Nanoparticles and microbubbles
Lead Research Organisation:
University of Oxford
Department Name: Engineering Science
Abstract
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Organisations
People |
ORCID iD |
| Eleanor Stride (Principal Investigator) |
Publications
Browning RJ
(2017)
Drug Delivery Strategies for Platinum-Based Chemotherapy.
in ACS nano
Carugo D
(2021)
Scaleable production of microbubbles using an ultrasound-modulated microfluidic device.
in The Journal of the Acoustical Society of America
Eltayeb M
(2016)
Electrosprayed nanoparticle delivery system for controlled release
in Materials Science and Engineering: C
Mulvana H
(2017)
Characterization of Contrast Agent Microbubbles for Ultrasound Imaging and Therapy Research.
in IEEE transactions on ultrasonics, ferroelectrics, and frequency control
Parhizkar M
(2016)
Electrohydrodynamic encapsulation of cisplatin in poly (lactic-co-glycolic acid) nanoparticles for controlled drug delivery.
in Nanomedicine : nanotechnology, biology, and medicine
Parhizkar M
(2017)
Performance of novel high throughput multi electrospray systems for forming of polymeric micro/nanoparticles
in Materials & Design
Parhizkar M
(2020)
Enhanced efficacy in drug-resistant cancer cells through synergistic nanoparticle mediated delivery of cisplatin and decitabine.
in Nanoscale advances
Reardon PJ
(2017)
Electrohydrodynamic fabrication of core-shell PLGA nanoparticles with controlled release of cisplatin for enhanced cancer treatment.
in International journal of nanomedicine
| Description | The work has demonstrated that loading microbubbles with solid nanoparticles can significantly alter their dynamics and this can potentially improve the penetration of drugs into tumours and hence the efficacy of treatment. The work has also led to the development of a new device for the fabrication of drug loaded particles which enables more rapid production. This is very important for the potential scale up of the technique. |
| Exploitation Route | We intend to conduct in vivo experiments to determine whether the hypothesised improvement in therapy is realised. If these tests are successful then we will pursue clinical translation of the work in collaboration with clinical colleagues with whom we are already working on ultrasound mediated drug delivery. The multiplexed device will be taken forward through our existing spin out company AtoCap Ltd. to improve production rates and increased the range of potential applications of the technology. More broadly this work should also increase the uptake of the technique as an industrially viable production process. |
| Sectors | Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
| Description | Symposium on Drug Delivery |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Symposium on Drug Delivery to complement the ongoing research in encapsulation and drug delivery, attended by 50-100 delegates from academia, research and industry. |
| Year(s) Of Engagement Activity | 2016 |