Functional Tissue Replacement and Substitution: Platform Grant
Lead Research Organisation:
University of Leeds
Department Name: Mechanical Engineering
Abstract
Our research in functional tissue replacement and substitution addresses both major societal needs and global economic opportunities. It impacts upon a spectrum of medical interventions from functional biomaterials and devices to tissue engineered constructs. It primarily focuses on degenerative deficiencies and ageing in the musculoskeletal and cardiovascular systems, by converging physical and biological sciences and technologies to address national and international opportunities. In particular it addresses the major societal needs of the functional ageing population, which has an increased retirement age, extended working life and increased longevity, by providing devices and therapeutic interventions to sustain mobility and relieve pain. Our research addresses increased patient expectation for earlier intervention, rapid rehabilitation, increased functional demand and personalized solutions.This will be delivered though research and development of devices and therapies that enable tissue preservation and regenerative capacity and more rapid restoration of natural biomechanical function. It will apply recent advances in biological sciences and nanoscale technologies, integrating this multidisciplinary science through a systems engineering approach to new technology discovery and product innovation.The program of research will build upon our previous research in wear of joint replacements in the hip and knee, in which we have researched and developed new materials and designs to provide longer lasting joints for young and active patients. It will address new approaches to partial joint replacement, cartilage substitution and tissue engineering, which have the potential to provide earlier intervention, tissue sparing and minimally invasive surgical therapies. It will also address functional tissue substitution in the spine, through bone preserving and augmentation therapies and new articulating implants and disc replacements. Particularly important in the spine is the development of functional simulation systems to replicate in the laboratory and in computer models the complex structure and function found in vivo. In the cardiovascular system novel biomimetic tissue scaffolds, which provide functional tissue regeneration solutions for blood vessels and heart valves, will be researched, through laboratory and clinical models.
Organisations
- University of Leeds (Lead Research Organisation)
- Procter & Gamble (Collaboration)
- Simulation Solutions (Collaboration)
- Biocomposites (Collaboration)
- JRI Orthapaedics (Collaboration)
- Depuy International (Collaboration)
- Corin Group PLC (Collaboration)
- Tissue Regenix Ltd (Collaboration)
- Mathys (Collaboration)
- Invibio (Collaboration)
- Vascutek Ltd (Collaboration)
- Surgical Innovations (Collaboration)
- NHS Blood and Transplant (NHSBT) (Collaboration)
Publications
Maiti R
(2014)
The influence of kinematic conditions and design on the wear of patella-femoral replacements.
in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
Li J
(2013)
The influence of size, clearance, cartilage properties, thickness and hemiarthroplasty on the contact mechanics of the hip joint with biphasic layers.
in Journal of biomechanics
Brockett CL
(2011)
The wear of fixed and mobile bearing unicompartmental knee replacements.
in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
Song Y
(2014)
Unsupervised content classification based nonrigid registration of differently stained histology images.
in IEEE transactions on bio-medical engineering
Wijayathunga VN
(2013)
Vertebroplasty: Patient and treatment variations studied through parametric computational models.
in Clinical biomechanics (Bristol, Avon)
Al-Hajjar M
(2013)
Wear of 36-mm BIOLOX(R) delta ceramic-on-ceramic bearing in total hip replacements under edge loading conditions.
in Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
Brockett CL
(2012)
Wear of ceramic-on-carbon fiber-reinforced poly-ether ether ketone hip replacements.
in Journal of biomedical materials research. Part B, Applied biomaterials
Brockett C
(2012)
Wear of knee prostheses
in Orthopedic Research and Reviews
Brockett C
(2012)
Wear of moderately cross-linked polyethylene in fixed-bearing total knee replacements
in Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
Al-Hajjar M
(2013)
Wear of novel ceramic-on-ceramic bearings under adverse and clinically relevant hip simulator conditions.
in Journal of biomedical materials research. Part B, Applied biomaterials
Description | Defintion of a new wear law for polyethylene in knee replacements Defintion of a novel computational model to predict wear of polyethylene in the knee replacement Experimental validation of knee wearprdictions ina fullknee joint simulation Defintion of low wear and low conforming polyethylene knee designs Development of improved knee joint simulation methods and simulation sytems. Development of advanced simulation systems to predict wear in hip joints undr a wider set of operating conditions. First demonstrations of effect of variation in surgical positioning on the microseparation , edge loading and wear of hip joints. Defintion of combined effect of variation in rotational position and translational positioning on edge loading and wear of hip joint prostheses. Development of improved hip joint simulation methods and simulation sytems Development of processes for manufacture of acellular scaffolds for vascular and cardiovascular tissues, including vascualr patches, vascular grafts and heart valves. Characterisation and evaluation of the acellular scaffolds, progression to in vivo evaluations |
Exploitation Route | Developemnt of new hip and knee joint simulation sytems by Simulation Solutions Development of lower wearing joint replacements, through collaborations with industry partners, DePuy and Mathys Development of acellular scaffolds by NHS Blood and Transplant Development of acellular scaffolds by University spin out Tissue Regenix Collaborative research to develop lower wearing and longer lasting joint replacements Development of improved pre- clincial joint simulation and testing systems Development of acellular scaffolds for tissue repair derived from human tissue for tissue transplantation and from animal tissues as medical devices |
Sectors | Healthcare |
URL | http://imbe.leeds.ac.uk |
Description | Natural knee simulation system has been designed , manufactured and sold by industry partner Simulation Solutions. Patent on acellular bone tendon bone, transferred to NS BT for manufacture of acellular human tissue grafts |
First Year Of Impact | 2014 |
Sector | Healthcare |
Impact Types | Societal Economic |
Description | international standards committee chair |
Geographic Reach | Asia |
Policy Influence Type | Membership of a guideline committee |
Impact | international pre clinical testing standards |
Description | Biocomposites |
Amount | £200,000 (GBP) |
Funding ID | LMJ |
Organisation | Biocomposites |
Sector | Private |
Country | United Kingdom |
Start | 01/2013 |
End | 01/2016 |
Description | Biomedical research unit |
Amount | £6,000,000 (GBP) |
Funding ID | Leeds musculoskeletal biomedical research unit |
Organisation | National Institute for Health Research |
Sector | Public |
Country | United Kingdom |
Start | 03/2014 |
End | 03/2017 |
Description | CDT 2014-22 |
Amount | £4,000,000 (GBP) |
Funding ID | CDT TERM |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 05/2014 |
End | 09/2022 |
Description | DTC 208-2017 |
Amount | £7,000,000 (GBP) |
Funding ID | DTC |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 05/2008 |
End | 09/2017 |
Description | DTP |
Amount | £2,000,000 (GBP) |
Funding ID | DTP |
Organisation | DePuy Synthes |
Sector | Private |
Country | United States |
Start | 01/2014 |
End | 01/2016 |
Description | EPSRC cartilage programme |
Amount | £4,600,000 (GBP) |
Funding ID | EPG01121721 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 05/2009 |
End | 06/2015 |
Description | Healthcare Impact Partnership |
Amount | £1,025,492 (GBP) |
Funding ID | EP/N02480X/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 05/2016 |
End | 05/2021 |
Description | Healthcare Technologies Programme Grant |
Amount | £3,962,447 (GBP) |
Funding ID | EP/N02480X/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2016 |
End | 09/2021 |
Description | IKC |
Amount | £10,000,000 (GBP) |
Funding ID | "EP G0324831, EPI0191031, EPJ0176201" |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2009 |
End | 04/2016 |
Description | Medical engineering centre |
Amount | £4,200,000 (GBP) |
Funding ID | WELMEC |
Organisation | Wellcome Trust |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2014 |
End | 09/2015 |
Description | NHSBT |
Amount | £200,000 (GBP) |
Funding ID | EI |
Organisation | NHS Blood and Transplant (NHSBT) |
Sector | Public |
Country | United Kingdom |
Start | 01/2014 |
End | 01/2017 |
Description | Tissue regenix |
Amount | £60,000 (GBP) |
Funding ID | EI |
Organisation | Tissue Regenix Ltd |
Sector | Private |
Country | United Kingdom |
Start | 01/2016 |
End | 01/2018 |
Description | invibio |
Amount | £400,000 (GBP) |
Funding ID | LMJ |
Organisation | Invibio |
Sector | Private |
Country | United Kingdom |
Start | 01/2014 |
End | 12/2016 |
Description | mathys |
Amount | £400,000 (GBP) |
Funding ID | LMJ |
Organisation | Mathys |
Sector | Private |
Country | Switzerland |
Start | 01/2014 |
End | 01/2016 |
Title | Biomechanical and biotribological simulation model natural hip |
Description | Biomechanical and biotribological model of natural hip |
Type Of Material | Computer model/algorithm |
Year Produced | 2013 |
Provided To Others? | Yes |
Impact | used in follow on research |
Title | Biomechanical model of functional spinal unit |
Description | model of functional spinal unit |
Type Of Material | Computer model/algorithm |
Year Produced | 2014 |
Provided To Others? | Yes |
Impact | used in follow on research |
Title | Biotribological model naturala knee |
Description | Biotribological model natural knee |
Type Of Material | Computer model/algorithm |
Year Produced | 2014 |
Provided To Others? | Yes |
Impact | Used in follow on research on regenerative devices |
Title | wear simulation model artificial hip |
Description | wear simulation model artificial hip |
Type Of Material | Computer model/algorithm |
Year Produced | 2010 |
Provided To Others? | Yes |
Impact | applied in industry contract research |
Title | wear simulation model artificial knee |
Description | wear simulation model artificial knee |
Type Of Material | Computer model/algorithm |
Year Produced | 2012 |
Provided To Others? | Yes |
Impact | used in industry contract research |
Description | Biocomposites Ltd |
Organisation | Biocomposites |
Country | United Kingdom |
Sector | Private |
PI Contribution | Calcium Phosphate Bone Void Filler - A Pin-on-Plate Study; Calcium Sulphate Bone Void Filler Comparison - A Pin-on-Plate Study |
Collaborator Contribution | participate in research and publication |
Impact | Publication |
Start Year | 2014 |
Description | Corin |
Organisation | Corin Group PLC |
Country | United Kingdom |
Sector | Private |
PI Contribution | Metal on metal hip wear |
Collaborator Contribution | materials |
Impact | multidiciplinary |
Start Year | 2009 |
Description | DePuy |
Organisation | Depuy International |
Country | United Kingdom |
Sector | Private |
PI Contribution | Thirty-three projects. |
Collaborator Contribution | funds , materilas staff |
Impact | publications |
Start Year | 2013 |
Description | Depuy International Ltd |
Organisation | Depuy International |
Country | United Kingdom |
Sector | Private |
Start Year | 2004 |
Description | Invibio |
Organisation | Invibio |
Country | United Kingdom |
Sector | Private |
PI Contribution | Four projects: PEEK low con knees; Investigation of biocompatibilty of PEEK wear debris; Investigation of PEEK as cervical disc bearing material; Low Cost Polymer Knee |
Start Year | 2010 |
Description | JRI |
Organisation | JRI Orthapaedics |
Country | United Kingdom |
Sector | Private |
PI Contribution | Ceramic composite hip wear |
Start Year | 2009 |
Description | Mathys Medical |
Organisation | Mathys |
Country | Switzerland |
Sector | Private |
PI Contribution | Four projects including: Evaluation of potential ceramic matrix hips Ceramic matrix composite hip Wear of Experimental Ceramics in Total Hip Replacement - A Hip Joint Simulator Study (Mathys IV) Wear of Experimental Ceramics in Total Hip Replacement - A Hip Joint Simulator Study (Mathys V) |
Collaborator Contribution | materials , research methods , analysis |
Impact | papres |
Start Year | 2013 |
Description | NHS NBTS |
Organisation | NHS Blood and Transplant (NHSBT) |
Department | National Blood Service |
Country | United Kingdom |
Sector | Public |
PI Contribution | 8 projects in collaboration with NHS NBTS Acellular bone ligament graft (Human) Acellular bone meniscus bone graft (Human) Acellular OC graft (Human) Allo vascular graft Allo heart valve Biocompatibility of acellular allogeanic dermis Acellular allogeneic aorta Development of dCELL bone-patella-bone allograft for anterior cruciate ligament replacement |
Collaborator Contribution | funds time |
Impact | multidiciplinary |
Start Year | 2010 |
Description | National Blood Service |
Organisation | NHS Blood and Transplant (NHSBT) |
Department | National Blood Service |
Country | United Kingdom |
Sector | Public |
Start Year | 2003 |
Description | Proctor and Gamble |
Organisation | Procter & Gamble |
Country | United States |
Sector | Private |
PI Contribution | Electronic Biomarker Detection (eTect) |
Start Year | 2010 |
Description | Simulation Solutions |
Organisation | Simulation Solutions |
Country | United Kingdom |
Sector | Private |
PI Contribution | 10 projects in collaboration with Simulation Solutions: High flex knee simulator Natural knee simulator Natural hip simulator Natural spine simulator Natural joint friction simulator knee joint simulator SOP for hip simulator SOP for knee simulator Natural Knee Simulation System Electro mechanical hip simulator method SOP and training |
Collaborator Contribution | equipment development |
Impact | publications |
Start Year | 2014 |
Description | Surgical Innovations |
Organisation | Surgical Innovations |
Country | United Kingdom |
Sector | Private |
PI Contribution | A total of 4 collaborations with Surgical Innovations A new Arthroscopic Port for use in Arthroscopic Surgery applications Arthroscopic Port Environment Test Cell Design improvements to existing laparoscopy scissors Intra-Abdominal Platform (IAP) development |
Start Year | 2010 |
Description | Tissue Regenix |
Organisation | Tissue Regenix Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | A total of 12 projects collaborating with Tissue Regenix Acellular ligament graft (Animal) Acellular bone meniscus bone graft (Animal) Acellular OC graft (Animal) Xeno vascular patch Xeno heart valve Decellularised bladder Decellularised meniscus (see also 12b) Acellular porcine flexor tendon graft Development of the dCELL Partial Meniscus In vivo testing of dCell bone to determine osseointegration and biocompatibility In vivo evaluation of decellularised porcine pulmonary roots. Long Term Evaluation of an Acellular Bovine Arterial Graft in an Ovine Arteriovenous Access Model |
Start Year | 2009 |
Description | Vascutec |
Organisation | Vascutek Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | Heart valve conduit |
Start Year | 2010 |
Title | ISO accredited simulation test laboratory |
Description | ISO accredited simulation test laboratory for pre clinical testing and trials widely used by customers around globe |
Type | Support Tool - For Medical Intervention |
Current Stage Of Development | Wide-scale adoption |
Year Development Stage Completed | 2013 |
Development Status | Under active development/distribution |
Impact | uptake by wide range of companies |
Title | acellular bone |
Description | under development and in in vivo trials |
Type | Therapeutic Intervention - Medical Devices |
Current Stage Of Development | Refinement. Non-clinical |
Year Development Stage Completed | 2014 |
Development Status | Under active development/distribution |
Impact | under development and in animal trials |
Title | acellular bone cartilage osteochondral graft |
Description | under development |
Type | Therapeutic Intervention - Medical Devices |
Current Stage Of Development | Initial development |
Year Development Stage Completed | 2014 |
Development Status | Under active development/distribution |
Impact | under developemnt |
Title | acellular bone cartilage osteochondral graft |
Description | under development NHSBT |
Type | Therapeutic Intervention - Medical Devices |
Current Stage Of Development | Initial development |
Year Development Stage Completed | 2015 |
Development Status | Under active development/distribution |
Impact | under development |
Title | acellular bone patellar bone graft |
Description | under development by NHSBT |
Type | Therapeutic Intervention - Surgery |
Current Stage Of Development | Refinement. Non-clinical |
Year Development Stage Completed | 2014 |
Development Status | Under active development/distribution |
Impact | under development by NHSBT |
Title | acellular dcell vascular patch |
Description | licensed to and commercialised by Tissue Regenix |
Type | Therapeutic Intervention - Medical Devices |
Current Stage Of Development | Small-scale adoption |
Year Development Stage Completed | 2010 |
Development Status | Under active development/distribution |
Clinical Trial? | Yes |
Impact | First dcell clinical product |
URL | https://clinicaltrials.gov/show/NCT00958230 |
Title | acellular dcell dermis |
Description | commercialised by Tissue regenix from 2014 |
Type | Therapeutic Intervention - Medical Devices |
Year Development Stage Completed | 2014 |
Development Status | Under active development/distribution |
Impact | sold and distributed in USA |
Title | acellular dermis |
Description | supplied as clinical product by NHSBT |
Type | Therapeutic Intervention - Surgery |
Current Stage Of Development | Small-scale adoption |
Year Development Stage Completed | 2014 |
Development Status | Under active development/distribution |
Impact | supplied by NHSBT, improved wound healing in chronic leg ulcers |
Title | acellular heart valve |
Description | clinical application through human tissue bank |
Type | Therapeutic Intervention - Medical Devices |
Current Stage Of Development | Small-scale adoption |
Year Development Stage Completed | 2010 |
Development Status | Under active development/distribution |
Impact | proof of clinical use acellular technology |
Title | acellular vascular graft |
Description | under development by NHSBT and Tissue Regenix |
Type | Therapeutic Intervention - Medical Devices |
Current Stage Of Development | Refinement. Non-clinical |
Year Development Stage Completed | 2014 |
Development Status | Under active development/distribution |
Impact | Under development by NHSBT an dTissue Regenix |
Title | all polymer knee |
Description | collaborative development with Invibio |
Type | Therapeutic Intervention - Medical Devices |
Current Stage Of Development | Initial development |
Year Development Stage Completed | 2015 |
Development Status | Under active development/distribution |
Impact | collaborative development with Invibio |
Title | ceramic on ceramic hip |
Description | Mathys |
Type | Therapeutic Intervention - Medical Devices |
Current Stage Of Development | Market authorisation |
Year Development Stage Completed | 2012 |
Development Status | Under active development/distribution |
Impact | successfully adopted an d commercilised |
Title | ceramic on ceramic and ceramic on metal hip |
Description | commercialised by DePuy and by Mathys |
Type | Therapeutic Intervention - Medical Devices |
Year Development Stage Completed | 2015 |
Development Status | Under active development/distribution |
Impact | successfully adopted an d commercilised |
Title | dcell ligament |
Description | Under commercial development by tissue Regenix, progressing to CE mark and product launch |
Type | Therapeutic Intervention - Medical Devices |
Current Stage Of Development | Refinement. Non-clinical |
Year Development Stage Completed | 2014 |
Development Status | Under active development/distribution |
Clinical Trial? | Yes |
Impact | under commercial development by Tissue Regenix in clinical trial started 2015 proceeding to Ce mark and product launch 2017 |
URL | https://clinicaltrials.gov/show/NCT02540811 |
Title | dcell meniscus |
Description | Developed by tissue Regenix In clinical trial started 2015 |
Type | Therapeutic Intervention - Medical Devices |
Current Stage Of Development | Late clinical evaluation |
Year Development Stage Completed | 2014 |
Development Status | Under active development/distribution |
Clinical Trial? | Yes |
Impact | first in man clinical trial started 2015 |
URL | https://clinicaltrials.gov/show/NCT02270905 |
Title | finite element simulation tools to capture patient variation for the analysis of orthopaedic devices across a patient cohort |
Description | This project has been led by Dr Ruth Wilcox in partnership with Simpleware Limited. The development of the software add-on has been completed and the final validations with the Leeds data set-set are coming to an end. It is anticipated that a technology demonstrator project will now be undertaken with a company that can demonstrate the utility of the software for evaluating spinal implants. The commercial team is now engaged and discussions with Simpleware around a possible license deal are on-going. It is envisaged that as part of this license deal Simpleware will engage Leeds expertise as part of their offer to companies. In addition Leeds personnel will retain the right to undertake consultancy in their own capacity. |
Type Of Technology | Software |
Year Produced | 2013 |
Impact | further research |
Title | hip joint simulator |
Description | hip joint simulator |
Type Of Technology | Physical Model/Kit |
Year Produced | 2012 |
Impact | commercial product Simulation solutions |
Title | knee joint simulator |
Description | knee joint simulator |
Type Of Technology | Physical Model/Kit |
Year Produced | 2013 |
Impact | Commercial product simulation solutions |
Title | natural hip simulator |
Description | natural hip simulator |
Type Of Technology | Physical Model/Kit |
Year Produced | 2014 |
Impact | commercial product simulation solutions |
Title | natural knee simulator |
Description | natural knee simulator |
Type Of Technology | Physical Model/Kit |
Year Produced | 2013 |
Impact | commercialised by simulation solutions |
Title | spinal disc simulator |
Description | spinal disc simulator |
Type Of Technology | Physical Model/Kit |
Year Produced | 2010 |
Impact | commercial product simulation solutions |