Assembly, disassembly, reassembly - New Routes to Extended Structures and Their Impact
Lead Research Organisation:
University of St Andrews
Department Name: Chemistry
Abstract
New methods for the preparation of extended structures are rightly highlighted as being of great importance to the UK. The EPSRC Grand Challenge 'Directed Assembly of Extended Structures with Targeted Properties' (referred to as the DA Grand Challenge) is championed by some of the UK's leading academic scientists. Interest from pharmaceutical companies in this initiative has been excellent, particularly based on the nucleation and crystallisation targets outlined in the Grand Challenge Documentation. Impact of the Grand Challenge Network on other areas is much less evident, although it is clear that the basic premise of the Challenge fits many other sectors. In this Established Career Proposal my vision is to demonstrate, through both transformative science and personal leadership, how the central tenets of the DA Grand Challenge Idea can be translated across disciplines. In particular I will focus on two areas, increasing the impact of the network in the chemicals sector, with a special emphasis on transformative new routes to heterogeneous zeolite catalysts (which strongly fits another EPSRC priority area), and novel multifunctionality in medical delivery agents. The proposed programme is firmly rooted in the EPSRC remit but is designed to be outward looking to maximise transdisciplinary impact cutting across to other important areas of science.
The specific science proposed here focuses on nanoporous materials. Zeolites are one of the most important class of industrially applied catalysts we have. Manipulation of zeolites into hierarchical porous structures and ultra-thin layers has also risen to great prominence as a method of introducing new and beneficial features into zeolite catalysts. The journal Science rated this type of research as one of the ten most important current areas of current science, and so its importance is recognised internationally. Metal organic frameworks (MOFs) are some of the most exciting and fast-developing materials that have been prepared in the last decade or so. The great versatility of the chemistry of these solids leads to ultra-high porosity, extreme flexibility, post synthetic modification potential and many other interesting and conceivably useful attributes. Because of this wide ranging chemistry and function, potential applications of these solids range from gas storage, separation and delivery, catalysis, and sensing all the way to biology and medicine.
The specific science proposed here focuses on nanoporous materials. Zeolites are one of the most important class of industrially applied catalysts we have. Manipulation of zeolites into hierarchical porous structures and ultra-thin layers has also risen to great prominence as a method of introducing new and beneficial features into zeolite catalysts. The journal Science rated this type of research as one of the ten most important current areas of current science, and so its importance is recognised internationally. Metal organic frameworks (MOFs) are some of the most exciting and fast-developing materials that have been prepared in the last decade or so. The great versatility of the chemistry of these solids leads to ultra-high porosity, extreme flexibility, post synthetic modification potential and many other interesting and conceivably useful attributes. Because of this wide ranging chemistry and function, potential applications of these solids range from gas storage, separation and delivery, catalysis, and sensing all the way to biology and medicine.
Planned Impact
The vision for this proposal begins with the fact that I believe that the targeted design of new materials through directed assembly offers great potential for impact in several different forms and the establishment of a Grand Challenge is extremely welcome. However, while there has been clear and significant engagement with the pharmaceutical industry there is, as yet, much less take up from other sectors (see the letter of support from Professor Paul Raithby, who leads the Directed Assembly Grand Challenge). The major vision of this fellowship proposal is to increase the impact of the grand challenge in these areas. As described in the Case for Support, the route to impact is very much a three-pronged approach. By completing world-leading science; By advocating the concept of directed assembly to interested parties in the targeted industries; By inspiring a research team who will become the next generation of practitioners and advocates
The two pieces of research work presented in this proposal are of direct interest to several different types of non-academic beneficiary. The use of zeolites in the chemicals industry is a well known and extensively used technology. In the very recent past there has, however, been a significant drive all around the world improve features like accessibility to increase the effectiveness of zeolite catalysts. This type of research is likely to be of interest to larger companies. In contrast, the work described on multifunctional delivery of therapeutic agents has potential interest to a wider range of company type and size and so far enthusiastic support has been shown by SMEs and by larger companies.
The two pieces of research work presented in this proposal are of direct interest to several different types of non-academic beneficiary. The use of zeolites in the chemicals industry is a well known and extensively used technology. In the very recent past there has, however, been a significant drive all around the world improve features like accessibility to increase the effectiveness of zeolite catalysts. This type of research is likely to be of interest to larger companies. In contrast, the work described on multifunctional delivery of therapeutic agents has potential interest to a wider range of company type and size and so far enthusiastic support has been shown by SMEs and by larger companies.
Organisations
- University of St Andrews (Fellow, Lead Research Organisation)
- PQ Silicas UK Ltd (PQ Corporation) (Project Partner)
- University of Bath (Project Partner)
- Sasol Technology Research Laboratory (Project Partner)
- Reckitt Benckiser (United Kingdom) (Project Partner)
- University of the Highlands and Islands (Project Partner)
- NovaBiotics (United Kingdom) (Project Partner)
- Czech Academy of Sciences (Project Partner)
- BluTest Laboratories Limited (Project Partner)
People |
ORCID iD |
Russell Morris (Principal Investigator / Fellow) |
Publications
Bignami GPM
(2017)
Synthesis, Isotopic Enrichment, and Solid-State NMR Characterization of Zeolites Derived from the Assembly, Disassembly, Organization, Reassembly Process.
in Journal of the American Chemical Society
Bignami GPM
(2018)
Cost-effective 17O enrichment and NMR spectroscopy of mixed-metal terephthalate metal-organic frameworks.
in Chemical science
Brown C
(2013)
Structure and spectroscopy of hydrogen adsorbed in a nickel metal-organic framework
in Chemical Physics
Cabañero JM
(2019)
Sodium Naphthalene-2,6-dicarboxylate: An Anode for Sodium Batteries.
in ChemSusChem
Cattaneo D
(2016)
Water based scale-up of CPO-27 synthesis for nitric oxide delivery.
in Dalton transactions (Cambridge, England : 2003)
Cattaneo D
(2016)
Tuning the nitric oxide release from CPO-27 MOFs.
in RSC advances
Chlubná P
(2013)
3D to 2D Routes to Ultrathin and Expanded Zeolitic Materials
in Chemistry of Materials
Chlubná-Eliášová P
(2014)
The Assembly-Disassembly-Organization-Reassembly Mechanism for 3D-2D-3D Transformation of Germanosilicate IWW Zeolite
in Angewandte Chemie
Chlubná-Eliášová P
(2014)
The assembly-disassembly-organization-reassembly mechanism for 3D-2D-3D transformation of germanosilicate IWW zeolite.
in Angewandte Chemie (International ed. in English)
Chlubná-Eliášová, Pavla
(2014)
The Assembly-Disassembly-Organization-Reassembly Mechanism for 3D-2D-3D Transformation of Germanosilicate IWW Zeolite
Desai AV
(2020)
Conversion of a microwave synthesized alkali-metal MOF to a carbonaceous anode for Li-ion batteries.
in RSC advances
Doyle R
(2019)
Nitric oxide production from nitrite by a series of zeolites produced via the ADOR route
in Microporous and Mesoporous Materials
Eliášová P
(2015)
The ADOR mechanism for the synthesis of new zeolites.
in Chemical Society reviews
Firth D
(2017)
Assembly-Disassembly-Organization-Reassembly Synthesis of Zeolites Based on cfi -Type Layers
in Chemistry of Materials
Grzybek J
(2019)
A new layered MWW zeolite synthesized with the bifunctional surfactant template and the updated classification of layered zeolite forms obtained by direct synthesis
in Journal of Materials Chemistry A
Henkelis S
(2018)
Monitoring the assembly-disassembly-organisation-reassembly process of germanosilicate UTL through in situ pair distribution function analysis
in Journal of Materials Chemistry A
Henkelis SE
(2019)
Kinetics and Mechanism of the Hydrolysis and Rearrangement Processes within the Assembly-Disassembly-Organization-Reassembly Synthesis of Zeolites.
in Journal of the American Chemical Society
Henkelis SE
(2019)
A procedure for identifying possible products in the assembly-disassembly-organization-reassembly (ADOR) synthesis of zeolites.
in Nature protocols
Kasneryk V
(2017)
Expansion of the ADOR Strategy for the Synthesis of Zeolites: The Synthesis of IPC-12 from Zeolite UOV.
in Angewandte Chemie (International ed. in English)
Kasneryk V
(2018)
Insight into the ADOR zeolite-to-zeolite transformation: the UOV case.
in Dalton transactions (Cambridge, England : 2003)
Kasneryk V
(2017)
Expansion of the ADOR Strategy for the Synthesis of Zeolites: The Synthesis of IPC-12 from Zeolite UOV
in Angewandte Chemie
Mazur M
(2016)
Synthesis of 'unfeasible' zeolites.
in Nature chemistry
Mazur M
(2018)
Pressure-induced chemistry for the 2D to 3D transformation of zeolites
in Journal of Materials Chemistry A
McHugh LN
(2018)
Hydrolytic stability in hemilabile metal-organic frameworks.
in Nature chemistry
McKinlay A
(2014)
Multirate delivery of multiple therapeutic agents from metal-organic frameworks
in APL Materials
Mocniak K
(2015)
Incorporation of cisplatin into the metal-organic frameworks UiO66-NH 2 and UiO66 - encapsulation vs. conjugation
in RSC Advances
Morris R
(2016)
Synthesis of Zeolites Using the ADOR (Assembly-Disassembly-Organization-Reassembly) Route
in Journal of Visualized Experiments
Morris RE
(2015)
Exploiting chemically selective weakness in solids as a route to new porous materials.
in Nature chemistry
Morris RE
(2017)
Coordination change, lability and hemilability in metal-organic frameworks.
in Chemical Society reviews
Morris SA
(2017)
In situ solid-state NMR and XRD studies of the ADOR process and the unusual structure of zeolite IPC-6.
in Nature chemistry
Morris SA
(2016)
Combined PDF and Rietveld studies of ADORable zeolites and the disordered intermediate IPC-1P.
in Dalton transactions (Cambridge, England : 2003)
Opanasenko M
(2016)
Zeolite-derived hybrid materials with adjustable organic pillars.
in Chemical science
Ren Y
(2013)
A solid with a hierarchical tetramodal micro-meso-macro pore size distribution.
in Nature communications
Rojas S
(2013)
Metal-organic frameworks as potential multi-carriers of drugs
in CrystEngComm
Roth WJ
(2014)
Two-dimensional zeolites: current status and perspectives.
in Chemical reviews
Roth WJ
(2013)
A family of zeolites with controlled pore size prepared using a top-down method.
in Nature chemistry
Shamzhy M
(2014)
Germanosilicate Precursors of ADORable Zeolites Obtained by Disassembly of ITH, ITR, and IWR Zeolites
in Chemistry of Materials
Shamzhy M
(2015)
Post-synthesis incorporation of Al into germanosilicate ITH zeolites: the influence of treatment conditions on the acidic properties and catalytic behavior in tetrahydropyranylation
in Catalysis Science & Technology
Shamzhy MV
(2016)
Post-Synthesis Stabilization of Germanosilicate Zeolites ITH, IWW, and UTL by Substitution of Ge for Al.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Tian Y
(2014)
Synthesis and structural characterization of a single-crystal to single-crystal transformable coordination polymer.
in Dalton transactions (Cambridge, England : 2003)
Tian Y
(2014)
Ionic Liquid assisted Synthesis of Zeolite-TON
in Zeitschrift für anorganische und allgemeine Chemie
Trachta M
(2014)
From double-four-ring germanosilicates to new zeolites: in silico investigation.
in Chemphyschem : a European journal of chemical physics and physical chemistry
Veselý O
(2019)
Hierarchical MTW zeolites in tetrahydropyranylation of alcohols: Comparison of bottom-up and top-down methods
in Catalysis Today
Vornholt SM
(2020)
Multifaceted Study of the Interactions between CPO-27-Ni and Polyurethane and Their Impact on Nitric Oxide Release Performance.
in ACS applied materials & interfaces
Wheatley P
(2014)
Zeolites with Continuously Tuneable Porosity
in Angewandte Chemie
Wheatley PS
(2016)
Synthesis of Zeolites Using the ADOR (Assembly-Disassembly-Organization-Reassembly) Route.
in Journal of visualized experiments : JoVE
Wheatley PS
(2014)
Zeolites with continuously tuneable porosity.
in Angewandte Chemie (International ed. in English)
Zhang Y
(2019)
Synthesis of Pt-MWW with controllable nanoparticle size
in Catalysis Today
Žilková N
(2016)
The effect of UTL layer connectivity in isoreticular zeolites on the catalytic performance in toluene alkylation
in Catalysis Today
Description | (1) The major development through this grant has been the invention of the ADOR process for the manufacture of new zeolites. These are important catalysts used in many industries and we have developed a method by which zeolites that were previously regarded as unfeasible synthetic targets can now be successfully made. This development has been the reason why a major European award was given to the PI, and is the subject of a successful ERC advanced grant. |
Exploitation Route | We are just beginning the process of seriously looking at developing this process for industry and this is the subject of a new grant application. |
Sectors | Chemicals |
Description | We have set up a vehicle (Actifrmae Ltd) to try and exploit some of the work that was carried out in this award - this vehicle has recently received funding for three more years of research to develop the process further. |
Sector | Chemicals,Healthcare |
Impact Types | Economic |
Title | Assembly-diassembly-organisation-reassembly synthesis of zeolites based on cfi-type layers (dataset) |
Description | |
Type Of Material | Database/Collection of data |
Year Produced | 2017 |
Provided To Others? | Yes |
Title | Cost-Effective 17O Enrichment and NMR Spectroscopy of Mixed- Metal Terephthalate Metal-Organic Frameworks (dataset) |
Description | |
Type Of Material | Database/Collection of data |
Year Produced | 2017 |
Provided To Others? | Yes |
Title | Data Underpinning: Synthesis of 'unfeasible' zeolites |
Description | |
Type Of Material | Database/Collection of data |
Year Produced | 2015 |
Provided To Others? | Yes |
Title | Data underpinning "Expansion of the ADOR strategy for the synthesis of new zeolites: The synthesis of IPC-12 from zeolite UOV" |
Description | The data files are not yet publicly available. Enquiries and requests for data should be directed to the publication's corresponding authors: Kasneryk, V, Shamzhy, M, Opanasenko, M, Wheatley, PS, Morris, SA, Russell, SE, Mayoral, A, Trachta, M, Cejka, J & Morris, RE 2017, 'Expansion of the ADOR strategy for the synthesis of new zeolites: the synthesis of IPC-12 from zeolite UOV' Angewandte Chemie, vol. 56, no. 15, pp. 4324-4327. DOI: 10.1002/anie.201700590 |
Type Of Material | Database/Collection of data |
Year Produced | 2019 |
Provided To Others? | Yes |
Title | Data underpinning "In situ solid-state NMR and XRD studies of the ADOR process and the unusual structure of zeolite IPC-6" |
Description | |
Type Of Material | Database/Collection of data |
Year Produced | 2017 |
Provided To Others? | Yes |
Title | Data underpinning - Tuning the Nitric Oxide Release from CPO-27 MOFs |
Description | |
Type Of Material | Database/Collection of data |
Year Produced | 2016 |
Provided To Others? | Yes |
Title | Data underpinning: Water Based Scale-up of CPO-27 Synthesis for Nitric Oxide Delivery |
Description | |
Type Of Material | Database/Collection of data |
Year Produced | 2015 |
Provided To Others? | Yes |
Title | High silica zeolites are widely used catalysts; those with different structural topologies being used for different applications. This protocol describes the Assembly-Disassembly-Organization-Reassembly (ADOR) process for preparing new zeolites. (dataset) |
Description | |
Type Of Material | Database/Collection of data |
Year Produced | 2019 |
Provided To Others? | Yes |
Title | Hydrolytic stability in hemilabile metal-organic frameworks (dataset) |
Description | |
Type Of Material | Database/Collection of data |
Year Produced | 2019 |
Provided To Others? | Yes |
Title | Kinetics and mechanism of the hydrolysis and rearrangement processes within the Assembly-Disassembly-Organization-Reassembly synthesis of zeolites (dataset) |
Description | |
Type Of Material | Database/Collection of data |
Year Produced | 2019 |
Provided To Others? | Yes |
Title | Monitoring the Assembly-Disassembly-Organisation-Reassembly Process of Germanosilicate UTL through in situ Pair Distribution Function Analysis (dataset) |
Description | |
Type Of Material | Database/Collection of data |
Year Produced | 2019 |
Provided To Others? | Yes |
Title | Multifaceted Study of the Interactions between CPO-27-Ni and Polyurethane and Their Impact on Nitric Oxide Release Performance (dataset) |
Description | |
Type Of Material | Database/Collection of data |
Year Produced | 2020 |
Provided To Others? | Yes |
URL | https://risweb.st-andrews.ac.uk/portal/en/datasets/multifaceted-study-of-the-interactions-between-cp... |
Title | Pressure-induced chemistry for the 2D to 3D transformation of zeolites (dataset) |
Description | |
Type Of Material | Database/Collection of data |
Year Produced | 2019 |
Provided To Others? | Yes |
Title | Synthesis, Isotopic Enrichment and Solid-State NMR Characterization of Zeolites Derived from the Assembly, Disassembly, Organisation, Reassembly Process (dataset) |
Description | |
Type Of Material | Database/Collection of data |
Year Produced | 2017 |
Provided To Others? | Yes |