Follow on: Self assembling biphasic gels and hydrogels for cartilage substitution therapies
Lead Research Organisation:
University of Leeds
Department Name: Mechanical Engineering
Abstract
Over forty percent of the population suffer from degenerative osteoarthritis of hip and knee and in ten percent this can result in the need for joint replacement. Articular cartilage has unique intrinsic biphasic lubrication properties. We have recently developed a novel joint simulation system for the medial compartment of the natural knee, and have shown the importance of the biphasic surface amorphous layer in articular cartilage on the reduction of friction and wear. We have shown a reduction in friction with simple geometry cartilage specimens using patented self assembling peptide (SAP) gels. In parallel, and in collaboration with an industrial partner, we have also shown the frictional advantage of a biphasic synthetic hydrogel in comparison with single phase polymer biomaterials.In this follow on fund application we intend to converge these three pieces of basic research and use our unique natural knee simulation system to evaluate the longer term performance of patented SAPs as potential injectable therapeutic lubricants for low grade cartilage degeneration. Additionally we will combine the SAPs with the synthetic biphasic hydrogels and evaluate the enhanced tribological performance in comparison with existing cartilage substitution biomaterials. Market potential and business opportunities will be evaluated and developed by the University technology transfer partners IP2IPO, BITECIC and industrial collaborator.
Publications
Graindorge S
(2006)
The role of the surface amorphous layer of articular cartilage in joint lubrication.
in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
Northwood E
(2007)
Investigation of the friction and surface degradation of innovative chondroplasty materials against articular cartilage.
in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
Bell CJ
(2006)
Influence of hyaluronic acid on the time-dependent friction response of articular cartilage under different conditions.
in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
Katta J
(2007)
Effect of load variation on the friction properties of articular cartilage
in Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology
Bell CJ
(2006)
Self-assembling peptides as injectable lubricants for osteoarthritis.
in Journal of biomedical materials research. Part A
Li J
(2014)
Hip contact forces in asymptomatic total hip replacement patients differ from normal healthy individuals: Implications for preclinical testing
in Clinical Biomechanics
Description | Characterisation of new materials |
Exploitation Route | taken forward into a programme grant and WELMEC |
Sectors | Healthcare |
Description | applications in cartilage substitution and in spinal disc nucleus repaair |
First Year Of Impact | 2007 |
Sector | Healthcare |
Description | BITECIC Ltd |
Organisation | BITECIC Ltd |
Country | United Kingdom |
Sector | Private |
Start Year | 2006 |
Description | Depuy C M W |
Organisation | DePuy Synthes |
Country | United States |
Sector | Private |
Start Year | 2006 |