Application of a High Field and High Resolution MRI to Tribological Studies of Articular Cartilage
Lead Research Organisation:
University of Leeds
Department Name: Mechanical Engineering
Abstract
Understanding the lubrication mechanism in healthy synovial joints such as hips and knees is important for not only understanding how these natural bearings operate in the human body but also developing intervention therapies. The unique load bearing material of articular cartilage in synovial joints is porous and elastic filled with water. Under loading, the interstitial water flows and supports a large percentage of external loading. The aims of this proposal are to develop and apply an advanced high resolution MRI to the lubrication studies of articular cartilage. The main objectives include the development of the MRI imaging methodology and design and development of a small scale experimental lubrication rig to be used inside the MRI to measure deformation, friction and wear. Once these methodologies are developed, applications will be made on both normal and degenerated tissues. Understanding the fluid flow and lubricating capacity for healthy and degenerated cartilage specimens in a range of loading conditions is important as cartilage substitution interventions and tissue engineering therapies are being developed. The outcome from the proposed research will provide timely guidelines for pre-clinical evaluation of these treatment options, and provide knowledge for the regulatory and standards bodies. This will have tremendous economic benefits to the UK NHS as well as clinical benefits to patients.
Organisations
Publications
Hogg P
(2015)
Development of a terminally sterilised decellularised dermis.
in Cell and tissue banking
Li J
(2014)
Hip contact forces in asymptomatic total hip replacement patients differ from normal healthy individuals: Implications for preclinical testing
in Clinical Biomechanics
Li J
(2014)
Biphasic investigation of contact mechanics in natural human hips during activities.
in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
Maiti R
(2014)
The influence of kinematic conditions and design on the wear of patella-femoral replacements.
in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
McCann L
(2009)
Influence of the meniscus on friction and degradation of cartilage in the natural knee joint.
in Osteoarthritis and cartilage
McCann L
(2009)
An investigation of the effect of conformity of knee hemiarthroplasty designs on contact stress, friction and degeneration of articular cartilage: a tribological study.
in Journal of biomechanics
Pawaskar SS
(2011)
Fluid load support and contact mechanics of hemiarthroplasty in the natural hip joint.
in Medical engineering & physics
Pawaskar SS
(2010)
Robust and general method for determining surface fluid flow boundary conditions in articular cartilage contact mechanics modeling.
in Journal of biomechanical engineering
Wang M
(2010)
A novel and non-destructive method to examine meniscus architecture using 9.4 Tesla MRI.
in Osteoarthritis and cartilage
Description | Structure of meniscus defined by high resolution MRI |
Exploitation Route | Support for developemnt acellular biological scafolds |
Sectors | Healthcare |
Description | Biocomposites |
Amount | £200,000 (GBP) |
Funding ID | LMJ |
Organisation | Biocomposites |
Sector | Private |
Country | United Kingdom |
Start | 01/2013 |
End | 01/2016 |
Description | DTC 208-2017 |
Amount | £7,000,000 (GBP) |
Funding ID | DTC |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 05/2008 |
End | 09/2017 |
Description | DTP |
Amount | £2,000,000 (GBP) |
Funding ID | DTP |
Organisation | DePuy Synthes |
Sector | Private |
Country | United States |
Start | 01/2014 |
End | 01/2016 |
Description | EPSRC cartilage programme |
Amount | £4,600,000 (GBP) |
Funding ID | EPG01121721 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 05/2009 |
End | 06/2015 |
Description | European Research Council advanced award |
Amount | £2,000,000 (GBP) |
Funding ID | Proposal 267114 |
Organisation | European Research Council (ERC) |
Sector | Public |
Country | Belgium |
Start | 03/2011 |
End | 04/2016 |
Description | IKC |
Amount | £10,000,000 (GBP) |
Funding ID | "EP G0324831, EPI0191031, EPJ0176201" |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2009 |
End | 04/2016 |
Description | LMBRU 2007 12 |
Amount | £6,700,000 (GBP) |
Funding ID | LMBRU |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 03/2007 |
End | 04/2012 |
Description | NHSBT |
Amount | £200,000 (GBP) |
Funding ID | EI |
Organisation | NHS Blood and Transplant (NHSBT) |
Sector | Public |
Country | United Kingdom |
Start | 01/2014 |
End | 01/2017 |
Description | Tissue regenix |
Amount | £60,000 (GBP) |
Funding ID | EI |
Organisation | Tissue Regenix Ltd |
Sector | Private |
Country | United Kingdom |
Start | 01/2016 |
End | 01/2018 |
Description | invibio |
Amount | £400,000 (GBP) |
Funding ID | LMJ |
Organisation | Invibio |
Sector | Private |
Country | United Kingdom |
Start | 01/2014 |
End | 12/2016 |
Description | mathys |
Amount | £400,000 (GBP) |
Funding ID | LMJ |
Organisation | Mathys |
Sector | Private |
Country | Switzerland |
Start | 01/2014 |
End | 01/2016 |
Description | senior investigator |
Amount | £100,000 (GBP) |
Funding ID | LMBRU |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 03/2014 |
End | 04/2015 |