RFI Phase 2
Lead Research Organisation:
Rosalind Franklin Institute
Department Name: Research
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
People |
ORCID iD |
| James Naismith (Principal Investigator) |
Publications
Alvarez-Borges F
(2022)
Comparison of Methods to Segment Variable-Contrast XCT Images of Methane-Bearing Sand Using U-Nets Trained on Single Dataset Sub-Volumes
in Methane
Berger C
(2023)
Plasma FIB milling for the determination of structures in situ.
in Nature communications
Buchanan CJ
(2022)
Pathogen-sugar interactions revealed by universal saturation transfer analysis.
in Science (New York, N.Y.)
Chatterjee G
(2022)
Torsionally broken symmetry assists infrared excitation of biomimetic charge-coupled nuclear motions in the electronic ground state.
in Chemical science
Cobo I
(2022)
Probing Site-Selective Conjugation Chemistries for the Construction of Homogeneous Synthetic Glycodendriproteins.
in Chembiochem : a European journal of chemical biology
De Boer C
(2022)
Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo.
in Proceedings of the National Academy of Sciences of the United States of America
Ding Z
(2022)
Three-dimensional electron ptychography of organic-inorganic hybrid nanostructures.
in Nature communications
Dumoux M
(2023)
Cryo-plasma FIB/SEM volume imaging of biological specimens.
in eLife
Fu X
(2023)
Stereoretentive Post-Translational Protein Editing
in ACS Central Science
Halfon Y
(2022)
Maintaining the momentum in cryoEM for biological discovery
in Faraday Discussions
| Description | Challenge reviewer and contributor to Nurse RDI |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| Impact | The RDI review will shape government policy. |
| URL | https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1140... |
| Description | Structural Biology: From Molecules to Cells. |
| Amount | £159,340 (GBP) |
| Funding ID | 099683 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2012 |
| End | 09/2016 |
| Title | SINGLE DOMAIN ANTIBODIES THAT TARGET SARS-COV-2 |
| Description | The present invention relates to improved single domain antibodies that target SARS-CoV-2, multivalent polypeptides and fusion proteins comprising the single domain antibodies. The present invention also provides coronavirus binding molecules that bind two different epitopes on the receptor binding domain of a spike protein of a coronavirus. The coronavirus binding molecules are based on joining two antigen binding molecules together via a linker. The present invention provides the use of said single domain antibodies, multivalent polypeptides, fusion proteins and coronavirus binding molecules in treating and/or preventing coronavirus, as well as the use of said single domain antibodies, multivalent polypeptides, fusion proteins and coronavirus binding molecules in the detection and diagnosis of coronavirus using various methods, assays and kits. |
| IP Reference | WO2022053839 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2022 |
| Licensed | Commercial In Confidence |
| Impact | The patent estate is in the final stages of agreement to licence. |
| Title | rosalindfranklininstitute/guanaco: |
| Description | No description provided. |
| Type Of Technology | Software |
| Year Produced | 2021 |
| Open Source License? | Yes |
| Impact | Shaping tomography practice |
| URL | https://zenodo.org/record/5185365 |
| Title | rosalindfranklininstitute/parakeet: |
| Description | Phantom generator |
| Type Of Technology | Software |
| Year Produced | 2022 |
| Open Source License? | Yes |
| Impact | Imported into major software packages |
| URL | https://zenodo.org/record/6493567 |
| Description | Media work for science media centre |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | I have supplied expert commentary on the pandemic and on science policy. |
| Year(s) Of Engagement Activity | 2020,2021,2022,2023 |
| URL | https://www.sciencemediacentre.org/?s=naismith&cat= |