Core Capability for Chemistry Research at the University of Liverpool
Lead Research Organisation:
University of Liverpool
Department Name: Chemistry
Abstract
This grant will underpin the Chemistry Department's core research capability by upgrading capital equipment in four key areas of Chemistry instrumentation, nuclear magnetic resonance spectroscopy, mass spectrometry, X-ray structural analysis and atomic level microscopy. These techniques provide the ability to characterise the new chemicals and materials produced in the Department of Chemistry at Liverpool, to determine their atomic structure and to examine their properties, supporting research activity across the entire Chemistry research portfolio. The new facilities will provide access to state of the art instrumentation for Chemistry academics, early career research staff, post-doctoral research workers and research students, enhancing the quality of the research carried out. Replacement of obsolete instrumentation and extending the capability of the instrumentation base will enhance sample throughput and productivity, permit unstable samples to be analysed, reduce the need for external analysis of samples and allow more complex analysis to be performed. Research programmes relying on these techniques include Materials Research, research into Green Catalysis and new Battery Materials, Drug Discovery and Drug Delivery, and the design of Functional Interfaces. Upgrading the instrument base will also ensure the training provided to research students remains compatible with the instrumentation they will meet in industry, supporting the skills needed by employers and the UK Chemical Industry.
Planned Impact
This proposal represents an ambitious project to provide an open distributed network of instrumentation and equipment across six of the N8 Research Partnership universities (Durham, Leeds, Liverpool, Manchester, Sheffield, and York) that will provide capacity to meet current and future chemistry research requirements. This will be achieved through the delivery of improved analytical facilities for chemical and materials characterisation, building on Chemistry's current capability with a co-ordinated approach to provide more specialist equipment. The funding will be used to refresh and upgrade the instrumentation available at Liverpool, leading to improvements in the capacity and levels of service that the Department of Chemistry can offer. Providing our researchers with ready access to state-of-the art analytical equipment is essential if the UK chemistry community is to continue to produce world-leading research. The research grants underpinning the bid vary from blue-skies academic research to applied and industrially co-funded projects, and the 'Pathways to Impact' that have been identified for these apply equally to this equipment bid.
Liverpool has an excellent record of bringing business interests and academic research together to drive economic and scientific success. The Department has strong funding links with many partners in the commercial sector, including Acal, Adisseo, Astrazeneca, Bayer, BP, Mristol-Myers Squibb, BNFL, GSK, Ineos Fluor, Iota Nanosolutions, Johnson Matthey, Lucite International, Merck, Millennium, Pfizer, SAFC Hitech and Sanofi-Aventis as well as with the charitable sector, including drug discovery charities, the Medicines for Malaria Venture, Wellcome Trust, the MRC and the IVCC. For example, the Centre for Materials Discovery and the recently announced Materials Innovation Factory (a £45M project jointly supported by the Government's Research Partnership Investment Fund, Unilever and the University of Liverpool) build on strong links with Unilever to provide a unique suite of facilities for Materials research, open to Industrial partners. Additional investment to provide state of the art instrumentation and equipment will strengthen these partnerships and facilitate new collaborations. In addition the Department has an extensive set of interactions with SMEs, who will benefit from the proposed equipment investment through joint research programmes, direct hosting of SME researchers and by the provision of enhanced analytical services.
A principal objective of the N8 Research Partnership is to create a culture of collaboration. The increased coordination underpinning this proposal will enable the equipment purchased to have the maximum benefit to individual departments and to the wider research community. The proposed collaboration will enable partner universities to provide cover and back-up services in the event of a major breakdown in service provision at a single university. An asset-sharing programme is being developed to create an integrated database of assets that are available for the use of researchers throughout the N8. Through this system, equipment and instrumentation funded through this application will be leveraged for a greater impact across both the individual department and the N8 organisation than if it was provided to a single institution.
Provision of new equipment and instrumentation will have a direct impact on the quality of training given to research staff. As available equipment and associated technologies develop, there is a continued need for researchers to have access to, and be fully trained in, the latest techniques. This grant will allow us to continue to train chemists, on state of the art equipment, to a standard that enables them to compete on national and international levels and to support UK industry.
Liverpool has an excellent record of bringing business interests and academic research together to drive economic and scientific success. The Department has strong funding links with many partners in the commercial sector, including Acal, Adisseo, Astrazeneca, Bayer, BP, Mristol-Myers Squibb, BNFL, GSK, Ineos Fluor, Iota Nanosolutions, Johnson Matthey, Lucite International, Merck, Millennium, Pfizer, SAFC Hitech and Sanofi-Aventis as well as with the charitable sector, including drug discovery charities, the Medicines for Malaria Venture, Wellcome Trust, the MRC and the IVCC. For example, the Centre for Materials Discovery and the recently announced Materials Innovation Factory (a £45M project jointly supported by the Government's Research Partnership Investment Fund, Unilever and the University of Liverpool) build on strong links with Unilever to provide a unique suite of facilities for Materials research, open to Industrial partners. Additional investment to provide state of the art instrumentation and equipment will strengthen these partnerships and facilitate new collaborations. In addition the Department has an extensive set of interactions with SMEs, who will benefit from the proposed equipment investment through joint research programmes, direct hosting of SME researchers and by the provision of enhanced analytical services.
A principal objective of the N8 Research Partnership is to create a culture of collaboration. The increased coordination underpinning this proposal will enable the equipment purchased to have the maximum benefit to individual departments and to the wider research community. The proposed collaboration will enable partner universities to provide cover and back-up services in the event of a major breakdown in service provision at a single university. An asset-sharing programme is being developed to create an integrated database of assets that are available for the use of researchers throughout the N8. Through this system, equipment and instrumentation funded through this application will be leveraged for a greater impact across both the individual department and the N8 organisation than if it was provided to a single institution.
Provision of new equipment and instrumentation will have a direct impact on the quality of training given to research staff. As available equipment and associated technologies develop, there is a continued need for researchers to have access to, and be fully trained in, the latest techniques. This grant will allow us to continue to train chemists, on state of the art equipment, to a standard that enables them to compete on national and international levels and to support UK industry.
Organisations
Publications
Draper ER
(2016)
Self-sorted photoconductive xerogels.
in Chemical science
Draper ER
(2017)
Opening a Can of Worm(-like Micelle)s: The Effect of Temperature of Solutions of Functionalized Dipeptides.
in Angewandte Chemie (International ed. in English)
Dunstan M
(2015)
Ion Dynamics in Li 2 CO 3 Studied by Solid-State NMR and First-Principles Calculations
in The Journal of Physical Chemistry C
Elliott EC
(2013)
Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles.
in Organic & biomolecular chemistry
Enciso-Maldonado L
(2015)
Computational Identification and Experimental Realization of Lithium Vacancy Introduction into the Olivine LiMgPO 4
in Chemistry of Materials
Evans K
(2015)
Stabilization of a Bimolecular Triplex by 3'-S-Phosphorothiolate Modifications: An NMR and UV Thermal Melting Investigation.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Evans PA
(2015)
Rhodium-catalyzed [(3+2)+2] carbocyclization of alkynylidenecyclopropanes with substituted allenes: stereoselective construction of tri- and tetrasubstituted exocyclic olefins.
in Angewandte Chemie (International ed. in English)
Fernandes A
(2018)
17O solid-state NMR spectroscopy of A2B2O7 oxides: quantitative isotopic enrichment and spectral acquisition?
in RSC advances
Fernández-Álvaro E
(2016)
Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action.
in Journal of medicinal chemistry
Festuccia C
(2014)
Trifluoroibuprofen Inhibits a-Methylacyl Coenzyme A Racemase (AMACR/P504S), Reduces Cancer Cell Proliferation and Inhibits in vivo Tumor Growth in Aggressive Prostate Cancer Models
in Anti-Cancer Agents in Medicinal Chemistry
Gerrard N
(2020)
Formation of Linear Water Chains on Ni(110).
in The journal of physical chemistry letters
Gerrard N
(2020)
Water Dissociation and Hydroxyl Formation on Ni(110).
in The journal of physical chemistry. C, Nanomaterials and interfaces
Gerrard N
(2019)
Strain Relief during Ice Growth on a Hexagonal Template.
in Journal of the American Chemical Society
Giovine R
(2017)
Study of Xenon Mobility in the Two Forms of MIL-53(Al) Using Solid-State NMR Spectroscopy
in The Journal of Physical Chemistry C
Giri N
(2015)
Liquids with permanent porosity.
in Nature
Gonzalez-De-Castro A
(2014)
Dehydrogenative a-oxygenation of ethers with an iron catalyst.
in Journal of the American Chemical Society
Gonzalez-De-Castro A
(2015)
Green and Efficient: Iron-Catalyzed Selective Oxidation of Olefins to Carbonyls with O2.
in Journal of the American Chemical Society
Grigoropoulos A
(2016)
Encapsulation of an organometallic cationic catalyst by direct exchange into an anionic MOF.
in Chemical science
Grisin A
(2015)
Diastereoselective construction of anti-4,5-disubstituted-1,3-dioxolanes via a bismuth-mediated two-component hemiacetal oxa-conjugate addition of ?-hydroxy-a,ß-unsaturated ketones with paraformaldehyde.
in Chemical communications (Cambridge, England)
Guo X
(2016)
Palladium-Catalyzed Ylidyl-Carbonylation of Aryl Halides To Produce a-Acylphosphoranes.
in Organic letters
Gülcemal D
(2015)
A New Phenoxide Chelated Ir III N-Heterocyclic Carbene Complex and Its Application in Reductive Amination Reactions
in Organometallics
Gülcemal S
(2016)
Acceptorless Dehydrogenative Oxidation of Secondary Alcohols Catalysed by Cp*Ir(III) -NHC Complexes.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Halat D
(2016)
Probing Oxide-Ion Mobility in the Mixed Ionic-Electronic Conductor La 2 NiO 4+d by Solid-State 17 O MAS NMR Spectroscopy
in Journal of the American Chemical Society
Description | This grant upgraded the NMR, mass spectrometry and surface analysis facilities in the department of Chemistry and underpins the characterisation of all the molecular species developed in the Department. These materials have applications across all areas of the Department's research activity, ranging, for example, from the development of new anti-malarial agents and inhibitors for human alpha-methylacyl CoA reacemase (AMACR) for the treatment of prostate cancer, through to new catalysts for the hydrogenation of imines. |
Exploitation Route | New materials developed by the Department will be investigated for commercial potential. |
Sectors | Chemicals Pharmaceuticals and Medical Biotechnology |
Description | The impact of this equipment grant will be on all aspects of the Department's research and impact portfolio over the next 10 years or longer. |
First Year Of Impact | 2013 |
Sector | Chemicals,Pharmaceuticals and Medical Biotechnology |