Exploitation of Advanced Photonic Boisensors(EAPho-Bio- A new tool for fast and untrasensitive detection of biochemical and biomolecular interactions
Lead Research Organisation:
Aston University
Department Name: Sch of Engineering and Applied Science
Abstract
This programme proposes to carry out novel research on the exploitation of a new class of photonic biosensors for fast, sensitive and real-time detection of very small biochemical samples and the dynamic analysis of protein/protein, protein/DNA and cellular interactions. The photonic biosensors will be developed using UV and femtosecond inscribed microstructures in speciality fibres, sensitised by post-inscription processing and bioactivated using bioactive affinity techniques. It is envisaged that, when developed, the highly bio-sensitive/selective optical sensors will have potential applications in genomics, proteomics and drug discovery research and development, as well as in environmental monitoring.The proposed programme intends making to form a strong interaction between the photonics technology and lifescience applications by carrying out this project collaboratively between the Photonics Research Group and Molecular Bioscience Research Group at Aston University.L. Beneficiaries
Organisations
Publications
Chen Liu X
(2015)
EDC-Mediated Oligonucleotide Immobilization on a Long Period Grating Optical Biosensor
in Journal of Biosensors & Bioelectronics
Chen X
(2007)
Real-time detection of DNA interactions with long-period fiber-grating-based biosensor.
in Optics letters
Lai Y
(2006)
Microchannels in conventional single-mode fibers.
in Optics letters
Luo B
(2014)
Novel glucose sensor based on enzyme-immobilized 81° tilted fiber grating.
in Optics express
Yan Z
(2015)
Numerical and Experimental Analysis of Sensitivity-Enhanced RI Sensor Based on Ex-TFG in Thin Cladding Fiber
in Journal of Lightwave Technology
Zhou K
(2006)
Implementation of optical chemsensors based on HF-etched fibre Bragg grating structures
in Measurement Science and Technology