Next generation molecular imaging and therapy with radionuclides

Lead Research Organisation: King's College London
Department Name: Imaging & Biomedical Engineering

Abstract

For the last half-century doctors have routinely used radioactive drugs - radiopharmaceuticals - to detect and diagnose disease in patients and to treat cancer. This speciality is known as nuclear medicine. Modern imaging with radiopharmaceuticals is known as molecular imaging, and treating cancer with them is known as radionuclide therapy. Currently there are economic and geographical barriers, both in the UK and overseas, for patients accessing these scans and treatments. Our programme will develop technologies to perform both molecular imaging and radionuclide therapy more cost-effectively, benefitting more patients and greatly enhancing quality of information, depth of understanding of the disease, and therapeutic benefit. We will use new chemistry to make synthesis of the radiopharmaceuticals faster, more cost-effective and usable in more locations, and hence more accessible for patients. It will improve healthcare by producing and clinically translating new radioactive probes for positron emission tomography (PET), single photon emission computed tomography (SPECT) and radionuclide therapy, to harness the potential of emerging new scanners and therapeutic radionuclides, and provide a diagnostic foundation for emerging advanced therapies.
Advanced medicines such as cell-based and immune therapies, targeted drug delivery and radionuclide therapy pose new imaging challenges such as personalised profiling to optimise benefit to patients and minimise risk, and tracking the fate of drug/radionuclide carriers and therapeutic cells in the body. New alpha-emitting radionuclides for cancer therapy are impressing in early trials. New understanding of cancer heterogeneity shows that imaging a single molecular process in a tumour cannot predict treatment outcome. New generation scanners such as combined PET-MR are finding clinical utility, creating niche applications for combined modality tracers; new gamma camera designs and world-wide investment in production of technetium-99m, the staple raw material for gamma camera imaging, demand a new generation of technetium-99m tracers; and "total body PET" will emerge soon, enhancing the potential of long-lived radionuclides for cell and nanomedicine tracking. Demand for new tracers is thus greater than ever, but their short half-life (minutes/hours) means that many of them must be synthesised at the time and place of use. Except for outdated technetium-99m probes, current on-site syntheses are complex and costly, limiting availability, patient access and market size, particularly for modern biomolecule-based probes. Therefore, to grasp opportunities to improve healthcare afforded by the aforementioned advances in therapies and scanners, they must be matched by new chemistry for tracer synthesis.
This Programme will dramatically enhance patient access to molecular imaging and radionuclide therapy in both developed and low/middle-income countries, by developing and biologically evaluating faster, simpler, more efficient, kit-based biomolecule labelling with radioactive isotopes for imaging and therapy, streamlining production and reducing need for costly and complex automated synthesisers.
In addition, it will maximise future impacts of total body PET, SPECT, PET-MR by evaluating and developing the potential of multiplexed PET to harness the full potential of total body PET: combined imaging of multiple molecular targets, not just one, using fast chemistry for several very short half-live tracers in tandem in a single session to offer a new level of personalised medicine.
The programme will also enable the tracking of nanomedicines and cells within the body using long half-life radionuclides - an area where total body PET and PET-MR will be transformative). Finally, we will secure additional funding of selected probes into clinical use in heart disease, cancer, inflammation and neurodegenerative disease.

Planned Impact

The beneficiaries will be hospitals in the UK (NHS) and abroad, and their patients with various diseases including those with major socioeconomic impact - cancer, cardiovascular disease, neurodegenerative disease and other brain disorders, transplantation, metabolic disease (e.g. diabetes), inflammatory disease and infectious disease. Molecular imaging plays a role in both research in these diseases and the management of patients, while radionuclide therapy is important in cancer and arthritis. These impacts will be achieved both through development of new tracers for aspects of disease not hitherto imageable, or even not yet perceived as important; and by making tracers more widely available for diseases that can currently be imaged. This is because short-lived tracers must be synthesised on-site in the hospital; the complexity of current synthesis and labelling requires costly and complex technology and expertise that is not universally available. This Programme emphasises fast, simple synthesis, reducing dependence on costly equipment (e.g. automated synthesisers, local cyclotron), making scanning available to more hospitals and hence more patients. This applies also to therapeutic radiopharmaceuticals, particularly in LMICs where large distances make delivery of ready-made radiopharmaceuticals impractical or uneconomic. The gains in diagnostic potential will improve decision making for individual patients, and hence their quality of life and survival. They will also improve patient stratification in clinical trials and use of drugs - personalised medicine. This benefits health services by identifying patients who will or will not benefit from treatments that may be costly or impair quality of life, allowing treatments to be targeted more effectively to the right patients.

The new chemistry will benefit companies, and hence the economy and jobs, both in pharma and medical and engineering. Pharma will benefit both by direct involvement in the development and supply chain for radiopharmaceuticals (e.g. GE Healthcare, Theragnostics), and by use of molecular imaging in clinical evaluation and use of new drugs (e.g. GSK and other industrial collaborators in the drug delivery field) to stratify patients in trials and measure clinical outcomes. Engineering companies (GE Healthcare, Siemens, Philips etc.) will benefit by expansion of the market for new advanced scanners (PET-CT, PET-MR, SPECT-CT and new SPECT designs such as D-SPECT, solid-state SPECT) to hospitals far from major PET centres, and the opportunity to develop new scanning technology to complement the new tracers.

Radionuclide therapy is well-established in cancer and arthritis. Recent years have seen tantalising advances in this field using alpha-emitting radionuclides. This Programme will provide new chemistry and radiobiological insight to help apply alpha-emitters in treating cancer patients, providing benefit both to patients, pharma and companies producing the radionuclides (see letters of support for examples).

The Programme will impact on workforce training. Multidisciplinary radiochemistry and medical engineering skills, particularly for working with short half-life radionuclides, are in short supply. This is being addressed by the current EPSRC Centre for Doctoral Training (CDTs) in imaging at King's and Imperial. The Programme will provide outlets to employ and further train PhDs emerging from CDTs, as well as a setting for training a new generation of PhD students attached to the Programme. This field is also attractive for encouraging students in schools and universities into science and technology because of its interdisciplinarity (accessible from physics, chemistry, biology, engineering, medicine and mathematics backgrounds) and its clear impact on health. The Programme has activities to achieve this impact at school and undergraduate level (including supporting undergraduate research projects), and for the general public.

Publications

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Alshamrani AFA (2021) Scandium calix[n]arenes (n = 4, 6, 8): structural, cytotoxicity and ring opening polymerization studies. in Dalton transactions (Cambridge, England : 2003)

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Anbu S (2021) A Single-Pot Template Reaction Towards a Manganese-Based T1 Contrast Agent. in Angewandte Chemie (International ed. in English)

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Ashmore-Harris C (2020) Non-invasive Reporter Gene Imaging of Cell Therapies, including T Cells and Stem Cells. in Molecular therapy : the journal of the American Society of Gene Therapy

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Beatson RE (2021) TGF-ß1 potentiates V?9Vd2 T cell adoptive immunotherapy of cancer. in Cell reports. Medicine

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Blower JE (2020) Protocols for Dual Tracer PET/SPECT Preclinical Imaging. in Frontiers in physics

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Blower JE (2021) The Hantzsch reaction for nitrogen-13 PET: preparation of [13N]nifedipine and derivatives. in Chemical communications (Cambridge, England)

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Blower P (2021) Recent Highlights I

 
Description A patent has been filed for a cell-labelling kit for PET cell-tracking.
Exploitation Route The kit will be used in clinical trials of cell-based therapies by collaborators worldwide.
Sectors Healthcare,Pharmaceuticals and Medical Biotechnology

 
Description Appointment to BNMS Science and Engagement Committee
Geographic Reach National 
Policy Influence Type Participation in a guidance/advisory committee
 
Description Participation in advocacy leading to £6m treasury award to BEIS to conduct assessment and research on domestic supplies of medical radionuclides
Geographic Reach National 
Policy Influence Type Contribution to a national consultation/review
URL https://www.linkedin.com/posts/beisgovuk_lifesciences-activity-7007491663434502144-k1Lu/?utm_source=...
 
Description Publishing of guidelines to assist Nuclear Medicine Specialists in performing Lacrimal Scitigraphy
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
 
Description Strategic Advisory Committee member on Total Body PET for Medical Research Council
Geographic Reach National 
Policy Influence Type Contribution to a national consultation/review
Impact Government funding for infrastructure grant for total body PET facilities in the UK.
URL https://www.ukri.org/opportunity/establish-a-total-body-pet-facility/
 
Description Subject matter expert to Chief Scientific Advisors at Department of Health and Social Care and at Business Energy and Industrial Strategy
Geographic Reach National 
Policy Influence Type Implementation circular/rapid advice/letter to e.g. Ministry of Health
Impact There was an announcement of £6 million government investment in a Medical Radionuclide Innovation Programme (MRIP) from BEIS December 2022 https://www.linkedin.com/posts/beisgovuk_lifesciences-activity-7007491663434502144-k1Lu/?utm_source=share&utm_medium=member_desktop https://www.bnms.org.uk/news/626065/BEIS-Announcement.htm Discussion in parliament about medical radioisotope supply https://www.ipem.ac.uk/news/medical-radioisotope-supply-discussed-in-parliament/ Covered on BBC news https://www.bbc.com/news/uk-wales-64212469
 
Description White paper launch for UK Radionuclides for Health
Geographic Reach National 
Policy Influence Type Contribution to new or improved professional practice
Impact There was an announcement of £6 million government investment in a Medical Radionuclide Innovation Programme (MRIP) from BEIS December 2022 https://www.linkedin.com/posts/beisgovuk_lifesciences-activity-7007491663434502144-k1Lu/?utm_source=share&utm_medium=member_desktop (see also details listed under entry as subject matter expert to DHSC and BEIS, linked activities)
URL https://www.bartscancer.london/wp-content/uploads/2022/10/Radionuclides-for-Health-UK-FINAL.pdf
 
Description 11C and 18F labelling of novel radiotracers
Amount £559,416 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start  
 
Description A "Shake and Use" Theranostic System for Combined Radio-imaging and Photodynamic Therapy
Amount £355,094 (GBP)
Funding ID EP/T026367/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 06/2020 
End 10/2022
 
Description A multi-user radiochemical synthesis facility for molecular imaging research
Amount £908,556 (GBP)
Funding ID EP/W021307/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 07/2022 
End 06/2025
 
Description A new chemical toolbox for development of diagnostic whole body SPECT imaging agents
Amount £16,396 (GBP)
Funding ID PhD2020 100018 
Organisation Rosetrees Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2020 
End 06/2021
 
Description Assembling and investigating 201Tl radiolabelled texaphyrin nanoparticles targeted to prostate cancer cells for Auger electron radiotherapy
Amount £9,629 (GBP)
Funding ID NE/T014407/1 
Organisation Natural Environment Research Council 
Sector Public
Country United Kingdom
Start 04/2020 
End 03/2021
 
Description CCP in Synergistic Reconstruction for Biomedical Imaging
Amount £476,024 (GBP)
Funding ID EP/T026693/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 04/2020 
End 03/2025
 
Description CRUK CoL 2021 Consumables - Manufacture of tracers
Amount £50,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2021 
End 10/2021
 
Description CRUK KHP Centre
Amount £7,000 (GBP)
Funding ID C7893/A26233 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2019 
End 03/2020
 
Description CRUK KHP Centre
Amount £7,000 (GBP)
Funding ID C7893/A26233 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2020 
End 03/2021
 
Description CRUK funded studentship
Amount £149,740 (GBP)
Funding ID 2418758 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2020 
End 09/2024
 
Description Centre for Medical Engineering Extension
Amount £3,849,460 (GBP)
Organisation Wellcome / EPSRC Centre for Medical Engineering 
Sector Public
Country United Kingdom
Start 04/2022 
End 04/2027
 
Description Chemical & Radiation Hazards and Threats
Amount £337,456 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2020 
End 05/2025
 
Description CoL: CRUK City of London Centre renewal
Amount £4,489,426 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2022 
End 03/2027
 
Description Combining Precision Radiotherapy with Immunotherapy for the Treatment of Head and Neck Cancers
Amount £149,740 (GBP)
Funding ID S_4335 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2020 
End 09/2024
 
Description Combining immunotherapy and precision radiotherapy in preclinical head and neck cancer
Amount £35,000 (GBP)
Organisation Guy’s & St Thomas’ Charity 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2020 
End 12/2022
 
Description Deep-learning PET-MR longitudinal reconstruction for lower-dose antibody-imaging in the understanding and treatment of cancer
Amount £25,413 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 10/2020 
End 09/2022
 
Description Development and evaluation of Carbon-11 labeled compounds for PET imaging of Alzheimer's disease progression
Amount £15,625 (GBP)
Organisation Bodossaki Foundation 
Sector Charity/Non Profit
Country Greece
Start 07/2021 
End 06/2023
 
Description Development of a radiotracer library for measuring abnormal placental function
Amount £11,940 (GBP)
Organisation Wellcome / EPSRC Centre for Medical Engineering 
Sector Public
Country United Kingdom
Start 10/2020 
End 04/2022
 
Description Development of novel acyclic chelators for gallium-68 and scandium-44 used in PET
Amount £534,368 (GBP)
Funding ID EP/V027549/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 06/2021 
End 06/2024
 
Description Do nanoparticulate environmental pollutants enter the brain when inhaled nasally? A potential answer from SPECT and PET in humans
Amount £9,540 (GBP)
Organisation Wellcome / EPSRC Centre for Medical Engineering 
Sector Public
Country United Kingdom
Start 10/2020 
End 04/2022
 
Description Do nanoparticulate environmental pollutants enter the brain when inhaled nasally? A potential answer from SPECT and PET in humans
Amount £57,737 (GBP)
Organisation Wellcome / EPSRC Centre for Medical Engineering 
Sector Public
Country United Kingdom
Start 03/2021 
End 02/2022
 
Description Enhancing efficacy of injectable radioactive therapies with fluorouracil in neuroendocrine cancer
Amount £24,809 (GBP)
Funding ID PhD2022 100001 
Organisation Rosetrees Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2022 
End 09/2023
 
Description GSTT Charity Funding
Amount £35,000 (GBP)
Organisation Guy’s & St Thomas’ Charity 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2020 
End 12/2021
 
Description GSTT Charity Special Funding
Amount £84,377 (GBP)
Funding ID W15 and X28 
Organisation Guy’s & St Thomas’ Charity 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2021 
End 01/2023
 
Description Imaging the Redox Microenvironment to Predict Tumour Resistance to Therapy
Amount £2,407,240 (GBP)
Funding ID 220221 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2021 
End 02/2026
 
Description Imaging-guided Development of Polysarcosine-based Drug-delivery Systems
Amount £52,000 (GBP)
Funding ID 2605674 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 09/2021 
End 09/2025
 
Description Improving diagnosis and monitoring response to chelation therapy in Wilson's disease (WD) by 64Cu PET
Amount £15,900 (GBP)
Organisation Wellcome / EPSRC Centre for Medical Engineering 
Sector Public
Country United Kingdom
Start 10/2020 
End 04/2022
 
Description In vivo biodistribution of IgE antibodies as cancer biotherapeutics
Amount £7,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2019 
End 03/2020
 
Description Industrial co-funding of Studentship
Amount £85,627 (GBP)
Organisation NanoMab 
Sector Private
Country United Kingdom
Start 09/2020 
End 08/2024
 
Description KHP R&D Challenge Fund
Amount £79,999 (GBP)
Organisation King’s Health Partners 
Sector Academic/University
Country United Kingdom
Start 06/2021 
End 05/2022
 
Description King's College London - Confidence in Concept 2019
Amount £79,835 (GBP)
Funding ID MC_PC_19041 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2020 
End 03/2022
 
Description King's College London Medical Engineering Centre of Research Excellence
Amount £1,924,730 (GBP)
Funding ID 203148/A/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2022 
End 04/2024
 
Description MICA/NIRG - Radiobiology for effective alpha particle and Auger electron molecular radionuclide therapy in neuroendocrine cancer
Amount £854,965 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description Matrix metalloproteinase activated Multimodal 'Theranostic' Drug Delivery Imaging Agents for thrombosis
Amount £703,625 (GBP)
Funding ID MR/T002573/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2020 
End 03/2024
 
Description Monitoring of chemotherapeutics through smart dual 19F/1H MRI contrast agents in cancer
Amount £19,670 (GBP)
Organisation Wellcome / EPSRC Centre for Medical Engineering 
Sector Public
Country United Kingdom
Start 10/2020 
End 04/2022
 
Description New PET imaging agents to track cellular events in cancer
Amount £7,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2020 
End 03/2021
 
Description Non-invasive imaging of immune-mediated tumour ferroptosis
Amount £39,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2019 
End 03/2022
 
Description Public engagement to enhance radiotherapy research
Amount £73,061 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2022 
End 10/2024
 
Description Re-establishing the UK supply of radionuclides
Amount £49,816 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 05/2021 
End 03/2023
 
Description Research Grant
Amount £534,368 (GBP)
Funding ID EP/V027549/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 02/2021 
End 01/2024
 
Description Smart cell nuclear-localising 125/131I-labelled octreotates for sandwiched ß- and Auger-particle therapy of metastatic neuroendocrine tumours
Amount £52,073 (GBP)
Organisation GE Healthcare Limited 
Sector Academic/University
Country United Kingdom
Start 10/2020 
End 09/2024
 
Description State-of-the-art equipment for preclinical molecular imaging and targeted radiotherapy
Amount £597,916 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 11/2022 
End 03/2023
 
Description Studying metal trafficking in vivo in health and disease with PET imaging
Amount £17,490 (GBP)
Organisation Wellcome / EPSRC Centre for Medical Engineering 
Sector Public
Country United Kingdom
Start 10/2020 
End 04/2022
 
Description Understanding the role of inflammatory-derived senescent T cells during type 2 diabetes
Amount £184,055 (GBP)
Funding ID 19/0006057 
Organisation Diabetes UK 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2020 
End 03/2022
 
Description Untangling the link between cisplatin and copper trafficking with dual-isotope radionuclide imaging
Amount £13,515 (GBP)
Organisation Wellcome / EPSRC Centre for Medical Engineering 
Sector Public
Country United Kingdom
Start 10/2020 
End 04/2022
 
Description Academic Collaboration with Altra Cyclotron Services Ltd and the University of Birmingham 
Organisation Altra Cyclotron Services Ltd
Country United Kingdom 
Sector Private 
PI Contribution Collaborative work to deign new processes to produce radionuclides including; Cu-64, Zn-62 and Mn-52.
Collaborator Contribution Supply of irradiated materials that are transported to KCL for processing and production of radionuclides.
Impact Production of radionuclides that are used in further work.
Start Year 2019
 
Description Collaboration with Advanced Accelerator Applications Ltd 
Organisation Advanced Accelerator Applications
Country France 
Sector Private 
PI Contribution Have organised meetings and invited them to larger events.
Collaborator Contribution They have arranged the delivery of a spent clinical generator for Rubidium-82 from University College London Hospitals
Impact Nothing to report yet.
Start Year 2020
 
Description Collaboration with AstraZeneca 
Organisation AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution Expertise and intellectual input on novel imaging methods to develop and evaluate the novel nanoparticle-based drug delivery systems developed by the company
Collaborator Contribution In kind contribution of novel drug delivery systems and nanomedicines, expertise and intellectual inpout on these systems, access to facilities
Impact None yet
Start Year 2020
 
Description Collaboration with AstraZeneca 
Organisation AstraZeneca
Country United Kingdom 
Sector Private 
PI Contribution Expertise and intellectual input on novel imaging methods to develop and evaluate the novel nanoparticle-based drug delivery systems developed by the company
Collaborator Contribution In kind contribution of novel drug delivery systems and nanomedicines, expertise and intellectual inpout on these systems, access to facilities
Impact None yet
Start Year 2020
 
Description Collaboration with GE 
Organisation GE Healthcare Limited
Country United Kingdom 
Sector Academic/University 
PI Contribution Arrangement for GE to use facilities at KCL. Attendance to meetings and integration into the department of imaging chemistry and biology.
Collaborator Contribution Sharing of knowledge and expertise, use of FASTLAB facilities.
Impact Nothing to report yet.
Start Year 2019
 
Description Collaboration with GSK 
Organisation GlaxoSmithKline (GSK)
Country Global 
Sector Private 
PI Contribution Inviting GSK collaborators to attend meetings and work on collaborative projects using facilities at King's
Collaborator Contribution A representative from GSK has been appointed as the chair of the programme's external review board, GSK are also co-sponsoring PhD students in their research.
Impact None yet.
Start Year 2019
 
Description Collaboration with Levco Pharmaceuticals 
Organisation Levco Pharmaceuticals
Country Israel 
Sector Private 
PI Contribution Expertise and intellectual input on novel imaging methods to develop and evaluate the novel nanoparticle-based drug delivery systems developed by the company
Collaborator Contribution In kind contribution of novel drug delivery systems and nanomedicines, expertise and intellectual input on these systems, access to facilities
Impact none yet
Start Year 2021
 
Description Collaboration with LipoMedix 
Organisation Lipomedix
Country Israel 
Sector Private 
PI Contribution Expertise and intellectual input on novel imaging methods to develop and evaluate the novel nanoparticle-based drug delivery systems developed by the company
Collaborator Contribution In kind contribution of novel drug delivery systems and nanomedicines, expertise and intellectual input on these systems
Impact Man, F, Lim, L, Volpe, A, Gabizon, A, Shmeeda, H, Draper, B, Parente-Pereira, AC, Maher, J, Blower, PJ, Fruhwirth, GO & T. M. de Rosales, R*, In vivo PET Tracking of 89Zr-labeled V?9Vd2 T-cells to Mouse Xenograft Breast Tumors Activated with Liposomal Alendronate, Molecular Therapy, 2019, 27, 219-229 Gabizon AA, de Rosales RTM, La-Beck NM. Translational considerations in nanomedicine: The oncology perspective. Adv Drug Deliv Rev. 2020;158:140-157.
Start Year 2019
 
Description Collaboration with LipoMedix 
Organisation Lipomedix
Country Israel 
Sector Private 
PI Contribution Expertise and intellectual input on novel imaging methods to develop and evaluate the novel nanoparticle-based drug delivery systems developed by the company
Collaborator Contribution In kind contribution of novel drug delivery systems and nanomedicines, expertise and intellectual input on these systems
Impact Man, F, Lim, L, Volpe, A, Gabizon, A, Shmeeda, H, Draper, B, Parente-Pereira, AC, Maher, J, Blower, PJ, Fruhwirth, GO & T. M. de Rosales, R*, In vivo PET Tracking of 89Zr-labeled V?9Vd2 T-cells to Mouse Xenograft Breast Tumors Activated with Liposomal Alendronate, Molecular Therapy, 2019, 27, 219-229 Gabizon AA, de Rosales RTM, La-Beck NM. Translational considerations in nanomedicine: The oncology perspective. Adv Drug Deliv Rev. 2020;158:140-157.
Start Year 2019
 
Description Collaboration with NanoMab 
Organisation NanoMab
Country United Kingdom 
Sector Private 
PI Contribution Support of NanoMab employees to work in our department using our facilities.
Collaborator Contribution Supply of a Re-188 generator (valued at around £20k), support of a PhD student and support of clinical trials of a SPECT imaging agent.
Impact This is a multidisiplinary project, clinical and chemistry. Outputs will be recorded in time in the relevant sections.
Start Year 2019
 
Description Collaboration with Viewpoint Molecular Targeting 
Organisation Viewpoint Molecular Targeting
Country United States 
Sector Private 
PI Contribution research endeavours
Collaborator Contribution in kind provision of radionuclides, generators, proprietary compounds and expertise.
Impact N/A
Start Year 2022
 
Description Collaboration with the National Nuclear Laboratory 
Organisation National Nuclear Laboratory
Country United Kingdom 
Sector Public 
PI Contribution A collaboration between this EPRSC programme and the CRUK City of London RADNET unit supported the National Nuclear Laboratory in opening discussions with UK researchers, academics and industry on progressing an opportunity to re-establish the domestic supply of radionuclides in the UK. This would be in the form of existing stocks purified from nuclear waste, and would focus on more novel radioisotopes that are not currently routinely available, including (but not limited to) both beta and alpha particle emitters for use in molecular radiotherapy. This programme and the RADNET unit supported a roundtable meeting to discuss this, a follow up report has been prepared and a survey sent out in order to compile a list of the radionuclides of most interest to the research and user community. Funding is being sort to support more workshops and research into this.
Collaborator Contribution The NNL are a valuable collaborator and in time may be able to support the supply of radionuclides for medical therapy.
Impact Multi-disciplinary collaboration with engineers, clinicians, biologists and chemists
Start Year 2020
 
Description GE KCL research Collaboration 
Organisation GE Healthcare Limited
Country United Kingdom 
Sector Academic/University 
PI Contribution Hosting GE for collaborative research activities
Collaborator Contribution Hosting GE at our laboratory facilities
Impact ..
Start Year 2022
 
Description Innovation Hub Hong Kong 
Organisation University of Hong Kong
Country Hong Kong 
Sector Academic/University 
PI Contribution Collaborations in synthetic chemistry and chemical biology
Collaborator Contribution Collaborations in synthetic chemistry and chemical biology
Impact None yet
Start Year 2020
 
Description National Nuclear Laboratory - King's College London 
Organisation National Nuclear Laboratory
Country United Kingdom 
Sector Public 
PI Contribution NNL are co-sponsoring a PhD studentship for which I am first supervisor. In this project, we are developing new chelators for coordination of radiotherapeutic metal ions. As leading supervisor, I am directing the research chemistry.
Collaborator Contribution NNL, including an NNL supervisor, are co-supervising this project, including leading on separation chemistry of radioisotopes. They have also contributed 50% of costs of this PhD studentship.
Impact PhD studentship with research currently in progress
Start Year 2022
 
Description Precision small animal radiotherapy equipment and study 
Organisation Precision X Ray
Country United States 
Sector Private 
PI Contribution expertise in radiotherapy research
Collaborator Contribution PXI have provided a small animal precision irradiator on loan for 2 years with a net worth of £600,000. Also they have provided £75,401 towards a postdoc salary and 2 year project using the irradiator.
Impact none yet
Start Year 2021
 
Title Diphosphine Compounds and Complexes 
Description Diphosphine Compounds and Complexes 
IP Reference PCT/EP2022/072494 
Protection Patent / Patent application
Year Protection Granted
Licensed No
Impact Further development of intellectual property
 
Title 68GaDFO 
Description The product is a radiopharmaceutical for PET imaging of microbial infection. It consists of a gallium-68 complex of the siderophore desferrioxamine-B (DFO), a complex which is isostructural with the iron(III) complex of the same siderophore, and which consequently is accumulated in microorganisms that use DFO to accumulate iron. A GMP method for its radiolabelling has been developed, preclinical evaluation in vitro and in mice (using PET imaging) has been completed. The funding source for the development is the EPSRC programme grant to which this entry is attached (Next generation molecular imaging and therapy with radionuclides), combined with a PhD studentship. 
Type Diagnostic Tool - Imaging
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2020
Development Status On hold
Impact none 
 
Description Activity: International Women's Day event at University of Manchester 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Postgraduate students
Results and Impact Was one of 3 presenters at IWD event, and also participated in panel discussions around improving gender and other diversity in STEM
Year(s) Of Engagement Activity 2022
 
Description Animation video "Radiolabelling: What is it? Why does it matter?" 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact Radiopharmaceutical Sciences Olympiad Video Competition - This project was awarded with the 2nd prize at the international meeting (iSRS2022) in Nantes in May 2022.
SRS meeting: around 600 people

Online video: 378 views in the video published on youtube
Year(s) Of Engagement Activity 2022
URL https://www.youtube.com/watch?v=FX2p1KEZQYI
 
Description Annual Meeting 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Industry/Business
Results and Impact The event was intended to showcase the progress in the first year of the research programme to internal colleagues along with external academic and industrial collaborators. Of the 86 attendees, 22% were external collaborators, who gave very positive feedback of the style of the meeting and since a number of focused meetings have been conducted.
Year(s) Of Engagement Activity 2021
 
Description Arts&Science Collaboration - Anthony Gee group with Mike Barrett 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact an arts and science collaboration, which ended with a video that is published on youtube
Year(s) Of Engagement Activity 2020
URL https://vimeo.com/464248312
 
Description Blogs 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Blogs on
- A Creative Collaboration with our 'Radioactivity is Everywhere' Photography Project
- STEM4Britain
Year(s) Of Engagement Activity 2020
 
Description Blogs 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Blogs on
- A Creative Collaboration with our 'Radioactivity is Everywhere' Photography Project
- STEM4Britain
Year(s) Of Engagement Activity 2020
 
Description Brilliant Club Tutoring Program 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact KS3 (age 11-14, first 3 years of secondary school) or KS4 (GCSE years 10 and 11, aged 14-15) , tutoring in groups of 3 pupils per session, 13 weeks. linked with the government scheme to catch pupils up on subjects they have fallen behind in due to COVID (https://thebrilliantclub.org/brilliant-tutoring-programme/) I will be tutoring on the Biology Program. This is a set course where teachers pick 3 modules for you to tutor over the term to help pupils from KS3 or KS4 catch up on areas the teachers think they need help in. Its two hours a week after school, they have an assessment at the start and at the end of term and I think I will be tutoring in groups of 3 pupils per session all over Zoom or an equivalent software!
Year(s) Of Engagement Activity 2021
 
Description British Science Week twitter takeover @kingsmedicine 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Set up videos, images, and twitter posts. >2800 followers and >4500 impressions. "there was a lot more engagement on your takeover day compared to the rest of the month. So yes, a definite success!"
Year(s) Of Engagement Activity 2022
 
Description Bromley High school 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Years 1-3. All girls. 124 pupils across the 3 year groups.
Feedback collected from year 3 by getting them to write something they learnt/enjoyed on a stickynote after the session. Year 1+2 feedback to be collected by teachers. "I loved meeting the wonderful scientists and learning lots of interesting body facts" "I loved how you showed me the MRI scanner"
Year(s) Of Engagement Activity 2022
URL https://twitter.com/Sophie_Langdon6/status/1526558325319647232
 
Description CAR-T immunotherapy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact A presentation at the introductory even of Pint of Science 2019 delivered by a team member.
Year(s) Of Engagement Activity 2019
 
Description Chaired Panel Discussions at IUPAC Global Women's Breakfast, for the RSC, virtual 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chaired a panel discussion about Inclusion and Diversity in the Chemical Sciences - virtual/online
Year(s) Of Engagement Activity 2022
 
Description Chaired Panel Discussions at IUPAC Global Women's Breakfast, for the RSC, virtual 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Chaired a discussion around Breaking the Barriers (Gender Diversity) with a panel of chemists from industry, academia and PhD student.
Year(s) Of Engagement Activity 2023
 
Description Cheltenham Science Festival: 'The Inner Selfie: Cell imaging live' 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Cheltenham Science Festival. Range of ages, genders, ethnicities and accessibility needs.40 in person due to COVID restrictions, also shown live online
Year(s) Of Engagement Activity 2021
URL https://science.cheltenhamfestivals.online/events/inner-selfie-cell-imaging-live/
 
Description Chemistry - Innovating for a Better Future 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact with Sir John Lawes School, Hertfordshire
9 x classes for Y9/Y10 pupils
briefly discussed aspects of F-18 carriers for PET; teachers picked this up as examples to teach about main group chemistry
Year(s) Of Engagement Activity 2021
 
Description Civic challenge 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact King's Civic Challenge brings together teams of students, staff and local charities to co-create solutions to some of the challenges our communities face. Designed in collaboration with our partners in Lambeth, Southwark and Westminster, King's Civic Challenge invites local charities to work with the King's community to develop fresh perspectives on local issues.

Feedback: "Working with the team of researchers from King's was a unique experience. They work in a very different way to how community workers do at a grassroots level and look at things from a completely different perspective using science and statistics. They have stretched our thinking and have helped us move into this post-lockdown world in a much more strategic way" from Natalie, Head of Youth and Community Programmes, Coin Street Centre Trust. Relations have continued; we have since also worked with the Children's Centre at Coin Street to produce 2 summer workshops around 'body detectives' (ages 1 - 4 years). Based on parent feedback, they want us to come back and create workshops for older age groups.
Year(s) Of Engagement Activity 2021,2022
URL https://www.kcl.ac.uk/news/local-collaborations-between-students-staff-and-community-partners-secure...
 
Description Coin street family centre summer workshops - hot stuff /MRI scanned plant images 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Other audiences
Results and Impact adults - 11, children - 26 attended 2 workshops at the Children's Centre at Coin Street (6 months to 4 years in age).

positively received by parents and staff. Adjustments needed to make it more appropriate from early years audience. eager to do more sessions in the future. Welcomed back
Year(s) Of Engagement Activity 2022
 
Description Deutschlandfunkabout physics-informed AI for image reconstruction in Positron Emission Tomography 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact unsure
Year(s) Of Engagement Activity 2021
URL https://www.deutschlandfunk.de/krebsforschung-weniger-strahlenbelastung-durch-kuenstliche-100.html
 
Description European Research Showcase 2021 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact On the 24th and 25th September 2021, many researchers in cities across Europe opened the doors to research. They ran events to share, show, explain, or to involve their local residents, in the exciting projects they work on for the rest of the year.

However, intersections was not hosted in just 1 city, but across Europe. 360 views
Year(s) Of Engagement Activity 2021
URL https://twitter.com/globalscishow/status/1441371845018591238
 
Description European chemical society Global womens breakfast 2021 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact highlighted women in science
153 participants from 33 different countries. Most of them from Europe, of course, with Italy firmly in the first place, but also from USA (7 participants), several African countries, Australia, ...... Distribution of participants across career levels was similar for early, mid and established career. There were also 17 university students and two retired colleagues. 60% of participants attended the event due to curiosity and big majority is in favour of both proposals i.e. (i) setting up a European Chemistry Women Group and (ii) introducing annual European Women's Chat Lab
Year(s) Of Engagement Activity 2021
URL https://www.youtube.com/watch?v=tl-ZTJNaIE8&t=2715s
 
Description Final Plenary lecture at the British Nuclear Medicine Society "Molecular imaging of cardiovascular disease: Old dogs, new tricks" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Final invited plenary lecture aimed at giving an overview of our work as an example of the state of the art in new radiotracer design and validation. Presented to the national conference in nuclear imaging, comprising all members of the nuclear medicine community, from basic scientist to technician to clinician specialists and managers.
Year(s) Of Engagement Activity 2021
 
Description Gave talk and chaired Science and the Parliament at Dynamic Earth, Edinburgh 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Talk and chaired event focussed on innovation, science and technology in Scotland
Year(s) Of Engagement Activity 2022
URL https://www.rsc.org/news-events/articles/2022/nov/science-and-the-parliament-2022/
 
Description Great Exhibition Road Festival 2022 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact approximately 1000 people reached with a stand of interactive activities
Year(s) Of Engagement Activity 2022
 
Description Great Exhibition Road Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Great Exhibition Road Festival at Imperial, London
Year(s) Of Engagement Activity 2021
 
Description Great Exhibition Road Festival 2022 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Festival reaching approximately 100 people
Year(s) Of Engagement Activity 2022
 
Description I Can Be @Home 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact video portraying what it means to be a lecturer and what I do in daily life. uploaded to ECHO charity youtube account and submitted to ICan Be@Home
Year(s) Of Engagement Activity 2020
URL http://www.youtube.com/watch?v=hp12FYixbsY&list=PLvgHuyQvvcrxuwmrFhbfMxzFELnBQFr7z&index=4
 
Description I Can Be @home - Madeleine Iafrate 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact I Can Be @home - I can be a scientist video by Madeleine Iafrate
Year(s) Of Engagement Activity 2020
URL https://www.youtube.com/watch?v=W6yDyY38G1A&list=PLvgHuyQvvcrxuwmrFhbfMxzFELnBQFr7z&index=5
 
Description I'm a scientist - stay at home 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact I'm a scientist - stay at home, Gould, Sarah-May, Julia Blower and Enrico De Vita, Aishwarya Mishra and Peter Gawne - total 20 chats with school children online.
Year(s) Of Engagement Activity 2020
URL https://health20.imascientist.org.uk/2020/11/27/the-final-scientist-of-the-week-is-aishwarya-%e2%9a%...
 
Description I'm a scientist get me out of here 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact I'm a scientist get me out of here - up to 100 pupils, constant stream and online questions and dialogue
Year(s) Of Engagement Activity 2022
 
Description In2Science mentorship 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact In2Science mentorship, 3 students

The selection criteria was set by In2Science, but acording to their information for mentors "In2scienceUK exists to unlock the potential of young people from disadvantaged backgrounds and boost diversity and inclusion in the sector to ensure the UK remains at the forefront of science, technology, engineering and maths (STEM) based industries." "External evaluation shows that young people on the programme have statistically significant increases in key indicators after the programme supporting their knowledge, skills and career progression."
Allowed to develop presentation skills and how to communicate PET research to a wider audience
Student left a review "I nominate my mentor for mentor of the week because she was a great help in telling me, the life of a pharmacist and the different branches and specialties that you can go into, which was really valuable!" Details on the impact evaluation by the program can be found at https://in2scienceuk.org/impact/
Year(s) Of Engagement Activity 2021
URL https://in2scienceuk.org/
 
Description Inclusion and Diversity Panelist at GapSummit 2022, Cambridge - focussed on PhD students and ECRs in the biotech areas 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Member of the I&D Panel taking questions from the audience and discussion on I&D matters
Year(s) Of Engagement Activity 2022
 
Description International Day of Women and Girls in Science 2021 - instagram project 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact highlighted women in science - photos and quotes of women at different stages of career
Samantha Terry - Senior Lecturer
Emma Robinson - Lecturer
Truc Pham - Postdoc
Joana Do Mar Machado - PhD student
Gill Reid -Professor

Instagram radiation_hotstuff: 1479 reached, 200 likes, 51 profile visits
Twitter syaterry: 6300 impressions, 3.9% engagement
Twitter MITHRASproject: 664 impressions, 22 engagement
Year(s) Of Engagement Activity 2021
URL https://www.instagram.com/radiation_hotstuff/?hl=en
 
Description Invited Webinar to the International Society for Heart Research 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact In response to the COVID-19 lockdown, The International Society for Heart Research set up a live weekly international webinar series, where experts were invited to present their work, and engage society members with an online Q&A session. The sessions were recorded and are now hosted on the Society's youtube Channel. My invited lecture was attended by over 150 attendees, and the youtube video of the session has had 347 views to date.
Year(s) Of Engagement Activity 2020
URL https://www.youtube.com/watch?v=W4suoXUs4ZE
 
Description Invited lecture "the future of nuclear molecular imaging in cardiology" 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Invited lecture to the Centre for Advanced Biomedical Imaging at University College London.

Used as an opportunity to share our most recent research ideas and results, and to generate new ideas and opportunities for future collaboration.
Year(s) Of Engagement Activity 2022
 
Description Invited talk at the European Society for Molecular Imaging - Salzburg, Austria 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited presentation in the EMIM session on Molecular imaging in Cardiology. Work presented covers the development and characterisation of our rodent model of cardiac hypertrophy, and shows that our novel imaging agents are capable of non-invasively and longitudinally detecting the cardiac hypoxia which drives the disease.
Year(s) Of Engagement Activity 2023
 
Description King's Health Partner Summer School 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact year 11, lewisham, southwark, lambeth school kids, 40 participants. Students were asked to take photos of radioactive items as per our instagram account.

The feedback we received during and subsequently from the session demonstrated the students enjoyed the session and that they understood that research and science teams are made up of people of many different backgrounds, to get a creative environment with different points of view in the department, which fulfilled our key aims for the Summer School and session
Year(s) Of Engagement Activity 2021
URL https://www.guysandstthomasbrc.nihr.ac.uk/2021/03/30/kings-health-partners-summer-school-returns-onl...
 
Description King's Health Partner Summer School 2021 blog 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact blog
Year(s) Of Engagement Activity 2021
URL https://kingsimaging.wordpress.com/2021/08/25/kings-health-partners-summer-school-2021/#more-1037
 
Description Making the Invisible, Visible 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact 350-400 people attending the stand (150-200 children) at the Southampton Science and Engineering Festival (SOTSEF).
Year(s) Of Engagement Activity 2022
URL https://www.sotsef.co.uk/SED/whats-on/?id=61
 
Description New Scientist Live 2021 career Q&A 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact New Scientist Live 2021 career Q&A
Year(s) Of Engagement Activity 2021
URL https://www.newscientist.com/science-events/future-of-healthcare
 
Description New Scientist Live 2022 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact 1188 people were chatted to over the 3 days around radioactivity is everywhere and can be used to image and treat disease. Influenced 1-+ teachers (10+) and Astrazeneca too.
Feedback: "I've learnt lots of things that I didn't know before"
"My friend already told me that you have to eat 650 bananas a day. "? people are talking and sharing about what they learn
Year(s) Of Engagement Activity 2022
URL https://www.kcl.ac.uk/events/hospital-of-the-future-at-new-scientist-live-2022
 
Description New Scientist Live Podcast 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact New Scientist Live Podcast
Year(s) Of Engagement Activity 2021
URL https://www.newscientist.com/science-events/future-of-healthcare
 
Description Next Generation Medical Imaging: Public and Patient Involvement Advisory Group - Alex Hammers 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact PPI session around total body PET bid
Year(s) Of Engagement Activity 2022
 
Description Open day 2021 Southampton University 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact 60 students attended as a group from St Augustine's CofE School; 30 from King Solomon School
Year(s) Of Engagement Activity 2021
 
Description PPI for NIHR fellowship 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact 5 patients provided feedback on a fellowship proposal - NIHR
Year(s) Of Engagement Activity 2022
 
Description PPI group Young Person's Advisory Group 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact 3 females in year 12 gave feedback on the total body PET bid
Year(s) Of Engagement Activity 2022
 
Description Pint of Science 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Pint of science talk around use of radioactivity to image and treat cancer. Very interactive.
Year(s) Of Engagement Activity 2022
 
Description Podcast The Cost of PhDing 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Discussed the reality and financial and emotional cost of doing a PhD. Led to a petition to increase student stipends as early on as July 2022 - before the cost of living crisis and UKRI and CRUK increased the stipends.
Year(s) Of Engagement Activity 2022
URL https://theacademinist.buzzsprout.com/1007881/10886636-the-cost-of-phding-with-sophie-langdon
 
Description Poster and the Preclinal Nuclear Imaging congress, Hull, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Postgraduate students
Results and Impact Poster presentation on our demonstration that we can non-invasively imaging the cardiac hypoxia which underpins the progression of cardiac hypertrophy to heart failure
Year(s) Of Engagement Activity 2023
 
Description Publication on Lise Meitner 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Schools
Results and Impact Manuscript on Lise Meitner, the Scientist Who Changed Medicine by Splitting Atoms. Peer-reviewed by several girls ages approximately 11. Also, picked up by a secondary school student in Mexico who got in touch with the authors.
Year(s) Of Engagement Activity 2022
URL https://kids.frontiersin.org/articles/10.3389/frym.2022.722112#:~:text=Dr%20Lise%20Meitner%20discove...
 
Description Radiation Reveal workshops 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact This was a highly impactful and successful creative, collaborative, and multi-partner public engagement project, called Radiation Reveal. It brought together ten 17-25-year-olds with experience of radiotherapy with 5 researchers at Cancer Research UK RadNet City of London across three 2-hour online workshops. Our aims were to 1) initiate discussions between young adults and radiation researchers, thereby influencing research, 2) identify what people wish they had known about radiotherapy before/during treatment. These aims were surpassed; other benefits included peer support, lasting friendships, creation of support groups for others, creation and national dissemination of top 10 tips for medical professionals, e.g. therapeutic radiographers, public appearances, and social media resources.
Year(s) Of Engagement Activity 2022
URL https://www.kcl.ac.uk/news/were-young-people-first-and-patients-second-public-engagement-project-rad...
 
Description Radiation is Here Instagram project 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact photo project describing radiation is everywhere. 12 posts, 3419 accounts, 326 content interactions.
Year(s) Of Engagement Activity 2021
URL http://www.instagram.com/p/COz8ESuDT0r
 
Description RadioNuclear Episode 5: Cancer and Scientific Research 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact >50 downloads of podcast created with Aidan Michaels on all things cancer and life as a scientist
Year(s) Of Engagement Activity 2020
URL http://www.buzzsprout.com/984589/5516995-episode-5-cancer-and-scientific-research-with-dr-samantha-t...
 
Description RadioNuclear Podcast: Episode 6: Science in the Fast Lane: Life as a PhD Student with Inês Costa 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact RadioNuclear Podcast: Episode 6: Science in the Fast Lane: Life as a PhD Student with Inês Costa
Year(s) Of Engagement Activity 2020
URL https://www.buzzsprout.com/984589/5962885-episode-6-science-in-the-fast-lane-life-as-a-phd-student-w...
 
Description Research input 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact Chat with 2 patients on research direction related to radiation
Year(s) Of Engagement Activity 2022
 
Description Royal Society Summer Exhibition 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Royal Society Summer Exhibition organised online for 2020 featured in video 'Labs in lockdown: Where are they now' Live Q&A session
https://www.youtube.com/watch?v=JhN24fpwqVU
513 views
Year(s) Of Engagement Activity 2020
URL https://royalsociety.org/
 
Description Royal Society Summer Science 2020 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact >700 students watched the live release of the prerecorded video on 'What are they up to now? Hot stuff: when radioactivity is good for you'
Year(s) Of Engagement Activity 2020
URL https://www.youtube.com/watch?v=JhN24fpwqVU
 
Description STEM 4 Britain - George Firth 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact STEM4Britain poster by George Firth on PET metallomics - USING RADIOACTIVITY TO TRACK ESSENTIAL TRACE METALS IN THE BODY - Winner of Winner of The Nutrition Society Prize
Year(s) Of Engagement Activity 2020
URL https://www.youtube.com/watch?v=6P06ODyp7MM
 
Description STEM ambassador - girl's school - Aishwarya Mishra 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact STEM ambassador at a girl's school in Lambeth guiding students with a science project (30 year 9 students).
Year(s) Of Engagement Activity 2020
 
Description Solving the World's Problems with Chemistry - Careers week 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Brighton 6th Form College careers week
Year(s) Of Engagement Activity 2022
 
Description Southampton Science and Engineering Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Organisation and delivery of hands-on activities associated with structural and materials chemistry at a large scale Science and Engineering Day; ~3000 visitors in total, ~300 children together with their parents/carers/extended families participating in this activity. Discussions around atoms. structures and properties, which sparked questions.
Year(s) Of Engagement Activity 2022
URL https://www.southampton.ac.uk/per/university/festival/science-and-engineering-day.page
 
Description Tales from the lab videos 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact videos to showcase scientists at work intertwined with their story on immigrating to the UK, starting a PhD during a pandemic and having a young family at home.
Year(s) Of Engagement Activity 2021
URL https://www.youtube.com/channel/UCu1imIy8nSDuglCJ4TQDp9A/videos
 
Description The Bigger Picture Podcast 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact 4500 downloads
Year(s) Of Engagement Activity 2021
URL http://thebiggerpicture.buzzsprout.com
 
Description Twilight Gardens 2021 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact purpose: connect with local community
feedback:Inspired, waiting to soak in other people's knowledge and experience. Also made me want to grow a whole scientific mind! I did enjoy showing what I am myself good at and knowledgeable about.
Year(s) Of Engagement Activity 2021
 
Description Twilight garden - two sessions 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Reach: east Southwark. Audience - 18+ in surrey quays/ Canada water - mixed economic status, reflected some of the cultural diversity of the area

Activity description:
This was 2 sessions within the Twilight Gardening programme, which overall delivered 8 fun, informal sessions that brought researchers and local community members together to discuss health, science and nature, take part in gardening activities and eat together at Paper Garden, Canada Water, Southwark. It aimed to build trust with our local communities, giving space to be present and connect with the lived experiences of people in our local area, share health research knowledge and explore health and nature themes together. The community members responded positively to the presence of King's researchers at sessions and the opportunity find out more about the research they were doing. Outcomes included personal connections that were made researchers and community through lived experiences and strengthening the working partnership between King's and the community partner.
Year(s) Of Engagement Activity 2022
 
Description University of Southampton Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact University of Southampton Open Day
Year(s) Of Engagement Activity 2021
 
Description Westminster STEAM assembly 2021 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Peeking inside the body - medical research career panel and Q&A. Participants:
Jie Tang
Aishwarya Mishra
Joana do Mar Machado
Samantha Terry
and 8 others from BMEIS

"105 attendees in total, all post 16 students  (year 12 & year 13)

30 students attended as a school group from King Solomon Academy
60 students attended as a group from St Augustine's CofE School
10 students attended as a group from St Marylebone Bridge School

5 students attended as independent learners

3 from Harris Westminster 6th form
2 from Westminster Kingsway College"

"Westminster have been in touch to pass on their sincere thanks and appreciation to all involved as they were truly inspiring. They specifically said your stage management and execution was excellent and the event was to be a highlight of the week. 'Our Year 12 students greatly enjoyed the event.
It was particularly useful for them to hear about not just the research conducted by the team, but how each team member brought in their particular disciplinary knowledge and strengths to produce new knowledge collaboratively.
Each team member was honest about the joys and challenges of doing science, and our students asked a number of questions through the Teams channel about coping with the challenges and the necessary failures in scientific research.
Overall a very informative event!'"
Year(s) Of Engagement Activity 2021
URL https://www.eventbrite.co.uk/e/kings-college-presents-peeking-inside-the-body-tickets-143296346229
 
Description Why Chemistry? Talk and Q&A 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact Richard Huish College, Taunton
Queen Mary's College, Basingstoke
Claremont High School, Brent

Career talk online
Year(s) Of Engagement Activity 2021
 
Description Women in Stem in Bioconjugate Chemistry Interview - Dr Michelle Ma 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact This interview was published in a scientific journal to highlight Women in Stem.
Year(s) Of Engagement Activity 2019
URL https://www.facebook.com/notes/bioconjugate-chemistry/dr-michelle-ma/2307897709432693/
 
Description Work shadowing in lab - Gill Reid 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact 4 year 12 student had an open day
Year(s) Of Engagement Activity 2022