EPSRC IRC in Targeted Delivery for Hard-to-Treat Cancers

Lead Research Organisation: University of Cambridge
Department Name: Engineering

Abstract

While the survival rate for most cancers has doubled over the last 40 years, hard-to-treat cancers show survival rates below 14%. To combat these cancers, multiple pathways (immune/inflammatory, neoangiogenic, cell replication) need to be targeted and this necessitates a multimodal delivery approach that will increase not only the amount but also the range of therapeutic agents that reach the target site. This IRC will address this challenge by developing (i) delivery vehicles that are based on metal organic frameworks and organic cages and show substantially increased payload capacity, and (ii) implantable/injectable delivery platforms that are based on gels and electrophoretic pumps and enhance drug penetration through e.g. the blood-brain barrier. By combining these two approaches, we will achieve a step change in the amount and range of drugs that reach the tumour site. Two crosscutting translational activities, on material delivery & additive manufacturing and on validation, will consider the whole chain from the conception of the delivery system to its clinical application, leading to a holistic approach to the problem of targeted drug delivery. The proposed research program builds on an institutional-level initiative on therapeutic science and strong links with CRUK and with national labs and industry leaders in drug development. The interdisciplinary team involved in this IRC includes groups from five universities with expertise ranging from materials synthesis and characterisation, through device engineering and manufacturing, to pharmacology and cancer, and will deliver scientific breakthroughs that extend beyond the field of targeted drug delivery. Economic and societal impacts will be delivered and measured through a joined-up approach to market analysis, industry feedback and embedded anticipation of risks to translation. Engagement of end-users and stakeholders, which will begin as early as the preparation of the second-round proposal, will play a critical role in steering the IRC throughout its lifetime.

Planned Impact

The chief impact from this project will be the development of new treatments for hard-to-treat cancers. Over the long term, these treatments will improve patient outcomes and quality of life by increasing the amount and range of drugs that reach the tumour site. In the short term, stakeholders and end-users including clinicians, patient groups, regulatory agencies and members of the healthcare technology supply chain, will benefit from the creation of an ecosystem that engages them at the early stages of the generation of a novel therapeutic solution. Industry will benefit by participating in a project that brings together state-of-the-art materials and device solutions to the field of drug delivery in a way that de-risks their transition to the market. The general public will benefit from a wide range of outreach events that target increased awareness of the future of medical treatments. The academic community will benefit from new scientific knowledge and engineering solutions that will be created by this interdisciplinary project.

Publications

10 25 50
 
Description We developed peptide-functionalized hyaluronic acid (HACF) cross-linked by cucurbit[8]uril (CB[8]), a new class of drug-delivery reservoirs, and used these materials to enable improved drug bioavailability for glioblastoma tumors in patient-derived xenograft (PDX) models. We showed that treatment with drug-loaded hydrogels allows for a significant survival impact of 45% (55.5 to 80.5 days). These biocompatible and tailorable materials warrant use as drug delivery reservoirs in PDX resection models, where the the mechanical properties can be readily adjusted to match the stiffness of local tissue and thus have potential to improve the survival of GB patients.

We have advanced in the creation of new formulations and in vitro validation of proof-of-concept solutions using high-capacity vehicles. On the one hand, we have included new coatings to increase the stability of the developed materials. On the other hand, we have developed new methods to assess the biocompatibility and immune response of the materials.

Biocompatible drug nanocarriers that mimic biopolymers from skin have been designed using a green and adjustable chemical strategy. A drug candidate that showed initial promise for treatment of pancreatic cnacer, but suffers from limited stability and delivery efficiency, was loaded within the nanocarrier together with the compound that can ease the transport within pancreatic cancer tissue. It was shown that the nanocarrier enter the cancer cells without posing any damaging effect on the healthy cells. A new line of research has also been developed focusing on mechanical properties of the tumour vs healthy tissues to help design of more effient drug nanocarries.
Exploitation Route On the long term, we aim to take these technologies to the clinic, thereby changing the standard of care in hard-to-treat cancers. The work can be generalised to address other diseases where localised delivery of drugs past biological barriers is important, for example epilepsy. Advances in hydrogel synthesis and functionalisation of vehicles can be adopted by others in the field of tossue engineering and energy storage.

A microfluidic device that mimics the flow of blood will be useful to the wider research community to test nanocarriers prior to in vivo, pre-clinical validation. Biopolymer nanocarriers have attracted the attention of immunologists within Addenbrooks hospital interested in making use of these systems to target cancer promoting signalling proteins, and researchers working on targeting of senescent cells.
Sectors Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology

 
Description Development of Hydrogels for Treatment of Glioblastoma
Amount £800,000 (GBP)
Organisation AstraZeneca 
Department MedImmune
Sector Private
Country United Kingdom
Start 11/2019 
End 09/2024
 
Description EPSRC Impact Acceleration Account
Amount £8,078 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 03/2019 
End 12/2019
 
Description Medical implant to deliver precision cancer treatment through targeted chemotherapeutic delivery
Amount £180,000 (GBP)
Funding ID EF2020\100033 
Organisation Rosetrees Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2020 
End 12/2023
 
Description WELLCOME TRUST - INSTITUTIONAL TRANSLATION PARTNERSHIP AWARD: UNIVERSITY OF CAMBRIDGE
Amount £50,000 (GBP)
Funding ID RG93172 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2019 
End 05/2020
 
Description IRC-ARM 
Organisation Arm Limited
Country United Kingdom 
Sector Private 
PI Contribution Hosting a meeting to discuss collaborative opportunities
Collaborator Contribution None as yet
Impact None as yet
Start Year 2018
 
Description IRC-AZ 
Organisation AstraZeneca
Department Research and Development AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution Expertise in the devices and chemistries being deployed as part of the project.
Collaborator Contribution AstraZeneca have provided expertise in drug delivery by providing a representative to sit on the steering committee for the project. They have also contributed by providing guidance in developing target product profiles and hosting a meeting to explore wider possibilities for collaboration. In addition to in-kind support AstraZeneca have also provided substantial additional funding for translation work on hydrogels for the treatment of glioblastoma
Impact This is a multidisciplinary collaboration involving engineers, chemists and clinicians. The main outcome of the collaboration to-date has been to assist in shaping the strategic direction of the IRC.
Start Year 2019
 
Description IRC-CPI 
Organisation Centre for Process Innovation (CPI)
Country United Kingdom 
Sector Private 
PI Contribution Expertise in the technologies we are developing
Collaborator Contribution Expertise in high value manufacturing
Impact Assistance in shaping the approach we have taken to the manufacturing challenges associated with the project
Start Year 2019
 
Description IRC-MDC 
Organisation Medicines Discovery Catapult
Country United Kingdom 
Sector Private 
PI Contribution Expertise in the drug delivery technologies being developed
Collaborator Contribution Assistance in identifying possible additional project partners
Impact Contacts made with potential industrial collaborators
Start Year 2018
 
Description IRC-NPL 
Organisation National Physical Laboratory
Country United Kingdom 
Sector Academic/University 
PI Contribution Expertise in the drug delivery technologies being developed.
Collaborator Contribution Expertise in medical instrumentation and mass spectrometry imaging
Impact No outcomes as yet
Start Year 2018
 
Description 'Summer in the CDT' talk series held by University of Nottingham 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Talk as part of seminar series given over the summer for a number of research postgraduate students at doctoral training centre.
Year(s) Of Engagement Activity 2020
 
Description BBC1 Naked scientist Question time guest 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Ljiljana Fruk joined a group of Panelist to answer the questions from the listeners concerning chemistry, nanotechnology and nano medicine in BB1 Naked scientist question time
Year(s) Of Engagement Activity 2019
URL https://www.thenakedscientists.com/podcasts/naked-scientists-podcast/extremely-curious-qna
 
Description BNOS online research workshop 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Presented 30 minute lecture virtually, then held a panel discussion with questions taken from audience located internationally.
Year(s) Of Engagement Activity 2020
 
Description Brain Tumour Charity's Research Involvement Network 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact We developed a questionnaire for patients/carers together with the Brain Tumour Charity's Research Involvement Network and establishing a panel to guide future work targeting brain cancer. Their feedback was very helpful in clarifying patient preferences for different treatment modalities.
Year(s) Of Engagement Activity 2021
 
Description CRUK Cambridge PPI panel 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Patients, carers and/or patient groups
Results and Impact We asked a PPI group to weigh in on various treatment scenarios. We received very helpful feedback on drug/imaging agent/placebo selection for hydrogels & on the design of the electrophoretic pumps
Year(s) Of Engagement Activity 2019
 
Description Cambridge Experimental Cancer Medicine Centre PPI Panel 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Patients, carers and/or patient groups
Results and Impact Presentation to Cambridge Experimental Cancer Medicine Centre Patient and Public Involvement Panel to inform them of our progress and to obtain their input on which drugs to use (tried and tested versus novel molecularly targeted therapies) and on design of implantable devices.
Year(s) Of Engagement Activity 2019
 
Description Cambridge Festival panel discussion, live activity, in-person and live-streamed event entitled 'What can we do about difficult cancers?' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact This event brought together a neurosurgeon (Mr Stephen Price), an engineer (Dr Ronan Daly) and chemists (Prof. Oren Scherman & Dr Ljiljana Fruk) to discuss the problems in delivering drugs to combat some of the most difficult to treat cancers, and how we can use new advances in engineering and chemistry to overcome them. There was also an opportunity to see simulated brain surgery to remove a tumour to help understand the challenges being addressed.
Year(s) Of Engagement Activity 2021
URL https://www.eventbrite.co.uk/e/what-can-we-do-about-difficult-cancers-tickets-182059594147#
 
Description Cambridge Philosophical Society invited lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Undergraduate students
Results and Impact Cambridge Philosophical Society talks are aimed at general public and the member of the University of Cambridge, and the lecturers are invited based on their expertise and ability to engage audiences with their chosen topic. The topic was Modern Molecular Science and how is it changing our life.
Year(s) Of Engagement Activity 2020
URL https://www.cambridgephilosophicalsociety.org/lectures-visits/modern-molecular-science-and-how-it-ch...
 
Description Cambridge Science Festival March 2019 hands-on microscopy activities for the general public (all ages) over two weekends. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact The Cambridge Science Festival is a series of events held annually in March in Cambridge, and is the United Kingdom's largest free science festival.[1] The festival attracts more than 30,000 visitors to over 250 events.[2] University researches and students open their lecture halls and laboratories to the general public, and hold Talks, Exhibitions and Demonstrations, mostly free of charge.[1]

The Marciniak lab plays a leading part in representing the Cambridge Institute for Medical Research (CIMR) in organising hands on cell biology activities. For young children these involve toys and games teaching about the structure of cells. For older children and adults, we use a variety of microscopes including fluorescence microscopy to illustrate how modern microscopy aids in the understanding of the molecular cell biology of disease.


[1] "University of Cambridge Science Festival 2011". BBC News. Retrieved 21 March 2015.
[2] "About - www.sciencefestival.cam.ac.uk". Retrieved 21 March 2015.
Year(s) Of Engagement Activity 2015,2016,2017,2018,2019
URL https://www.sciencefestival.cam.ac.uk/events/grander-view-how-modern-microscopy-illuminates-disease
 
Description Conference presentation by Dr Niamh Willis-Fox at The Inkjet Conference 2019, Dusseldorf. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact Conference presentation by Dr Niamh Willis-Fox at The Inkjet Conference 2019, Dusseldorf. This is the major industry-academic joint conference that looks at inkjet technologies.
Year(s) Of Engagement Activity 2019
 
Description Conference to celebrate the international day of Women and Girls in Science 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact The online conference was organised by ICESCO (Islamic World Educational, Scientific and Cultural Organisation) and live-streamed from Marocco. The guests included high-ranking politicians, prominent scientists including Nobel price winners and policymakers. It was aimed at the celebration of the international day of Women and girls in science and it was streamed globally reaching audiences from all over the world, and it was organised in collaboration with Leibnitz Association (Germany) and Space Foundation.
Year(s) Of Engagement Activity 2021
URL https://www.icesco.org/en/wp-content/uploads/sites/2/2019/12/Celebration-of-the-International-Day-of...
 
Description Creation and distribution of the publication - The IfM colouring book "How Stuff Gets Made". 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Creation and distribution of the publication - The IfM colouring book "How Stuff Gets Made". This outreach activity was a highly popular contribution to the Cambridge Science Festival 2019 by the postdoctoral researcher on this grant Dr. Niamh Willis-Fox.
Year(s) Of Engagement Activity 2019
 
Description IRC website 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact Website giving details of the work undertaken by the IRC, and contact details
Year(s) Of Engagement Activity 2019
 
Description Interview and summary on the role of design for manufacturing on the path from laboratory to clinic 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Manufacturing is a cross-cutting theme that runs through the IRC research programme. Dr Ronan Daly, Associate Professor in Science and Technology of Manufacturing, based at the Institute for Manufacturing at the University of Cambridge, leads this theme for the IRC, and in this interview and report describes why asking questions early in the research stage and looking ahead to manufacturing is key to getting products quickly to patients.
Year(s) Of Engagement Activity 2021
URL https://www.teddy.eng.cam.ac.uk/cancer-sight-blog/november-2021-ahead-game-role-design-manufacturing...
 
Description Invited Lecture at anniversary symposium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Gave an invited lecture as part of Prof. Bert Meijers' anniversary symposium. 250 members in the audience.
Year(s) Of Engagement Activity 2020
 
Description Keynote presentation at 18th International Conference on Nanosciences and Nanotechnologies 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote presentation: "Technology for bioelectronic medicine", 18 International Conference on Nanosciences and Nanotechnologies (N&N), July 6-9, Thessaloniki, Greece (via teleconference due to COVID restrictions).
Year(s) Of Engagement Activity 2021
URL https://www.nanotexnology.com/index.php/nn
 
Description Keynote presentation at 3rd International Conference on Flexible Electronics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote presentation: "Technology for bioelectronic medicine", 3rd International Conference on Flexible Electronics (ICFE), Nov. 12-14, 2021, Hangzhou, China (via teleconference due to COVID restrictions).
Year(s) Of Engagement Activity 2021
 
Description Keynote presentation at 72nd Annual Meeting of the International Society of Electrochemistry 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote presentation: "Electronics on the brain", 72nd Annual Meeting of the International Society of Electrochemistry, Aug. 29 - Sept. 3, 2021, Jeju Island, Korea (via teleconference due to COVID restrictions).
Year(s) Of Engagement Activity 2021
 
Description Keynote talk at Nanotexnology 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote talk at nanotechnology conference, attended by physical scientist and engineers
Year(s) Of Engagement Activity 2019
URL https://www.nanotexnology.com/2019/
 
Description Lecture to a Summer School 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact A presentation to the CDT Summer School on pancreatic cancer and the activity in EPSRC IRC.
Year(s) Of Engagement Activity 2020
 
Description MRS Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Large international conference; spoke at a symposium within the conference as invited speaker. 100-200 audience members attended talk, with healthy discussion afterwards.
Year(s) Of Engagement Activity 2019
 
Description NeuroTechX talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Talk "Electronics on the Brain" at NeuroTechX, Jan. 25, 2021, held virtually (via teleconference due to COVID restrictions).
Year(s) Of Engagement Activity 2021
URL https://neurotechx.com/
 
Description Outreach Talk at ASPIRE Research Showcase 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact Outreach Talk: "Technology for bioelectronic medicine", ASPIRE Research Showcase, Medical School, Keele University, Nov. 17, 2021, Keele, UK (via teleconference due to COVID restrictions).
Year(s) Of Engagement Activity 2021
 
Description Outreach Talk at Rosalind Franklin Conference 2021 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Undergraduate students
Results and Impact Outreach Talk: "Electronics on the brain", Rosalind Franklin Conference 2021, Newnham College, April 9, 2021, Cambridge, UK (via teleconference due to COVID restrictions).
Year(s) Of Engagement Activity 2021
 
Description Outreach Talk, IEEE Turkey Student Branches Engineering in Medicine and Biology Society Convention 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Undergraduate students
Results and Impact Outreach Talk: "Electronics on the brain", IEEE Turkey Student Branches Engineering in Medicine and Biology Society Convention, May 8, 2021, Istanbul, Turkey (via teleconference due to COVID restrictions).
Year(s) Of Engagement Activity 2021
 
Description Outreach Talk: Digitalize in Stockholm 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Outreach Talk: "Technology for bioelectronic medicine", Digitalize in Stockholm, Stockholm, Sweden, Oct. 21, 2021 (via teleconference due to COVID restrictions).
Year(s) Of Engagement Activity 2021
URL https://digitalizeinsthlm21.se/
 
Description Pint of Science talk by Ljiljana Fruk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact A presentation by Ljiljana Fruk (Co-PI on the award) as part of the Pint of Science series of talks. As well as the talk by an IRC Co- PI the event was sponsored by the IRC, publicising its activities to an audience who may not attend more formal presentations
Year(s) Of Engagement Activity 2019
 
Description Plenary Talk at British Cochlear Implant Group 2021 Virtual Meeting 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Plenary Talk: "Electronics on the Brain", British Cochlear Implant Group 2021 Virtual Meeting, May 11-12, 2021 (via teleconference due to COVID restrictions).
Year(s) Of Engagement Activity 2021
 
Description Plenary talk at EANS 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Plenary talk at the European Association of Neurosurgical Societies, attended mostly by clinicians
Year(s) Of Engagement Activity 2019
URL https://eans2019.com/
 
Description Plenary talk at Fpi14 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Plenary talk at the 14th International Symposium on Functional p-Electron Systems (Fp14) in Berlin
Year(s) Of Engagement Activity 2019
URL http://www.fpi14.de
 
Description Plenary talk at International Conference for Flexible Electronics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Plenary talk at probably largest Flexible Electronics meeting in Asia
Year(s) Of Engagement Activity 2019
URL http://icfe.gfeit.com/
 
Description Plenary talk at MNE 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Plenary talk at key microfabrication conference attended by scientists and engineers
Year(s) Of Engagement Activity 2019
URL https://www.mne2019.org/
 
Description Plenary talk at ORBITALY 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Plenary talk at ORBITALY, attended by scientists interested in applications of organic electronic materials in biology
Year(s) Of Engagement Activity 2019
URL https://www.orbitaly2019.eu/
 
Description Plenary talk at Virtual FLEX 2021 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Plenary Talk: "Electronics on the brain", Virtual FLEX 2021, Feb. 22-26, 2021 (via teleconference due to COVID restrictions).
Year(s) Of Engagement Activity 2021
URL https://flex.semi.org/
 
Description Poster given by Dr Kasapidou at RSC Macrocyclic and Supramolecular Chemistry meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact This annual meeting strives to be on the frontier of science in the field of supramolecular chemistry. The short presentation time allocated during the poster sessions offered Dr Kasapidou an excellent opportunity to highlight and showcase her research to all conference attendees, and network with fellow delegates. Dr Kasapidou was able to add to her knowledge about current state-of-the-art topics and make valuable contacts with many researchers across the UK.
Year(s) Of Engagement Activity 2019
 
Description Poster presentation by Dr Kasapidou at OxCD3 Oncological Drug Delivery Conference 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact This conference seeks to transform both clinical and industry practice in drug delivery by demonstrating the value and feasibility of engineering approaches, involving a combination of stimulus-responsive nanocarriers and medical devices, for improved tumour uptake and therapeutic outcome. The purpose of this conference in oncological drug delivery is to share the findings with the expert community, but also to identify and re-focus efforts on those therapeutic strategies. All invited key-note speakers were presenting exciting data which helped to understand the current challenges and opportunities in the field. The presentations defined and analysed the most important state-of-the-art ideas in the area of drug delivery systems. After each session the speakers listed a list of bullet points to encourage the discussion from audience. Dr Kasapidou participated in this meeting with a poster presentation, a great opportunity for her to meet and discuss with experts from this field.
Year(s) Of Engagement Activity 2019
 
Description Presentaton at the House of Lords 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact Presented our IRC to the House of Lords during day organised by EPSRC
Year(s) Of Engagement Activity 2020
 
Description Project Partners Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact A meeting to engage with potential partners with expertise in drug delivery technologies.These included small biotech companies, contract research organisations, pharma and engineering companies as well as charity representatives
Year(s) Of Engagement Activity 2019
 
Description Public presentation at Cambridge Alumni Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Gave talk on brain implants to Cambridge Alumni Festival
Year(s) Of Engagement Activity 2020
URL https://www.alumni.cam.ac.uk/festival/events/electronics-on-the-brain
 
Description Public presentation at Cambridge Society for Application of Research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Gave talk to Cambridge Society for Application of Research - https://www.csar.org.uk/ - on implantable devices for the brain
Year(s) Of Engagement Activity 2020
URL https://www.csar.org.uk/lectures/2020-2021/tbc_20201012/
 
Description Seminar - Constantin C. Coussios 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Seminar by Professor Constantin C. Coussios addressing attendees from various departments, including discussions on future collaborations
Year(s) Of Engagement Activity 2019
 
Description Seminar - Uli Weisner 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Seminar by Professor Uli Weisner (Cornell University) to research community at University of Cambridge
Year(s) Of Engagement Activity 2019
 
Description Seminar -Snow Stolnik & Cameron Alexander 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact A seminar attended by academics/researchers from various departments within University of Cambridge, followed by disucssions of how to collaborate more closely in future,
Year(s) Of Engagement Activity 2019
 
Description Seminar by Chris McConville 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Seminar on "ChemoSeed: a solid biodegradable implant for the localised treatment of glioblastoma". Pprompted discussion on regulatory pathway to the clinic.
Year(s) Of Engagement Activity 2020
 
Description Seminar by Claudia Fischbach 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Seminar entitled "Engineering models to analyze tumorstroma interactions and their relevance to cancer progression and therapy" prompted discussions on role of matrix in timour progression
Year(s) Of Engagement Activity 2021
 
Description Seminar by Hayley Francies 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Seminar entitled "Towards the next generation of cancer". Pormpted discussion on pre-clinical pathway
Year(s) Of Engagement Activity 2020
 
Description Seminar by Marco Siccardi 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact An on-line seminar by Marco Siccardi on "Mechanistic Modelling for the Prediction of Nanobiomaterial Biodistribution"
Year(s) Of Engagement Activity 2020
 
Description Seminar by Ruman Rahman 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact An online seminar titled "Targeting glioblastoma residual disease using neurosurgically-applied drug delivery systems" which lead to a new research collaboration.
Year(s) Of Engagement Activity 2020
 
Description TEDx talk Dusseldorf 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Talk by Ljiljana Fruk at TEDxKoenigsallee in Düsseldorf within the theme "Outside the Bubble"
Year(s) Of Engagement Activity 2019
 
Description TEDx talk on Nanocarriers (Duesseldorf, Germany) 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact TED platform is one of the most popular platform to highlight the ideas and personalities. I was invited to give a talk in front of 1000 audience in Duessledorf concert hall, which was distributed further on a TEDx you tube channel generating wider interest. The talk was on the topic on design of nano carriers.
Year(s) Of Engagement Activity 2019
URL https://www.youtube.com/watch?v=3QgJIuT33w0
 
Description Talk at EuroMOF 2019, Paris. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact European MOF conference
Year(s) Of Engagement Activity 2019
 
Description Talk at public outreach event organised by Fundación Ramón Areces 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Talk on symposium organised by Fundación Ramón Areces, attended by the general public
Year(s) Of Engagement Activity 2020
URL https://www.fundacionareces.es/fundacionareces/en/events/biomimetic-sensors-their-use-and-potential-...
 
Description Twitter account 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Twitter account established to dissemenate news relevant to the work of the IRC
Year(s) Of Engagement Activity 2019
 
Description Virtual booth at Festival of Tomorrow 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Held virtual booth at Festival of Tomorrow 2021
Year(s) Of Engagement Activity 2021
URL https://www.scienceswindon.com/festival-of-tomorrow