Very High Intensity Single Crystal Diffractometers (VHISCD)
Lead Research Organisation:
University of Nottingham
Department Name: Sch of Chemistry
Abstract
The School of Chemistry at The University of Nottingham is a vigorous, innovative hub for internationally-recognised research. The School was ranked 2nd in the UK (between Cambridge and Oxford) by the 2008 RAE, and current grant income exceeds £20M. One of our highlighted strengths is the close interaction between synthetic chemistry and detailed structural characterisation and analysis. This proposal is aimed squarely at building on this strength and increasing its capacity and breadth.
Single crystal X-ray crystallographic analysis underpins the productivity of all our research involving synthetic chemistry. It is essential for the unambiguous characterisation of new materials, but also reveals relationships between structure, properties and function. In many cases structural data define the next generation of target materials and underpin the optimisation of their design. Over 1200 samples are submitted to the School's Crystal Structure Facility each year, but many are too difficult to study using our older instruments - these are now several technological generations behind what is currently available. We are now looking for really major upgrades to our instrumentation, by taking advantage of some exciting, recently-developed technologies including very bright laboratory X-ray sources.
Single crystal X-ray crystallographic analysis underpins the productivity of all our research involving synthetic chemistry. It is essential for the unambiguous characterisation of new materials, but also reveals relationships between structure, properties and function. In many cases structural data define the next generation of target materials and underpin the optimisation of their design. Over 1200 samples are submitted to the School's Crystal Structure Facility each year, but many are too difficult to study using our older instruments - these are now several technological generations behind what is currently available. We are now looking for really major upgrades to our instrumentation, by taking advantage of some exciting, recently-developed technologies including very bright laboratory X-ray sources.
Planned Impact
The proposed new X-ray diffraction instrumentation will enable research outputs which will have major impact across academia, industry and society. In terms of Knowledge, structural information will contribute directly to major scientific advances in the research areas described in the proposal covering Grand Challenge areas of energy, sustainability, materials discovery, catalysis, healthcare, nanoscience and dial-a-molecule, and will provide a strong driver for their development, implementation and transfer to industry. The research will inform stakeholders, funding agencies and policy makers across the physical sciences, and chemistry specifically. In terms of People, incoming early-career scientists (20 PDRAs and 35 PhD students per year) will gain important high-level skills and training in structural analysis which will be vital for their research and will augment their employability within and across the UK economy. Thus, the project will train scientists to enhance the necessary skills-base of the UK in important and timely scientific areas. The Economy will benefit in the short-term via employment of newly trained early-career scientists, and in the medium-to-longer term through development of new products and processes based upon new research discoveries. In due course, new companies of direct economic benefit to Society will be launched from the scientific advances developed within the current programme. Short-term beneficiaries of the research will include academics working across engineering and physical, biological and pharmaceutical sciences where the outputs of high quality research, underpinned by the proposed instrumentation, will drive progress and guide the development of new scientific approaches, technologies and products. All the above will work to improve and enhance the quality of life in the UK and world populations though the positive impacts of this research on energy, sustainability, healthcare, nanoscience and catalysis.
Organisations
Publications
Gardner BM
(2015)
An Inverted-Sandwich Diuranium µ-?(5):?(5)-Cyclo-P5 Complex Supported by U-P5 d-Bonding.
in Angewandte Chemie (International ed. in English)
Gardner BM
(2015)
Isolation of Elusive HAsAsH in a Crystalline Diuranium(IV) Complex.
in Angewandte Chemie (Weinheim an der Bergstrasse, Germany)
Gardner BM
(2015)
Isolation of Elusive HAsAsH in a Crystalline Diuranium(IV) Complex.
in Angewandte Chemie (International ed. in English)
Gardner BM
(2015)
An Inverted-Sandwich Diuranium µ-?5:?5-Cyclo-P5 Complex Supported by U-P5 d-Bonding.
in Angewandte Chemie (Weinheim an der Bergstrasse, Germany)
Gardner BM
(2015)
Triamidoamine uranium(IV)-arsenic complexes containing one-, two- and threefold U-As bonding interactions.
in Nature chemistry
Gardner BM
(2014)
Triamidoamine-uranium(IV)-stabilized terminal parent phosphide and phosphinidene complexes.
in Angewandte Chemie (International ed. in English)
Eccleshare L
(2016)
Diversification of ortho-Fused Cycloocta-2,5-dien-1-one Cores and Eight- to Six-Ring Conversion by s Bond C-C Cleavage.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Easun T
(2014)
Modification of coordination networks through a photoinduced charge transfer process
in Chem. Sci.
Drigo NA
(2017)
Approaches for Selective Synthesis of Ullazine Donor-Acceptor Systems.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Delor M
(2014)
Dynamics of ground and excited state vibrational relaxation and energy transfer in transition metal carbonyls.
in The journal of physical chemistry. B
Dean WM
(2016)
Versatile C(sp(2) )-C(sp(3) ) Ligand Couplings of Sulfoxides for the Enantioselective Synthesis of Diarylalkanes.
in Angewandte Chemie (International ed. in English)
Dawood RS
(2017)
Asymmetric Synthesis of Pyrrolidine-Containing Chemical Scaffolds via Tsuji-Trost Allylation of N-tert-Butanesulfinyl Imines.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Cully SJ
(2016)
Expedient synthesis of an atypical oxazolidinone compound library.
in Bioorganic & medicinal chemistry
Cooper OJ
(2014)
Reactivity of the uranium(IV) carbene complex [U(BIPM(TMS))(Cl)(µ-Cl)2Li(THF)2] (BIPM(TMS) = {C(PPh2NSiMe3)2}) towards carbonyl and heteroallene substrates: metallo-Wittig, adduct formation, C-F bond activation, and [2 + 2]-cycloaddition reactions.
in Dalton transactions (Cambridge, England : 2003)
Cooper OJ
(2013)
The nature of the U=C double bond: pushing the stability of high-oxidation-state uranium carbenes to the limit.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Cleaves PA
(2017)
Terminal Uranium(V/VI) Nitride Activation of Carbon Dioxide and Carbon Disulfide: Factors Governing Diverse and Well-Defined Cleavage and Redox Reactions.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Cleaves PA
(2014)
Two-electron reductive carbonylation of terminal uranium(V) and uranium(VI) nitrides to cyanate by carbon monoxide.
in Angewandte Chemie (International ed. in English)
Cini M
(2015)
Asymmetric Pentafulvene Carbometalation--Access to Enantiopure Titanocene Dichlorides of Biological Relevance.
in Angewandte Chemie (International ed. in English)
Chamberlain TW
(2015)
Switching intermolecular interactions by confinement in carbon nanotubes.
in Chemical communications (Cambridge, England)
Casula A
(2017)
Halogen-substituted ureas for anion binding: solid state and solution studies
in Supramolecular Chemistry
Callingham M
(2017)
Enantioselective Rhodium-Catalyzed Coupling of Arylboronic Acids, 1,3-Enynes, and Imines by Alkenyl-to-Allyl 1,4-Rhodium(I) Migration.
in Angewandte Chemie (International ed. in English)
Burroughs L
(2015)
One-Pot Cannizzaro Cascade Synthesis of ortho -Fused Cycloocta-2,5-dien-1-ones from 2-Bromo(hetero)aryl Aldehydes
in Angewandte Chemie International Edition
Bradley MA
(2017)
1,8-Bis(silylamido)naphthalene complexes of magnesium and zinc synthesised through alkane elimination reactions.
in Dalton transactions (Cambridge, England : 2003)
Blake AJ
(2013)
Heterometallic gold(I)-thallium(I) compounds with crown thioethers.
in Dalton transactions (Cambridge, England : 2003)
Blake A
(2015)
The continuing development and expansion of Acta Crystallographica Section B
in Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials
Bikas R
(2017)
Electronic Effects of Aromatic Rings on the Catalytic Activity of Dioxidomolybdenum(VI)-Hydrazone Complexes
in European Journal of Inorganic Chemistry
Benson O
(2016)
Amides Do Not Always Work: Observation of Guest Binding in an Amide-Functionalized Porous Metal-Organic Framework.
in Journal of the American Chemical Society
Argent S
(2016)
Assembly of high nuclearity clusters from a family of tripodal tris-carboxylate ligands
in Polyhedron
Alsmail NH
(2014)
Analysis of high and selective uptake of CO2 in an oxamide-containing {Cu2(OOCR)4}-based metal-organic framework.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Allan DR
(2015)
Structural aspects of metal-organic framework-based energy materials research at Diamond.
in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
Allan DR
(2014)
High-pressure studies of palladium and platinum thioether macrocyclic dihalide complexes.
in Acta crystallographica Section B, Structural science, crystal engineering and materials
Aliev S
(2015)
Dilithium cyclohexanediacetate: A layered coordination polymer with non-valent hydrophobic contacts
in Journal of Structural Chemistry
Description | This equipment grant has funded a number of major enhancements to the single crystal X-ray facilities which support a large part of our research effort: -the installation of a new very high intensity Rigaku Oxford Diffraction Xtalab MM007 rotating anode diffractometer - the installation of two new high intensity Rigaku Oxford Diffraction SuperNovaII diffractometers - the upgrade of our Rigaku Oxford Diffraction SuperNova to a dual-wavelength (Cu/Mo) instrument - the upgrade of our existing Rigaku Oxford Diffraction Mo microfocus source for high pressure crystallography. These enhancements have allowed us to conduct more demanding and ambitious experiments than were possible previously. For example, many samples which previously could only be studied in a limited manner during our sparse synchrotron beamtime could now be studied more extensively in-house, with significant benefits for our overall productivity. Two of the main groups of users (PIs Liddle and Schroder) moved to the University of Manchester in 2015, but the ramping up of the research efforts of new and existing research groups meant that the productivity of the new instruments increased during 2016. |
Exploitation Route | The acquisition of new and upgraded equipment has benefited many important areas of EPSRC-funded research within chemistry, materials, medicine and energy, such as sustainable chemistry, metal-organic frameworks, surface science, organic synthesis, catalysis, alkaline-earth chemistry, etc. |
Sectors | Chemicals,Education,Energy,Environment,Healthcare,Pharmaceuticals and Medical Biotechnology |
Description | Multiple publications have already resulted from this award. The equipment was upgraded by the suppliers in December 2015. New and exisiting equipment provided under the grant continues to support the research efforts of 20+ groups in the School of Chemistry, including those of new high-profile appointees and early-career researchers. |
First Year Of Impact | 2014 |
Sector | Chemicals,Education,Energy,Environment,Healthcare,Pharmaceuticals and Medical Biotechnology,Transport |
Description | EPSRC IAA fKTS |
Amount | £53,253 (GBP) |
Funding ID | RR0507 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 10/2014 |
End | 10/2015 |