Alignment of Synthesis, Medicinal Chemistry and Structural Genomics to Accelerate UK Drug Discovery: Network SMS-Drug
Lead Research Organisation:
University of Strathclyde
Department Name: Pure and Applied Chemistry
Abstract
This programme will establish an Academia-Users Network in Chemical Biology to initiate, establish and nurture collaborative projects for the advancement of the drug discovery process. It aims to expand the capability of UK drug discovery, with new drug targets, new tools to validate targets and new multidisciplinary partnerships to explore the platforms, tools and targets of the future.
In the post-genomic age opportunities for the development of new clinically validated targets for drug discovery and ultimately medicines are considerable. Drug discovery resources in academia and industry are not used efficiently, to the detriment of industry and society. Duplication could be reduced, and productivity could be increased, by performing basic biology and clinical proofs of concept within open access industry-academia partnerships.
The major obstacle to clinical validation of new drug targets and the invention of new medicines is the availability and efficient delivery of small-molecules probes in order to understand the basic biology. Provision of these probes will allow for pre-clinical validation of drug targets and reduce the duplication of efforts across the pharmaceutical industry. Failures of potential drug molecules in late stage clinical trials result in enormous cost to the companies involved, the pharmaceutical industry in general and also dashes the hopes of countless patients.
A relatively poor understanding of disease mechanisms, particularly in humans, confounds the drug discovery process and represents a pivotal area of biological research. Potent, selective and cell-permeable chemical probes are valued reagents in both fundamental and applied biological research, and they are essential for preclinical target validation in academic and industrial laboratories.
Strategic alignment of academic synthetic chemists, molecular modellers and structural biologists with industrial end users will provide a blueprint for the provision of open access chemical probes to support clinical validation and drug discovery efforts within the UK.
In the post-genomic age opportunities for the development of new clinically validated targets for drug discovery and ultimately medicines are considerable. Drug discovery resources in academia and industry are not used efficiently, to the detriment of industry and society. Duplication could be reduced, and productivity could be increased, by performing basic biology and clinical proofs of concept within open access industry-academia partnerships.
The major obstacle to clinical validation of new drug targets and the invention of new medicines is the availability and efficient delivery of small-molecules probes in order to understand the basic biology. Provision of these probes will allow for pre-clinical validation of drug targets and reduce the duplication of efforts across the pharmaceutical industry. Failures of potential drug molecules in late stage clinical trials result in enormous cost to the companies involved, the pharmaceutical industry in general and also dashes the hopes of countless patients.
A relatively poor understanding of disease mechanisms, particularly in humans, confounds the drug discovery process and represents a pivotal area of biological research. Potent, selective and cell-permeable chemical probes are valued reagents in both fundamental and applied biological research, and they are essential for preclinical target validation in academic and industrial laboratories.
Strategic alignment of academic synthetic chemists, molecular modellers and structural biologists with industrial end users will provide a blueprint for the provision of open access chemical probes to support clinical validation and drug discovery efforts within the UK.
Planned Impact
This programme is a fully integrated network which will deliver the strategic alignment of academic synthetic chemists, molecular modellers and structural biologists with industrial end users to provide a blueprint for the provision of open access chemical probes to support clinical validation and drug discovery efforts within the UK. It will establish an Academia-Users Network in Chemical Biology to initiate, establish and nurture collaborative projects for the advancement of the drug discovery process. It aspires to expand the capability of UK drug discovery, with new drug targets, new tools to validate targets and new multidisciplinary partnerships to explore the platforms, tools and targets of the future.
Key to the success of this programme will be to identify funding mechanisms to deliver the resources necessary to undertake the collaborative ventures identified by the network. Working groups will be established at each interface to enable the realization of potential impact and to ensure the future success of activities initiated within this programme.
The pharmaceutical industry contributes an estimated trade balance surplus of £3.5 billion to the UK economy and is the world's third largest exporter of medicines. This research-driven industry is one of the UK's most dynamic industries and of key importance to the economy. Global spending on prescription drugs was in excess of $643 billion (2006) with emerging markets such as China, Russia, South Korea and Mexico experiencing a colossal 81% increase in expenditure during this period. Despite this huge economic driving force only 26 new drugs were launched worldwide in 2009.
Despite advances in technology and scientific understanding of biological systems, drug discovery is still a lengthy, expensive, difficult and inefficient process with a low rate of new therapeutic discovery. The cost of developing a new drug is estimated to be $1 billion (not including marketing expenses) which has also contributed to a global slowdown in drug development. In 2007 it was estimated that in the USA alone $40 billion of sales was lost by the top ten pharmaceutical companies as a result of slowdown in R&D innovation and the expiry of patents on major products.
The impact of drug development is clear. In order to maintain the UK at the forefront of world research it is essential that drug discovery efforts are underpinned by a scientific community that can provide the appropriate chemical tools, developed to perform basic fundamental biology to clinically validate potential drug targets. The need for innovative medicines acting via novel mechanisms of action to tackle debilitating disease states is essential for human health and well being. The provision and validation of new targets for chronic disease states of interest, including rheumatoid arthritis, metabolic disease, neurological disease, and cancer, will provide a focal point to the activities of this network.
Key to the success of this programme will be to identify funding mechanisms to deliver the resources necessary to undertake the collaborative ventures identified by the network. Working groups will be established at each interface to enable the realization of potential impact and to ensure the future success of activities initiated within this programme.
The pharmaceutical industry contributes an estimated trade balance surplus of £3.5 billion to the UK economy and is the world's third largest exporter of medicines. This research-driven industry is one of the UK's most dynamic industries and of key importance to the economy. Global spending on prescription drugs was in excess of $643 billion (2006) with emerging markets such as China, Russia, South Korea and Mexico experiencing a colossal 81% increase in expenditure during this period. Despite this huge economic driving force only 26 new drugs were launched worldwide in 2009.
Despite advances in technology and scientific understanding of biological systems, drug discovery is still a lengthy, expensive, difficult and inefficient process with a low rate of new therapeutic discovery. The cost of developing a new drug is estimated to be $1 billion (not including marketing expenses) which has also contributed to a global slowdown in drug development. In 2007 it was estimated that in the USA alone $40 billion of sales was lost by the top ten pharmaceutical companies as a result of slowdown in R&D innovation and the expiry of patents on major products.
The impact of drug development is clear. In order to maintain the UK at the forefront of world research it is essential that drug discovery efforts are underpinned by a scientific community that can provide the appropriate chemical tools, developed to perform basic fundamental biology to clinically validate potential drug targets. The need for innovative medicines acting via novel mechanisms of action to tackle debilitating disease states is essential for human health and well being. The provision and validation of new targets for chronic disease states of interest, including rheumatoid arthritis, metabolic disease, neurological disease, and cancer, will provide a focal point to the activities of this network.
Publications
Greaves J
(2019)
Detection of Heterogeneous Protein S-Acylation in Cells.
in Methods in molecular biology (Clifton, N.J.)
Hanson JR
(2019)
Diterpenoids of terrestrial origin.
in Natural product reports
Hassell-Hart S
(2019)
Synthesis and Biological Investigation of (+)-JD1, an Organometallic BET Bromodomain Inhibitor
in Organometallics
Jamieson LE
(2018)
Tracking intracellular uptake and localisation of alkyne tagged fatty acids using Raman spectroscopy.
in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Jones DH
(2017)
Regioselective Three-Component Reaction of Pyridine N-Oxides, Acyl Chlorides, and Cyclic Ethers.
in Organic letters
Jones DH
(2016)
Synthesis of dibenzylamino-1-methylcyclohexanol and dibenzylamino-1-trifluoromethylcyclohexanol isomers.
in Organic & biomolecular chemistry
Khalaf AI
(2011)
Amide isosteres in structure-activity studies of antibacterial minor groove binders.
in European journal of medicinal chemistry
Knapp S
(2013)
A public-private partnership to unlock the untargeted kinome.
in Nature chemical biology
Kruger FA
(2012)
Global analysis of small molecule binding to related protein targets.
in PLoS computational biology
Lang S
(2013)
Oligoamides of 2-amino-5-alkylthiazole 4-carboxylic acids: anti-trypanosomal compounds
in Medicinal Chemistry Research
Description | Key metrics from the grant include: 1. Over 1000 people from 78 organisations have engaged with SMSdrug.net. 2. Involvement from 44 universities, 19 companies, 15 other networks, 9 funding bodies. 3. Further Funding of over £5M from core members of Network. 4. 5 studentships and 3 major grants secured. 5. Members have attended events at 45 different venues. 6. ChEMBL tour visited 14 universities. 7. 196 contacts from 48 organisations have attended 16 major events. 8. 10 projects, 18 publications, and over 40 presentations on the Network from committee. 9. International involvement of the Network with Europe, North America, South America and Asia. 10. SMSdrug.net promoted at 12 Indian institutions during 2012 visit. |
Exploitation Route | The extensive research outputs from the Network will be of use to those working in the area. Working groups developed will continue beyond the duration of the grant. New funding secured through the Network will allow for further research. |
Sectors | Chemicals Healthcare Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
URL | http://www.smsdrug.net |
Description | Response to EPSRC as consultation exercise for new Centres of Doctoral Training (Nov 2012) |
Geographic Reach | National |
Policy Influence Type | Contribution to a national consultation/review |
Impact | Training/educational developments (including courses and course material) Following the identification of priority areas from the consultation, two new CDT's were established: EPSRC Centre for Doctoral Training in Physical Sciences Innovation in Chemical Biology for Bioindustry and Healthcare (EP/L015498/1) and EPSRC Centre for Doctoral Training in Advanced Therapeutics & Nanomedicines (EP/L01646X/1) |
Description | A new strategy to approach orphan disease: disrupting dominant negative activity in nuclear receptors |
Amount | £1,440 (GBP) |
Organisation | Royal Society of Chemistry |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2014 |
End | 08/2014 |
Description | Alpha-Helical Mimetics |
Amount | £92,750 (GBP) |
Funding ID | EP/M507568/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2015 |
End | 09/2019 |
Description | Cancer Research UK. Drug Discovery Project award |
Amount | £200,000 (GBP) |
Organisation | Cancer Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 05/2015 |
End | 05/2017 |
Description | DHHC drug discovery programme |
Amount | £375,000 (GBP) |
Organisation | Ono Pharmaceutical |
Sector | Private |
Country | Japan |
Start | 06/2015 |
End | 09/2019 |
Description | Fatty Acid Specificity in the DHHC Family of S-Acyltransferases: From Mechanisms to Functional Outcomes |
Amount | £460,842 (GBP) |
Funding ID | BB/L022087/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 08/2014 |
End | 09/2017 |
Description | Fatty Acid Specificity in the DHHC Family of S-Acyltransferases: From Mechanisms to Functional Outcomes |
Amount | £567,126 (GBP) |
Funding ID | BB/L022087/1 |
Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2015 |
End | 12/2018 |
Description | First in class selective IKKalpha Inhibitors for Evaluation in Pancreatic Cancer |
Amount | £200,001 (GBP) |
Organisation | Cancer Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2014 |
End | 10/2015 |
Description | First-in-class drugs for CRPC |
Amount | £249,289 (GBP) |
Organisation | Prostate Cancer UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 04/2013 |
End | 04/2016 |
Description | IKKalpha Inhibitors for the Treatment of Castrate Resistant Prostate Cancer (CRPC) and Pancreatic Cancer |
Amount | £1,230,000 (GBP) |
Funding ID | MR/M025276/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 05/2015 |
End | 05/2017 |
Description | Identification of pre-clinical SK1 inhibitors for the treatment of Pulmonary Hypertension |
Amount | £49,073 (GBP) |
Organisation | Scottish Universities Life Sciences Alliance |
Sector | Academic/University |
Country | United Kingdom |
Start | 09/2013 |
End | 10/2014 |
Description | MRC Centre for Regenerative Medicine (CRM): A hub for Engineering and exploiting the stem cell niche (April 2013) |
Amount | £4,590,070 (GBP) |
Funding ID | MR/K026666/1 |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 11/2013 |
End | 10/2017 |
Description | Neuroprotective compounds acting as antagonists at A2a receptors |
Amount | £20,000 (GBP) |
Organisation | Scottish Universities Life Sciences Alliance |
Sector | Academic/University |
Country | United Kingdom |
Start | 02/2012 |
End | 07/2012 |
Description | Rescuing p53 Mutants in Cancer |
Amount | £165,000 (GBP) |
Funding ID | 14-1002 |
Organisation | Association for International Cancer Research |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 08/2015 |
End | 08/2017 |
Description | Small Molecules to Target Stem Cells and the Niche to Improve Endogenous Repair |
Amount | £171,652 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 01/2015 |
End | 12/2016 |
Description | Small molecule regulators of the p53 interacting kinases |
Amount | £145,000 (GBP) |
Organisation | Cancer Research UK |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2015 |
End | 09/2019 |
Description | Synthesis and Evaluation of Copper probes for NPC |
Amount | £72,000 (GBP) |
Organisation | Niemann-Pick Research Foundation |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 04/2015 |
End | 04/2016 |
Description | Synthesis of Bioinorganic Probes |
Amount | £75,000 (GBP) |
Organisation | Government of Thailand |
Sector | Public |
Country | Thailand |
Start | 09/2015 |
End | 08/2018 |
Description | Joint research with University of Sussex |
Organisation | University of Sussex |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | University of Strathclyde researchers worked on this project with researchers from University of Sussex |
Start Year | 2011 |
Description | Allosteric Drug Design 30th April 2014 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Allosteric Drug Design Seminar with presentations from speakers from University of Geneva, an SME and EBI to audience of ~45 postgraduates and acadmics. Followed by a round table with 10 participants who discussed potential funding applications. This engagement led to an application for a Marie Curie fellowship in Sept 2014 by one of the participants. The event was part of Engage With Strathclyde week of events to encourage external enagement with the University of Strathclyde. |
Year(s) Of Engagement Activity | 2014 |
Description | Allosterism in Scotland 12th April 2012 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Participant : Participation in workshop, seminar, course (8 participants) Organiser : Participation in conference : Developing a UK allosteric network - University of Edinburgh. Meeting between 8 Participants from University of Edinburgh, University of Strathclyde and Koc University Turkey |
Year(s) Of Engagement Activity | 2012 |
Description | Beyond the paper resume and how to develop an online profile as a scientist |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | Beyond the paper resume and how to develop an online profile as a scientist Presented by visitor from Royal Society of Chemistry at University of Strathclyde. Audience of 25 postgraduates. Networking between RSC and University of Strathclyde |
Year(s) Of Engagement Activity | 2014 |
Description | Brighton and Sussex Cancer Working Group, meeting 15th August 2014 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | First meeting of new Brighton and Sussex Cancer Research Network Plans were made for a programme of events and set up of dedicated web page . |
Year(s) Of Engagement Activity | 2014 |
Description | CRUK Glasgow Centre and SMS Drug Network Chemical Biology-Cancer Biology Meeting 14th May 2014 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | SMSdrug.net and CRUK Beatson organised this meeting. Around 70 participants attended this event which was a series of 5 minute talks by 21 participants from across the city of Glasgow: CRUK Beatson, University of Glasgow, University of Strathclyde and NHS. The aim was to stimulate new collaborations. A follow up meeting focused towards supporting researchers to apply for CRUK Glasgow Centre development funding planned for October 2014 |
Year(s) Of Engagement Activity | 2014 |
Description | Centre for Rational Allosteric Drug Design |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | CRADD Monthly meetings CRADD: Centre for rational allosteric drug discovery Through a combined research effort of molecular modelling, informatics, synthesis, medicinal chemistry and biological evaluation across three Departments within the University of Strathclyde together with structural support provided by the SGC Oxford. This research grouping aims to: • Deliver the first in silico designed allosteric binding inhibitor for a kinase • Establish SID-MD analysis as a major tool for structure-based allosteric drug discovery through crystallographic validation • Provide a bespoke method for the identification and validation of allosteric binding sites within proteins SMSdrug Administrator organised a series of meetings for the CRADD group. Meeting Dates: 11th October 2012 06 November 2012 15 January 2013 12 March 2013 17 April 2013 30 August 2013 03 October 2013 26 November 2013 21st January 2014 20 February 2014 23 July 2014 26 September 2014 One member of this group has organised the Allosteric Drug Design Event that took place on 30th April 2014 and made an application for Marie Curie Fellowship during 2014. Another member has plans for a Placement with a Spanish group due to take place in 2015. Research efforts are ongoing so full impact unknown at this stage. |
Year(s) Of Engagement Activity | 2012,2013,2014 |
Description | ChEMBL / SMSdrug.net tour of UK Chemistry Departments (April 2013) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | ChEMBL / SMSdrug.net tour of UK Chemistry Departments: Monday 8th April 2013 University of Edinburgh, Tuesday 9th April 2013 University of Strathclyde, Wednesday 10th April 2013 Durham University & Newcastle University , Thursday 11th April 2013 University of Bradford & University of Sheffield, Friday 12th April 2013 University of Birmingham , Monday 15th April 2013 University of Nottingham & University of Warwick, Tuesday 16th April 2013 University of Bath & Cardiff University, Wednesday 17th April 2013 University of Southampton, Thursday 18th April 2013 University of Sussex, Friday 19th April 2013 University of Oxford. ~230 total audience who fed back ideas on potential improvements to ChEMBL Feedback was used for future updates of ChEMBL. |
Year(s) Of Engagement Activity | 2013 |
Description | ChEMBL Tour EU 2014 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | ChEMBL Tour EU 2014 Following the success of the 2013 ChEMBL Tour SMSdrug.net supported last year, the ChEMBL curator was supported to fundertake a 2014 ChEMBL tour. The EU 2014 tour visited mainland Europe and some dates will included a presentation on Allosteric Modulators which refer to this recent publication: van Westen GJP, Gaulton A, Overington JP (2014) Chemical, Target, and Bioactive Properties of Allosteric Modulation. PLoS Comput Biol 10(4): e1003559. doi:10.1371/journal.pcbi.1003559. Dates as follows: 19th of May - Maastricht University- Host Egon Willighagen / ChEMBL + Allosteric modulators 20th of May - Maastricht University- Host Jos Kleinjans / ChEMBL + Advanced ChEMBL 20th of May - KU Leuven - Host Pieter Annaert / ChEMBL 22nd of May - Universiteit Antwerpen - Host Koen Augusteyns / ChEMBL 26th of May - VU University Amsterdam - Host Rob Leurs & Universiteit van Amsterdam - Host Willem Stiekema / ChEMBL + Allosteric modulators 28th of May - University of Groningen - Host Alexander Domling / ChEMBL + Advanced ChEMBL 6th of June - Utrecht University - Host Roland Pieters / ChEMBL 6th of June - Universiteit Leiden - Host Ad IJzerman / ChEMBL 17th of June - Erasmus Medical Centre, Rotterdam - Host Roland Kanaar / ChEMBL 18th of June - Radboud University Nijmegen - Host Tina Ritschel / ChEMBL + Allosteric modulators Feedback via ChEMBL-og has resulted in plans for a USA leg of the tour. |
Year(s) Of Engagement Activity | 2014 |
Description | ChEMBL in Allosterism |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Member : To be assigned Teleconference to update on Allostery Working Group Progress Preparation for meeting on Predictive and Rational Allosteric Drug Design: 5th December 2012 in Edinburgh |
Year(s) Of Engagement Activity | 2012 |
Description | Chemical Probes for REV-ERBalpha |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Poster presentation at RICT 2014: Title of Meeting: Rencontres Internationales de Chemie Thérapeutique 2014 (RICT 2014): Interfacing Chemical Biology and Drug Discovery Title of poster: Chemical Probes for REV-ERBalpha Brief description of poster content: The circadian clock is responsible for the day and night cycle of many of the planet's organisms. The clock is responsible for many important biological pathways such as sleep cycles, metabolism and inflammation. It has been reported that REV-ERB? is at the centre of the circadian clock and is part of the mechanism that controls the inflammatory response and the metabolic state of the organism. Therefore further studies into the function and responses of REV-ERB? will allow a greater insight into the circadian rhythm with the ultimate goal of identifying a receptor as a therapeutic target for a broad range of diseases, including inflammation. Poster won RICT Poster Prize 2014 Details of what was won: Free attendance to RICT2015 in Avignon with 2 nights accommodation |
Year(s) Of Engagement Activity | 2014 |
Description | Chemistry Life Science Interface |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | SMSdrug / Biocity Scotland Research Opportunities Visit to Newhouse 26/11/12 |
Year(s) Of Engagement Activity | 2012 |
Description | Chemistry Life Science interface meeting (19th April 2012) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Meeting between SMSdrug.net members and BioCity Scotland. Secured follow Up meeting on 25th May 2012 at Newhouse |
Year(s) Of Engagement Activity | 2012 |
Description | Clyde CHEM |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Chair : To be assigned . Clyde CHEM meeting between University of Strathclyde and University of Glasgow Chemists PI chaired meeting |
Year(s) Of Engagement Activity | 2013 |
Description | Cooking your results with microwaves |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Professional Practitioners |
Results and Impact | Seminar: Cooking your results with microwaves, presentation by CoI at Teacher's CPD conference, University of Sussex 32 delegates Teacher's CPD conference, University of Sussex 32 delegates |
Year(s) Of Engagement Activity | 2014 |
Description | DDP and RSC Meeting Dec 2013 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Meeting between Drug Discovery Portal researchers and RSC ChemSpider team. Plans for future collaboration |
Year(s) Of Engagement Activity | 2013 |
Description | Developing Opportunities at the Chemistry-Life Science Interface |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Contributor : To be assigned . 23 - 28 April 2012 Developing Opportunities at the Chemistry Life Science Interface PI visit to India Potential Collaborations / Networking Mithibi College, Vile Parle, Mumbai Medical Research Centre - Katsurba Health Society Ruia College, Mutanga, Mumbai Institute of Chemical Technology, Matunga, Mumbai V.G. Vaze College, Miland, Mumbai Sir Parashurambhau College, Pune Emcure Pharmaceuticals, Pune University of Naigpur Institute of Science and Forensic Science University of Naigpur, Chemistry Department SM Pandav College of Engineering, Naigpur |
Year(s) Of Engagement Activity | 2012 |
Description | Dial-a-Moleclule annual meeting 02/07/2012 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Participant : Participation in workshop, seminar, course. |
Year(s) Of Engagement Activity | 2012 |
Description | Drug discovery: leveraging academic impact through novel fragments 05/02/2013 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Organiser: PI & Participant: SMSdrug.net committee member Dial-a-molecule, 3D Frag, The Royal Society, University of Huddersfield, 3M Buckley Innovation Centre and SMSdrug.net - Huddersfield Numbers max: 40, A committee member attended on behalf of SMSdrug.net, PI wasan organiser of this meeting |
Year(s) Of Engagement Activity | 2013 |
Description | From Natural Product Synthesis to Chemical Intervention in Aging |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Presentation by CoI , Presentation at Universiteit Gent, Belgium on 30th May 2013 and Katholieke Universiteit Leuven, Belgium on 31st May 2013. Around 20 academics in audience for each presentation. 20 participants from academia at each presentation |
Year(s) Of Engagement Activity | 2013 |
Description | Glasgow Chemical Biology Network - Cancer Meeting |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | A Cancer Clinician visited Glasgow Chemical Biology Network and gave an overview on cancer research taking place in Glasgow followed by discussion. Plans made to hold a future sandpit type event for researchers in the city of Glasgow |
Year(s) Of Engagement Activity | 2013 |
Description | Glasgow Chemical Biology Network 11th June 2014 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Glasgow Chemical Biology Network - Seminar with speakers from University of Strathclyde SIPBS followed by discussion. Meeting took place by request from Chemists from University of Glasgow |
Year(s) Of Engagement Activity | 2014 |
Description | Glasgow Chemical Biology Network December 2013 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Presentations at University of Glasgow, followed by discussion Plans for future interactions made by some of the group members |
Year(s) Of Engagement Activity | 2013 |
Description | Identifying and Developing Opportunities at the Chemistry Life Science Interface 4th May 2012 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Participant : Organiser of special symposia : Network SMS drug meeting between 12 Chemists and Biologists to identify mechanisms to promote interaction between the disciplines. discussion to identify mechanisms to promote interaction between the disciplines. |
Year(s) Of Engagement Activity | 2012 |
Description | Identifying and developing opportunities at the Chemistry Life Science interface 10/05/2012 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Meeting with University of Dundee. Dundee library added to DDP |
Year(s) Of Engagement Activity | 2012 |
Description | Identifying and developing opportunities at the Chemistry Life Science interface 15/06/2012 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Member : Participation in workshop/networks with non-academic organisation. Meeting with BioQuarter. |
Year(s) Of Engagement Activity | 2012 |
Description | Identifying and developing opportunities at the Chemistry Life Science interface 25/05/2012 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Member : Participation in workshop/networks with non-academic organisation. Meeting with BioCity Scotland at Newhouse. |
Year(s) Of Engagement Activity | 2012 |
Description | Imaging and Pathway Profiling: Advancing cancer drug discovery towards improved clinical efficacy 16th Jan 2013 |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Presentation by visitor from University of Edinburgh at University of Strathclyde, followed by discussions with academics. 40 attended presentation followed by networking and discussions with academics |
Year(s) Of Engagement Activity | 2013 |
Description | Innovative targets for circadian drug discovery REV-ERBa and RORa |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Postgraduate students |
Results and Impact | A member of PIs group Presented talk titled: Innovative targets for circadian drug discovery REV-ERBa and RORa. European Medicines Research Training Network (EMTRAIN). Drug discovery: development workshop for public-private partnership PhDs and PostDocs held at GSK, Stevenage, UK. 14-17 April 2014 Networking activity |
Year(s) Of Engagement Activity | 2014 |
Description | Matchmaking Ethical Medium Throughput Screening with Chemistry 12th June 2012 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | SMSdrug.net and CBID Meeting to explore potential collaborations at RSC Chemistry Centre 14 Participants |
Year(s) Of Engagement Activity | 2012 |
Description | Mechanical Loading and Disease: Model systems to investigate the interactions between genotypes associated with osteoporosis, osteoarthritis and sarcopenia (11th Jan 2013) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Consortium meeting, Hilton Hotel, Heathrow. 17 participants from EU academia and industry Collaboration/Partnership - Consortium Meeting, Hilton Hotel, Heathrow. Mechanical Loading and Disease: Model systems to investigate the interactions between genotypes associated with osteoporosis, osteoarthritis and sarcopaenia 17 participants from EU academia and industries. Contributor: CoI |
Year(s) Of Engagement Activity | 2013 |
Description | Mechanisms, regulation and uses of OTU deubiquitinases |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Postgraduate students |
Results and Impact | SMSdrug.net and Glasgow Chemical Biology Network organised visiting lecturer who presented: Mechanisms, Regulation and Uses of OTU Deubiquitinases on Wednesday 19th March, Department of Pure and Applied Chemistry, University of Strathclyde Part of Glasgow Chemical Biology Network activities |
Year(s) Of Engagement Activity | 2014 |
Description | NOVEL SYNTHETIC LIGANDS TO PROBE THE ROLE OF REV-ERBa IN INFLAMMATORY DISEASES |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | EFMC-ISMC 2014 XXIII International Symposium on Medicinal Chemistry Lisbon, Portugal - September 7-11, 2014 Poster Presentation: NOVEL SYNTHETIC LIGANDS TO PROBE THE ROLE OF REV-ERBa IN INFLAMMATORY DISEASES Presentation of Circadian Research to academic audience |
Year(s) Of Engagement Activity | 2014 |
Description | Natural Products and Their Biological Targets |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Postgraduate students |
Results and Impact | SMSdrug.net and Glasgow Chemical Biology Netwrok organised a visiting lecturer to gave a seminar at the University of Strathclyde 5th March The title of the talk: Natural Products and Their Biological Targets. Part of Glasgow Chemical Biology Network's activities. |
Year(s) Of Engagement Activity | 2014 |
Description | Network of Networks |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Network of Networks SMSdrug.net participated in the Chemical Biology Network of Networks meetings: 28 October 2011 02 March 2012 19 March 2012 13 June 2012 10 September 2012 30 September 2012 SMSdrug.net secured CBID support for 3 meetings as a result of contacts made. |
Year(s) Of Engagement Activity | 2011,2012 |
Description | Open Drug Discovery 15/10/13 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | 51 participants attended a seminar organised by SMSdrug.net to celebrate the launch of the new drug discovery portal website. This event led to further meetings between University of Strathclyde and BioAscent; University of Strathclyde and RSC ChemSpider team. |
Year(s) Of Engagement Activity | 2013 |
Description | Opportunities for Chemists in Stem Cell Research |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Primary Audience | |
Results and Impact | Member : To be assigned . |
Year(s) Of Engagement Activity | 2012 |
Description | Opportunities in Synthetic Biology |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Primary Audience | |
Results and Impact | Member : To be assigned . |
Year(s) Of Engagement Activity | 2012 |
Description | Parallel Synthetic Routes to Heterocycles of Biological Importance 4th Jan 2013 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Committee member of SMSdrug.net presentation at RSC Heterocyclic and Synthesis Group, January meeting 2013, QMUL. 98 participants from academia and industry. |
Year(s) Of Engagement Activity | 2013 |
Description | Predictive and Rational Allosteric Site Identification 29th June 2012 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Working Group Meeting at RSC Chemistry Centre, supported by CBID and SMSdrug.net. The group of 12, identified actions to help ascertain whether a suitable allosteric target could be identified. The results of these actions were collated and circulated to the group. Another meeting planned as a follow up and discussions continued at that meeting. |
Year(s) Of Engagement Activity | 2012 |
Description | Privileged Druglike Libraries for Biological Evaluation and An Introduction to SMSdrug.net |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Society for General Microbiology at Sussex in Sept (2-4) 2013. http://www.sgm.ac.uk/en/media_centre/society-news.cfm/sgm-autumn-conference-2-4-sept-2013-university-of-sussex Presentation given to 98 participants. "Privileged Druglike Libraries for Biological Evaluation and An Introduction to SMSdrug.net" by CoI and committeee member (University of Sussex) A short presentation on the role of SMSdrug.net, a MRC-BBSRC-EPSRC joint initiative for bringing together chemists and biologists to collaborate on drug discovery, was given . This was followed by a short account on the types of molecules (libraries) made in the Spencer laboratory, of potential use to microbiologists for testing and as chemical tools for biological research. The libraries consist of a number of privileged scaffolds including benzodiazepines, oxazoles, pyrimidines and benzotriazepines. |
Year(s) Of Engagement Activity | 2013 |
Description | Privileged Structures and Metallodrugs in Medicinal Chemistry 22 November 2013 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | SMSdru.net committee member presented;Privileged Structures and Metallodrugs in Medicinal Chemistry" at Universit? de Strasbourg International Symposium of Metal-Mediated Chemistry, 22/11/2013 22 novembre 2013, Salle des Th?ses du Nouveau Patio, Campus Esplanade Networking |
Year(s) Of Engagement Activity | 2013 |
Description | Privileged Structures and Metallodrugs in Medicinal Chemistry 28th June 2013 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Presentation at Departemento de Quimica, Faculade de Ciencias e Tecnologia,Univeridade Nova de Lisboa, 2829-516 Caparia, Portugal 20 participants. SMSdrug.net committee member (University of Sussex) "Privileged Structures and Metallodrugs in Medicinal Chemistry" presented at **Departamento de Quimica, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal 20 participants. |
Year(s) Of Engagement Activity | 2013 |
Description | RICAS - SMSdrug 16th August 2013 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Meeting between SMSdrug.net and RICAS members to establish areas of common interest. |
Year(s) Of Engagement Activity | 2013 |
Description | RNA Splicing Group 1 Meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | A group of researchers met and agreed to write and submit an sLola BBSRC application on RNA Splicing research. Funding application made as a result of this meeting, but was not successful. A further meeting planned for late 2014 or 2015 to discuss the next steps. |
Year(s) Of Engagement Activity | 2014 |
Description | RNA Splicing Group 3 Meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | SMSdrug.net organised a meeting for a group of researchers to discuss making applications to the SULSA Assay Development Fund 2 Applications were made as a result of this meeting and accepted |
Year(s) Of Engagement Activity | 2014 |
Description | Radiopharmaceuticals working group meeting 13 Aug 2014 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Radiopharmaceuticals working group meeting 13 Aug 2014 Discussed workplans and future funding applications |
Year(s) Of Engagement Activity | 2014 |
Description | Rational and Predictive Allosteric Design (5th Dec 2012) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Organised Meeting. Program of activities agreed with a view to trying to achieve PoC which should allow funding application or collaborative venture to be initiated in future. Established interest in working towards achieving funding for new project. Established group working towards achieving funding for new project. |
Year(s) Of Engagement Activity | 2012 |
Description | Relevant Challenges in Chemical Biology 27th Sept 2012 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Meeting of Industry Panel Members and SMSdrug.net Committee. Informed future direction for SMSdrug.net |
Year(s) Of Engagement Activity | 2012 |
Description | SMSdrug interface with cancer research 10/04/2012 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Member : Participation in workshop/networks with non-academic organisation. SMSdrug.net Interface with Cancer Research PI participation with workshop. |
Year(s) Of Engagement Activity | 2012 |
Description | SMSdrug.net Poster |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Poster Presentation by SMSdrug.net at EPSRC Theme day in London on 3rd December 2013 Attendence requested by EPSRC |
Year(s) Of Engagement Activity | 2013 |
Description | School visit (Godalming College) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Schools |
Results and Impact | 30 people came to this meeting. I would estimate that 28 were female, which is very exciting in terms of STEM engagement and possible future applications.This was an informal lecture and many students asked questions as we went along. We hope to host the college over the summer for a lab event or for them to participate in Spectroscopy in a Suitcase. |
Year(s) Of Engagement Activity | 2019 |
Description | Second Cancer Biology/Chemical Biology Meeting 28th October 2014 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | 43 Researchers and KE professionals met to present, discuss and share opportunities for collaborative interactions in cancer at the chemical biology interface. Glasgow CRUK Development fund of £25,000 has been ring-fenced for this year to collaborative projects between Chemists' and Biologists' working in Cancer Therapy. |
Year(s) Of Engagement Activity | 2014 |
URL | http://www.smsdrug.net/showNews.php?ID=133 |
Description | Synthetic Chemistry for the Life Sciences 11/01/2012 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Participant : Participation in workshop, seminar, course : Network event to develop Chemistry at the Life Sciecne interface. Synthetic Chemistry for the Life Sciences. Participant : Participation in workshop, seminar, course : Network event to develop Chemistry at the Life Science interface University of Liverpool |
Year(s) Of Engagement Activity | 2012 |
Description | The Untargeted Kinome 27/03/2012 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Participant : Organiser of major conference. The Untargeted Kinome PI attended conference, organiser. |
Year(s) Of Engagement Activity | 2012 |
Description | Therapeutic Strategies Targeting the Spliceosome Sept 2013 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | SMSdrug.net organised a meeting at the RSC for a group of 19 researchers in RNA Splicing Researchers in the UK RNA splicing community agreed to meet again during 2014 with the purpose of making funding applications. Further meetings held during Q1 2014 |
Year(s) Of Engagement Activity | 2013 |
Description | Therapeutic strategies targeting the spliceosome 12th December 2012 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | SMSdrug.net and RSC CBID Meeting at RSC Chemistry Centre: 18 participants Follow Up meeting planned for Feb 2013 |
Year(s) Of Engagement Activity | 2012 |
Description | Therapeutic strategies targeting the spliceosome 2nd February 2013 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | PI's meeting (29) and session 5 of 3rd UK RNA Splicing Conference at Rydal Hall (85 registered) supported by SMSdrug.net. Discussion around potential for an RNA Splicing network for UK. Follow Up meeting planned for Sept 2013 at RSC Chemistry Centre, London |
Year(s) Of Engagement Activity | 2013 |
Description | Understanding the Rhythm of Pulmonary Inflammation |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | PI's group member Presented talk and poster titled: Understanding the Rhythm of Pulmonary Inflammation. Drug Discovery Chemistry, San Diego, CA, USA. 23rd & 24th April 2014 Poster was distinguished and selected by the conference organisers for a talk delivered in the Anti-inflammatories: Small Molecules Approaches track. |
Year(s) Of Engagement Activity | 2014 |
Description | University of Sussex, School of Life Sciences Visiting Lecturers Programme |
Form Of Engagement Activity | Participation in an open day or visit at my research institution |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | University of Sussex, School of Life Sciences Visiting Lecturers Programme Organised by CoI of SMSdrug.net 29 October 2012: Small molecule screen for altered sleep in zebrafish 31 October 2012: Electronic, Molecular and Materials Systematics: The 'Stamp Collecting' Approach To Answering Chemical Questions 07 November 2012: Equisetin, Reutericyclin and Streptolodygin: Natural Product Lead Structures for Novel Antibiotics 21st November 2012: Adventures in Non-Covalent Chemistry: From Self Assembly to Protein-Surface Recognition 05 December 2012: Synthesis and Evaluation of New Cancer Medicines 13 February 2013: Alzheimer's Disease; from Bench to Bedside 20 February 2013: Chemistry Illuminating Biology: the Design and Synthesis of Chemical probes for Biological Systems 06 March 2013: Highly Reactive Nitrogen Heterocycles - Synthesis and Properties 13 March 2013: Chemistry and biology of englerin A 15 May 2013: Microscopy for Synthetic Chemists and Dual-Metal Catalysis with Gold 29 May 2013: Ion Binding and Asymmetric Catalysis 22 May 2013: Minimal artificial tissues from communicating droplet networks 11 July 2013: Nature's medicine chest: opportunities for drug discovery Networking activity |
Year(s) Of Engagement Activity | 2012,2013 |
Description | Using Synthetic Biology to Dial-a-Molecule (18 February 2013) |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other academic audiences (collaborators, peers etc.) |
Results and Impact | Dial-a-molecule, SMSdrug.net, GSK supported meeting PI Chaired meeting PI Chair chaired meeting |
Year(s) Of Engagement Activity | 2013 |
Description | What's the use of Chemistry? 8th Feb 2013 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Schools |
Results and Impact | Presentation by CoI at Sir George-Monoux 6th Form College. 40 participants from secondary education. |
Year(s) Of Engagement Activity | 2013 |