The CHELL : A Bottom-Up approach to in vitro and in silico Minimal Life-like Constructs
Lead Research Organisation:
University of Oxford
Department Name: Oxford Chemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
Publications
Nunes C
(2013)
Inhibition of SnRK1 by metabolites: tissue-dependent effects and cooperative inhibition by glucose 1-phosphate in combination with trehalose 6-phosphate.
in Plant physiology and biochemistry : PPB
Parry AL
(2013)
'Multicopy multivalent' glycopolymer-stabilized gold nanoparticles as potential synthetic cancer vaccines.
in Journal of the American Chemical Society
Parry Alison L.
(2009)
Glycopolymer-functionalized gold nanoparticles: A new strategy toward synthetic anticancer vaccines
in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
Pasparakis G
(2010)
Controlled polymer synthesis--from biomimicry towards synthetic biology.
in Chemical Society reviews
Patel MK
(2010)
Flow chemistry kinetic studies reveal reaction conditions for ready access to unsymmetrical trehalose analogues.
in Organic & biomolecular chemistry
Patel MK
(2013)
Control of phosphoryl migratory transesterifications allows regioselecive access to sugar phosphates.
in Organic letters
Patel MK
(2010)
Analysis of the dispersity in carbohydrate loading of synthetic glycoproteins using MALDI-TOF mass spectrometry.
in Chemical communications (Cambridge, England)
Patel SM
(2011)
High throughput discovery of heteroaromatic-modifying enzymes allows enhancement of novobiocin selectivity.
in Chemical communications (Cambridge, England)
Pincu M
(2011)
Isotopic hydration of cellobiose: vibrational spectroscopy and dynamical simulations.
in The journal of physical chemistry. A
PĂ©rez-Victoria I
(2015)
Glycosyldiselenides as lectin ligands detectable by NMR in biofluids.
in Chemical communications (Cambridge, England)
Description | We found that we were not only able to make an artificial chemical cell (something we called the 'chell') but that we could also create sufficient information from its metabolism for it to communicate with living (bacterial cells). This 'conversation' between artificial cells and living cells highlights that our notions of cellularity (and life) can be examined through fundamental experiments. |
Exploitation Route | These ideas have provoked various communities that examine cells right down to those who are interested in the emergence of complexity and even studying the origins of life. It provoked an analysis of the use of 'chemical cells' as potential 'living drugs', for example - see https://vimeo.com/10274649. |
Sectors | Education,Pharmaceuticals and Medical Biotechnology |
URL | http://users.ox.ac.uk/~dplb0149/index.html |
Description | BGD and group members have appeared on the radio, television, (BBD, Channel 5), newspapers (Times, New Scientist) science festivals around the world (Cheltenham, Kent, Edinburgh, Times Lit., Sydney) describing this work. We have given talks in schools to inspire the next generation. This work has been widely featured as one of the very first SynBio grants and that led to an expansion of the UK's SynBio community. It has also provoked a community of those more broadly interested in these concepts, including designers and artists - see https://vimeo.com/10274649 or http://www.daisyginsberg.com/work/synthesis-exchange-laboratory |
First Year Of Impact | 2009 |
Sector | Chemicals,Creative Economy,Education,Pharmaceuticals and Medical Biotechnology,Other |
Impact Types | Cultural,Societal,Economic,Policy & public services |
Company Name | Glycoform Ltd |
Description | drug delivery and glycoprotein specialist; biopharmaceuticals |
Impact | Employed >20 people over 10 years and provided a model for how synthetic protein drugs might be constructed and used. The technology for this company has now been used by major US companies. |
Website | http://isis-innovation.com/news/glycoform-ltd-improve-drug-delivery/ |