From Dynamic Combinatorial to Systems Chemistry
Lead Research Organisation:
University of Cambridge
Department Name: Chemistry
Abstract
The field of dynamic combinatorial chemistry has been growing exponentially over the last decade, with the UK playing a leading role. We have been at the forefront of this rapid expansion, thanks to uninterrupted support from the EPSRC over the last 10 years. As a result, dynamic combinatorial chemistry is now a powerful and established method for the development of synthetic receptors. But this is only part of the promise that dynamic combinatorial chemistry holds: the technique has largely untapped potential for exploring self-assembly by making use of molecular recognition between library members and for exploring the folding of synthetic molecules by making use of molecular recognition within library members. Both of these dimensions of molecular recognition should respond to externally added templates, which represents a third dimension of recognition. The first part of this grant is about developing dynamic combinatorial chemistry to study the interplay between these three dimensions. The second part explores a conceptually new area of systems chemistry, focussing on the new properties that may emerge from the interplay between molecules in a complex mixture. Through this work we aim to establish systems chemistry as a new discipline.
Publications
Cougnon FB
(2012)
Evolution of dynamic combinatorial chemistry.
in Accounts of chemical research
Cougnon FB
(2012)
Templated dynamic synthesis of a [3]catenane.
in Angewandte Chemie (International ed. in English)
Au-Yeung HY
(2010)
A water soluble donor-acceptor [2]catenane that can switch between a coplanar and a Gemini-sign conformation.
in Angewandte Chemie (International ed. in English)
Beeren SR
(2011)
From static to dynamic: escaping kinetic traps in hydrazone-based dynamic combinatorial libraries.
in Chemical communications (Cambridge, England)
Rodriguez-Docampo Z
(2011)
Dynamic combinatorial development of a neutral synthetic receptor that binds sulfate with nanomolar affinity in aqueous solution.
in Chemical communications (Cambridge, England)
Klein JM
(2011)
A remarkably flexible and selective receptor for Ba2+ amplified from a hydrazone dynamic combinatorial library.
in Chemical communications (Cambridge, England)
Beeren S
(2011)
Ferrocene-amino acid macrocycles as hydrazone-based receptors for anions
in Chemical Science
Au-Yeung H
(2010)
Exploiting donor-acceptor interactions in aqueous dynamic combinatorial libraries: exploratory studies of simple systems
in Chemical Science
Belenguer A
(2011)
Solid-state dynamic combinatorial chemistry: reversibility and thermodynamic product selection in covalent mechanosynthesis
in Chemical Science
Cougnon FB
(2012)
Structural parameters governing the dynamic combinatorial synthesis of catenanes in water.
in Journal of the American Chemical Society
Beeren SR
(2011)
Discovery of linear receptors for multiple dihydrogen phosphate ions using dynamic combinatorial chemistry.
in Journal of the American Chemical Society
Cougnon FB
(2011)
Exploring the formation pathways of donor-acceptor catenanes in aqueous dynamic combinatorial libraries.
in Journal of the American Chemical Society
Ponnuswamy N
(2014)
Homochiral and meso figure eight knots and a Solomon link.
in Journal of the American Chemical Society
Frišcic T
(2013)
Real-time and in situ monitoring of mechanochemical milling reactions.
in Nature chemistry
Klein JM
(2012)
Dynamic combinatorial libraries for the recognition of heavy metal ions.
in Organic & biomolecular chemistry
Ponnuswamy N
(2012)
Discovery of an Organic Trefoil Knot
in Science
Carnall J
(2010)
Mechanosensitive Self-Replication Driven by Self-Organization
in Science
Au-Yeung HY
(2011)
Dynamic combinatorial donor-acceptor catenanes in water: access to unconventional and unexpected structures.
in The Journal of organic chemistry
Description | How to use an evolutionary approach to study molecular recognition |
Exploitation Route | Further funding was provided by EP/J01110X/1 |
Sectors | Pharmaceuticals and Medical Biotechnology |
Description | DSTL |
Amount | £350,966 (GBP) |
Funding ID | DSTLX-1000032238 |
Organisation | Defence Science & Technology Laboratory (DSTL) |
Sector | Public |
Country | United Kingdom |
Start | 02/2010 |
End | 07/2012 |
Description | DSTL |
Amount | £350,966 (GBP) |
Funding ID | DSTLX-1000032238 |
Organisation | Defence Science & Technology Laboratory (DSTL) |
Sector | Public |
Country | United Kingdom |
Start | 02/2010 |
End | 07/2012 |
Description | EPSRC |
Amount | £836,027 (GBP) |
Funding ID | EP/J01110X/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2012 |
End | 09/2015 |
Description | European Commission (EC) |
Amount | £140,825 (GBP) |
Funding ID | 252843 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 01/2011 |
End | 12/2012 |
Description | European Commission (EC) |
Amount | £2,529,363 (GBP) |
Funding ID | 289723 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 01/2012 |
End | 12/2016 |
Description | European Commission (EC) |
Amount | £152,957 (GBP) |
Funding ID | 274181 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 02/2012 |
End | 01/2014 |
Description | European Commission (EC) |
Amount | £141,622 (GBP) |
Funding ID | 236281 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 01/2010 |
End | 12/2011 |
Description | European Commission (EC) |
Amount | £2,529,363 (GBP) |
Funding ID | 289723 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 01/2012 |
End | 12/2016 |
Description | European Commission (EC) |
Amount | £140,825 (GBP) |
Funding ID | 252843 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 01/2011 |
End | 12/2012 |
Description | European Commission (EC) |
Amount | £197,440 (GBP) |
Funding ID | 264645 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 11/2010 |
End | 10/2014 |
Description | European Commission (EC) |
Amount | £197,440 (GBP) |
Funding ID | 264645 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 11/2010 |
End | 10/2014 |
Description | European Commission (EC) |
Amount | £141,622 (GBP) |
Funding ID | 236281 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 01/2010 |
End | 12/2011 |
Description | European Commission (EC) |
Amount | £152,957 (GBP) |
Funding ID | 274181 |
Organisation | European Commission |
Sector | Public |
Country | European Union (EU) |
Start | 02/2012 |
End | 01/2014 |
Description | European Research Council |
Amount | £1,249,416 (GBP) |
Funding ID | 280030 |
Organisation | European Research Council (ERC) |
Sector | Public |
Country | Belgium |
Start | 09/2011 |
End | 08/2016 |
Description | European Research Council |
Amount | £1,249,416 (GBP) |
Funding ID | 280030 |
Organisation | European Research Council (ERC) |
Sector | Public |
Country | Belgium |
Start | 09/2011 |
End | 08/2016 |
Description | Netherlands Org for Scientific Res (NWO) |
Amount | £416,555 (GBP) |
Funding ID | 728.011.203 |
Organisation | Netherlands Organisation for Scientific Research (NWO) |
Sector | Public |
Country | Netherlands |
Start | 03/2012 |
End | 03/2016 |
Description | Netherlands Org for Scientific Res (NWO) |
Amount | £216,609 (GBP) |
Funding ID | 53448 |
Organisation | Netherlands Organisation for Scientific Research (NWO) |
Sector | Public |
Country | Netherlands |
Start | 11/2010 |
End | 10/2014 |
Description | Netherlands Org for Scientific Res (NWO) |
Amount | £216,609 (GBP) |
Funding ID | 53448 |
Organisation | Netherlands Organisation for Scientific Research (NWO) |
Sector | Public |
Country | Netherlands |
Start | 11/2010 |
End | 10/2014 |
Description | Netherlands Org for Scientific Res (NWO) |
Amount | £416,555 (GBP) |
Funding ID | 728.011.203 |
Organisation | Netherlands Organisation for Scientific Research (NWO) |
Sector | Public |
Country | Netherlands |
Start | 03/2012 |
End | 03/2016 |