The CHELL : A Bottom-Up approach to in vitro and in silico Minimal Life-like Constructs
Lead Research Organisation:
University of Oxford
Department Name: Oxford Chemistry
Abstract
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Organisations
Publications
Wyszynski FJ
(2010)
Inverted regioselectivity of C-H amination: Unexpected oxidation at beta- rather than gamma-C-H.
in Organic & biomolecular chemistry
Errey JC
(2010)
Mechanistic insight into enzymatic glycosyl transfer with retention of configuration through analysis of glycomimetic inhibitors.
in Angewandte Chemie (International ed. in English)
Kemper S
(2010)
Group epitope mapping considering relaxation of the ligand (GEM-CRL): including longitudinal relaxation rates in the analysis of saturation transfer difference (STD) experiments.
in Journal of magnetic resonance (San Diego, Calif. : 1997)
Chalker JM
(2010)
Chemical mutagenesis: selective post-expression interconversion of protein amino acid residues.
in Current opinion in chemical biology
Scanlan EM
(2010)
Synthesis and solution-phase conformation of the RG-I fragment of the plant polysaccharide pectin reveals a modification-modulated assembly mechanism.
in Journal of the American Chemical Society
Wyszynski F
(2010)
Dissecting tunicamycin biosynthesis by genome mining: cloning and heterologous expression of a minimal gene cluster
in Chemical Science
Pasparakis G
(2010)
Controlled polymer synthesis--from biomimicry towards synthetic biology.
in Chemical Society reviews
Lin Y
(2010)
The allylic chalcogen effect in olefin metathesis
in Beilstein Journal of Organic Chemistry
Hong SY
(2010)
Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging.
in Nature materials
Patel MK
(2010)
Analysis of the dispersity in carbohydrate loading of synthetic glycoproteins using MALDI-TOF mass spectrometry.
in Chemical communications (Cambridge, England)
Description | We found that we were not only able to make an artificial chemical cell (something we called the 'chell') but that we could also create sufficient information from its metabolism for it to communicate with living (bacterial cells). This 'conversation' between artificial cells and living cells highlights that our notions of cellularity (and life) can be examined through fundamental experiments. |
Exploitation Route | These ideas have provoked various communities that examine cells right down to those who are interested in the emergence of complexity and even studying the origins of life. It provoked an analysis of the use of 'chemical cells' as potential 'living drugs', for example - see https://vimeo.com/10274649. |
Sectors | Education,Pharmaceuticals and Medical Biotechnology |
URL | http://users.ox.ac.uk/~dplb0149/index.html |
Description | BGD and group members have appeared on the radio, television, (BBD, Channel 5), newspapers (Times, New Scientist) science festivals around the world (Cheltenham, Kent, Edinburgh, Times Lit., Sydney) describing this work. We have given talks in schools to inspire the next generation. This work has been widely featured as one of the very first SynBio grants and that led to an expansion of the UK's SynBio community. It has also provoked a community of those more broadly interested in these concepts, including designers and artists - see https://vimeo.com/10274649 or http://www.daisyginsberg.com/work/synthesis-exchange-laboratory |
First Year Of Impact | 2009 |
Sector | Chemicals,Creative Economy,Education,Pharmaceuticals and Medical Biotechnology,Other |
Impact Types | Cultural,Societal,Economic,Policy & public services |
Company Name | Glycoform Ltd |
Description | drug delivery and glycoprotein specialist; biopharmaceuticals |
Impact | Employed >20 people over 10 years and provided a model for how synthetic protein drugs might be constructed and used. The technology for this company has now been used by major US companies. |
Website | http://isis-innovation.com/news/glycoform-ltd-improve-drug-delivery/ |