinION Enhanced Starter Pack, a fully supported start to nanopore sequencing Potentially presentations at bi-annual meetings.
Impact MinION starter pack
Start Year 2017
 
Description Prof McKendry Group and Dr Alice Pyne collaboration with Great Ormonds Street Hospital 
Organisation Great Ormond Street Hospital (GOSH)
Country United Kingdom 
Sector Hospitals 
PI Contribution The UCL team are developing a novel nanocantilever method to rapidly detect AMR. Lead PDRA is Dr Alice Pyne.
Collaborator Contribution GOSH have provided microbiology expertise and clinical isolates for nanocantilever experiments
Impact High impact publication in preparation. Led to new collaboration with GOSH, LGC and EU funding
Start Year 2016
 
Description Prof McKendry Group i-sense collaboration with TwistDX 
Organisation TwistDx
Country United Kingdom 
Sector Private 
PI Contribution This collaboration brings together world class expertise from i-sense and Prof McKendry's research group at UCL to develop rapid smartphone connected tests for diagnostics tests for HIV and TB. The lead i-sense PDRA is Dr Harriet Gliddon.
Collaborator Contribution Twist DX are pioneering the development of isothermal RPA-based molecular testing and technology. Working with Professor Paul Dalby's group in the UCL Department of Biochemical Engineering, i-sense researchers have been developing a method for freeze-drying RPA components onto glass fibre to allow the integration of an RPA step with a lateral flow assay.
Impact This is an early stage collaboration are there are no reported outcomes to date. This is a highly interdisciplinary team including physical and life scientists, engineers and medics
Start Year 2017
 
Description Prof McKendry Group i-sense collaboration with the Foundation for Innovative New Diagnostics 
Organisation Foundation for Innovative New Diagnostics (FIND)
Country Switzerland 
Sector Charity/Non Profit 
PI Contribution This is a collaboration between Prof McKendry's team (UCL) and the not-for-profit organisation FIND. The McKendry team contribute expertise on smartphone connected tests for infectious diseases.
Collaborator Contribution FIND contributes high level strategic advice, mentorship and engagement with key organizations in the diagnostics industry
Impact Highly multidisciplinary teams: physical and life sciences, engineering, computer science, medicine.
Start Year 2016
 
Description Prof McKendry group i-sense mobility fellowships and UCLA 
Organisation University of California, Los Angeles (UCLA)
Country United States 
Sector Academic/University 
PI Contribution This i-sense Mobility Fellowship aimed to increase the sensitivity of microfluidic paper analytical devices (µPADs), exploring membrane transparency, nanoparticle selection, and readout methods. The fellowship proposal was developed by Prof McKendry's team (UCL) in partnership with Prof Ozcan's group (UCLA) with the aim of future collaboration on optical device design. The McKendry group contribution included: study conception, background IP, resources and supervision.
Collaborator Contribution The Ozcan group are world leaders in nano-photonics. Their contribution included: study conception, resources and research supervision
Impact Continuing collaboration. Joint publication underway.
Start Year 2016
 
Description Prof McKendry i-sense collaboration with Oxford Nanopore Technologies 
Organisation Oxford Nanopore Technologies
Country United Kingdom 
Sector Private 
PI Contribution This is a collaboration between the i-sense EPSRC IRC teams led by Prof McKendry and Prof Pillay (Africa Health Research Institute) with Oxford Nanopore Technologies, to explore the use of portable sequencing devices for the early detection of infectious diseases. Dr Gliddon is the lead i-sense PDRA. The i-sense team's contribution includes knowledge of infectious diseases, population level digital test beds in KwaZulu Natal, molecular diagnostics, novel biomarkers and real-time public data dashboards.
Collaborator Contribution Oxford Nanopore Technologies is pioneering nanopore DNA sequencing technology The MinION is a portable, real-time, long-read, low-cost device and has been commercially available since 2015. ONT has donated a starter kit to i-sense.
Impact None so far
Start Year 2016
 
Description Prof McKendry i-sense collaboration with Swiss Federal Institute of Technology in Lausanne 
Organisation Swiss Federal Institute of Technology in Lausanne (EPFL)
Country Switzerland 
Sector Public 
PI Contribution Extensive expertise of cantilever sensors, AMR, clinical samples and data analysis
Collaborator Contribution Prof Dietler's group at EPFL pioneered a novel cantilever sensors method to rapidly detect AMR.
Impact i-sense Mobility Fellowship. Publications in progress. Disciplines involves: biophysics, biochemistry, microbiology and medicine
Start Year 2016
 
Description Prof McKendry, Dr Alice Pyne and LGC, London UK 
Organisation Laboratory of the Government Chemist (LGC) Ltd
Country United Kingdom 
Sector Private 
PI Contribution UCL team are developing a novel cantilever sensor method for AMR
Collaborator Contribution LGC are experts in metrology and lead on the large consortium grant AntiMicroResist.
Impact Paper being written for submission. Further funding from ERC
Start Year 2016
 
Description Prof Peeling - University of Umea, Sweden 
Organisation Umea University
Country Sweden 
Sector Academic/University 
PI Contribution Knowledge and expertise
Collaborator Contribution Collaboration on research
Impact Impact: Engagement with high level stakeholders and shaping international policy for the development, implementation and adoption of rapid diagnostic tests
Start Year 2017
 
Description Prof Peeling Group and University of North Carolina 
Organisation University of North Carolina Hospitals
Country United States 
Sector Hospitals 
PI Contribution University of North Carolina
Collaborator Contribution Impact: Engagement with high level stakeholders and shaping international policy for the development, implementation and adoption of rapid diagnostic tests
Impact Impact: Engagement with high level stakeholders and shaping international policy for the development, implementation and adoption of rapid diagnostic tests.
Start Year 2017
 
Description Prof Peeling and Fondation Merieux 
Organisation Merieux Foundation
Country France 
Sector Charity/Non Profit 
PI Contribution Expertise and knowledge
Collaborator Contribution Collaboration on research
Impact Impact: Engagement with high level stakeholders and shaping international policy for the development, implementation and adoption of rapid diagnostic tests
Start Year 2017
 
Description Prof Peeling and Institut Pasteur, Sengal 
Organisation Pasteur Institute, Paris
Country France 
Sector Charity/Non Profit 
PI Contribution Collaboration on research from Institut Pasteur, Senegal
Collaborator Contribution Expertise and knowledge
Impact Impact: Engagement with high level stakeholders and shaping international policy for the development, implementation and adoption of rapid diagnostic tests
Start Year 2016
 
Description Prof Peeling and Institute of Tropical Medicine, Antwerp, Belgium 
Organisation Institute of Tropical Medicine Antwerp
Country Belgium 
Sector Academic/University 
PI Contribution Knowledge and expertise
Collaborator Contribution Collaboration on research
Impact Impact: Engagement with high level stakeholders and shaping international policy for the development, implementation and adoption of rapid diagnostic tests
Start Year 2017
 
Description Prof Peeling and Instituto de Medicina Tropical Pedro Kourí (IPK) 
Organisation Institute of Tropical Medicine " Pedro Kouri "
Country Cuba 
Sector Charity/Non Profit 
PI Contribution Expertise and knowledge
Collaborator Contribution Collaboration on research projects
Impact Impact: Engagement with high level stakeholders and shaping international policy for the development, implementation and adoption of rapid diagnostic tests
Start Year 2016
 
Description Prof Peeling and the Swiss Tropical and Public Health Institute 
Organisation Swiss Tropical & Public Health Institute
Country Switzerland 
Sector Academic/University 
PI Contribution Knowledge and expertise
Collaborator Contribution Collaboration on research projects
Impact Impact: Engagement with high level stakeholders and shaping international policy for the development, implementation and adoption of rapid diagnostic tests
Start Year 2017
 
Description Public Health England 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution PHE have worked closely with i-sense over the past five years, with a series of successful outcomes including the development of Google and Twitter tools that are intended to strengthen national surveillance of influenza through early warning; the use of social media to evaluate the community impact of a new paediatric influenza vaccination programme and Exploratory projects to determine the feasibility of self-testing through a web-enrolled cohort and the cost-effectiveness of near patient testing for managing seasonal and pandemic influenza. Through fur the r collaboration including joint studentships between PHE and the other IRC partners, i-sense2 intends to extend these approaches to predictive modelling for influenza and to other emerging infections.
Collaborator Contribution PHE would envisage at this stage that the contribution in-kind from PHE, in in terms of my own time for consultancy and attendance of bi-monthly progress meetings, and that of the lab would be estimated as contribution in-kind over the period of the i-sense follow-on project.
Impact PHE have worked closely with i-sense over the past five years, with a series of successful outcomes including the development of Google and Twitter tools that are intended to strengthen national surveillance of influenza through early warning
Start Year 2013
 
Description QVQ 
Organisation QVQ B.V.
Country Netherlands 
Sector Private 
PI Contribution Expertise in diagnostic test development, advanced nanomaterials, molecular modelling and virology
Collaborator Contribution QVQ bring a wealth of expertise in llama antibody development
Impact Loynachan, C.N., Thomas, M.R., Gray, E.R., Richards, D.A., Kim, J., Miller, B.S., Brookes, J.C., Agarwal, S., Chudasama, V., McKendry, R.A., Stevens, M.M. 'Platinum Nanocatalyst Amplification: Redefining the Gold Standard for Lateral Flow Immunoassays with Ultrabroad Dynamic Range' ACS Nano (2017); DOI: 10.1021/acsnano.7b06229; urbé, V., Gray, E. R., Lawson, V. E., Nastouli, E., Brookes, J. C., Weiss, R. A., Pillay, D., Emery, V. C., Verrips, C. T., Yatsuda, H., Athey, D., McKendry, R. A. 'Towards an ultra-rapid smartphone- connected test for infectious diseases' Scientific Reports 7, Article number: 11971 (2017); DOI:10.1038/s41598-017-11887-6; Gray, E.R., Brookes, J.C., Caillat, C., Turbe, V., Webb, B.L., Granger, L.A., Miller, B.S., McCoy, L.E., El Khattabi, M., Verrips, C.T., Weiss, R.A., Duffy, D.M., Weissenhorn, W., McKendry, R.A. 'Unravelling the molecular basis of high affinity nanobodies against HIV p24: in vitro functional, structural and in silico insights.' ACS Infectious Diseases (2017); DOI: 10.1021/acsinfecdis.6b00189
Start Year 2012
 
Description Rapid sequencing of influenza virus with Eleni Nastouli's group 
Organisation University College London Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution We are conducting the MinION sequencing for them
Collaborator Contribution Clinical samples from UCLH and MiSeq sequencing done by Eleni's group.
Impact n/a
Start Year 2018
 
Description Royal College of General Practitioners 
Organisation Royal College of General Practitioners
Country United Kingdom 
Sector Academic/University 
PI Contribution i-Sense has investigated how the network of primary care data can be supplemented with syndromic data derived from Twitter and Google search logs. This approach, using RCGP RSC data for machine learning purpose, was evaluated by PHE, and is very likely to be incorporated into PHE's weekly influenza reports for the 2017/18 flu season. RCGP RSC data has also been used in a very innovative method to assess the effectiveness of a PHE child influenza vaccination pilot. Once again RCGP data was used to train models based on Twitter, Google, and Microsoft Bing data to estimate influenza prevalence in both pilot and control regions. This work was reported in a paper entitled "Assessing the Impact of a Health Intervention via User-generated Internet Content", published in Data Mining and Knowledge Discovery, Volume 29, Issue 5, Page 1434-1457, 2015.
Collaborator Contribution The Royal College of General Practitioners (RCGP) has a access to regularly updated primary care data based on our network of 200 Research and Surveillance Centre (RSC) practices, encompassing approximately 1.5m patient datasets all pseudoannonymised and downloaded on a weekly basis. This data is used for a variety of approved public health and research purposes, including estimation of the prevalence of influenza on the general population for Public Health England (PHE). Raw data are kept on the RCG RSC data and analytics hub at University of Surrey. This network complies with NHS requirements for a secure network and personal data does not leave this network.
Impact All data provision will follow RCGP RSC data approval processes to ensure secure network protocols are met.
Start Year 2017
 
Description Secondment to Microsoft research 
Organisation Microsoft Research
Department Microsoft Research Cambridge
Country United Kingdom 
Sector Private 
PI Contribution PDRA seconded to as a visiting researcher to work on Microsoft Research project
Collaborator Contribution In kind financial support for 12 month salary of PDRA
Impact List papers, ongoing collaborative work etc.
Start Year 2016
 
Description Strategic collaboration with Africa Health Research Institute (AHRI) 
Organisation Africa Health Research Institute
Country South Africa 
Sector Charity/Non Profit 
PI Contribution This strategic partnership with AHRI aims to build a digital test bed in the heart of the HIV and TB pandemic in KwaZulu Natal South Africa. Our contribution includes world-class expertise in nano sensors, telecommunications, big data and bioengineering.
Collaborator Contribution The Africa Health Research Institute is a £63M new institute in KwazuluNatal South Africa, and is a merger between Wellcome Trust funded Africa Centre and the Howard Hughes Medical Institute. AHRI brings a wealth of world-class expertise in HIV, state of the art research facilities in Durban, a demographic surveillance household survey of 100,000 people, and a biobank of patient samples.
Impact Turbé, V., Gray, E. R., Lawson, V. E., Nastouli, E., Brookes, J. C., Weiss, R. A., Pillay, D., Emery, V. C., Verrips, C. T., Yatsuda, H., Athey, D., McKendry, R. A. 'Towards an ultra-rapid smartphone- connected test for infectious diseases' Scientific Reports 7, Article number: 11971 (2017); DOI:10.1038/s41598-017-11887-6; Loynachan, C.N., Thomas, M.R., Gray, E.R., Richards, D.A., Kim, J., Miller, B.S., Brookes, J.C., Agarwal, S., Chudasama, V., McKendry, R.A., Stevens, M.M. 'Platinum Nanocatalyst Amplification: Redefining the Gold Standard for Lateral Flow Immunoassays with Ultrabroad Dynamic Range' ACS Nano (2017); DOI: 10.1021/acsnano.7b06229
Start Year 2015
 
Description Telefonica 
Organisation O2 Telefonica Europe plc
Country United Kingdom 
Sector Private 
PI Contribution A strong research team which does research and field testing. There are now opportunities to scale up the testing and healthcare prevention to a systems level
Collaborator Contribution Advisory and Steering group representation on digital technologies & industrial links to key players
Impact Strategic guidance on the Advisory Board
Start Year 2016
 
Description University College Hospitals, London 
Organisation University College London Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Used clinical data for sequencing and dashboards
Collaborator Contribution Provided clinical data for analysis
Impact TBC
Start Year 2015
 
Description University of California, LA 
Organisation University of California, Los Angeles (UCLA)
Country United States 
Sector Academic/University 
PI Contribution UCLA have been collaborating with i-sense for approximately 2 years now, and have already hosted two graduate students from Prof. McKendry's lab to transfer some of our lab's expertise on mobile phone based sensing and diagnostics technologies toward infectious disease surveillance. Prior to this, UCLA also had an opportunity to visit UCL's lab in 2014 and presented at the i-sense EPSRC IRC New Frontiers in Digital Technologies for Influenza workshop that she organized at the Institute of Materials in London.
Collaborator Contribution As an i-sense2 Project Partner UCLA will contribute to the design and prototyping of novel smartphone connected photonic diagnostic tests developed in partnership with i-sense and hosting students. In turn, I look forward to the opportunity to work together on pilot studies of these devices in the UK and South Africa, write joint papers and new grant proposals together.
Impact Collaborations on the use of computational imaging, sensing and diagnostics technologies for mobile health, infectious disease screening and related applications.
Start Year 2014
 
Description University of Surrey 
Organisation University of Surrey
Country United Kingdom 
Sector Academic/University 
PI Contribution Surrey is a research collaborator on the i-sense 2
Collaborator Contribution Also, developed test-beds for health care with industrial partners Huawei, Os, BT/EE, 3, BBC, McLaren & NHS
Impact Surrey will be recruiting a Professor and Lecturer specifically into the e-health space and this equates to an investment of some £200,000 as part of our research support. For priming our research theme activities we have also committed £100,000 per annum to our Innovation for Health programme.
Start Year 2013
 
Description i-sense (Imperial) Mologic collaboration 
Organisation Mologic
Country United Kingdom 
Sector Private 
PI Contribution This collaboration with Mologic aims to develop a new generation of point of care tests for infectious diseases. It benefits from Molly Stevens group's wealth of expertise in advanced nanomaterials and also the McKendry group's novel capture ligands and mobile phone app readers.
Collaborator Contribution Mologic have donated tests and provided access to facilities for rapid prototyping
Impact donation of tests and access to facilities
Start Year 2013
 
Description i-sense EPSRC IRC collaboration with The United States Army Medical Research Institute of Infectious Diseases 
Organisation US Army
Country United States 
Sector Public 
PI Contribution This strategic collaboration between i-sense EPSRC IRC and AMRIID aims to develop a new generation of smartphone connected tests for Ebola. The i-sense teams of Prof Stevens (Imperial) and Prof McKendry (UCL) contribute knowledge of smartphone connected tests, IP, advanced nanomaterials, ink jet printing and device prototyping and characterisation facilities. Dr Polina Brangel is the lead i-sense PDRA.
Collaborator Contribution AMRIID is the U.S Army's main institution and facility, based in Frederick, Maryland US, for defensive research into counter measures against biological warfare and investigates disease outbreaks or threats to public health. The team led by Dr. Dye won the Geneva Foundation Researcher of the Year Award 2016 for his cutting edge of research and development of medical counter measures against filoviruses (e.g., Ebola virus, Marburg virus) and other biological threat agents.
Impact Brangel, P., Sobarzo, A., Parolo, C., Miller, B.S., Howes, P.D., Gelkop, S., Lutwama, J.J., Dye, J.M., McKendry, R.A., Lobel, L., Stevens, M.M. 'A Serological Point-of-Care Test for the Detection of IgG Antibodies against Ebola Virus in Human Survivors' ACS Nano (2018); DOI: 10.1021/acsnano.7b07021 ; This collaboration brings together a highly multidisciplinary team: virologists, engineers, physical and life scientists and medics.
Start Year 2016
 
Description i-sense EPSRC IRC collaboration with the Uganda Virus Research Institute 
Organisation Uganda Virus Research Institute
Country Uganda 
Sector Public 
PI Contribution This is a strategic partnership between the i-sense EPSRC IRC and the Uganda Virus Research Institute and AMRIID to develop a new generation of smartphone connected tests for Ebola serology. The i-sense teams led by Prof Molly Steves (Imperial) and Prof McKendry (UCL) contributions include knowledge of smartphone connected test, device prototypes, advanced nanomaterials, apps, ink jet printing, prototyping and characterisation facilities.
Collaborator Contribution The Uganda Virus Research Institute, is a medical research institute owned by the Uganda government that carries out research on communicable diseases in man and animals, with emphasis on viral transmitted infections. The team UVRI led by Leslie Lobel and Julius Lutwama bring world-class expertise in Ebola serology and patient samples.
Impact Brangel, P., Sobarzo, A., Parolo, C., Miller, B.S., Howes, P.D., Gelkop, S., Lutwama, J.J., Dye, J.M., McKendry, R.A., Lobel, L., Stevens, M.M. 'A Serological Point-of-Care Test for the Detection of IgG Antibodies against Ebola Virus in Human Survivors' ACS Nano (2018); DOI: 10.1021/acsnano.7b07021; This collaboration brings together a highly multidisciplinary team of virologists, engineers, physical and life scientists and medics.
Start Year 2015
 
Description i-sense Exploratory Project collaboration with Flusurvey 
Organisation Engineering and Physical Sciences Research Council (EPSRC)
Department Flusurvey
Country United Kingdom 
Sector Public 
PI Contribution i-sense funded an Exploratory project with Flusurvey, led by John Edmunds LSHTM which piloted the feasibility of flu-self swabbing. i-sense contributed know in syndromic surveillance of influenza, diagnostics for virological confirmation of influenza and app development.
Collaborator Contribution Flu survey is an online service that any member of the UK public can log onto to report flu like symptoms they may experience during the winter months. This data is used by researchers at Public Health England and London School of Hygiene and Tropical Medicine to monitor flu trends in the UK. The UK Flusurvey was launched on 16th July 2009, during the swine flu pandemic, and is part of a Europe-wide initiative to monitor influenza-like illness (ILI) activity. They currently have more than 7,500 people, from all over the UK, participating in this survey and would like to increase this number to make our interpretations more meaningful. If you have participated in previous years please do so again this year. Key contributions to the collaboration included relevant know how, data access and infrastructure to survey instances of flu.
Impact Multidisciplinary research: epidemiologists, computer scientists, human-interaction design, chemists, virologists. Publications in progress Wenham, C. & Edmunds, J. 'How effective is this year's flu vaccine' BMJ Blogs (2015) youtube video showing how to take a flu self test: https://www.youtube.com/watch?v=0Xbj6P1Jjoo Smartphone app
Start Year 2014
 
Description i-sense Mobility Fellowships to work with Ozcan group (UCLA) collaboration on mobile phone-linked diagnostics 
Organisation University of California, Los Angeles (UCLA)
Country United States 
Sector Academic/University 
PI Contribution i-sense funded two Partnership Resource Fund Mobility Fellowships for Ben Miller and Isabel Bennett to visit Professor Ozcan's group in UCLA for 4 months. The team brough expertise in paper microfluidic lateral flow tests, advanced nanomaterials and antibacterial resistance.
Collaborator Contribution World expert in nanophotonics and mobile phone-linked devices for infectious diseases
Impact Novel devices Two publications in progress Prof Ozcan is a partner on the i-sense2 EPSRC IRC Next Steps grant
Start Year 2016
 
Description i-sense Newcastle collaboration with Cambridge Life Sciences 
Organisation Cambridge Life Sciences Ltd
Country United Kingdom 
Sector Private 
PI Contribution Creation of smartphone connected tests for MRSA and C Difficile
Collaborator Contribution Strategic advice, instrumentation, and experience in the commercialisation of in-vitro diagnostics
Impact Publications in progress
Start Year 2013
 
Description i-sense PRF Knowledge Transfer Award with NIHR DEC London 
Organisation National Institute for Health Research
Department Diagnostic Evidence Co-operative London
Country United Kingdom 
Sector Public 
PI Contribution The development of 4th generation point of care tests for HIV with mobile connectivity. Device prototypes. Landscaping review of needs.
Collaborator Contribution Diagnostic Evidence Co-operative (DEC) London is one of four NIHR centres in England that generate evidence to support the development of diagnostic tests. i-sense and DEC London have formed a new partnership to evaluate the health economic impact of i-sense diagnostic test for HIV.
Impact Collaboration to begin in April 2017
Start Year 2015
 
Description i-sense PRF Mobility Fellowship with Microsoft Melbourne 
Organisation Microsoft Research
Country Global 
Sector Private 
PI Contribution i-sense funded an incoming Partnership Resource Fund Mobility fellowship with Microsoft Research Melbourne.
Collaborator Contribution Relevant knowhow and expertise
Impact Publications in progress.
Start Year 2016
 
Description i-sense UCL strategic partnership with Microsoft Research 
Organisation Microsoft Research
Country Global 
Sector Private 
PI Contribution Joint research to explore the use of online data to nowcast flu outbreaks and study the effectiveness of flu vaccines
Collaborator Contribution We have formed a strategic partnership with Elad Yom-Tov from Microsoft Research Israel. His contribution to our collaboration includes his knowledge of machine learning and access to data e.g. bing search queries and Twitter.
Impact Lampos, V., Yom-Tov, E., Pebody, R. & Cox, I.J. 'Assessing the impact of a health intervention via user-generated Internet content' Data Mining and Knowledge Discovery 5, 1434-1457 (2015); DOI: 10.1007/s10618-015-0427-9. Yom-Tov, E., Cox, I.J., Lampos, V. & Hayward, A.C. 'Estimating the secondary attack rate and serial interval of influenza-like illnesses using social media' Influenza and other respiratory viruses 9, 191-199 (2015); DOI: 10.1111/irv.12321. Yom-Tov, E., Borsa, D., Hayward, A.C., McKendry, R.A. & Cox, I.J. 'Automatic Identification of Web-Based Risk Markers for Health Events' Journal of Medical Internet Research 17(1):e29, (2015); DOI: 10.2196/jmir.4082 Yom-Tov, E., Borsa, D., Cox, I.J. & McKendry, R.A. 'Detecting Disease Outbreaks in Mass Gatherings Using Internet Data' J. Med. Internet Res. 16(6):e154, (2014); DOI: 10.2196/jmir.3156. Lloyd's Science of Risk Runner Up Prize 2015 Models evaluated for national flu surveillance by Public Health England
Start Year 2013
 
Description i-sense collaboration with BD - donation of tests for research purposes 
Organisation Becton, Dickinson and Company
Country United States 
Sector Private 
PI Contribution BD donated point of care flu tests for an i-sense research programme into flu self-tests. Estimated value £15K.
Collaborator Contribution BD provided an in-kind contribution to point of care tests for influenza diagnostics.
Impact Research publications currently in preparation. Multidisciplinary - The research is highly multidisciplinary with teams of chemists, biochemists, engineers, computer scientists and epidemiologists.
Start Year 2014
 
Description i-sense collaboration with Microdrop Technologies 
Organisation microdrop
Country Germany 
Sector Private 
PI Contribution Expertise in nanosensor for disease diagnosis
Collaborator Contribution Microdrop contributed 50k discount on bespoke instrument development to functionsliase cantilever arrays, SAWs and paper microfluidic tests micro drop's contribution to the project includes their expertise in equipment, software and services for advanced microdispensing and inkjet printing applications. Their team of scientists, engineers and technicians has more than 15 years experience in inkjet-technology and micro-fluidics.
Impact Publications in progress
Start Year 2014
 
Description i-sense collaboration with Penny Wilson from Innovate UK 
Organisation Innovate UK
Country United Kingdom 
Sector Public 
PI Contribution Invited Penny to give keynote talk at our i-sense Strategy Retreat
Collaborator Contribution Strategic overview of the diagnostic landscape in the UK.
Impact The outcomes of the workshop have shaped the i-sense EPSRC IRC Next Steps Proposal Rosanna Peeling gave a keynote talk at the British In Vitro Diagnostic association meeting 2016 Partnership Resource Fund grant led by Rosanna Peeling to explore the barriers to diagnostic test development in the UK and globally.
Start Year 2016
 
Description i-sense strategic partnership with Google 
Organisation Google
Country United States 
Sector Private 
PI Contribution i-sense PDRA Bill Lampos was seconded as a visiting researcher to Google Flu Trends team
Collaborator Contribution In kind financial support to Bill's salary for 6 months; Unique access to Google API data sets $50k sponsorship
Impact Lampos, V., Miller, A.C., Crossan, S. & Stefansen, C. 'Advances in nowcasting influenza-like influenza rates using search query logs' Scientific Reports 5, 12760 (2015); DOI: 10.1038/srep12760. A public facing dashboard shows uses the Google API to nowcast influenza outbreaks across the UK http://fludetector.cs.ucl.ac.uk Multidisciplinary Team: computer scientists, engineers, epidemiologists and clinicians.
Start Year 2014
 
Description i-sense/CeSHHAR collaboration on mHealth tools for HIV testing 
Organisation Centre for Sexual Health and HIV AIDS Research Zimbabwe (CeSHHAR Zimbabwe)
Country Zimbabwe 
Sector Charity/Non Profit 
PI Contribution The aim is to co-create an mHealth tool to assist distribution of HIVST at various universities in Zimbabwe. Valerian Turbe works closely with the team at CeSHHAR on building the server, database and android app prototype. This collaboration originated as a result of the work conducted at i-sense and mAfrica, with the Africa Health Research Institute.
Collaborator Contribution CeSHHAR provided hundreds of used HIV self tests that the i-sense team could take pictures of, in order to train/validate their machine learning models on a different type of HIV RDT.
Impact mHealth tool for HIVST distribution. Library of pictures of Oraquick HIVST.
Start Year 2018
 
Description i-sense/LSHTM collaboration on Trachoma testing project 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Supervision of Masters student: Developing and evaluating trachoma diagnosis training tools in preparation for the trachoma elimination endgame.
Collaborator Contribution Training on focus group qualitative analysis. Focus groups were conducted with members of the community in Tanzania to investigate the acceptibility of using mHealth tool for training and/or to assist testing children for trachoma.
Impact Masters student passed. Paper in preparation to publish the results of focus group qualitative analysis.
Start Year 2019
 
Description iXscient 
Organisation iXscient
Sector Private 
PI Contribution A study done with Newcastle University within the current i-sense project has highlighted the growing need for the detection of Anti-Microbial Resistance (AMR), an area in which UNEW has both extensive experience and the developed bioinformatics tools required to identify unique AMR biomarkers.
Collaborator Contribution iXscient would be willing to act in an advisory capacity on sensor design and manufacture and in addition conducting market research for relevant applications. The support we can provide will be an in-kind contribution to the work.
Impact There is currently a lack of developed technology around rapid AMR detection and implementation in healthcare work flows. The would be keen to work with iXscient on the design and manufacture considerations for the electrochemical lateral flow AMR sensor systems which you are proposing to develop.
Start Year 2017
 
Title IN VITRO DIAGNOSTIC ASSAY METHODS 
Description Nanodiamonds with background subtraction for in vitro diagnostics 
IP Reference GB1814532.6 
Protection Patent application published
Year Protection Granted 2018
Licensed No
Impact IN VITRO DIAGNOSTIC ASSAY METHODS-1814532.6-Nanodiamonds with background subtraction for in vitro diagnostics
 
Title McKendry Group - Antibiotic Therapeutic Monitoring Method - Analyte extraction apparatus and method 
Description Disclosed is a method and apparatus for determining a concentration of a glycopeptide antibiotic containing a phenol moiety such as Vancomycin in a complex sample matrix by extracting the glycopeptide antibiotic from a metered portion of the complex sample matrix by exposing said metered portion to an extraction material having an affinity with the glycopeptide antibiotic; and exposing the extraction material to a metered portion of an eluent for releasing the glycopeptide antibiotic from the extraction material; and by determining a concentration of the glycopeptide antibiotic by adding a Gibbs reagent (2,6 dichloroquinone-4-chloroimide) to the metered portion of the complex sample matrix or the eluent; activating the Gibbs reagent and, after the reaction between the activated Gibbs reagent and the antibiotic has stabilized; detecting the reaction product of the activated Gibbs reagent and the antibiotic in said eluent; and determining the concentration of the antibiotic in the complex sample matrix from the detected reaction product. A method of designing a personalized drug administration regime using the thus obtained concentration is also disclosed. 
IP Reference WO2014125300 
Protection Patent granted
Year Protection Granted 2014
Licensed Commercial In Confidence
Impact TBC
 
Title Newcastle team - Biomarker for identification of Clostridium difficile 
Description This invention relates to a unique biomarker for identification of Clostridium difficile. Additionally, the invention relates to antibodies that specifically bind to a unique biomarker for identification of Clostridium difficile and the use of such antibodies in diagnosis and therapy. 
IP Reference GB1707113.5 
Protection Patent application published
Year Protection Granted 2017
Licensed No
Impact Biomarker and antibody discovery
 
Title Cantilever nanosensors to detect antimicrobial resistant bacteria 
Description Development of nano mechanical sensors to detect antimicrobial resistant bacteria and for therapeutic monitoring of antibiotics 
Type Of Technology Detection Devices 
Year Produced 2015 
Impact Patil, S.B., Manuel V., Webb, B., Mazza, G., Pinzani, M., Soh, Y., McKendry, R.A. & Ndieyira, J.W. 'Decoupling competing surface binding kinetics and reconfiguration of receptor footprint for ultrasensitive stress assays' Nature Nanotechnology 10, 899-907 (2015); DOI: 10.1038/nnano.2015.174. Kappeler, N. 'Cantilevers for biological monitoring: opportunities for classical and quantum physics' Contemporary Physics, (2014); DOI: 10.1080/00107514.2014.966615 Ndieyira, J. W., Kappeler, N., Logan, S., Cooper M.A., Abell, C., McKendry R.A. & Aeppli, G. 'Surface-stress sensors for rapid and ultrasensitive detection of active free drugs in human serum' Nature Nanotechnology 9, 225-232 (2014); DOI: 10.1038/nnano.2014.33. Kappeler N. 'Thoughts on an education' Nature Nanotechnology 8, 794-796 (2013); DOI: 10.1038/nnano.2013.239. McKendry R.A. & Kappeler N. 'Sensors: Good vibrations for bad bacteria' Nature Nanotechnology 8, 483-484 (2013); DOI: 10.1038/nnano.2013.127. McKendry, R.A. & Saxl, T.E. 'EPSRC IRC Submission of Evidence to the House of Commons Science & Technology Select Committee Inquiry into Antimicrobial Resistance' (2013). 
URL https://www.ucl.ac.uk/mathematical-physical-sciences/maps-news-publication/maps1544/
 
Title Flu Detector 
Description Public Facing Dashboard which provides unto date information of influenza outbreaks in eh UK based on millions of symptoms reported each day on Twitter and searches (Google and Bing) 
Type Of Technology Webtool/Application 
Year Produced 2016 
Impact Zou, B., Lampos, V., Gorton, R. & Cox, I.J. 'On Infectious Intestinal Disease Surveillance using Social Media Content' Proceedings of the 6th International Conference on Digital Health (2016); PDF. Preotiuc-Pietro, D., Lampos, V. & Aletras, N. 'An analysis of the user occupational class through Twitter content' Proceedings of the 53rd annual meeting of the Association for Computational Linguistics, ACL (2015); PDF Lampos, V., Miller, A.C., Crossan, S. & Stefansen, C. 'Advances in nowcasting influenza-like influenza rates using search query logs' Scientific Reports 5, 12760 (2015); DOI: 10.1038/srep12760. Lampos, V., Yom-Tov, E., Pebody, R. & Cox, I.J. 'Assessing the impact of a health intervention via user-generated Internet content' Data Mining and Knowledge Discovery 5, 1434-1457 (2015); DOI: 10.1007/s10618-015-0427-9. Yom-Tov, E., Cox, I.J., Lampos, V. & Hayward, A.C. 'Estimating the secondary attack rate and serial interval of influenza-like illnesses using social media' Influenza and other respiratory viruses 9, 191-199 (2015); DOI: 10.1111/irv.12321. Zhang, C., Zhou, S., Miller, J.C., Cox, I.J. & Chain, B.M. 'Optimizing Hybrid Spreading in Metapopulations' Scientific Reports 5, 9924 (2015); DOI: 10.1038/srep09924. Yom-Tov, E., Borsa, D., Hayward, A.C., McKendry, R.A. & Cox, I.J. 'Automatic Identification of Web-Based Risk Markers for Health Events' Journal of Medical Internet Research 17(1):e29, (2015); DOI: 10.2196/jmir.4082 Yom-Tov, E., Borsa, D., Cox, I.J. & McKendry, R.A. 'Detecting Disease Outbreaks in Mass Gatherings Using Internet Data' J. Med. Internet Res. 16(6):e154, (2014); DOI: 10.2196/jmir.3156. 
URL http://fludetector.cs.ucl.ac.uk
 
Title Llama antibodies against HIV and influenza biomarkers 
Description Novel llama antibodies against HIV and influenza biomarkers have been developed in partnership with QVQ, 
Type Of Technology New Material/Compound 
Year Produced 2017 
Impact Publications in progress 
URL https://www.i-sense.org.uk/research/core-research
 
Title Mobile phone connected test for HIV based on surface acoustic wave biochips 
Description A handheld smartphone connected device to detect HIV biomarkers in a finger prick of blood 
Type Of Technology Detection Devices 
Year Produced 2017 
Impact Publications in progress Brookes, J.C., Bufacchi, R., Kondoh, J., Duffy, D.M., McKendry, R.A. 'Determining biosensing modes in SH-SAW device using 3D finite element analysis' Sensors & Actuators: B. Chemical 234, 412-419 (2016); DOI: 10.1016/j.snb.2016.03.103. 
URL https://www.i-sense.org.uk/i-sense-and-ucl-researchers-meet-japans-saw-experts
 
Title Smartphone app to read lateral flow diagnostic tests 
Description Smartphone app to interpret commercial lateral flow tests (e.g. HIV, influenza) and also multiplexed tests made in-house for Ebola. The app harnesses a smartphone camera and uses computer vision software to recognise the test region of interest, interpret the result (a test line), display the result and securely connect it to healthcare data bases. In future we plan to link the iReader app to online care pathways 
Type Of Technology Webtool/Application 
Year Produced 2014 
Impact m-Africa MRC GCRF award to pilot the app with the Africa Health Research institute in KwaZulu Natal 
URL https://www.i-sense.org.uk/news/using-mobile-technologies-test-and-treat-those-hardest-hit-hiv
 
Title Smartphone application based online care pathway for HIV self testing 
Description Smartphone application based online care pathway for HIV self testing, co-creaed with AHRI. The app was in English and isi Zulu, with audiovisual guide to HIV self testing and a timer to ensure the test is read at the correct time. The app was successfully piloted on 30 patients in a clinic. 
Type Of Technology Webtool/Application 
Year Produced 2019 
Impact publication underway 
 
Title i-sense Exploratory Project to build an online care pathway for HIV self testing 
Description Web application that enables a person to self-test and self manager remote from traditional health care systems 
Type Of Technology Webtool/Application 
Year Produced 2017 
Impact m-Africa MRC GCRF award https://www.i-sense.org.uk/news/using-mobile-technologies-test-and-treat-those-hardest-hit-hiv 
URL https://www.i-sense.org.uk/news/using-mobile-technologies-test-and-treat-those-hardest-hit-hiv
 
Title i-sense IDRIS Biomarker Discovery Platform (Newcastle university) 
Description A major problem in the development of new medical diagnostic systems for infectious disease is the development of a suitable affinity reagent, such as an antibody, that binds specifically to the target organism. The process of finding these reagents for new emerging threats can take months or even years. A novel bioinformatics cloud computing-based system has been developed as an output of the projects listed above (termed IDRIS). The IDRIS pipeline is able to predict physiological biomarkers for a given group of organisms from genome sequence data. These biomarkers can be used to generate novel diagnostic reagents. In the projects above we have both developed the pipeline and showed how it can be applied to predict biomarkers for two major bacterial pathogens: Methicillin resistant Staphylococcus aureus (MRSA) and Clostridium difficile. We also showed how these biomarkers could be used to produce antibodies that were, in turn, used to develop point of care diagnostic devices. 
Type Of Technology Grid Application 
Year Produced 2017 
Impact Flanagan K., Harwood C., Lawry B. & Wipat A. 'A distributed computational search strategy for the identification of diagnostics targets: application to finding aptamer targets for methicillin-resistant staphylococci', J Integr Bioinform., 11, 242, (2014); DOI: 10.2390/biecoll-jib-2014-242 
URL https://www.i-sense.org.uk/research/flagship-3-sensing-systems-detect-and-identify-bacteria
 
Title i-sense real-time Digital Dashboard linking HIV home tests to care in local clinics 
Description i-sense have teamed up with the Wellcome Trust Africa Centre for Health and Population Studies and The Bartlett Centre for Advanced Spatial Analysis (CASA) at UCL to harness the power of mobile technologies and link newly diagnosed HIV patients to treatment. As part of this new international collaboration, i-sense researchers have developed an innovative, digital public health dashboard with the ultimate aim of improving care provision for all newly diagnosed individuals. The research builds on a major Treatment as Prevention (TasP) trial in Kwazulu-natal, South Africa and CASA's vast experience building dashboards to nowcast events and visualise big data. The TasP trial, hosted by The Africa Centre, aims to show the crucial role regular home-based HIV testing and immediate treatment for the newly diagnosed has in reducing HIV incidence. 
Type Of Technology Software 
Year Produced 2016 
Impact https://www.i-sense.org.uk/news/harnessing-mobile-phones-stop-spread-hiv-international-collaboration 
URL https://www.i-sense.org.uk/news/harnessing-mobile-phones-stop-spread-hiv-international-collaboration
 
Description Nanomaterials for biosensing and regenerative medicine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Molly Stevens , invited talk: 30th Conference of The European Colloid and Interface Society (ECIS) ECIS Rome, Italy, 06-Sep-16: Nanomaterials for biosensing and regenerative medicine
Year(s) Of Engagement Activity 2016
URL https://ecis2016.org/
 
Description "i-sense mapping workshop: Innovations in mapping and spatial epidemiology: potential applications in public health practice" 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact 30 students, researchers and professionals attended a workshop organised to spark discussion around a new project and create a networking opportunity for potential collaborators
Year(s) Of Engagement Activity 2018
 
Description 'Improving the development and deployment of rapid diagnostic tests in South East Asia' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact A talk was given at a public policy conference organised by the Academy of Medical Sciences with the purpose of creating diagnostics policy cohesion across ASEAN member states
Year(s) Of Engagement Activity 2018
URL https://acmedsci.ac.uk/policy/policy-projects/improving-the-development-and-deployment-of-rapid-diag...
 
Description 1st International Conference on Re-emerging Infectious Diseases  
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Description to follow
Year(s) Of Engagement Activity 2018
 
Description 2016 International Symposium on Nanobiotechnology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Stevens delivered a keynote address at the 2016 International Symposium on Nanobiotechnology in February 2016.
Year(s) Of Engagement Activity 2016
 
Description 2019 Chief Scientific Officer's Annual Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact This annual event for healthcare scientists will explore the evolving role of healthcare science and healthcare scientists in delivering the NHS Long Term Plan. The format will be a mix of plenary sessions, interactive panel discussions and workshops all delivered by experts in their field. Alongside this, networking opportunities and the presentation of the 2019 Healthcare Science Awards will provide the chance to learn from, and inspire others.
Year(s) Of Engagement Activity 2012,2019
URL https://www.events.england.nhs.uk/events/chief-scientific-officers-annual-conference
 
Description 2nd ISN2A Congress on Nanoparticles and Nanomaterials 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Stevens delivered a Plenary talk entitled "Bio-inorganic Nanomaterials for Ultrasensitive Biosensing"
Year(s) Of Engagement Activity 2016
 
Description 30th Conference of The European Colloid and Interface Society (ECIS) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Stevens delivered a Plenary Talk in September 2016.
Year(s) Of Engagement Activity 2016
 
Description 4th annual future of medicine: The role of doctors 2028 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Erin to add some information
Year(s) Of Engagement Activity 2018
 
Description 4th annual research innovation symposium 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Led a talk on Tracking Epidemics with Nanotechnology to explain key developments within the i-sense project to improve early diagnosis of infectious disease by harnessing the power of mobile phones, biomedical engineering, nanotechnology, genomics and big data. Key highlights include the i-sense flu project that tracks influenza rates through self-reported measures online, the development of low-cost, user-friendly, mobile phone-connected tests to accurately diagnose infections at point-of-care, and the embedding of diagnostic tools and digital technologies into new models of online patient pathways.
Year(s) Of Engagement Activity 2018
URL http://www.hslpathology.com/wp-content/uploads/2018/12/2018-HSL-Show-Guide.pdf
 
Description 6th EuCheMS Chemistry Congress 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Stevens delivered a Plenary talk in September 2016.
Year(s) Of Engagement Activity 2016
 
Description 8th SA AIDS Conference in South Africa 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact "Conference Presentation at the 8th SA AIDS Conference in Durban South Africa (13-15 June 2017). Plenary Session, Theme: Basic sciences Putting the spanner in the works- the nuts and bolts of HIV prevention"". The content covered HIV transmission dynamics, drug resistance, and barriers to elimination. "To raise awareness on HIV prevention in South Africa by understanding various aspects of HIV: HIV transmission, drug resistance, preventative measures etc. To contribute towards HIV prevention by understanding HIV transmission dynamics, drug resistance, and barriers to elimination"
Year(s) Of Engagement Activity 2017
 
Description A Diagnostic Biomarker Discovery Platform 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact The conference provides a multidisciplinary forum for disseminating the latest developments in bioinformatics and computational biology. ISMB 2016 offers a diverse, engaging scientific program and the broadest scope of any international bioinformatics/computational biology conference. ISMB 2016 is accepting submissions for proceedings, highlight talks, and posters.
Year(s) Of Engagement Activity 2016
URL https://www.iscb.org/ismb2016
 
Description An introduction to digital health surveillance from online user-generated content 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Vasileios Lampos, Guest Lecture at University of Copenhagen, 08-Mar-16: An introduction to digital health surveillance from online user-generated content
Year(s) Of Engagement Activity 2012,2016
 
Description Andreas Demosthenous talk titled 'Biosensors and Biolectronics' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Conference presentation at École polytechnique fédérale de Lausanne
Year(s) Of Engagement Activity 2019
 
Description Art piece interview-Jenny Brookes 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Jenny spoke about her art work, she would like to interview and transcribe the piece as part of her project which will be exhibited at Timespan in Scotland June-Sept this year (publication and podcast)
Year(s) Of Engagement Activity 2019
 
Description Article about our research in The Times Newspaper 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact This was a an article in the Times Newspaper on 3D printing and how it can influence healthcare in the future
Year(s) Of Engagement Activity 2016
URL https://www.raconteur.net/healthcare/how-3d-printing-could-revolutionise-medicine
 
Description Assessing the impact of a health intervention via user-generated Internet content 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lampos Bill Conference Talk ECML PKDD 2015 Porto 2015-09-07 Assessing the impact of a health intervention via user-generated Internet content
Year(s) Of Engagement Activity 2015
 
Description BBC The Truth About HIV 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact In 2017, BBC created a documentary titled 'The Truth About HIV'. Part of the documentary saw presenter Dr van Tulleken visit KwaZulu-Natal, South Africa and speak with Prof Deenan Pillay about the Treatment as Prevention trial. During this interview, the i-sense data dashboards were showcased.
Year(s) Of Engagement Activity 2017
URL http://www.bbc.co.uk/programmes/b08rvdwp
 
Description BMES Cell & Molecular Bioengineering Conference (Keynote Lecture), Key Largo, FL, USA, 5 January 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Research talk given to international audience.
Year(s) Of Engagement Activity 2018
 
Description Bio-Inspired Materials 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Stevens delivered a talk entitled "Designing materials for regenerative medicine and ultrasensitive biosensing" in September 2016.
Year(s) Of Engagement Activity 2016
 
Description BioEl2019 International Winterschool on Bioelectronics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact This will be a forum to bring together both veteran and young researchers to learn and discuss emerging topics in the field of bioelectronics.
Year(s) Of Engagement Activity 2018
URL https://www.jku.at/en/institute-of-physical-chemistry-and-linz-institute-of-organic-solar-cells/conf...
 
Description Broto Talk - CRUK-AACR Joint conference on physical sciences in oncology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Research poster presented to an international audience
Year(s) Of Engagement Activity 2019
 
Description Broto Talk - Exploiting the potential of rapid diagnostic test technology and mobile connectivity 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Research talk presented to an international audience
Year(s) Of Engagement Activity 2019
 
Description Broto Talk - Minaturized Systems for Chemistry and Life Sciences, µTAS 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Research poster presented to an international audience
Year(s) Of Engagement Activity 2019
 
Description Bug Hunters 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Ran an 'Infectious Disease Diagnostics' workshop at Gunnersbury Catholic School on 14th July 2015. The workshop was very interactive, with students running their own ELISA tests and then using lateral flow tests for flu with mock samples, and using our 'App' to analyse them. This was made possible by an Outreach Grant from the Biochemical Society.
Year(s) Of Engagement Activity 2015
URL https://www.biochemistry.org/Portals/0/Education/Docs/Harriet%20Gliddon.pdf
 
Description Building Mobile Phone-connected Diagnostics and Online Pathways for HIV care: Early findings from the m-Africa Formative Study in KwaZulu-Natal, South Africa. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact In July 2018 (Adeagbo OA, Herbst C, Dlamini N, Mhlongo T, Luthuli M, Xulu S, Sonnenberg P, Estcourt C, Blandford A, Turbe V, Thomas M, Herbst K, Pillay D, McKendry RA, Shahmanesh M) presented their research at the 22nd International AIDS Conference, Amsterdam,
Year(s) Of Engagement Activity 2018
URL https://onlinelibrary.wiley.com/doi/full/10.1002/jia2.25148
 
Description Business Report 3D Printing for Healthcare, Trends, R and D and Revenue Forecasts 2016-2026 by Stephen Hilton 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Business report on Three dimensional printing for medicine - your new guide to trends, opportunities and sales potentials. What is the future of fabricating objects from digital models with 3D printers? Visiongain's new report gives you that data and analysis, letting you explore developments, technology and revenue predictions for uses in healthcare industries. Our investigation forecasts those revenues to 2026 at overall world market, submarket and national level. Avoid falling behind in knowledge, missing opportunities or losing influence. Instead see what the future holds for additive manufacturing and find the potential gains.
Year(s) Of Engagement Activity 2016
URL https://www.visiongain.com/Report/1582/3D-Printing-for-Healthcare-Trends-R-D-and-Revenue-Forecasts-2...
 
Description CMV in the immunocompromised host 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Vince Emery talk International Cytomegalovirus workshop International conference Australia 2015 (April) CMV in the immunocompromised host
Year(s) Of Engagement Activity 2014
 
Description Chemistry and Industry magazine by Stephen Hilton 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Wiley Online Library hosts the world's broadest and deepest multidisciplinary collection of online resources covering life, health and physical sciences, social science, and the humanities. It delivers seamless integrated access to over 6 million articles from over 1500 journals, over 20,000 online books, and hundreds of reference works, laboratory protocols and databases.
Year(s) Of Engagement Activity 2016
URL http://onlinelibrary.wiley.com/store/10.1002/cind.801_15.x/asset/
 
Description Chen Talk - 6th International Conference on Multifunctional, Hybrid and Nanomaterials 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Research poster presented to an international audience
Year(s) Of Engagement Activity 2019
 
Description Chen Talk - Imperial College Post-graduate Research Day 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Research poster presented to Imperial College researchers
Year(s) Of Engagement Activity 2019
 
Description Chen Talk - i-sense Biannual Meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Research poster presented to an international audience
Year(s) Of Engagement Activity 2019
 
Description Claudia Estcourt at BASHH National Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The Digital Divide: are we excluding the most vulnerable in the move to online sexual health care? (plenary)
Year(s) Of Engagement Activity 2017
 
Description Co-developing and piloting Zenzele, a mobile-phone enabled HIV testing and linkage to care pathway for young people in rural KwaZulu-Natal, South Africa' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Accepted as an oral presentation at STI/HIV World Congress in Vancouver July 2019
Year(s) Of Engagement Activity 2019
 
Description Conference oral presentation (RAEng Frontiers in Engineering Development 2018) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Conference talk: Paper microfluidic diagnostics: quantitative techniques and sensitivity improvements
Year(s) Of Engagement Activity 2018
 
Description Conference oral presentation (World Congress on Biosensors 2018) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Conference talk: Watching biomolecular interactions using video paper analytical devices
Year(s) Of Engagement Activity 2018
 
Description Conference paper at IEEE Conference on Ph.D. Research in Microelectronics and Electronics (PRIME) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact IEEE SENSORS 2016 is the flagship conference of the IEEE Sensors Council, an organization currently consisting of 25 IEEE member societies. They showcased high quality technical presentations on a broad range of multidisciplinary topics related to sensors and sensor applications. The event attracted over 1049 abstracts from over 45 different countries.
Year(s) Of Engagement Activity 2016
URL http://ieee-sensors2016.org/
 
Description Conference paper at IEEE EMBC 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact The 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'16) will be hosted at Disney's Contemporary Resort at Walt Disney World® Resort, Lake Buena Vista (Orlando), Florida USA on August 16-20. The overall theme of the conference is "Empowering Individual Healthcare Decisions through Technology" and will cover diverse topics from cutting-edge biomedical and healthcare technology research and development to clinical applications and biomedical education. The conference program will also feature high-profile keynote lectures, minisymposia, workshops, invited sessions, oral and poster sessions, sessions for students and young professions, and exhibitions.
Year(s) Of Engagement Activity 2016
URL https://embc.embs.org/2016/
 
Description Conference paper at IEEE ISCAS 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact ISCAS 2017 aims to appeal to industrial delegates, so the technical program will feature sessions on innovation themes which are aligned with important industrial segments as well as invited talks by recognized technical leaders from industry. ISCAS 2017 will also expand and strengthen our educational mission to support the new paradigm of advancement of the art through circuits and systems fundamentals rather than materials progress. The ISCAS 2017 technical highlight Circuits and Systems contributions related to the following innovation themes: Internet of Things, Cognitive Computing & Deep Learning, Hardware Security, Brain: Innovative NeuroTechnologies, Analog and Digital Senses, Autonomous Vehicles, Robotics, and UAVs & Smart Buildings and Cities
Year(s) Of Engagement Activity 2017
URL http://iscas2017.org/
 
Description Conference presentation at IEEE SENSORS conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact PRIME has been established over the recent years as an important conference where PhD students and post-docs with less than one year post-PhD experience can present their research results and network with experts from industry, academia and research. The main objectives of PRIME are:
•to encourage favourable exposure to Ph.D. students in the early stages of their careers,
•to benchmark Ph.D. research in a friendly and cooperative environment,
•to enable sharing of student and supervisor experiences of scientific and engineering research,
•to connect Ph.D. students and their supervisors with companies and research centres.
IEEE Conference on Ph.D. Research in Microelectronics and Electronics (PRIME)
Year(s) Of Engagement Activity 2017
URL http://prime2017.unisa.it/
 
Description Conference talk- Species specific recognition of bacterial pathogens using targeted antibody design-Christopher Johnson 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact The aim was to assemble researchers and leaders from the region to share their experience and progress made in diverse fields from cancer biology and immunology to biodiscovery, diagnostics and therapeutics.
Year(s) Of Engagement Activity 2017
URL http://www.mdbd.usm.my/
 
Description Courtyard Festival, Kings Cross 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact First seen in Wales during the 2016 Green Man Festival, Llama Outbreak! is a live game that aims to simulate the spread of an infectious disease throughout a festival. The project was produced by Einstein's Garden, in collaboration with researchers from i-sense at the University College London (UCL) and funded by a Wellcome Trust Society Award. Researchers tracked the spread of the infection throughout Courtyard festival, explained the nanotechnology used in the diagnostic test, talked to festival-goers about the ethics of sharing health data, and explained how llama nanobodies are used in rapid diagnostic test. Researchers at the festival used a mobile phone app to read test results from festival-goers. The demonstration showed people how technologies they use everyday could help us diagnose an infectious disease outbreak earlier than is currently possible.
Year(s) Of Engagement Activity 2017
URL https://www.i-sense.org.uk/news/llama-outbreak-courtyard-festival
 
Description Creamer Talk - BioEI 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Research talk presented to an international audience
Year(s) Of Engagement Activity 2019
 
Description Creamer Talk GRC/GRS 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Research poster presented to an international audience
Year(s) Of Engagement Activity 2019
 
Description Demostration of I-sense dashboards, interest in dashboards. A number of conversations asking for further information 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Demostration of I-sense dashboards, interest in dashboards. A number of conversations asking for further information
Year(s) Of Engagement Activity 2018
 
Description Designing Nanomaterials for Regenerative Medicine and Biosensing 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Molly Stevens, Invited Talk, 2016 International Symposium on Nanobiotechnology, Los Angeles, USA Feb-16: "Designing Nanomaterials for Regenerative Medicine and Biosensing"
Year(s) Of Engagement Activity 2016
URL http://cnsi.ctrl.ucla.edu/nanobiotechnology/pages/agenda
 
Description Designing materials for ultrasensitive biosensing and regenerative medicine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Molly Stevens , plenary lecture, 6th EuCheMS Chemistry Congress (Plenary Talk) EuCheMS Seville, Spain 13-Sep-16: "Designing materials for ultrasensitive biosensing and regenerative medicine"
Year(s) Of Engagement Activity 2016
URL http://euchems-seville2016.eu/wp-content/uploads/2016/07/6TH-EUCHEMS-CONGRESS-PROGRAM-DEF1.pdf
 
Description Deutschlandfunk radio broadcast 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact This was an article/ broadcast on German radio and an online article covering 3D printing and its potential impacts
Year(s) Of Engagement Activity 2016
URL http://www.deutschlandfunk.de/herba-digitalis-die-revolution-erfasst-die-pharmabranche.740.de.html?d...
 
Description Development in Materials based approaches for regenerative medicine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Molly Stevens , invited talk, 2016 MRS Fall Meeting & Exhibit, MRS, Boston, MA, USA on 01-Dec-16 : Development in Materials based approaches for regenerative medicine
Year(s) Of Engagement Activity 2016
URL https://www.mrs.org/fall2016/
 
Description Development of diagnostics against group b streptcoccus by Hannah Swinburne 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact The conference aims to bring together researchers and leaders from the region to share their experience and progress made in diverse fields from cancer biology and immunology to biodiscovery, diagnostics and therapeutics.
Year(s) Of Engagement Activity 2017
URL http://www.mdbd.usm.my/
 
Description Digital Health Technology Show 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact i-sense stand at the Digital Health Technology Show, for HealthTech Industry in UK
Year(s) Of Engagement Activity 2018
 
Description Digital health workshop -Claudia Estcourt was an invited speaker and contributed to report 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact The Workshop provided a forum for the development of a roadmap for engineering and physical sciences research leading to improvements in the diagnosis, monitoring and treatment pathways for care at home, particularly across multiple clinical conditions. Speakers from clinical, engineering and industrial communities, gave their perspectives on the requirements that should be driving the development of these pathways, the technical opportunities that lie ahead and the barriers that exist which must be overcome for eventual adoption in the public healthcare system.
Year(s) Of Engagement Activity 2017
URL http://www.fast-healthcare.org.uk/digital-health-workshop/
 
Description Direcotorate of Health, KZN- in Durban South Africa 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Health policy makers and researchers
Year(s) Of Engagement Activity 2018
 
Description Dr Alice Pyne - Women in Science and Engineering( WISE) Talk at School in Barnet, London, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact WISE (Women in Science and Engineering) careers talk for girls
Year(s) Of Engagement Activity 2017
 
Description Dr Alice Pyne Careers talk at Bryanston School, Dorset, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Talk on STEM research in a school environment to stimulate STEM careers discussion - one student subsequently carried out a work experimence placement in the lab.
Year(s) Of Engagement Activity 2017
 
Description Dr Alice Pyne School talk at St Pauls London 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Talk on STEM research in a school environment to stimulate STEM careers discussion
Year(s) Of Engagement Activity 2018
 
Description Dr Brangel and Dr Gibbs Invited Talk at UCL Population Health Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Dr Polina Brangel has developed a smartphone-based point of care test, allowing for detection and surveillance of Ebola virus survivors. This technology has immense potential to meet unmet need due to its portability and abilities in geological tagging.
Dr Jo Gibbs highlighted an innovative eSexual Health Clinic System for STI diagnosis, management and prevention, and whether this sytem can be used for infections such as HIV.
Year(s) Of Engagement Activity 2017
URL https://blogs.ucl.ac.uk/events/2017/01/20/ucl-populations-lifelong-health-domain-symposium-2017/
 
Description Dr Christopher Johnson - talk Sensors in Medicine 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The conference will explore new developments in sensor technology and advances in their application in medicine and healthcare. Uniquely among a plethora of sensor conferences, Sensors in Medicine 2017 highlights those sensor developments which can improve patient outcomes.
Year(s) Of Engagement Activity 2017
URL http://www.globaleventslist.elsevier.com/events/2017/10/sensors-in-medicine-2017/
 
Description Dr GIbbs Talk What does the future hold for sexual health services? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Jo Gibbs discussed the topic was What does the future hold for sexual health services? at BASHH Scientific Meeting
Year(s) Of Engagement Activity 2017
URL https://www.bashh.org/events/training-courses-and-meetings/bashh-scientific-meeting-march-2016/
 
Description Dr James Wilson - Philosophy and Ethics Consultant for the Wellcome funded Surgeon X Comic (Image Comics, Portland Oregon, 2017) by James Wilson 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Media coverage includes: National Geographic, http://news.nationalgeographic.com/2016/10/surgeon-x-comic-explores-world-without-antibiotics/ National Geographic and Entertainment Weekly http://ew.com/books/2017/05/03/surgeon-x-sara-kenney-antibiotics-politics/. I was interviewed about the project in "Dr. James Wilson on raising ethical questions in Surgeon X", http://www.freaksugar.com/dr-james-wilson-surgeon-x-interview-image-comics Freaksugar May 12 2017. http://surgeonx.co.uk/ James Wilson was the ethics and philosophy consultant for a Wellcome Trust funded comic, Surgeon X. The comic brought together some very regarded figures from the comics world, and a variety of academics, to create a powerful story about London in a near-future antibiotic apocalypse. The comic itself was combined in an app with explanations and commentary on the scientific, ethical, and historical issued raised by a panel of academics including Wilson.
Year(s) Of Engagement Activity 2017
URL http://news.nationalgeographic.com/2016/10/surgeon-x-comic-explores-world-without-antibiotics
 
Description Dr James Wilson - Panel to discuss communication of data policy 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact James Wilson took part in a well-attended panel which brought together representatives from NHS Digital, patient groups, Wellcome Trust as well as academics and clinicians to discuss communication of policy around health data.
Year(s) Of Engagement Activity 2017
URL http://www.imperial.ac.uk/media/imperial-college/administration-and-support-services/centre-for-lang...
 
Description Dr James Wilson Invited Colloquium at Kings College London - Privacy, consent and health data 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact James Wilson delivered a talk at Colloquium on Philosophy and Medicine which was a public lecture as part of a series on philosophy and medicine at KCL
Year(s) Of Engagement Activity 2017
URL https://www.youtube.com/watch?v=kknQaVT70u0
 
Description Dr James Wilson Invited Talk to Global Experts - The ethics of secondary use research using clinical tissue and data without patient consent 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact James gave a talk to a small group of global experts on "Can analysing tweets for disease surveillance purposes violate privacy?" It was later published as the Rumbold and Wilson paper mentioned in publications
Year(s) Of Engagement Activity 2014,2016
 
Description Dr James Wilson Invited Talk to Small Group of Global Experts - Can analysing tweets for disease surveillance purposes violate privacy? 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact James gave a talk to a small group of global experts. It was later published as the Rumbold and Wilson paper mentioned in another tab.
Year(s) Of Engagement Activity 2016
 
Description Dr James Wilson Invited Talk to global Experts - Privacy, consent and health data: using health data for secondary purposes ethically, but without consent 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Academic talk to a sizable group of global experts on data usage. Bioethicists were main target audience.
Year(s) Of Engagement Activity 2016
URL https://web.archive.org/web/20150715000000*/http://iab2016.com/
 
Description Dr James Wilson Wellcome Trust Funded Film To Explore the Scientific and Ethical Issues Raised by the Videogame - The Last of Us 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact James Wilson participated in a Wellcome Trust funded film, which explored the scientific and ethical issues raised by the videogame The Last of Us. The videogame depicts a world in which an infectious disease that turns people into zombies spreads rapidly, and the player must guard the one person who might provide a cure. See "The Science of the Last ofUS", https://www.youtube.com/watch?v=lzGOdJoFsrM. Media coverage includes: "Listen to Some Scientists Break Down the Science of The Last of Us" http://www.kotaku.co.uk/2016/09/26/listen-to-some-scientists-break-down-the-science-of-the-last-of-us Kotaku; "Here's how a deadly zombie pandemic would play out in the world", http://uk.businessinsider.com/last-of-us-wellcome-trust-zombie-pandemic-2016-9?r=US&IR=T, Business Insider; "The Last of Us gets taken down a peg by scientists and ethicists", http://www.gamesradar.com/the-last-of-us-gets-taken-down-a-peg-by-scientists-and-ethicists/, Games Radar.
Year(s) Of Engagement Activity 2016
URL http://uk.businessinsider.com/last-of-us-wellcome-trust-zombie-pandemic-2016-9?r=US&IR=T
 
Description Dr Jo Gibbs Talk at Europe IUSTI Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Jo Gibbs discussed the the topic was STI information apps - challenges and potential
Year(s) Of Engagement Activity 2017
URL https://www.iusti.org/events/default.htm
 
Description Dr Pyne Invited Biophysics Seminar Series at University of Sheffield 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Invited seminar talk on Determining DNA structure at °Angstrom resolution in solution (invited)
Year(s) Of Engagement Activity 2017
 
Description Dr Stephen Hilton Talk at UCL Rosetrees Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Rosetrees and UCL hosted our "Interdisciplinary Symposium - Smart Technologies for Health. The event included six world-class researchers discussing innovations in technology, and how they can be applied to improve human health. With an audience of approximately 150 including researchers and supporters of Rosetrees, the talks gave an exciting lay overview of how technology will impact the future of healthcare.
Year(s) Of Engagement Activity 2015
URL http://www.rosetreestrust.co.uk/blog/rosetreesucl-smart-technologies-for-health-symposium-2/
 
Description Dr Steve Gary - Google Tensorflow Meetup London - Pratical uses of Tensorflow in the Wild 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact 60 machine learning experts from around the country invited to Google Campus where Stephen Gray talked about the Machine learning work which CASA have untertaken and setup a small example of classification for mobile applications around the framework designed for overall work. The National Audience was invited to London by Google
Year(s) Of Engagement Activity 2017
 
Description Dr Steve Hilton - Talk at Royal Society of Medicine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk on healthcare technolgies at Royal Society of Medicine
Year(s) Of Engagement Activity 2016
 
Description Dr Steve Hilton - Talk at UK Automated Synthesis Forum 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Talk on Chemical synthesis at UK Automated Synthesis Forum 2015
Year(s) Of Engagement Activity 2014,2016
 
Description Dr Steve Hilton Featured in Visiongain 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact 3D Printing for Healthcare, Trends, R&D and Revenue Forecasts 2016-2026. Explore Dental Products, Medical Implants, Pharmaceuticals, Bio-printing and Other Uses for Additive Manufacturing
Year(s) Of Engagement Activity 2016
URL https://www.visiongain.com/Report/1582/3D-Printing-for-Healthcare-Trends-R-D-and-Revenue-Forecasts-2...
 
Description EBI-Sanger-Cambridge PhD Symposium (eSCAMPS) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Stevens delivered a keynote address at the EBI-Sanger-Cambridge PhD Symposium (eSCAMPS) in February 2016.
Year(s) Of Engagement Activity 2016
 
Description EPSRC Science for a Successful Nation exhibition 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact On 21 February 2018 the EPSRC held a showcase event at the Royal Society, London to promote the importance of EPSRC investments, in the context of UK prosperity. Addressing industry, government departments and researchers. The event featured research exhibition and panel discussions and debate, for which i-sense help an exhibition stand.
Year(s) Of Engagement Activity 2018
 
Description ESPRC Royal society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Demostration of I-sense dashboards at an event for ESPRC members. Great interest in dashboards. A number of conversations asking for further information and the dashboards were featured on the ESPRC twiiter account that day
Year(s) Of Engagement Activity 2018
 
Description Earlsmead School, Tottenham 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Gave a talk to approx 200 pupils (aged 4-11) on infectious diseases.
Year(s) Of Engagement Activity 2018
 
Description Early detection of infectious disease: modelling capture proteins in HIV and Influenza 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Jennifer Brookes Invited speaker UCL Infection, Immunology and Inflammation (III) symposium UCL UK 2015-10-12 Early detection of infectious disease: modelling 'capture' proteins in HIV and Influenza
Year(s) Of Engagement Activity 2015
 
Description Eden Girls School, Waltham Forest 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Gave a talk to approx 50 pupils aged 14-16 at Eden Girls School, Waltham Forest on our work.
Year(s) Of Engagement Activity 2018
 
Description Exhibition Road Festival 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Public engagement event to promote scientific research of Imperial College and Exhibiiton Road museums.
Year(s) Of Engagement Activity 2019
 
Description Expert Meeting on developing a platform for biomarker-based surveillance 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact More details to follow from Noah
Year(s) Of Engagement Activity 2018
 
Description Extracting Interesting Concepts from Large Scale Textual Data 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Lampos Bill, Invited Talk at New Frontiers of Automated Content Analysis in the Social Sciences (ACA) University of Zurich Switzerland, 2015-07-01: Extracting Interesting Concepts from Large Scale Textual Data
Year(s) Of Engagement Activity 2015
 
Description Formlabs blog post 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact This was an online blog covering our discoveries in the area of 3D printing
Year(s) Of Engagement Activity 2018
URL https://formlabs.com/blog/pharmacology-research-and-education-with-3d-printed-models-at-ucl/
 
Description Frenette - Pint of Science Atoms to Galaxies Division 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Research talks presented to general public
Year(s) Of Engagement Activity 2019
 
Description Frenette Talk - 9th Annual Department of Materials Postdoc and Fellow Symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Research poster presented to Imperial Researchers
Year(s) Of Engagement Activity 2019
 
Description Frenette Talk - isense Digital Health Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Research poster presented to an international audience
Year(s) Of Engagement Activity 2019
 
Description Future of Individualised Medicine 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact In 2019, the newly renamed Future of Individualized Medicine (formerly Future of Genomic Medicine) conference will expand to include additional perspectives on how to tailor medicine to the individual. Individualized medicine takes into account a person's genes-and genomics will remain a core topic for exploration and discussion-but it also considers the full spectrum of a person's uniqueness from their biologic, physiologic, anatomic, lifestyle and environmental information. The Future of Individualized Medicine conference will thus incorporate perspectives from the emerging fields of digital medicine, artificial intelligence and machine learning, behavioral science and others. This is truly a multidisciplinary forum designed to accelerate the transformation of medicine.
Year(s) Of Engagement Activity 2019
URL https://emea01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.scripps.edu%2Fscience-and-med...
 
Description German public radio-station Deutschlandfunk by Stephen Hilton 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Broadcast on German radio station
Year(s) Of Engagement Activity 2016
URL http://www.deutschlandfunk.de/herba-digitalis-die-revolution-erfasst-die-pharmabranche.740.de.html?d...
 
Description Going Viral - The Digital Future of Health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Rachel McKendry Public lecture UCL Rosetrees Interdisciplinary Symposium UCL London/UK 2015-10-22 Going Viral - The Digital Future of Health
Year(s) Of Engagement Activity 2015
 
Description Gordon Research Conference: Colloidal Semiconductor Nanocrystals 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Stevens delivered a talk entitled "Nanoparticles for Biosensing Applications" in August 2016.
Year(s) Of Engagement Activity 2016
 
Description Guardian Newspaper Podcast by Stephen Hilton 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Approval of a 3D-printed drug opens up a new world of customised medication, but also the possibility of counterfeit drugs, mislabelling and a regulatory vacuum. Further invites to talk about the imapct of 3d printing on the NHS
Year(s) Of Engagement Activity 2016
URL https://www.theguardian.com/sustainable-business/2015/aug/21/welcome-to-complex-world-of-3d-printed-...
 
Description Guardian Podcast 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact This was a podcast with the Guardian and covered impacts of 3D printing on healthcare and a discussion as to how it can change in the future
Year(s) Of Engagement Activity 2016
URL http://www.theguardian.com/technology/audio/2016/jan/21/can-tech-save-the-national-health-service-te...
 
Description Guardian article spritam related 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact This was an article on 3D printing and its impacts across the sciences and how it will affect the future
Year(s) Of Engagement Activity 2015
URL http://www.theguardian.com/sustainable-business/2015/aug/21/welcome-to-complex-world-of-3d-printed-d...
 
Description Hong Kong University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Phones, Drones & Disease Workshop organised by HKU
Year(s) Of Engagement Activity 2018
 
Description Hosting work experience students 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Hosted 2 work experience students for 2 weeks, one as part of the in2science program which aims to 'support young people from low income backgrounds progress to apprenticeships, degrees and careers in science, technology and engineering and maths (STEM)'. They shadowed a range of activities in the group.
Year(s) Of Engagement Activity 2019
 
Description IEEE VIS 2018 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Presentation on my PhD at the conference. Received feedback on the subject that have been incorprated into the project
Year(s) Of Engagement Activity 2018
 
Description IHE Symposium Day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Erin to add description later
Year(s) Of Engagement Activity 2018
 
Description IMakr Website by Stephen Hilton 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Blogs about his Department using 3D printing where he describes noticeable development in the sciences, specifically chemistry within UCL's School of Pharmacy. Stephen says that 3D printing has been integrated into the first year program at the school because of the improved learning capabilities. Using printers from iMakr like Ultimaker, Stephen has been able to create brain models based off MRI scans, orbital models, molecular structures, etc which allows students to actually see and touch the items that he lectures about. Stephen says that this kinesthetic interaction makes the basic principles easier to digest as students can see how the molecules interact and better grasp how it all works. This was something that was harder to do before they implemented 3D printing into the course. Overall, Stephen says that they have saved thousands just by making things themselves and the best part is, the students can have what they need in order to start tinkering around with new research ideas immediately and get more insight into how an experiment comes together.
Year(s) Of Engagement Activity 2016
URL https://www.imakr.com/en/blog/53_Meet-The-Makrs-UCL-School-of-Pharmacy
 
Description If she tests negative, it means I am also negative": Men's construction of HIV testing in KwaZulu-Natal, South Africa. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Abstract presented at HIV Research for Prevention (HIVR4P) 2018 Conference, Madrid, 23 October 2018 by Adeagbo OA, Herbst C, Dlamini N, Mhlongo T, Luthuli M, Xulu S, Sonnenberg P, Estcourt C, Blandford A, Turbe V, Thomas M, Herbst K, Pillay D, McKendry RA, Shahmanesh M.
Year(s) Of Engagement Activity 2018
URL https://www.hivsharespace.net/event/hiv-research-prevention-hivr4p-2018
 
Description Initated discussions for a joint-meeting with Wellcome Trust Africa Centre, Durban 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Initated discussions for a joint-meeting with Wellcome Trust Africa Centre, Durban
Visit
Collaboration


Identified Royal Society Funding Opportunities
Future opportunities to evalute mobile health technologies in the heart of the HIV pandemic
Year(s) Of Engagement Activity 2013,2015
 
Description International Workshop on Phones, Drones and Disease 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Two-day workshop at the University of Hong Kong which brought together researchers and practitioners from science and technology studies, public health, medicine, history, and anthropology to consider the strategic uses of communication technologies in managing disease and delivering health.
Year(s) Of Engagement Activity 2018
URL http://www.chm.hku.hk/phones_drones_disease.html
 
Description Invited talk at international conference on transplantation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This was an invited plenary talk at a session within the American Transplant Congress in Seattle 2018. The title of the presentation was Why is my patient sick: tell me quick. Next generation viral diagnostics. Seattle June 2018.
Year(s) Of Engagement Activity 2018
 
Description Llama Outbreak! Greenman Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact In August 2016, i-sense researchers asked festival goers at Greenman Festival to help us contain a mysterious outbreak that is turning people into Llamas! As thousands of people gathered at Einstein's Garden, a unique area of Greenman Festival that brings science to life through art, nature and interactive experiences, they came across a rather unique stall. The Llama Outbreak Control Clinic was set up in response to a public health emergency that had descended upon the festival- a strange virus that was turning people into Llamas! The exhibit was a great opportunity for i-sense researchers to engage with the general public about their work in an engaging way.
Year(s) Of Engagement Activity 2016
URL https://www.i-sense.org.uk/news/i-sense-contain-llama-outbreak-greenman-festival-2016
 
Description London International Youth Forum 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Schools engagement event to promote scientific research of Imperial College
Year(s) Of Engagement Activity 2019
 
Description Loynachan Talk - MRS Fall 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Research talk presented to an international audience
Year(s) Of Engagement Activity 2019
 
Description Loynachan Talk - i-sense Biannual Meeting 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Research talk presented to an international audience
Year(s) Of Engagement Activity 2019
 
Description Loynachan talk - Multifunctional, Hybrid, and Nanomaterials 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Colleen Loynachan delivered talk at Multifunctional, Hybrid, and Nanomaterials.
Year(s) Of Engagement Activity 2017
 
Description Materials-based approaches for regenerative medicine 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Molly Stevens, Oral/Award 2016 World Biomaterials Congress Montreal, Canada May-16: Materials-based approaches for regenerative medicine and Clemson Award for Basic Research
Year(s) Of Engagement Activity 2016
URL http://www.wbc2016.org/index.php/program
 
Description McKendry Group meeting with HIV patient group representative 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Meeting with HIV patient group representative Christopher Sandford to discuss about our i4i project and learn more about end-user needs

- better understanding of HIV patients needs
- highlighted issues of need to link to follow up care and confidentiality
Year(s) Of Engagement Activity 2014
URL https://www.i-sense.org.uk/power-patient-interview-patient-representative-chris-sandford
 
Description Media interview 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Initially an interview with local Surrey BBC further to a press relaese but this was then syndicated to national BBC news programmes.
Year(s) Of Engagement Activity 2017
URL https://www.youtube.com/watch?v=A7-GOZ1rFrU
 
Description Media stream by Stephen Hilton 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The stream describes research and this led to ongoing discussions about funding and visit to my laboratory from the Rosetrees trust
Year(s) Of Engagement Activity 2015
URL https://www.ucl.ac.uk/stream/media/swatch?v=90a469bcbe03
 
Description Mining socio-political and socio-economic signals from social media content 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Vasileios Lampos, Invited Lecture: Summer School on Big Data & Networks in Social Sciences, University of Warwick UK, 21-Sep-16: Mining socio-political and socio-economic signals from social media content
Year(s) Of Engagement Activity 2016
 
Description Mobile-phone connected diagnostics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Forum: Institute Of Global Health Innovation: Developments and Applications in Digital Health from a Global Perspective
Year(s) Of Engagement Activity 2019
 
Description New Scientist Live exhibition 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact i-sense and m-africa members attended the New Scientist live exhibition over four days. The purpose of having an exhibition space what to have the opportunity to engage with the general public about our research and gain ideas and insights from different audiences. We organised the booth into three spaces - track, test and treat - and had various elements of hands on engagement, including a model demonstration of our lateral flow tests and mobile app, and a 'wall of voices' for people to engage in discussions on how they felt about their health data being shared. This exhibit was highly beneficial for i-sense PhD students and postdocs to discuss their work with a very broad audience from young children to healthcare professionals. Following the event, we had a few students contact us to enquire about internships or work experience and one student who did a feature on our exhibit for their school project.
Year(s) Of Engagement Activity 2017
URL https://www.i-sense.org.uk/news/i-sense-science-bug-spreads-across-new-scientist-live
 
Description News article for Institute of Mechanical Engineers by Stephen Hilton 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Press report on Stephen Hilton's research
Year(s) Of Engagement Activity 2015
URL http://www.imeche.org/news/news-article/keep-printing-the-tablets
 
Description PHE annual flu report 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Public Health England publishes overviews each year of influenza surveillance results from the winter period.
Year(s) Of Engagement Activity 2017
URL https://www.gov.uk/government/statistics/annual-flu-reports
 
Description Positive East 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Positively managing HIV viral loads' workshop
Year(s) Of Engagement Activity 2018
 
Description Positively Managing HIV Workshop-Jobie Budd 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact 25 members of the public attended a workshop hosted at the London HIV charity Positive East
Year(s) Of Engagement Activity 2018
 
Description Preparing a Global Health Response: An i-sense workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Professor Rosanna Peeling and Dr Penny Wilson from Innovate UK recently led an interactive workshop on open platform technologies and global health regulations.

i-sense students and researchers were challenged to come up with solutions to three central issues for academics working within industry, that could impact the development of open platform technology.

As part of this event, they were exposed to a simulated global health emergency run by Global Health Sim and asked to pitch their diagnostic technologies in response to the challenge. This enabled them to better understand the complexities of a global health response and place their technologies into a real-life context.

This workshop was part of the i-sense Education Allliance, created to introduce new teaching and training courses in order to grow the skills of our students and researchers.
Year(s) Of Engagement Activity 2016
URL https://www.i-sense.org.uk/news/preparing-global-health-response-i-sense-workshop
 
Description Presentation at Spatial Data Science conference in New York City 2019 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact This was an invited talk at Spatial Data Science conference in New York City 2019.
Year(s) Of Engagement Activity 2019
URL https://spatial-data-science-conference.com/2019/index.html
 
Description Presentation at pHealth conference in Crete 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact This was an invited talk at a phealth conference: 13th international conference on wearable micro and nano technologies for personalised health. There was extensive Q and A and also continued discussions following the formal presentation.
Year(s) Of Engagement Activity 2016
URL https://ec.europa.eu/digital-single-market/en/news/phealth-2016-13th-international-conference-wearab...
 
Description Prof Claudia Estcourt -talk BASHH Scotland meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact The Digital Divide: are we excluding the most vulnerable in the move to online sexual health care? (plenary)
Year(s) Of Engagement Activity 2017
 
Description Prof Cox Group talk at the Web Conference Lyon France 2018 (not happened yet) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact The talk describes that they investigate the utility of multi-task learning to disease surveillance using Web search data.
Year(s) Of Engagement Activity 2018
URL https://www2018.thewebconf.org/program/health-on-the-web/
 
Description Prof Cox Group talk at the World Wide Web (WWW) Conference 2017, Perth Australia 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Two talks were made (1) A Concept Language Model for Ad-hoc Retrieval & (2) Enhancing Feature Selection Using Word Embeddings: The Case of Flu Surveillance
Year(s) Of Engagement Activity 2017
URL https://dl.acm.org/citation.cfm?doid=3038912.3052622
 
Description Prof Cox and Dr Lampos - Talk Web Search and Data Mining (WSDM) 2017 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact The workshop on Mining Online Health Reports (MOHRS) draws upon the rapidly developing field of Computational Health, focusing on textual content that has been generated through the various facets of Web activity. Online user-generated information mining, especially from social media platforms and search engines, has been in the forefront of many research efforts, especially in the fields of Information Retrieval and Natural Language Processing. The incorporation of such data and techniques in a number of health-oriented applications has provided strong evidence about the potential benefits, which include better population coverage, timeliness and the operational ability in places with less established health infrastructure. The workshop aims to create a platform where relevant state-of-the-art research is presented, but at the same time discussions among researchers with cross-disciplinary backgrounds can take place. It will focus on the characterisation of data sources, the essential methods for mining this textual information, as well as potential real-world applications and the arising ethical issues. MOHRS '17 will feature 3 keynote talks and 4 accepted paper presentations, together with a panel discussion session.
Year(s) Of Engagement Activity 2017
URL http://dx.doi.org/10.1145/3018661.3022761
 
Description Prof De Cristofaro - Internal usability test of prototype 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact This was a session whose goal was to get feedback about the prototype we are developing. This prototype takes the form of a Chrome purpose whose purpose is to collect search queries from people. It gathered researchers and students from the Computer Science department for one hour, during which they invidivually filled a feedback form, before engaging altogether in a focus group.
Year(s) Of Engagement Activity 2018
 
Description Prof De Cristofaro Invited Talk at Workshop on personal data systems 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Emiliano De Cristofaro did a talk entitled "Building and Measuring Privacy-Preserving Analytics" given during a workshop.
Year(s) Of Engagement Activity 2017
URL https://haddadi.github.io/PDS2017/
 
Description Prof Demosthenous Invited Talk - Compact pixel architecture for CMOS lateral flow immunoassay readout systems 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact A novel pixel architecture for CMOS image sensors is presented. It uses only one amplifier for both integration of the photocurrent and in-pixel noise cancelation, thus minimizing power consumption. The circuit is specifically designed to be used in readout systems for lateral flow immunoassays. In addition a switching technique is introduced enabling the use of column correlated double sampling technique in capacitive transimpedance amplifier pixel architectures without the use of any memory cells. As a result the reset noise which is crucial in these architectures can be suppressed. The circuit has been designed in a 0.35-µm CMOS technology and simulations are presented to show its performance.
Year(s) Of Engagement Activity 2017
URL http://discovery.ucl.ac.uk/1574493/
 
Description Prof Demosthenous Invited Talk on An improved wideband CMOS current driver for bioimpedance applications 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact A wideband, CMOS current driver for bioimpedance measurement applications has been designed employing nonlinear feedback. With the introduction of phase compensation, the circuit is able to operate at frequencies higher than the pole frequency of the output transconductor with minimum phase delay. Moreover, it isolates the poles required for stability from the high frequency characteristics of the output transconductor. The circuit has been simulated in a 0.35-µm CMOS technology and operates from ±2.5 V power supplies. Simulations show that for a 1 mAp-p output current, the phase delay is less than 1° for frequencies up to 3 MHz, rising to 1.5° at 5 MHz. Dual frequency currents to the load are demonstrated.
Year(s) Of Engagement Activity 2016
URL http://ieeexplore.ieee.org/abstract/document/7539087/
 
Description Prof Demosthenous Invited Talk on CMOS microelectrode array for capacitive biosensing and impedance spectroscopy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact This paper presents the design of a 1024-channel dual-modality CMOS biosensor suitable for both capacitive sensing and impedance spectroscopy. The chip serves as a platform for detection, localization and monitoring of bacteria and can be adopted for affinity-based assays. The chip features a 32×32 array of unpassivated metal electrodes formed on the top metal of a 0.18µm CMOS process, with an overall sensing area of 2.06 mm2. The system design is based on a shared in-pixel integrator that can be used as a charge amplifier for capacitive sensing (CS) or as part of a transimpedance amplifier for electrical impedance spectroscopy (EIS). The CS mode is capable of a operation bandwidth of 50 MHz at a current consumption of 82 µA per pixel. The EIS channel operates over a bandwidth between 100 Hz and 1 MHz with a total input-referred current noise of 48 pArms and a current consumption of 210 µA per channel.
Year(s) Of Engagement Activity 2017
URL http://discovery.ucl.ac.uk/10039265/
 
Description Prof Demosthenous Invited Talk on Dual-mode CMOS analog front-end (AFE) for electrical impedance spectroscopy (EIS) systems. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact This paper presents the operation of a dual-mode wideband CMOS analog front-end (AFE) for electrical impedance spectroscopy. The chip combines two current-readout (CR) channels and four voltage-readout (VR) channels suitable for both bipolar and tetrapolar EIS analysis. The chip addresses the need for flexible readout units for real-time simultaneous single-cell and large scale tissue/organ analysis. Postlayout simulations show that the VR channel is capable of wideband operation up to 12 MHz with noise floor as low as 16.4 nV/Hz
1/2. A 2-bit control allows to select between a high-frequency low-gain channel and a bandwidth-limited high-gain channel. Each VR channel occupies an area of 0.48 mm
2. The CR channel is capable of 80 dB of dynamic range, by converting currents between 1 nA to 10µA, while achieving a noise floor of 1.4 pA/Hz
1/2. An automatic gain control (AGC) unit can be enabled in order maintain the sensor signal within the ADC dynamic range. Each CR channel occupies an area of 0.21 mm
2. The chip consumes between 290 µA and 690 µA per channel and operates from a 1.8 V supply. The chip will be part of a fully flexible and configurable dual-mode EIS systems for impedance sensors and bioimpedance analysis.
Year(s) Of Engagement Activity 2016
URL https://www.semanticscholar.org/paper/Dual-mode-CMOS-analog-front-end-(AFE)-for-electric-Valente-Jia...
 
Description Prof Demosthenous Talk on Wireless Paper-Based Biosensor Reader for the Detection of Infectious Diseases at the Point of Care 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact A handheld wireless optical reader for the detection of infectious diseases at the point of care is presented. The device is battery powered and interfaces with paper-based biosensors for the quantification of concentration in biological fluids using colorimetric analysis. The results are wirelessly transmitted to a smartphone. The device has been successfully tested with various concentrations of Influenza A nucleoprotein.
Year(s) Of Engagement Activity 2016
URL http://ieeexplore.ieee.org/document/7808907/
 
Description Prof Emery Invited Talk International Roche Infectious Disease Symposium - Infectious Diseases: from ancient to modern times 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Vince Emery talk International Roche Infectious Disease Symposium Roche Istanbul 2014 (November) Infectious Diseases - from ancient to modern times
Year(s) Of Engagement Activity 2014
 
Description Prof McKendry Feature in MD Magazine 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact In October 2017, i-sense and Prof Rachel McKendry appeared in an article in the online magazine 'MD Magazine'. The article, titled 'Ultra-Rapid HIV Testing Possible With
Smartphone App,' was focused around recently published research by i-sense researchers on a biochip attached to a smartphone that demonstrated in a proof-of-concept study that it can be used to detect HIV in a drop of blood from a finger prick and display the results within 10 seconds.
Year(s) Of Engagement Activity 2017
URL http://www.mdmag.com/medical-news/ultrarapid-hiv-testing-possible-smartphone-app
 
Description Prof McKendry Group - Jobie budd Talk at Workshop in Basel - Meeting Sustainable Development Goals: An Affordable Mobile Diagnostic to Aid Vaccination in the Developing World 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact The Summer School focuses on developments and current methodologies in industrial biotechnology such as :
•Tissue engineering
•Functional genomics
•Production of biomolecules
•Drug discovery
•Diagnostics - Point of care
•Applied biotechnology
Moreover, the Summer School promotes contacts between attendants and encourages students and young researchers to consider future career plans.The programme is designed to meet these goals through lectures given by invited speakers form both academia and industry.
Year(s) Of Engagement Activity 2017
URL https://www.hevs.ch/en/minisites/events/summer-school-on-advanced-biotechnology/
 
Description Prof McKendry Group - Poster Royal Society of Chemistry 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Poster presentation at the Royal Society on M-AFRICA
Year(s) Of Engagement Activity 2017
 
Description Prof McKendry Group - Sky News filmed at LCN 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact In October 2017, i-sense PhD student, Isabel Bennett, appeared on Sky News talking about work into mobile phone-connected diagnostic tools for AMR. The piece was in a segment following Dame Sally Davies renewed her warning about what she descibed as a 'post-antibiotic apcalypse'
Year(s) Of Engagement Activity 2017
 
Description Prof McKendry Group Presentation on m-Africa by Valerian Turbe at i-sense industry and 5G workshop Surrey 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Talk on m-Africa research project to industry, policy and academic research teams
Year(s) Of Engagement Activity 2017
 
Description Prof McKendry Group and Dr Pyne Talk at AntiMicroResist Consortium meeting at LGC 2015 and 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Biannual consortium meeting on Cantilever based methods for detection of AMR
Year(s) Of Engagement Activity 2017
 
Description Prof McKendry Invite Talk - Diagnostics for the Developing World Brunel University 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact The conference brings together clinicians, academics, epidemiologists, engineers and key stakeholders who have a keen interest in the area of diagnostics for the developing world. DDW provides a platform for collaborations between a unique group of stakeholders from across the globe to tackle the key issues and challenges being faced, such as - the slow pace of diagnostic development, regulatory approval and technology adoption bottlenecks.
Year(s) Of Engagement Activity 2017
URL https://www.brunel.ac.uk/research/News-and-events/events/The-3rd-Diagnostics-and-the-Developing-Worl...
 
Description Prof McKendry Invited Annual Institute of Engineering and Technology (IET) Lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Annual Lecture of the Institute of Engineering and Technology IET
Year(s) Of Engagement Activity 2015
URL http://www.i-sense.org.uk
 
Description Prof McKendry Invited Cambridge Annual WiSETI Lecture - The Mobile Revolution: From M-Health to M-Powering Women 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Prof McKendry gave the Cambridge Annual WiSETI Lecture, Cambridge University, Cambridge, UK "The Mobile Revolution: From M-Health to M-Powering Women"
Year(s) Of Engagement Activity 2014
URL https://www.equality.admin.cam.ac.uk/projects/wiseti/wiseti-activities/annual-wiseti-lecture/past-le...
 
Description Prof McKendry Invited Speaker and Panel Member Science for a Successful Nation - Fighting Antimicrobial Resistance 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact McKendry Talk EPSRC Science for a Successful Nation EPSRC Royal Society, London Fighting Antimicrobial Resistance
Year(s) Of Engagement Activity 2014
 
Description Prof McKendry Invited to International Womens Day Reception with the Prime Minister at Number 10 Downing Street 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Invited to a Reception with the Prime Minister at Number 10 Downing Street for International Women's Day
Year(s) Of Engagement Activity 2016
URL http://www.i-sense.org.uk
 
Description Prof McKendry Public Lecture at UCL IBME Medtech Week - Harnessing the Power of Nanotechnology, Mobile Phones and Big Data for Global Health 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Rachel McKendry Public lecture UCL IBME Medtech Week UCL London/UK 2015 Harnessing the Power of Nanotechnology, Mobile Phones and Big Data for Global Health
Year(s) Of Engagement Activity 2015
 
Description Prof McKendry Radio Interview Deutsche Welle 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Deutsche Welle interviewed Rachel and the UCL group for a radio program about science, aimed at the general interested public. The program is broadcast in English.

Engaging research with international public.
Year(s) Of Engagement Activity 2013
URL http://www.london-nano.com/news-and-events/news/professor-mckendry-in-international-radio-broadcast
 
Description Prof McKendry and Isabel Bennett - Primary School Visit London to Raise Awareness of AMR 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact As part of 2017 National Science Week, Professor Rachel McKendry and i-sense PhD student, Isabel Bennett, visited St. Joseph's Catholic Primary School in Maida Vale, London.
In front of an assembly of students from Year 2, Professor McKendry and Isabel discussed their backgrounds and what inspired them to get into scientific research. Part of the aim of the event was to encourage young people to change their perceptions of what a scientist is - they are not always men in white coats with glasses and wild hair! Women are under-represented in science, and it is important to address gender stereotypes to encourage more girls to study science.The work carried out to detect and track infectious diseases by the i-sense team was also introduced and an interactive activity about antibiotics and bacterial resistance was carried out with volunteers from different year groups.
The activity involved using balloons as a model for bacteria, with a wooden skewer acting as the antibiotic that could burst the bacteria. Some of the bacteria were made resistant using tape so they were no longer 'killed' by the antibiotic skewers. This activity was based on the PhD work carried out by Isabel using atomic force microscopy to study the effects of novel antibiotics. The floor was then open to discussion, with many children asking questions, demonstrating an interest in the research discussed, and wanting to know more about what it means to be a scientist. Overall the event was well received by both the students and teachers."
Year(s) Of Engagement Activity 2017
 
Description Prof McKendry featured on BBC 100 women (2016) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Creation of Wikipedia research page by BBC journalist, led to increased visibility of Prof McKendry and her research team. Featured on BBC World service - see links belowhttp://www.bbc.co.uk/programmes/p04jnwtz
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/programmes/p04jnwtz
 
Description Prof McKendry group - Talk at EPSRC IRC Future of Healthcare Technology conference, Bath  
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact TBC
Year(s) Of Engagement Activity 2017
 
Description Prof McKendry group - Jobie Budd talk at EPSRC IRC Future of Healthcare Technology conference, Bath 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact On the 28 and 29 June 2017, the three EPSRC funded Interdisciplinary Research Collaboration (IRC) came together in Bath for the Future of Healthcare Technology conference.

As the first of its kind, the conference focused on the latest developments in healthcare technologies, central to the core theme of each research group. The three IRCs (i-sense, Sphere, and Proteus) bring together:
•11 leading UK universities
•£30M in funding from EPSRC
•200+ academics
Year(s) Of Engagement Activity 2017
 
Description Prof McKendry talk at MAPS Festival - Connecting for Global Health: nanosensors, mobile phones and big data 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Postgraduate students
Results and Impact Rachel McKendry Talk MAPS Research Festival MAPS, UCL London, UK 2015-07-07 Connecting for Global Health: nanosensors, mobile phones and big data
Year(s) Of Engagement Activity 2015
 
Description Prof McKendry talk i-sense industry meeting Surrey 5G Centre 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Industry/Business
Results and Impact The aim of the industry workshop was to share the outputs that have been created as part of the i-sense IRC and to explore how they intersect with emerging 5G technologies and their potential to meet industry needs. Involved industrial partners from 5G and a range of different areas including diagnostics, telecommunications, data analytics and technology
Year(s) Of Engagement Activity 2017
 
Description Prof Peeling - Interview with policy makers through the advanced course in diagnostics in Annecy, France. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact Policy makers from these countries were interviewed on the diagnostic priorities for antimicrobial resistance in their respective countries and how they think regulatory approval for diagnostics can be streamlined
Year(s) Of Engagement Activity 2017
URL http://www.panafrican-med-journal.com/content/article/28/271/full/
 
Description Prof Peeling - Interview with product developers during the advanced course in diagnostics 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Product developers were interviewed on the challenges and barriers in the implementation of point of care tests and how small and medium size companies can be incentivised to be innovative and engaged in diagnostics.
Year(s) Of Engagement Activity 2017
URL http://www.panafrican-med-journal.com/content/article/28/271/full/
 
Description Prof Peeling - Oral presentation of policy findings during 1st international conference on re-emerging infecftious diseases in Addis Ababa, Ethiopia 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Policymakers/politicians
Results and Impact This oral presentation was intended to inform our global audience on the diagnostic priorities for AMR implementation by the Africa CDC AMR surveillance network
Year(s) Of Engagement Activity 2018
 
Description Prof Peeling Interview on BBC Television 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Gave an interview on BBC television on the importance of diagnostics in UK's response to the growing threat of antimicrobial resistance in 2017 after Dame Sally Davies warned the public that there are few effective antibiotics left to treat infectious diseases.
Year(s) Of Engagement Activity 2017
 
Description Prof Peeling Interview on Diagnosis of Zika Virus infections for Massive Open Online Course 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Undergraduate students
Results and Impact Gave an interview on the diagnosis of zika virus infections for the Massive Open Online Course on ZIKA run by the London School of Hygiene and Tropical Medicine in 2016.
Year(s) Of Engagement Activity 2016
 
Description Prof Peeling Invited Talk American Society for Tropical Medicine - Use of New Technologies in Public Health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact November 2017: "Use of New Technologies in Public Health" at the American Society for Tropical Medicine meeting in Baltimore, USA
Year(s) Of Engagement Activity 2017
 
Description Prof Peeling Invited Talk European Pediatric Society for Infectious Diseases - Diagnostics in a Digital Age 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact May 12 2017: "Diagnostics in a digital age" at the European Pediatric Society for Infectious Diseases, Brighton, UK
Year(s) Of Engagement Activity 2017
 
Description Prof Peeling Invited Talk International Medical Devices Regulatory Forum - Regulatory Challenges and Strategies to Successfully Market a New Test for AMR 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact September 2017: "Regulatory Challenges and Strategies to Successfully Market a New Test for AMR" at the International Medical Devices Regulatory Forum (IMDRF) meeting in Ottawa, Canada
Year(s) Of Engagement Activity 2017
 
Description Prof Peeling Invited Talk Learned Society Workshop for Early Career Scientists - Diagnostics for Antimicrobial Resistance 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact November 2017: "Diagnostics for Antimicrobial Resistance" at the Learned Society Workshop for Early Career Scientists, London
Year(s) Of Engagement Activity 2010,2017
 
Description Prof Peeling Invited Talk The Chief Scientific Officer's Annual Conference, London - Opening Innovation: Building Partnerships to Advance the Future NHS 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact March 6 2018: "Opening Innovation: Building Partnerships to Advance the Future NHS" at The Chief Scientific Officer's Annual Conference, London.
Year(s) Of Engagement Activity 2018
 
Description Prof Peeling Invited Talk UK Diagnostics Summit - The Business Case for Diagnostics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact November 2017: "The Business Case for Diagnostics" at the UK Diagnostics Summit, London
Year(s) Of Engagement Activity 2014,2017
 
Description Prof Robin Weiss - Invited Talk World AIDS Day @ Crick 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Robin Weiss resented talk on HIV diagnostics and vaccine research. The audience was primarily for academic and general public
Year(s) Of Engagement Activity 2017
 
Description Prof Robin Weiss Invited Talk at Italian HIV Meeting, Naples 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Follow up from Italian media
Year(s) Of Engagement Activity 2017
 
Description Prof Robin Weiss Invited Talk at Retrovirus International Workshop 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Opening talk on oncogenic retroviruses led to questions from Czech and Japanese media
Year(s) Of Engagement Activity 2017
 
Description Prof Vince Emery Invited Talk International Roche Infectious Disease Symposium - Emerging Infections: the Ebola Outbreak 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Prof Vince Emery talk International Roche Infectious Disease Symposium Roche Istanbul 2014 (November) Emerging inections - the Ebola outbreak
Year(s) Of Engagement Activity 2010,2011,2014
 
Description ProfMcKendry and Demonthenous Groups - Evening Standard article - tiny tech 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact In June 2017, i-sense was mentioned in the Evening Standard article titled 'the big things that come in remarkably small packages making out world a better, safer place'. The article mentioned. "Another research programme using nanotechnology to monitor diseases is i-sense. The five-year, £11 million EPSRC-funded programme aims to engineer a new generation of early warning sensing systems to identify outbreaks of serious infections -including influenza, MRSA, HIV and Ebola - much earlier, using mobile phone-connected diagnostic tests. The tests are designed to be small, low-cost and easy to use, says Shaffer, whose colleagues are working on the project. "At the heart of it you want to have affordable rapid tests that can be distributed around the world, perhaps in the developing world." Rachel McKendry, Professor of biomedical nanotechnology at UCL
and Director of i-sense, adds: "Our interdisciplinary team are investigating the use of advanced nanomaterials to detect the very early stages of an infection. We are using
smartphone sensors such as the camera to interpret test results and securely send the data to local clinics, supporting faster access to potentially life-saving treatment.
Year(s) Of Engagement Activity 2017
 
Description Public Health England (PHE) Weekly National Influenza Report 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Summary of UK surveillance of influenza and other seasonal respiratory illnesses on UK Government website
Year(s) Of Engagement Activity 2017
URL https://www.gov.uk/government/statistics/weekly-national-flu-reports
 
Description Public Health England annual conference 2018 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Daily Google Search Queries - Added Value to National Influenza Surveillance?
Year(s) Of Engagement Activity 2018
 
Description Public Health England weekly reports include FluSurvey data 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Official national statistics -Weekly national flu reports-UK Government website
Year(s) Of Engagement Activity 2017
URL https://www.gov.uk/government/statistics/weekly-national-flu-reports
 
Description Public engagement event at Green Man Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme?