500 MHz NMR Spectrometer to Support Organic, Bio-organic and Inorganic Chemistry
Lead Research Organisation:
University of Bath
Department Name: Chemistry
Abstract
NMR spectroscopy is a key tool in the elucidation of chemical structure. A new NMR spectrometer operating at higher field (500 MHz) than currently available is required by a group of synthetic chemists interested in organic, bio-organic and inorganic chemistry. This spectrometer will facilitate new research areas in the Department of Chemistry at Bath by providing access to NMR facilities with (a) high sensitivity (somewhere in the region of a 40% increase over our current 400 MHz NMR spectrometer will be provided), (b) greater resolution that will allow resonances from more complex molecules to be separated out and (c) new hardware (for example, lower frequency nuclei can be studied, while an inverse detection probe will give higher proton sensitivity, allowing compounds only available in very small amounts to be characterised and and their structures established). Specific areas that will be enabled include the synthesis of chiral molecules, modification of peptides and proteins and the development of new catalysts.
Organisations
Publications
Guard L
(2011)
[Ru(NHC)(P-P)(CO)HF] (NHC = N-heterocyclic carbene; P-P = xantphos, dppf) complexes: Efforts to prepare new hydrodefluorination catalysts
in Journal of Organometallic Chemistry
Crittall MR
(2008)
Abnormal coordination of Arduengo's carbene upon reaction with M(3)(CO)(12) (M = Ru, Os).
in Dalton transactions (Cambridge, England : 2003)
Ellul CE
(2007)
Abnormally bound N-heterocyclic carbene complexes of ruthenium: C-H activation of both c4 and c5 positions in the same ligand.
in Angewandte Chemie (International ed. in English)
Häller L
(2009)
Activation of an Alkyl C-H Bond Geminal to an Agostic Interaction: An Unusual Mode of Base-Induced C-H Activation
in Journal of the American Chemical Society
Burling S
(2007)
C-H activation reactions of ruthenium N-heterocyclic carbene complexes: application in a catalytic tandem reaction involving C-C bond formation from alcohols.
in Journal of the American Chemical Society
Burling S
(2006)
Cationic Tris N-Heterocyclic Carbene Rhodium Carbonyl Complexes: Molecular Structures and Solution NMR Studies
in Organometallics
Batool M
(2011)
Comparison of the photochemistry of organometallic N-heterocyclic carbene and phosphine complexes of manganese.
in Chemical communications (Cambridge, England)
Collins LR
(2014)
Copper diamidocarbene complexes: characterization of monomeric to tetrameric species.
in Inorganic chemistry
Häller LJ
(2010)
Experimental and computational investigation of C-N bond activation in ruthenium N-heterocyclic carbene complexes.
in Journal of the American Chemical Society
Page MJ
(2011)
Formation and reactivity of the cyclometallated N-heterocyclic carbene complexes [Ru(NHC)'(dppe)(CO)H].
in Dalton transactions (Cambridge, England : 2003)
Häller LJ
(2009)
Formation of [Ru(NHC)4(eta(2)-O2)H]+: an unusual, high frequency hydride chemical shift and facile, reversible coordination of O2.
in Journal of the American Chemical Society
Bramananthan N
(2012)
Formation of Cyclometallated N-Heterocyclic Carbene (NHC) Complexes from L n RuCl 2 (L = Cyclooctadiene, PPh 3 , DMSO) Precursors
in European Journal of Inorganic Chemistry
Holdroyd R
(2010)
Intramolecular C-H insertion in ring-expanded N-heterocyclic carbenes
in Tetrahedron Letters
Schwartsburd L
(2014)
Mechanistic Studies of the Rhodium NHC Catalyzed Hydrodefluorination of Polyfluorotoluenes
in Organometallics
Davies CJ
(2010)
Ni(I) and Ni(II) ring-expanded N-heterocyclic carbene complexes: C-H activation, indole elimination and catalytic hydrodehalogenation.
in Chemical communications (Cambridge, England)
Ampt KA
(2006)
Photochemical isomerization of N-heterocyclic carbene ruthenium hydride complexes: in situ photolysis, parahydrogen, and computational studies.
in Journal of the American Chemical Society
Batool M
(2012)
Photochemistry of Cp'Mn(CO) 2 (NHC) (Cp' = ? 5 -C 5 H 4 Me) Species: Synthesis, Time-Resolved IR Spectroscopy, and DFT Calculations
in Organometallics
Chatwin S
(2010)
Reactivity of the N-heterocyclic carbene complexes [Ru(IMes)2(CO)HX] (X=OH, Cl) with alkynes
in Inorganica Chimica Acta
Bramananthan N
(2014)
Rh-FHF and Rh-F Complexes Containing Small N -Alkyl Substituted Six-Membered Ring N-Heterocyclic Carbenes
in Organometallics
Segarra C
(2012)
Ring-Expanded N-Heterocyclic Carbene Complexes of Rhodium with Bifluoride, Fluoride, and Fluoroaryl Ligands
in Organometallics
Armstrong R
(2010)
Ring-Expanded N-Heterocyclic Carbene Complexes of Ruthenium
in Organometallics
Poulten RC
(2014)
Stereoelectronic effects in C-H bond oxidation reactions of Ni(I) N-heterocyclic carbene complexes.
in Inorganic chemistry
Chantler VL
(2008)
Stoichiometric and catalytic reactivity of the N-heterocyclic carbene ruthenium hydride complexes [Ru(NHC)(L)(CO)HCl] and [Ru(NHC)(L)(CO)H(eta2-BH4)] (L=NHC, PPh3).
in Dalton transactions (Cambridge, England : 2003)
Davies C
(2013)
Synthesis and Small Molecule Reactivity of trans -Dihydride Isomers of Ru(NHC) 2 (PPh 3 ) 2 H 2 (NHC = N-Heterocyclic Carbene)
in Organometallics
Poulten RC
(2013)
Synthesis, electronic structure, and magnetism of [Ni(6-Mes)2]+: a two-coordinate nickel(I) complex stabilized by bulky N-heterocyclic carbenes.
in Journal of the American Chemical Society
Burling S
(2009)
The influence of N-heterocyclic carbenes (NHC) on the reactivity of [Ru(NHC)(4)H](+) with H(2), N(2), CO and O(2).
in Chemistry (Weinheim an der Bergstrasse, Germany)
Page MJ
(2013)
Three-coordinate nickel(I) complexes stabilised by six-, seven- and eight-membered ring n-heterocyclic carbenes: synthesis, EPR/DFT studies and catalytic activity.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Collins L
(2014)
Use of Ring-Expanded Diamino- and Diamidocarbene Ligands in Copper Catalyzed Azide-Alkyne "Click" Reactions
in Organometallics
Description | Range of projects covered by the instrument ranging from inorganic, organic, materials, pharmaceuticals and bilogical chemistry. |
Exploitation Route | Follow on funding as well as citations of the results by other acdemics in the literature. |
Sectors | Chemicals |
Description | Findings from research instrumentation have been used in both academic and industrial environments. Multi-user instrument so PI does not have exact details for each user. |
First Year Of Impact | 2006 |
Sector | Chemicals |
Impact Types | Societal |