CoSMoS: Complex Systems Modelling and Simulation
Lead Research Organisation:
University of York
Department Name: Computer Science
Abstract
Our proposal builds capacity in generic modelling tools and simulation techniques for complex systems, to support the modelling, analysis and prediction of complex systems, and to help design and validate complex systems. Drawing on our state-of-the-art expertise in many aspects of computer systems engineering, we will develop CoSMoS, a modelling and simulation process and infrastructure specifically designed to allow complex systems to be explored, analysed, and designed within a uniform framework.
Publications
Alden K
(2013)
Spartan: a comprehensive tool for understanding uncertainty in simulations of biological systems.
in PLoS computational biology
Alden K
(2015)
Using argument notation to engineer biological simulations with increased confidence.
in Journal of the Royal Society, Interface
Hoverd T
(2014)
Environment orientation: a structured simulation approach for agent-based complex systems
in Natural Computing
Hoverd T
(2010)
A Transactional Architecture for Simulation
Patel A
(2012)
Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems.
in Science signaling
Pedersen J
(2018)
The symbiosis of concurrency and verification: teaching and case studies
in Formal Aspects of Computing
Polack F
(2010)
Reflections on the Simulation of Complex Systems for Science
Polack F
(2014)
Principled simulation of cell proliferation dynamics using the CoSMoS approach
in Natural Computing
Polack F
(2014)
Filling gaps in simulation of complex systems: the background and motivation for CoSMoS
in Natural Computing
Read M
(2014)
Modelling biological behaviours with the unified modelling language: an immunological case study and critique.
in Journal of the Royal Society, Interface
Read M
(2012)
Techniques for grounding agent-based simulations in the real domain: a case study in experimental autoimmune encephalomyelitis
in Mathematical and Computer Modelling of Dynamical Systems
Read M
(2013)
Determining disease intervention strategies using spatially resolved simulations.
in PloS one
Ritson C
(2010)
A process-oriented architecture for complex system modelling
in Concurrency and Computation: Practice and Experience
Stepney S
(2008)
Grand Challenge 7: Journeys in Non-Classical Computation
Stepney S
(2015)
CoSMoS special issue editorial
in Natural Computing
Stepney, Susan; Polack, Fiona; Welch, Peter
(2008)
Cosmos 2008: Complex Systems Modelling and Simulation
Susan Stepney
(2011)
Reflecting on Open-Ended Evolution
in ECAL 2011, Paris, France, August 2011
Susan Stepney (Author)
(2008)
Complex Systems Models
Susan Stepney (Author)
(2011)
CoSMoS process, models, and metamodels
Susan Stepney (Author)
(2008)
Investigating Patterns for the Process-Oriented Modelling and Simulation of Space in Complex Systems
Susan Stepney (Author)
(2011)
Multiple model simulation
Tim Hoverd
(2010)
Formalising Harmony Seeking Rules of Morphogenesis
in ALife XII, Odense, Denmark, August 2010
Tim Hoverd
(2009)
Environment orientation: an architecture for simulating complex systems
in CoSMoS workshop, York, UK, August 2009
Tim Hoverd
(2011)
Energy as a driver of diversity in open-ended evolution
in ECAL 2011, Paris, France, August 2011
Timmis J
(2008)
An interdisciplinary perspective on artificial immune systems
in Evolutionary Intelligence
Timmis J
(2010)
Editorial for special issue on the interaction between computation and biology
in Natural Computing
Timmis J
(2016)
An immune-inspired swarm aggregation algorithm for self-healing swarm robotic systems.
in Bio Systems
Wan C
(2015)
Predicting the Pro-Longevity or Anti-Longevity Effect of Model Organism Genes with New Hierarchical Feature Selection Methods.
in IEEE/ACM transactions on computational biology and bioinformatics
Welch P
(2012)
To boldly go: an occam-p mission to engineer emergence
in Natural Computing
Williams R
(2014)
Computational Models of the NF-KB Signalling Pathway
in Computation
Williams R
(2018)
Lessons learned on development and application of agent-based models of complex dynamical systems
in Simulation Modelling Practice and Theory
Williams RA
(2016)
Statistical Techniques Complement UML When Developing Domain Models of Complex Dynamical Biosystems.
in PloS one
Williams RA
(2013)
In silico investigation into dendritic cell regulation of CD8Treg mediated killing of Th1 cells in murine experimental autoimmune encephalomyelitis.
in BMC bioinformatics
Description | We have developed a new approach to building fit-for-purpose computer simulations of complex systems, and applied this to various domains, initially mainly immunology, but extending to other areas from cancer to social segregation. This new approach focuses on the early stages of the development, ensuring that domain experts are contributing early in the process, and the the purpose of the simulation is clearly captures, to allow fitness-for-purpose argumentation to be applied. |
Exploitation Route | Others can use the developed process to build and have reasonable confidence in computatioal simulations of complex systems of interest. |
Sectors | Agriculture Food and Drink Communities and Social Services/Policy Digital/Communication/Information Technologies (including Software) Education Environment Healthcare Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
URL | http://www.cs.york.ac.uk/nature/cosmos/ |
Description | Within the project, the developed process has been used mainly for simulation of immunological systems and processes. This has led to a spinoff centre: the York Centre of Computational Immunology, which has taken and further developed the approach, to integrate it into a specific experimental scientific domain. Subsequently, the spinoff company Simomics was formed, exploiting and selling the modelling and argumentation approach developed in the project. Additionally, members of the project have used the approach in their subsequent research simulation projects. |
Sector | Communities and Social Services/Policy,Digital/Communication/Information Technologies (including Software),Education,Environment,Healthcare,Pharmaceuticals and Medical Biotechnology |
Impact Types | Societal Economic |
Description | Living Technologies call of ICT EU FP7 |
Amount | € 2,629,000 (EUR) |
Funding ID | 610427 |
Organisation | European Commission |
Department | Seventh Framework Programme (FP7) |
Sector | Public |
Country | European Union (EU) |
Start | 11/2013 |
End | 10/2016 |