The CHELL : A Bottom-Up approach to in vitro and in silico Minimal Life-like Constructs
Lead Research Organisation:
University of Oxford
Department Name: Oxford Chemistry
Abstract
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Organisations
Publications
Lee Seung Seo
(2011)
Biosynthesis of nucleoside antibiotic tunicamycin proceeds via a unique
exo-glycal intermediate
in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Lee SS
(2011)
Mechanistic evidence for a front-side, SNi-type reaction in a retaining glycosyltransferase.
in Nature chemical biology
Lercher L
(2015)
Generation of a synthetic GlcNAcylated nucleosome reveals regulation of stability by H2A-Thr101 GlcNAcylation.
in Nature communications
Lercher L
(2013)
DNA modification under mild conditions by Suzuki-Miyaura cross-coupling for the generation of functional probes.
in Angewandte Chemie (International ed. in English)
Li WW
(2011)
Tuning the cavity of cyclodextrins: altered sugar adaptors in protein pores.
in Journal of the American Chemical Society
Lin Y
(2010)
The allylic chalcogen effect in olefin metathesis
in Beilstein Journal of Organic Chemistry
Lin YA
(2010)
Olefin cross-metathesis on proteins: investigation of allylic chalcogen effects and guiding principles in metathesis partner selection.
in Journal of the American Chemical Society
Lin YA
(2009)
Olefin metathesis for site-selective protein modification.
in Chembiochem : a European journal of chemical biology
Lin YA
(2013)
Rapid cross-metathesis for reversible protein modifications via chemical access to Se-allyl-selenocysteine in proteins.
in Journal of the American Chemical Society
Liu F
(2014)
Rationally designed short polyisoprenol-linked PglB substrates for engineered polypeptide and protein N-glycosylation.
in Journal of the American Chemical Society
Lo Conte M
(2011)
Multi-molecule reaction of serum albumin can occur through thiol-yne coupling.
in Chemical communications (Cambridge, England)
Mayorkas N
(2011)
Heavy water hydration of mannose: the anomeric effect in solvation, laid bare
in Chemical Science
Mayorkas N
(2011)
Carbohydrate hydration: heavy water complexes of a and ß anomers of glucose, galactose, fucose and xylose.
in Physical chemistry chemical physics : PCCP
Monrad R
(2014)
Dissecting the reaction of Phase II metabolites of ibuprofen and other NSAIDS with human plasma protein
in Chem. Sci.
Nielsen MM
(2011)
Substrate and metal ion promiscuity in mannosylglycerate synthase.
in The Journal of biological chemistry
Nunes C
(2013)
Inhibition of SnRK1 by metabolites: tissue-dependent effects and cooperative inhibition by glucose 1-phosphate in combination with trehalose 6-phosphate.
in Plant physiology and biochemistry : PPB
Parry AL
(2013)
'Multicopy multivalent' glycopolymer-stabilized gold nanoparticles as potential synthetic cancer vaccines.
in Journal of the American Chemical Society
Parry Alison L.
(2009)
Glycopolymer-functionalized gold nanoparticles: A new strategy toward synthetic anticancer vaccines
in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Pasparakis G
(2010)
Controlled polymer synthesis--from biomimicry towards synthetic biology.
in Chemical Society reviews
Patel MK
(2010)
Flow chemistry kinetic studies reveal reaction conditions for ready access to unsymmetrical trehalose analogues.
in Organic & biomolecular chemistry
Patel MK
(2013)
Control of phosphoryl migratory transesterifications allows regioselecive access to sugar phosphates.
in Organic letters
Patel MK
(2010)
Analysis of the dispersity in carbohydrate loading of synthetic glycoproteins using MALDI-TOF mass spectrometry.
in Chemical communications (Cambridge, England)
Patel SM
(2011)
High throughput discovery of heteroaromatic-modifying enzymes allows enhancement of novobiocin selectivity.
in Chemical communications (Cambridge, England)
Pincu M
(2011)
Isotopic hydration of cellobiose: vibrational spectroscopy and dynamical simulations.
in The journal of physical chemistry. A
Pérez-Victoria I
(2015)
Glycosyldiselenides as lectin ligands detectable by NMR in biofluids.
in Chemical communications (Cambridge, England)
Description | We found that we were not only able to make an artificial chemical cell (something we called the 'chell') but that we could also create sufficient information from its metabolism for it to communicate with living (bacterial cells). This 'conversation' between artificial cells and living cells highlights that our notions of cellularity (and life) can be examined through fundamental experiments. |
Exploitation Route | These ideas have provoked various communities that examine cells right down to those who are interested in the emergence of complexity and even studying the origins of life. It provoked an analysis of the use of 'chemical cells' as potential 'living drugs', for example - see https://vimeo.com/10274649. |
Sectors | Education,Pharmaceuticals and Medical Biotechnology |
URL | http://users.ox.ac.uk/~dplb0149/index.html |
Description | BGD and group members have appeared on the radio, television, (BBD, Channel 5), newspapers (Times, New Scientist) science festivals around the world (Cheltenham, Kent, Edinburgh, Times Lit., Sydney) describing this work. We have given talks in schools to inspire the next generation. This work has been widely featured as one of the very first SynBio grants and that led to an expansion of the UK's SynBio community. It has also provoked a community of those more broadly interested in these concepts, including designers and artists - see https://vimeo.com/10274649 or http://www.daisyginsberg.com/work/synthesis-exchange-laboratory |
First Year Of Impact | 2009 |
Sector | Chemicals,Creative Economy,Education,Pharmaceuticals and Medical Biotechnology,Other |
Impact Types | Cultural,Societal,Economic,Policy & public services |
Company Name | Glycoform Ltd |
Description | drug delivery and glycoprotein specialist; biopharmaceuticals |
Impact | Employed >20 people over 10 years and provided a model for how synthetic protein drugs might be constructed and used. The technology for this company has now been used by major US companies. |
Website | http://isis-innovation.com/news/glycoform-ltd-improve-drug-delivery/ |