EPSRC IRC in Targeted Delivery for Hard-to-Treat Cancers
Lead Research Organisation:
University of Cambridge
Department Name: Engineering
Abstract
While the survival rate for most cancers has doubled over the last 40 years, hard-to-treat cancers show survival rates below 14%. To combat these cancers, multiple pathways (immune/inflammatory, neoangiogenic, cell replication) need to be targeted and this necessitates a multimodal delivery approach that will increase not only the amount but also the range of therapeutic agents that reach the target site. This IRC will address this challenge by developing (i) delivery vehicles that are based on metal organic frameworks and organic cages and show substantially increased payload capacity, and (ii) implantable/injectable delivery platforms that are based on gels and electrophoretic pumps and enhance drug penetration through e.g. the blood-brain barrier. By combining these two approaches, we will achieve a step change in the amount and range of drugs that reach the tumour site. Two crosscutting translational activities, on material delivery & additive manufacturing and on validation, will consider the whole chain from the conception of the delivery system to its clinical application, leading to a holistic approach to the problem of targeted drug delivery. The proposed research program builds on an institutional-level initiative on therapeutic science and strong links with CRUK and with national labs and industry leaders in drug development. The interdisciplinary team involved in this IRC includes groups from five universities with expertise ranging from materials synthesis and characterisation, through device engineering and manufacturing, to pharmacology and cancer, and will deliver scientific breakthroughs that extend beyond the field of targeted drug delivery. Economic and societal impacts will be delivered and measured through a joined-up approach to market analysis, industry feedback and embedded anticipation of risks to translation. Engagement of end-users and stakeholders, which will begin as early as the preparation of the second-round proposal, will play a critical role in steering the IRC throughout its lifetime.
Planned Impact
The chief impact from this project will be the development of new treatments for hard-to-treat cancers. Over the long term, these treatments will improve patient outcomes and quality of life by increasing the amount and range of drugs that reach the tumour site. In the short term, stakeholders and end-users including clinicians, patient groups, regulatory agencies and members of the healthcare technology supply chain, will benefit from the creation of an ecosystem that engages them at the early stages of the generation of a novel therapeutic solution. Industry will benefit by participating in a project that brings together state-of-the-art materials and device solutions to the field of drug delivery in a way that de-risks their transition to the market. The general public will benefit from a wide range of outreach events that target increased awareness of the future of medical treatments. The academic community will benefit from new scientific knowledge and engineering solutions that will be created by this interdisciplinary project.
Organisations
- University of Cambridge (Lead Research Organisation)
- University of Glasgow (Collaboration)
- Centre for Process Innovation (CPI) (Collaboration)
- Arm Limited (Collaboration)
- UNIVERSITY OF NOTTINGHAM (Collaboration)
- National Physical Laboratory (Collaboration)
- UNIVERSITY OF STRATHCLYDE (Collaboration)
- AstraZeneca (Collaboration)
- Riptide Bioscience (Collaboration)
- Medicines Discovery Catapult (Collaboration, Project Partner)
- UNIVERSITY OF LEEDS (Collaboration)
- UNIVERSITY OF LIVERPOOL (Collaboration)
- National Physical Laboratory (Project Partner)
- AstraZeneca (United Kingdom) (Project Partner)
- UK-CPI (dup'e) (Project Partner)
- ARM (United Kingdom) (Project Partner)
Publications
Abdalla Y
(2023)
Machine learning using multi-modal data predicts the production of selective laser sintered 3D printed drug products.
in International journal of pharmaceutics
Abánades Lázaro I
(2024)
Metal-organic frameworks for biological applications
in Nature Reviews Methods Primers
Alkahtani ME
(2024)
Electroactive Polymers for On-Demand Drug Release.
in Advanced healthcare materials
Awad A
(2021)
Connected healthcare: Improving patient care using digital health technologies.
in Advanced drug delivery reviews
Baker A
(2024)
An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence
in Angewandte Chemie
Baker AG
(2024)
An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence.
in Angewandte Chemie (International ed. in English)
Barnett SE
(2023)
BAP1 Loss Is Associated with Higher ASS1 Expression in Epithelioid Mesothelioma: Implications for Therapeutic Stratification.
in Molecular cancer research : MCR
Bradley KL
(2021)
Role of unfolded proteins in lung disease.
in Thorax
| Description | We developed peptide-functionalized hyaluronic acid (HACF) cross-linked by cucurbit[8]uril (CB[8]), a new class of drug-delivery reservoirs, and used these materials to enable improved drug bioavailability for glioblastoma tumours in patient-derived xenograft (PDX) models. We showed that treatment with drug-loaded hydrogels allows for a significant survival impact of 45% (55.5 to 80.5 days). These biocompatible and tailorable materials warrant use as drug delivery reservoirs in PDX resection models, where the mechanical properties can be readily adjusted to match the stiffness of local tissue and thus have potential to improve the survival of GB patients. We have advanced in the creation of new formulations and in vitro validation of proof-of-concept solutions using high-capacity vehicles. On one hand, we have included new coatings to increase the stability of the developed materials. On the other hand, we have developed new methods to assess the biocompatibility and immune response of the materials. Biocompatible drug nanocarriers that mimic biopolymers from skin have been designed using a green and adjustable chemical strategy. A drug candidate that showed initial promise for treatment of pancreatic cancer, but suffers from limited stability and delivery efficiency, was loaded within the nanocarrier together with the compound that can ease the transport within pancreatic cancer tissue. It was shown that the nanocarrier enter the cancer cells without posing any damaging effect on the healthy cells. A new line of research has also been developed focusing on mechanical properties of the tumour vs healthy tissues to help design of more efficient drug nanocarriers. We developed a novel type of electrophoretic delivery implant where a redox mediator solution is used to control electrode reactions and sustain continuous delivery for theoretically unlimited duration. As a proof-of-concept, we demonstrate a redox flow iontophoresis-based brain implant which can continuously deliver doxorubicin at stable rates exceeding 2 nmol/min. This new concept enables the continuous delivery of various potent drugs into the brain and spinal cord and therefore has the potential to improve treatment options for various diseases. It is currently undergoing validation of safety and efficacy in animal models. |
| Exploitation Route | On the long term, we aim to take these technologies to the clinic, thereby changing the standard of care in hard-to-treat cancers. The work can be generalised to address other diseases where localised delivery of drugs past biological barriers is important, for example epilepsy. Advances in hydrogel synthesis and functionalisation of vehicles can be adopted by others in the field of tissue engineering and energy storage. A microfluidic device that mimics the flow of blood will be useful to the wider research community to test nanocarriers prior to in vivo, pre-clinical validation. Biopolymer nanocarriers have attracted the attention of immunologists within Addenbrookes hospital interested in making use of these systems to target cancer promoting signalling proteins, and researchers working on targeting of senescent cells. We are also working on the translation of the implantable iontophoresis devices. |
| Sectors | Healthcare Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
| URL | https://www.teddy.eng.cam.ac.uk/ |
| Description | 1. High capacity vehicles A new spin-out company, Vector Bioscience, (see Spin Outs) has been founded by Prof David Fairen-Jimenez, to take forward IRC research on metal-organic frameworks as drug delivery vehicles for anti-cancer therapeutics. The company has now been awarded £2.2million investment from the European Innovation Council (EIC) Transition Challenge EIC and £500 000 Innovate UK funding (see Further Funding) which will enable the company to further develop this technology based on IRC research. Prof Fairen Jimenez is CEO of the company which has employed 4 staff including COO, Programme Manager and two scientists. 2. Hydrogels The secondment of an IRC post-doctoral researcher from Prof Oren Scherman's group to Acqot (see Secondments) has enabled the two-way transfer of expertise and knowledge between the University and industry. Within the company, the partnership has developed technical skills and know-how relating to the manufacturing scale-up and characterisation of novel drug-loaded hydrogels. Prof Oren Scherman has been awarded an MRC Confidence in Concept grant (see Further Funding) to validate the hydrogel technology in an in-vivo model, in order to support the translation of this research. Plans have been developed for the next stage of translation, with input from MHRA, our industry partners, and specialist toxicology and regulatory consultants. New partners for regulatory toxicology studies and accredited manufacturing, formulation and stability studies have been identified. A PPI programme has been undertaken with the University of Birmingham to gather patient input and feedback. 3. Electrophoretic devices We have filed a patent to protect the concept of redox electrophoresis, which allows continuous, long-term delivery of treatment. We are considering a spin-off that will take this invention to the clinic. |
| First Year Of Impact | 2022 |
| Sector | Pharmaceuticals and Medical Biotechnology |
| Impact Types | Economic |
| Description | A revolutionary, highly versatile drug delivery platform based on Metal-Organic Frameworks |
| Amount | € 2,500,000 (EUR) |
| Funding ID | 101113070 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 04/2023 |
| End | 04/2026 |
| Description | Development of Hydrogels for Localised Drug Delivery for the Treatment of Glioblastoma |
| Amount | £12,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 03/2023 |
| Description | Development of Hydrogels for Treatment of Glioblastoma |
| Amount | £800,000 (GBP) |
| Organisation | AstraZeneca |
| Department | MedImmune |
| Sector | Private |
| Country | United Kingdom |
| Start | 11/2019 |
| End | 09/2024 |
| Description | EPSRC Impact Acceleration Account |
| Amount | £8,078 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2019 |
| End | 12/2019 |
| Description | ERC Proof of Concept |
| Amount | € 150,000 (EUR) |
| Funding ID | GAP_ERC-2020-PoC_957514-MOHEDD |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | |
| Description | Fast Start: Innovation |
| Amount | £50,000 (GBP) |
| Funding ID | 10046360 |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2022 |
| End | 04/2023 |
| Description | GMP translated fabrication of dynamic cucurbit[8]uril based hydrogels for drug delivery in cancer treatment |
| Amount | £14,961 (GBP) |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2021 |
| End | 05/2021 |
| Description | Harnessing single cell sequencing technology to improve early diagnosis and prognostication |
| Amount | £92,596 (GBP) |
| Funding ID | MEDPG21F\4 |
| Organisation | British Lung Foundation (BLF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2021 |
| End | 08/2023 |
| Description | Medical implant to deliver precision cancer treatment through targeted chemotherapeutic delivery |
| Amount | £180,000 (GBP) |
| Funding ID | EF2020\100033 |
| Organisation | Rosetrees Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2020 |
| End | 12/2023 |
| Description | Metal-organic frameworks as a modular platform for advanced drug delivery |
| Amount | £449,693 (GBP) |
| Funding ID | 10037486 |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2022 |
| End | 11/2024 |
| Description | Senescence-detecting, urine-based nanobiosensor for early detection of lung cancer |
| Amount | £85,000 (GBP) |
| Funding ID | EDDPMA-May23/100051 |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2023 |
| End | 12/2025 |
| Description | SonoBacter: Ultrasound-guided Activation and Imaging of Engineered Bacteria for Stroma Reprogramming |
| Amount | £52,344 (GBP) |
| Funding ID | MR/Y008227/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2023 |
| End | 02/2025 |
| Description | Supramolecular local drug delivery hydrogel depot for Glioblastoma (GB) |
| Amount | £49,999 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2023 |
| End | 03/2023 |
| Description | WELLCOME TRUST - INSTITUTIONAL TRANSLATION PARTNERSHIP AWARD: UNIVERSITY OF CAMBRIDGE |
| Amount | £50,000 (GBP) |
| Funding ID | RG93172 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2019 |
| End | 05/2020 |
| Title | Mesothelioma organoids |
| Description | Mesobank is a repository of mesothelioma tissue and in vitro models. Recently, we generated new mesothelioma organoids (currently 19 models), which are 3D cell cultures that closely mimic the properties and behaviour of mesothelioma tumours found in patients. |
| Type Of Material | Cell line |
| Year Produced | 2022 |
| Provided To Others? | No |
| Impact | With Mesobank organdies, researchers can test potential therapies and develop new treatments. This resource is critical for advancing our understanding of mesothelioma and improving the lives of those affected by the disease. The use of organoids in research has the potential to greatly accelerate the pace of discovery and lead to new treatments that can help patients with mesothelioma. |
| URL | https://www.mesobank.com |
| Title | Quantitative monitoring and modelling of retrodialysis drug delivery in a brain phantom |
| Description | AbstractA vast number of drug molecules are unable to cross the blood-brain barrier, which results in a loss of therapeutic opportunities when these molecules are administered by intravenous infusion. To circumvent the blood-brain barrier, local drug delivery devices have been developed over the past few decades such as reverse microdialysis. Reverse microdialysis (or retrodialysis) offers many advantages, such as a lack of net volume influx to the intracranial cavity and the ability to sample the tumour's micro-environment. However, the translation of this technique to efficient drug delivery has not been systematically studied. In this work, we present an experimental platform to evaluate the performance of microdialysis devices in reverse mode in a brain tissue phantom. The mass of model drug delivered is measured by computing absorbance fields from optical images. Concentration maps are reconstructed using a modern and open-source implementation of the inverse Abel transform. To illustrate our method, we assess the capability of a commercial probe in delivering methylene blue to a gel phantom. We find that the delivery rate can be described by classical microdialysis theory, except at low dialysate flow rates where it is impacted by gravity, and high flow rates where significant convection to the gel occurs. We also show that the flow rate has an important impact not only on the overall size of the drug plume, but also on its shape. The numerical tools developed for this study have been made freely available to ensure that the method presented can be used to rapidly and inexpensively optimise probe design and protocol parameters before proceeding to more in-depth studies. |
| Type Of Material | Model of mechanisms or symptoms - in vitro |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| Impact | The brain tissue phantom and associated numerical tools are contributing to the development and validation of IRC drug delivery technologies. |
| URL | https://www.repository.cam.ac.uk/handle/1810/346048 |
| Title | CCDC 2005056: Experimental Crystal Structure Determination |
| Description | Related Article: Isabel N. Hegarty, Samuel J. Bradberry, June I. Lovitt, Jason M. Delente, Niamh Willis-Fox, Ronan Daly, Thorfinnur Gunnlaugsson|2023|Mater. Chem. Front.|7|906|doi:10.1039/D2QM00998F |
| Type Of Material | Database/Collection of data |
| Year Produced | 2023 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc259f75&sid=DataCite |
| Title | Research data supporting "A Single-Component Photorheological Fluid with Light-Responsive Viscosity" |
| Description | Data files here contain the XY data reported in graphs in the main manuscript and ESI. The file "Linear Rheology" contains the raw rheology data reported as viscosity (X) vs shear rate (Y) for the native trans, cis PSS and blue PSS samples. The file "Oscillatory Rheology" contains raw rheology data reported as Storage and Loss Moduli (X) vs frequency (Y) for the native trans and blue recovered samples. "Cycling viscosity" reports viscosity at a fixed shear rate, for varying irradiation conditions (cis or trans PSS). The file "UV-Vis Absorption Spectroscopy" provides the absorbance (X) and wavelength (Y) for the AzoPS in the native trans, cis PSS and trans PSS. "UV Vis_Blue" reports the wavelength and absorbance for the trans PSS, as a function of blue light irradiation. "UV Vis_UV" reports the wavelength and absorbance for the cis PSS, as a function of UV light irradiation. The folders beginning with "SAXS" contain the relevant SAXS data referred to in the rest of the filename. Each file contains the q range (X), scattering intensity (Y) and error on scattering intensity (Y error). The model fits performed using SASview are also reported in each case as q (X) vs scattering intensity (Y). |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | https://www.repository.cam.ac.uk/handle/1810/309628 |
| Title | Research data supporting "Quantitative monitoring and modelling of retrodialysis drug delivery in a brain phantom" |
| Description | The data was generated as part of the EPSRC IRC in Targeted Delivery for Hard-to-Treat Cancers . In this work we present a platform which can be used to investigate and optimise the performance of microdialysis probes in the context of drug delivery. Our detailed experimental rig and the software supplied with our work is aimed at facilitating the transition of this delivery technique to clinical trials. Above all, our work is a significant contribution to the field as we can rapidly image and measure drug concentration far from the probe and discuss the size and shape of the drug plume. The images are taken with the following setup: a collimated light source (CX0202-WHIIC, Edmund Optics) shines parallel beams through the brain phantom. A telecentric objective lens (TitanTL 0.184X, Edmund Optics) is mounted on a digital camera (Basler Ace acA1920-150um, 2/3" 10-bit monochromatic sensor). A pass-band filter (FB500-40, Thorlabs) centred around 500 nm, with a bandwidth of 40 nm is mounted at the back of the lens. Images are recorded at 1 frame per minute with a fixed exposure time for each series (in the range 9 ms to 11 ms). Images are processed using Python environment and open-source packages. The microdialysis probe used in this study is the 70 MD Bolt Catheter, from Mdialysis. The brain phantom is an agarose gel 0.6% in Dulbecco's phosphate-buffered saline. The model drug solution is methylene blue 0.2 mg/mL in DPBS. |
| Type Of Material | Database/Collection of data |
| Year Produced | 2022 |
| Provided To Others? | Yes |
| URL | https://www.repository.cam.ac.uk/handle/1810/341600 |
| Description | Collaboration with Helen Mulvana, University of Glasgow |
| Organisation | University of Glasgow |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have been working with Dr Mulvana on development of ultrasound sensitive poly dopamine nanoparticles for delivery to solid tumours. We have developed porous polydopamine nanoparticles and loaded them with SN38 drug. |
| Collaborator Contribution | Dr Mulvana has performed ultrasound experiments and PhD student working on the project spent 1 months doing measurements herself which we are just writing up. |
| Impact | We have secured MRC Primer award (18 months, £60k) for our work ( Grant Nr MR/Y008227/1) |
| Start Year | 2023 |
| Description | Collaboration with Nottingham (PDRA in Nottingham) |
| Organisation | University of Nottingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We are preparing a range of dynamic hydrogels with either a single API formulated within the gel or in combination with a polymeric nanoparticle that encapsulates a different drug. |
| Collaborator Contribution | Our partners in Nottingham are looking at a range of 3D spheroid models of GB patient cells, both invasive margin cells and core cells from the same patients and how APIs target these cells from solution as well as from our dynamic hydrogels. They are also looking at whether there are synergies with multimodal treatment. |
| Impact | chemistry, biology, materials, |
| Start Year | 2021 |
| Description | Collaboration with SN Bioscience, Korea |
| Organisation | Riptide Bioscience |
| Country | United States |
| Sector | Private |
| PI Contribution | Prepared the building blocks fro preparation of nano carriers and provided detailed protocols for preparation and loading of plutonic polydopamine with SN38 drug. SN Bioscience is a company based in Korea ( http://www.snbioscience.com) |
| Collaborator Contribution | Drug loading and in vivo testing of produced polydopaine-pluronic nano carrier |
| Impact | Complete protocols for drug loading established as well as scaled up reactions. In vivo experiments should be completed this year. |
| Start Year | 2023 |
| Description | Collaboration with University of Leeds |
| Organisation | University of Leeds |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Prof Oren Scherman and Prof George Malliaras are supplying samples of hydrogels and implantable drug delivery devices for testing. |
| Collaborator Contribution | Leeds is testing hydrogels and implantable drug delivery devices in patient-derived brain tumour assembloids and resection-recurrence surgical mouse models. |
| Impact | Outputs and outcomes are still emergent. |
| Start Year | 2023 |
| Description | Collaboration with University of Liverpool |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Prof Oren Scherman and Prof David Fairen Jimenez have provided samples of novel hydrogels and MOFs both unloaded and loaded with chemotherapeutic drugs. |
| Collaborator Contribution | Prof Judy Coulson has tested the samples provided using in ovo models to assess the toxicity of the materials and the action of drug-loaded materials on mesothelioma tumour cells. |
| Impact | Outputs and outcomes are still emergent. |
| Start Year | 2022 |
| Description | Collaboration with University of Strathclyde |
| Organisation | University of Strathclyde |
| Department | Department of Pure and Applied Chemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | IRC investigators Prof Duncan Jodrell, Prof Oren Scherman, Prof Ross Forgan and Prof David Fairen-Jimenez contributed to the development of the project plan, and provide advisory input to University of Strathclyde's role in the IRC. Researchers from Prof Oren Scherman, Prof Ross Forgan and Prof David Fairen Jimenez's groups synthesise and characterise materials for use in experiments at University of Strathclyde. |
| Collaborator Contribution | University of Strathclyde are contributing to the IRC through the validation of IRC technologies using in vivo mouse models for pancreatic cancer. |
| Impact | Outputs are still emergent. |
| Start Year | 2022 |
| Description | IRC-ARM |
| Organisation | Arm Limited |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Hosting a meeting to discuss collaborative opportunities |
| Collaborator Contribution | None as yet |
| Impact | None as yet |
| Start Year | 2018 |
| Description | IRC-AZ |
| Organisation | AstraZeneca |
| Department | Research and Development AstraZeneca |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Expertise in the devices and chemistries being deployed as part of the project. |
| Collaborator Contribution | AstraZeneca have provided expertise in drug delivery by providing a representative to sit on the steering committee for the project. They have also contributed by providing guidance in developing target product profiles and hosting a meeting to explore wider possibilities for collaboration. In addition to in-kind support AstraZeneca have also provided substantial additional funding for translation work on hydrogels for the treatment of glioblastoma |
| Impact | This is a multidisciplinary collaboration involving engineers, chemists and clinicians. The main outcome of the collaboration to-date has been to assist in shaping the strategic direction of the IRC. |
| Start Year | 2019 |
| Description | IRC-CPI |
| Organisation | Centre for Process Innovation (CPI) |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Expertise in the technologies we are developing |
| Collaborator Contribution | Expertise in high value manufacturing |
| Impact | Assistance in shaping the approach we have taken to the manufacturing challenges associated with the project |
| Start Year | 2019 |
| Description | IRC-MDC |
| Organisation | Medicines Discovery Catapult |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Expertise in the drug delivery technologies being developed |
| Collaborator Contribution | Assistance in identifying possible additional project partners |
| Impact | Contacts made with potential industrial collaborators |
| Start Year | 2018 |
| Description | IRC-NPL |
| Organisation | National Physical Laboratory |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Expertise in the drug delivery technologies being developed. |
| Collaborator Contribution | Expertise in medical instrumentation and mass spectrometry imaging |
| Impact | No outcomes as yet |
| Start Year | 2018 |
| Title | POLYDOPAMINE CO-POLYMER NANOPARTICLES |
| Description | The present invention relates to polydopamine co-polymer nanoparticles as defined in the application. The present invention also relates to processes for the preparation of these polydopamine co-polymer nanoparticles, to pharmaceutical compositions comprising them, and to their use in therapy. |
| IP Reference | WO2023194414 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2023 |
| Licensed | No |
| Impact | Collaboration with SN Bioscience interested in licensing the technology. We are currently working with them to establish clear protocols |
| Company Name | Vector Bioscience Cambridge |
| Description | Vector Bioscience Cambridge researches nanotechnology for use in drug delivery, including RNA-based cancer treatments, with the aim of commercialisation. |
| Year Established | 2021 |
| Impact | Vector Bioscience, a spin-out company of the Department of Chemical Engineering and Biotechnology at the University of Cambridge, has just received £2.2 million from the European Innovation Council (EIC) thanks to the "Transition Challenge" investment programme. This capital will allow Vector to develop its novel RNA delivery platform, increasing RNA therapies' safety, specificity, and effectiveness. Vector has already been awarded an additional £500k from Innovate UK |
| Website | https://www.vectorbiocam.com/home |
| Description | 'Made it my way', a set of kinetic sculptures that explore the concept of how different creative methods change the final product |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Creative Partnerships is a project that focuses on collaborations between researchers and local further education and higher education institutes with focus on creative arts. ''Made it my way' is a set of kinetic sculptures that explore the concept of how different creative methods change the final product. This piece is inspired by work of IRC researchers at the Institute for Manufacturing who are investigating how different manufacturing processes change the properties of new devices which deliver drugs for hard-to-treat cancers. Things that work perfectly, in a research lab, can fall down when they are made using real world processes which often have very different requirements. It is an interactive sculpture where people are invited to try for themselves and see if they can you make the same circle twice with both sculptures. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.cam.ac.uk/public-engagement/creative-encounters-2023/partnerships#section-Made-it-my-way... |
| Description | 'Summer in the CDT' talk series held by University of Nottingham |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Talk as part of seminar series given over the summer for a number of research postgraduate students at doctoral training centre. |
| Year(s) Of Engagement Activity | 2020 |
| Description | 2023 Cambridge Bioelectronics Symposium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Organised the Cambridge Bioelectronics Symposium, an event that combined comprehensive coverage of the state-of-the-art of the field with strong participation of young scientists (graduate students/postdocs), hands-on workshops, and career furthering opportunities. It offered: Coverage of fundamentals, materials, devices, applications, translation/commercialisation, ethical issues. Invited talks by world-class experts who convey their vision for the future of the field. Majority of contributed talks and posters presented by young scientists, selected by a committee of young scientists. Hands-on demonstrations: Interested in bioelectronics but do not know where to start? These demonstrations will give you some good ideas. Thematic panel discussion or road mapping exercise - more on this soon. "Meet the industry" session. Learn about startups in the field. Awards for best contributed talk and poster, selected by a committee of young scientists. Symposium dinner. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://bioelectronics.eng.cam.ac.uk/symposium-information |
| Description | BBC1 Naked scientist Question time guest |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Ljiljana Fruk joined a group of Panelist to answer the questions from the listeners concerning chemistry, nanotechnology and nano medicine in BB1 Naked scientist question time |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.thenakedscientists.com/podcasts/naked-scientists-podcast/extremely-curious-qna |
| Description | BNOS online research workshop |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Presented 30 minute lecture virtually, then held a panel discussion with questions taken from audience located internationally. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Brain Tumour Charity's Research Involvement Network |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | We developed a questionnaire for patients/carers together with the Brain Tumour Charity's Research Involvement Network and establishing a panel to guide future work targeting brain cancer. Their feedback was very helpful in clarifying patient preferences for different treatment modalities. |
| Year(s) Of Engagement Activity | 2021 |
| Description | British Neuro-Oncology Society (BNOS) conference (Liverpool) oral presentation (prize for highest scoring abstract). Title: Pro-drug nanoparticle loaded supramolecular hydrogels for drug delivery to IDH1 wild-type glioblastoma. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation at BNOS 2022 (Liverpool), delivered by Dr Rob Cavanagh, EPSRC IRC-funded post-doctoral fellow at University of Nottingham. Dr Cavanagh was selected as one of three top scoring abstracts, and invited to deliver a 15-minute presentation in a dedicated session for top abstracts. Approximately 300 delegates were in attendance, composed of diverse stakeholders within the UK brain cancer research community. The BNOS annual conference is the leading national symposia for neuro-oncology research, attended by academics, clinicians, patients, charities and industry. |
| Year(s) Of Engagement Activity | 2022 |
| Description | British Neuro-Oncology Society (BNOS) conference (Manchester) oral presentation (prize for highest scoring abstract). Title: Pro-drug nanoparticles as synergistic drug combination carriers for IDH-WT glioblastoma |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Oral presentation at BNOS 2023, delivered by Dr Rob Cavanagh, EPSRC IRC-funded post-doctoral fellow at University of Nottingham. Dr Cavanagh was selected as one of three top scoring abstracts, for the second year running, and invited to deliver a 15-minute presentation in a dedicated session for top abstracts. Approximately 300 delegates were in attendance, composed of diverse stakeholders within the UK brain cancer research community. The BNOS annual conference is the leading national symposia for neuro-oncology research, attended by academics, clinicians, patients, charities and industry. |
| Year(s) Of Engagement Activity | 2023 |
| Description | CRUK Cambridge PPI panel |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | We asked a PPI group to weigh in on various treatment scenarios. We received very helpful feedback on drug/imaging agent/placebo selection for hydrogels & on the design of the electrophoretic pumps |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cambridge Creative Partnerships |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Niamh Fox and Dr Etienne Rognin participated in the production of kinetic sculptures called 'made it my way' in collaboration with artist Mahija Mandalika from Cambridge School of Visual and Performing Arts. This sculpture was exhibited for 10 days during the Cambridge Festival. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.cam.ac.uk/public-engagement/creative-encounters-2023/partnerships |
| Description | Cambridge Experimental Cancer Medicine Centre PPI Panel |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Presentation to Cambridge Experimental Cancer Medicine Centre Patient and Public Involvement Panel to inform them of our progress and to obtain their input on which drugs to use (tried and tested versus novel molecularly targeted therapies) and on design of implantable devices. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Cambridge Festival - IfM open day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | As part of the Cambridge Festival IFM open day, Dr Niamh Fox gave a demonstration using the "brain in a box" model to simulate the delivery of drugs into the brain by experimental devices being developed by Prof George Malliaras's group. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.ifm.eng.cam.ac.uk/news/ifm-brain-in-a-box-to-feature-at-the-cambridge-festival/ |
| Description | Cambridge Festival - Youtube video on microscopy in research |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | As part of the Cambridge Festival, the University's annual public engagement festival, an IRC researcher from the Institute of Manufacturing created this short film explaining how microscopy is used in research. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.youtube.com/watch?v=RDC9ZAf5xwI&ab_channel=InstituteforManufacturing%28IfM%29%2CUniversi... |
| Description | Cambridge Festival panel discussion, live activity, in-person and live-streamed event entitled 'What can we do about difficult cancers?' |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | This event brought together a neurosurgeon (Mr Stephen Price), an engineer (Dr Ronan Daly) and chemists (Prof. Oren Scherman & Dr Ljiljana Fruk) to discuss the problems in delivering drugs to combat some of the most difficult to treat cancers, and how we can use new advances in engineering and chemistry to overcome them. There was also an opportunity to see simulated brain surgery to remove a tumour to help understand the challenges being addressed. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.eventbrite.co.uk/e/what-can-we-do-about-difficult-cancers-tickets-182059594147# |
| Description | Cambridge Philosophical Society invited lecture |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Cambridge Philosophical Society talks are aimed at general public and the member of the University of Cambridge, and the lecturers are invited based on their expertise and ability to engage audiences with their chosen topic. The topic was Modern Molecular Science and how is it changing our life. |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.cambridgephilosophicalsociety.org/lectures-visits/modern-molecular-science-and-how-it-ch... |
| Description | Cambridge Science Festival March 2019 hands-on microscopy activities for the general public (all ages) over two weekends. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | The Cambridge Science Festival is a series of events held annually in March in Cambridge, and is the United Kingdom's largest free science festival.[1] The festival attracts more than 30,000 visitors to over 250 events.[2] University researches and students open their lecture halls and laboratories to the general public, and hold Talks, Exhibitions and Demonstrations, mostly free of charge.[1] The Marciniak lab plays a leading part in representing the Cambridge Institute for Medical Research (CIMR) in organising hands on cell biology activities. For young children these involve toys and games teaching about the structure of cells. For older children and adults, we use a variety of microscopes including fluorescence microscopy to illustrate how modern microscopy aids in the understanding of the molecular cell biology of disease. [1] "University of Cambridge Science Festival 2011". BBC News. Retrieved 21 March 2015. [2] "About - www.sciencefestival.cam.ac.uk". Retrieved 21 March 2015. |
| Year(s) Of Engagement Activity | 2015,2016,2017,2018,2019 |
| URL | https://www.sciencefestival.cam.ac.uk/events/grander-view-how-modern-microscopy-illuminates-disease |
| Description | Conference presentation by Dr Niamh Willis-Fox at The Inkjet Conference 2019, Dusseldorf. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Conference presentation by Dr Niamh Willis-Fox at The Inkjet Conference 2019, Dusseldorf. This is the major industry-academic joint conference that looks at inkjet technologies. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Conference to celebrate the international day of Women and Girls in Science |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The online conference was organised by ICESCO (Islamic World Educational, Scientific and Cultural Organisation) and live-streamed from Marocco. The guests included high-ranking politicians, prominent scientists including Nobel price winners and policymakers. It was aimed at the celebration of the international day of Women and girls in science and it was streamed globally reaching audiences from all over the world, and it was organised in collaboration with Leibnitz Association (Germany) and Sp |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.icesco.org/en/wp-content/uploads/sites/2/2019/12/Celebration-of-the-International-Day-of... |
| Description | Connect Health Tech Live |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | A presentation on the IRC, reflecting on best practice in interdisciplinary collaboration, was given to an audience of knowledge exchange and commercialisation professionals. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://ie.cam.ac.uk/event/connect-health-tech-live/ |
| Description | Connect HealthTech podcast interview |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Prof Colin Watts and Prof Ronan Daly appeared in the Connect HealthTech "Joining the Dots" podcast, interviewed by Paula Rogers-Brown. Connect HealthTech is an online academia-industry community for life sciences and health technology. In the podcast they explained the IRCs mission and gave insights into the challenges and benefits of our inter-disciplinary approach, raising awareness of the work of the IRC to a broader audience across academia and the heath tech industry. Prof Colin Watts and Claire McGlynn (IRC Programme Manager) have been invited to present at a future Connect Health Tech event. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.teddy.eng.cam.ac.uk/news/listen-irc-investigators-conversation-connect-health-tech-podca... |
| Description | Creation and distribution of the publication - The IfM colouring book "How Stuff Gets Made". |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Creation and distribution of the publication - The IfM colouring book "How Stuff Gets Made". This outreach activity was a highly popular contribution to the Cambridge Science Festival 2019 by the postdoctoral researcher on this grant Dr. Niamh Willis-Fox. |
| Year(s) Of Engagement Activity | 2019 |
| Description | IRC website |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Website giving details of the work undertaken by the IRC, and contact details |
| Year(s) Of Engagement Activity | 2019 |
| Description | ISAC (Inspiring Scientists at CIMR): lab experience and mentoring event for less-advantaged Y12 pupils, 17th Feb 2023 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | ISAC/M is a four-day, non-residential work experience programme which will take place during school half term in February 2024. The first three days will be held at two University of Cambridge research Institutes (The Cambridge Institute for Medical Research; CIMR and the MRC Mitochondrial Biology Unit; MBU) which share the same building on the Cambridge Biomedical (Addenbrookes) campus. The ISAC/M programme will start at 10:00 and end at 16:00 every day from Tuesday, 20th February - Friday 23rd February. Students will take part in biomedical research and learn more about how that research can lead to new treatments. The final day of the programme (Friday 23rd February) will take place at St Catharine's College in central Cambridge, where ISAC/M students will make short presentations on the research they took part in, and obtain advice and guidance on applying to Cambridge and other universities. Lunch will be provided each day, and travel costs reimbursed for all students taking part in the programme. What will students taking part in ISAC/M do? Spend time in a research lab at either CIMR or MBU, 'shadow' researchers, learn about how research is carried out, and run an experiment Prepare a scientific presentation about the experiment they ran Attend interactive seminars to help develop scientific knowledge and skills Attend guided tours and demonstrations of scientific core facilities and see some of the different technologies used such as cutting-edge microscopes Spend an interactive day run in partnership with St Catharine's College, Cambridge with workshops on how to apply to Cambridge and similar universities, and getting guidance on personal statements Network with other placement students, admissions staff, postgraduate students, and scientists as well as attend optional mentoring slots about studying and working in research Background to the Cambridge Institute for Medical Research (CIMR) and MRC Mitochondrial Biology Unit (MBU) CIMR is a biomedical research Institute that is part of the School of Clinical Medicine at the University of Cambridge. CIMR's mission is to determine the molecular mechanisms of disease to advance human health. We focus on translation between biological research and clinical applications. The Institute has 24 research teams studying how normal biological processes inside cells can go wrong during infections, or because of rare genetic changes. By understanding these processes and the molecules involved (particularly proteins) we aim to discover better treatments for diseases and enable better outcomes for patients. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.cimr.cam.ac.uk/isacm-2024 |
| Description | IfM 'Brain in a Box' to feature at the Cambridge Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Two postdoctoral researchers from the IRC team explained and demonstrated what is glioblastoma using a full-scale model made from shop-bought dessert jelly. They demonstrated the approach that the project is taking to delivering drugs directly to the tumour and the challenges involved using this full-scale model. They also showed how we build tools within the project to help rapidly design implants for drug delivery. An imaging setup similar to the 'brain-in-a-box' developed and used within the IRC research was used. All images were projected onto the room's main screen to ensure everyone attending could see. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.ifm.eng.cam.ac.uk/news/ifm-brain-in-a-box-to-feature-at-the-cambridge-festival/ |
| Description | Interview and summary on the role of design for manufacturing on the path from laboratory to clinic |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Manufacturing is a cross-cutting theme that runs through the IRC research programme. Dr Ronan Daly, Associate Professor in Science and Technology of Manufacturing, based at the Institute for Manufacturing at the University of Cambridge, leads this theme for the IRC, and in this interview and report describes why asking questions early in the research stage and looking ahead to manufacturing is key to getting products quickly to patients. |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.teddy.eng.cam.ac.uk/cancer-sight-blog/november-2021-ahead-game-role-design-manufacturing... |
| Description | Invited Lecture at anniversary symposium |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave an invited lecture as part of Prof. Bert Meijers' anniversary symposium. 250 members in the audience. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Invited talks at the MRS Spring Meeting, May 8-13, 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Delivered two invited talks and several contributed (by group members) to a large and interdisciplinary audience interested in applications of novel materials |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.mrs.org/meetings-events/spring-meetings-exhibits/past-spring-meetings/2022-mrs-spring-me... |
| Description | June Hancock Mesothelioma Research Fund 'Meet the researchers' event speaker, |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Meet the Researchers events are an opportunity for researchers and academics to engage with patients and practitioners. Non-researchers can gain insight into the aims, objectives, challenges, and opportunities of current research; researchers can hear patients' and practitioners' priorities for research. These events are designed to promote discussion and allow questions to be asked in a relaxed and informal way. The aim is to break down the barriers between researchers and patients and enable conversations that will lead to meaningful engagement and a better understanding of research. The two-hour event was opened by Dr Kate Hill, a founding Trustee and pro bono Manager of the research activity for the June Hancock Mesothelioma Research Fund (JHMRF), a campaigning charity that sponsors and promotes vital research into the causes and treatment of mesothelioma. The online format allowed the charity to open the Meet the Researchers event - previously held in-person - to a wider audience, and participants attended from across the UK and internationally. Everyone was encouraged to ask questions throughout the event and the emerging conversations between researchers, patients and practitioners were engaging and informative. |
| Year(s) Of Engagement Activity | 2022,2023 |
| URL | https://www.teddy.eng.cam.ac.uk/news/irc-team-meet-researchers-public-event |
| Description | Keynote presentation at 18th International Conference on Nanosciences and Nanotechnologies |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote presentation: "Technology for bioelectronic medicine", 18 International Conference on Nanosciences and Nanotechnologies (N&N), July 6-9, Thessaloniki, Greece (via teleconference due to COVID restrictions). |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.nanotexnology.com/index.php/nn |
| Description | Keynote presentation at 3rd International Conference on Flexible Electronics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote presentation: "Technology for bioelectronic medicine", 3rd International Conference on Flexible Electronics (ICFE), Nov. 12-14, 2021, Hangzhou, China (via teleconference due to COVID restrictions). |
| Year(s) Of Engagement Activity | 2021 |
| Description | Keynote presentation at 72nd Annual Meeting of the International Society of Electrochemistry |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote presentation: "Electronics on the brain", 72nd Annual Meeting of the International Society of Electrochemistry, Aug. 29 - Sept. 3, 2021, Jeju Island, Korea (via teleconference due to COVID restrictions). |
| Year(s) Of Engagement Activity | 2021 |
| Description | Keynote presentation at Hellenic Conference on Solid-State Physics and Materials Science |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave the keynote presentation at national conference |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://fsk36.materials.uoc.gr/ |
| Description | Keynote presentation- Nanotexnology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gve keynote talk at Nanotexnology meeting |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.nanotexnology.com/2023/ |
| Description | Keynote talk at Nanotexnology |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote talk at nanotechnology conference, attended by physical scientist and engineers |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.nanotexnology.com/2019/ |
| Description | Keyonote presentation at International Conference on Intelligent Wearable Systems in Hong Kong |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave keynote presentation in Hong Kong at conference on werable electronics attended by academic and industrial scientists from around the world |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.polyu.edu.hk/en/riiwear/news-and-events/events/2022/jun/iciws-2022/ |
| Description | Lecture to a Summer School |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | A presentation to the CDT Summer School on pancreatic cancer and the activity in EPSRC IRC. |
| Year(s) Of Engagement Activity | 2020 |
| Description | MRS Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Large international conference; spoke at a symposium within the conference as invited speaker. 100-200 audience members attended talk, with healthy discussion afterwards. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Meet the Researcher June Hancock Mesothelioma Research Fund event |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | An online public engagement event was held with the June Hancock Mesothelioma Research Fund to share the IRC research relating to mesothelioma with an audience of patients, their relatives and carers, and health care professionals. The event was publicised by the June Hancock Mesothelioma Research Fund and shared on social media which led to attendees not only from within the UK but also Europe and South America. The event was chaired by Dr Kate Hill of the June Hancock Mesothelioma Research Fund. Prof Stefan Marciniak, Claire McGlynn (IRC Programme Manager) and three IRC researchers gave short presentations, followed by a lively question and answer session and further discussion. Feedback from attendees indicated that the presentations were clear and understandable to a lay audience, they valued the work being done by the IRC towards improving treatments, and they were interested in learning about future progress at a later date. The IRC researchers benefited from learning about the views and concerns of stakeholders in their research, and in developing their skills in presenting research to a lay audience. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.teddy.eng.cam.ac.uk/news/irc-team-meet-researchers-public-event |
| Description | National Symposium of Croatian Chemists and Chemical Engineers |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary talk at the annual conference in Rovinj, Croatia. It is an important national meeting with many participating companies and wider national reach. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.chemistryviews.org/28th-croatian-meeting-of-chemists-and-chemical-engineers-28hskiki/ |
| Description | Nature Creers Podcast: How ChatGPT and sounds from space brought a luminous jelly to life |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | nature podcast on the work of art inspired directly by hydrogels designed in Fruk lab |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.nature.com/articles/d41586-023-03392-w |
| Description | Nature career podcast on The unexpected outcomes of artist-scientist collaborations |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | POdcast/interview with Julie Gould on working with artists and turning scientific research into art |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.nature.com/articles/d41586-023-03390-y |
| Description | NeuroTechX talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Talk "Electronics on the Brain" at NeuroTechX, Jan. 25, 2021, held virtually (via teleconference due to COVID restrictions). |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://neurotechx.com/ |
| Description | Outreach Talk at ASPIRE Research Showcase |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | Outreach Talk: "Technology for bioelectronic medicine", ASPIRE Research Showcase, Medical School, Keele University, Nov. 17, 2021, Keele, UK (via teleconference due to COVID restrictions). |
| Year(s) Of Engagement Activity | 2021 |
| Description | Outreach Talk at Rosalind Franklin Conference 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Undergraduate students |
| Results and Impact | Outreach Talk: "Electronics on the brain", Rosalind Franklin Conference 2021, Newnham College, April 9, 2021, Cambridge, UK (via teleconference due to COVID restrictions). |
| Year(s) Of Engagement Activity | 2021 |
| Description | Outreach Talk, IEEE Turkey Student Branches Engineering in Medicine and Biology Society Convention |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Undergraduate students |
| Results and Impact | Outreach Talk: "Electronics on the brain", IEEE Turkey Student Branches Engineering in Medicine and Biology Society Convention, May 8, 2021, Istanbul, Turkey (via teleconference due to COVID restrictions). |
| Year(s) Of Engagement Activity | 2021 |
| Description | Outreach Talk: Digitalize in Stockholm |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Outreach Talk: "Technology for bioelectronic medicine", Digitalize in Stockholm, Stockholm, Sweden, Oct. 21, 2021 (via teleconference due to COVID restrictions). |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://digitalizeinsthlm21.se/ |
| Description | Participation in University of Birmingham Brain Cancer Patient Focus Group |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | Participation in University of Birmingham Brain Cancer Patient Focus Groups on 4th and 5th January 2023. Discussions with GB patients and carers around the use of dynamic hydrogels as a novel treatment option for patients with GB |
| Year(s) Of Engagement Activity | 2023 |
| Description | Participation in a documentary film Forever Young by Croatian National TV |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The documentary was shown at Croatian National TV, in a prime spot over 6 weeks ( 6 episodes). Follow up invitations to give talks to students and high school teachers in Croatia followed ( visits to universities and schools reaching additional 1000 people) |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://hrtprikazuje.hrt.hr/hrt1/zauvijek-mladi-10608110 |
| Description | Partners event - Advances in Targeted Delivery for Hard-to-Treat Cancers |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | We organised this event to share progress in IRC research with stakeholders on 4th May 2023 at the Maxwell Centre in West Cambridge. The event featured presentations by IRC investigators and a poster session. The event stimulated further discussions about future opportunities for collaboration. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.teddy.eng.cam.ac.uk/event-advances-targeted-delivery-4th-may-2023 |
| Description | Pint of Science talk by Ljiljana Fruk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | A presentation by Ljiljana Fruk (Co-PI on the award) as part of the Pint of Science series of talks. As well as the talk by an IRC Co- PI the event was sponsored by the IRC, publicising its activities to an audience who may not attend more formal presentations |
| Year(s) Of Engagement Activity | 2019 |
| Description | Plenary Talk at British Cochlear Implant Group 2021 Virtual Meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary Talk: "Electronics on the Brain", British Cochlear Implant Group 2021 Virtual Meeting, May 11-12, 2021 (via teleconference due to COVID restrictions). |
| Year(s) Of Engagement Activity | 2021 |
| Description | Plenary presentation - Micro Nano 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave plennary presentation at Micro Nano meeting |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://2023.micro-nano.gr/plenary-speakers/ |
| Description | Plenary presentation - NanoBio 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave plenary talk at NanoBio |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://nanobioconf.com/ |
| Description | Plenary presentation - RSC Chemical Nanoscience and Nanotechnology Interest Group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Gave keynote talk at national meeting |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.rsc.org/events/detail/76838/rsc-chemical-nanoscience-and-nanotechnology-network-annual-s... |
| Description | Plenary talk at EANS |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary talk at the European Association of Neurosurgical Societies, attended mostly by clinicians |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://eans2019.com/ |
| Description | Plenary talk at Fpi14 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary talk at the 14th International Symposium on Functional p-Electron Systems (Fp14) in Berlin |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.fpi14.de |
| Description | Plenary talk at International Conference for Flexible Electronics |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary talk at probably largest Flexible Electronics meeting in Asia |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://icfe.gfeit.com/ |
| Description | Plenary talk at MNE |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary talk at key microfabrication conference attended by scientists and engineers |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.mne2019.org/ |
| Description | Plenary talk at ORBITALY |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary talk at ORBITALY, attended by scientists interested in applications of organic electronic materials in biology |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.orbitaly2019.eu/ |
| Description | Plenary talk at Virtual FLEX 2021 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Plenary Talk: "Electronics on the brain", Virtual FLEX 2021, Feb. 22-26, 2021 (via teleconference due to COVID restrictions). |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://flex.semi.org/ |
| Description | Podcast on art/science interface |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Nature careers podcast on interface of science and art: Art and science: close cousins or polar opposites? by Julie Gould |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.nature.com/articles/d41586-023-03389-5 |
| Description | Poster given by Dr Kasapidou at RSC Macrocyclic and Supramolecular Chemistry meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | This annual meeting strives to be on the frontier of science in the field of supramolecular chemistry. The short presentation time allocated during the poster sessions offered Dr Kasapidou an excellent opportunity to highlight and showcase her research to all conference attendees, and network with fellow delegates. Dr Kasapidou was able to add to her knowledge about current state-of-the-art topics and make valuable contacts with many researchers across the UK. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Poster presentation by Dr Kasapidou at OxCD3 Oncological Drug Delivery Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | This conference seeks to transform both clinical and industry practice in drug delivery by demonstrating the value and feasibility of engineering approaches, involving a combination of stimulus-responsive nanocarriers and medical devices, for improved tumour uptake and therapeutic outcome. The purpose of this conference in oncological drug delivery is to share the findings with the expert community, but also to identify and re-focus efforts on those therapeutic strategies. All invited key-note speakers were presenting exciting data which helped to understand the current challenges and opportunities in the field. The presentations defined and analysed the most important state-of-the-art ideas in the area of drug delivery systems. After each session the speakers listed a list of bullet points to encourage the discussion from audience. Dr Kasapidou participated in this meeting with a poster presentation, a great opportunity for her to meet and discuss with experts from this field. |
| Year(s) Of Engagement Activity | 2019 |
| Description | Presentaton at the House of Lords |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Presented our IRC to the House of Lords during day organised by EPSRC |
| Year(s) Of Engagement Activity | 2020 |
| Description | Project Partners Meeting |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | A meeting to engage with potential partners with expertise in drug delivery technologies.These included small biotech companies, contract research organisations, pharma and engineering companies as well as charity representatives |
| Year(s) Of Engagement Activity | 2019 |
| Description | Public Seminar on Bioelectronic Medicine, University of Linkoping, Sweden. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Public seminar on the occasion of award of honorary doctorate, reaching current members, alumni and steakholders of Linkoping University. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Public presentation at Cambridge Alumni Festival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Gave talk on brain implants to Cambridge Alumni Festival |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.alumni.cam.ac.uk/festival/events/electronics-on-the-brain |
| Description | Public presentation at Cambridge Society for Application of Research |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Gave talk to Cambridge Society for Application of Research - https://www.csar.org.uk/ - on implantable devices for the brain |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.csar.org.uk/lectures/2020-2021/tbc_20201012/ |
| Description | Rapidly developing area of Bionanotechnology |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | An hour long interview with the podcaster Shaun in Science on the importance of bionanotechnology, posted on You tube and live video streamed from Cambridge |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.youtube.com/watch?v=kObqkoqG3XI |
| Description | RareFest 2022 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Rarefest 22 was a public engagement event focused on raising awareness and promoting understanding of rare diseases. The event was held in Cambridge and aimed to bring together individuals, families, and communities affected by rare diseases, as well as healthcare professionals and researchers. The goal of Rarefest 22 was to increase public knowledge and understanding of rare diseases, and to provide support and resources to those affected. The event featured informative talks, interactive workshops, and opportunities for attendees to connect with others who have similar experiences. Several hundred members of the public attended the even held in the Guild Hall, Cambridge. |
| Year(s) Of Engagement Activity | 2017,2022 |
| URL | https://www.camraredisease.org/rarefest22/ |
| Description | Royal Society of Chemistry Chemical Nanoscience and Nanotechnology Network Annual Symposium 2024 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at the annual meeting to talk about Bionano tools for hard to treat cancers |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.rsc.org/events/detail/76838/rsc-chemical-nanoscience-and-nanotechnology-network-annual-s... |
| Description | Seminar - Constantin C. Coussios |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Seminar by Professor Constantin C. Coussios addressing attendees from various departments, including discussions on future collaborations |
| Year(s) Of Engagement Activity | 2019 |
| Description | Seminar - Uli Weisner |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Seminar by Professor Uli Weisner (Cornell University) to research community at University of Cambridge |
| Year(s) Of Engagement Activity | 2019 |
| Description | Seminar -Snow Stolnik & Cameron Alexander |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | A seminar attended by academics/researchers from various departments within University of Cambridge, followed by disucssions of how to collaborate more closely in future, |
| Year(s) Of Engagement Activity | 2019 |
| Description | Seminar by Chris McConville |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Seminar on "ChemoSeed: a solid biodegradable implant for the localised treatment of glioblastoma". Pprompted discussion on regulatory pathway to the clinic. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Seminar by Claudia Fischbach |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Seminar entitled "Engineering models to analyze tumorstroma interactions and their relevance to cancer progression and therapy" prompted discussions on role of matrix in timour progression |
| Year(s) Of Engagement Activity | 2021 |
| Description | Seminar by Hayley Francies |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | Seminar entitled "Towards the next generation of cancer". Pormpted discussion on pre-clinical pathway |
| Year(s) Of Engagement Activity | 2020 |
| Description | Seminar by Marco Siccardi |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Postgraduate students |
| Results and Impact | An on-line seminar by Marco Siccardi on "Mechanistic Modelling for the Prediction of Nanobiomaterial Biodistribution" |
| Year(s) Of Engagement Activity | 2020 |
| Description | Seminar by Ruman Rahman |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | An online seminar titled "Targeting glioblastoma residual disease using neurosurgically-applied drug delivery systems" which lead to a new research collaboration. |
| Year(s) Of Engagement Activity | 2020 |
| Description | Symposium of Spanish Researchers in UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk at the annual symposium of Spanish Researchers in Uk on bio nano tools for drug delivery |
| Year(s) Of Engagement Activity | 2023 |
| Description | TEDx talk Dusseldorf |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk by Ljiljana Fruk at TEDxKoenigsallee in Düsseldorf within the theme "Outside the Bubble" |
| Year(s) Of Engagement Activity | 2019 |
| Description | TEDx talk on Nanocarriers (Duesseldorf, Germany) |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | TED platform is one of the most popular platform to highlight the ideas and personalities. I was invited to give a talk in front of 1000 audience in Duessledorf concert hall, which was distributed further on a TEDx you tube channel generating wider interest. The talk was on the topic on design of nano carriers. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.youtube.com/watch?v=3QgJIuT33w0 |
| Description | Talk at EuroMOF 2019, Paris. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | European MOF conference |
| Year(s) Of Engagement Activity | 2019 |
| Description | Talk at public outreach event organised by Fundación Ramón Areces |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Talk on symposium organised by Fundación Ramón Areces, attended by the general public |
| Year(s) Of Engagement Activity | 2020 |
| URL | https://www.fundacionareces.es/fundacionareces/en/events/biomimetic-sensors-their-use-and-potential-... |
| Description | Twitter account |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Twitter account established to dissemenate news relevant to the work of the IRC |
| Year(s) Of Engagement Activity | 2019 |
| Description | Virtual booth at Festival of Tomorrow |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Held virtual booth at Festival of Tomorrow 2021 |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.scienceswindon.com/festival-of-tomorrow |
| Description | YouTube video - Brain in the Box |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | A short video was created explaining the "Brain in a box" phantom developed by IRC researchers in the Institute of Manufacturing, and shared on social media to raise awareness and generate interest in the IFM Open Day as part of the Cambridge Festival. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.youtube.com/watch?v=aqYqj253UjQ&ab_channel=IRConTargetedDeliveryforHard-to-TreatCancers |
| Description | iSmart Distinguished Lecture of the International Journal of Smart and Nano Materials |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 17,000 people joined online for this lecture |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://mp.weixin.qq.com/s/qIJrRlQhwiP0SdAiu9vxWQ |
| Description | • Talk at a Mesothelioma UK patients' conference in Brighton on 5th October 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | One day meeting primarily for patients and carers relating to malignant mesothelioma. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.mesothelioma.uk.com/patient-carer-day-awards-night/ |