Core capability for Chemistry Research
Lead Research Organisation:
Imperial College London
Department Name: Chemistry
Abstract
The National Importance of a vibrant and successful university Chemistry research sector cannot be underestimated. The RSC's report on the Economic Benefits of Chemistry showed that the UK's upstream chemicals industry and downstream chemistry-using sectors contributed a combined total of £258 billion in added-value in 2007, equivalent to 21% of UK GDP, and supported over 6 million UK jobs. This output is underpinned by some of the world's most successful University Chemistry research, reflecting the fruits of many years of investment. On-going fundamental research is essential, not only to maintain a continuing flow of scientific and technological breakthroughs, but also to ensure that the UK maintains a highly skilled and innovative workforce; it is through these trained people that the UK will adopt and advance new ideas, successfully exploit new technologies, and develop new and better products and services. The ability to develop and exploit chemically-derived technology will fuel economic activity, and is a necessary condition for attracting inward investment to the UK. The RSC report also showed that the quality of UK chemists and the reputation for excellence of the UK's university chemical science base significantly influences companies in decisions to locate within the UK, or to retain a UK-based research presence.
Imperial College is an internationally leading centre for research, education and translation. It is the only UK higher education institution to focus exclusively on science, engineering, medicine and business. The College is renowned both for world-class fundamental research and for the translation of this research to benefit society and the economy; this combination was indeed defined as a core part of the College's mission at its foundation in 1907. Its research strengths reflect its focus on fundamental underpinning science and cover the breadth of engineering and the physical sciences. The College currently holds 270 research grants totalling over £285M that have been through the EPSRC's peer review process; these include 11 Programme Grants and 12 Platform Grants.
The equipment requested is to underpin the above activity.
Imperial College is an internationally leading centre for research, education and translation. It is the only UK higher education institution to focus exclusively on science, engineering, medicine and business. The College is renowned both for world-class fundamental research and for the translation of this research to benefit society and the economy; this combination was indeed defined as a core part of the College's mission at its foundation in 1907. Its research strengths reflect its focus on fundamental underpinning science and cover the breadth of engineering and the physical sciences. The College currently holds 270 research grants totalling over £285M that have been through the EPSRC's peer review process; these include 11 Programme Grants and 12 Platform Grants.
The equipment requested is to underpin the above activity.
Planned Impact
Please see Pathways to Impact
Organisations
Publications
Ab Rani M
(2014)
The potential of methylsiloxanes as solvents for synthetic chemistry applications
in Green Chem.
Affron DP
(2014)
Regio- and stereospecific synthesis of C-3 functionalized proline derivatives by palladium catalyzed directed C(sp3)-H arylation.
in Organic letters
Allen CE
(2015)
Efficient and facile synthesis of acrylamide libraries for protein-guided tethering.
in Organic letters
Amor B
(2014)
Uncovering allosteric pathways in caspase-1 using Markov transient analysis and multiscale community detection.
in Molecular bioSystems
Andernach R
(2015)
Synthesis and Exciton Dynamics of Triplet Sensitized Conjugated Polymers.
in Journal of the American Chemical Society
Ang DL
(2016)
Quadruplex DNA-Stabilising Dinuclear Platinum(II) Terpyridine Complexes with Flexible Linkers.
in Chemistry (Weinheim an der Bergstrasse, Germany)
Anwar A
(2015)
Abstracts of the 23rd International Isotope Society (UK group) Symposium: synthesis and applications of labelled compounds 2014 IIS_UK_2014
in Journal of Labelled Compounds and Radiopharmaceuticals
Armstrong A
(2015)
Tertiary Amine Promoted Aziridination: Preparation of NH-Aziridines from Aliphatic a,ß-Unsaturated Ketones
in Synlett
Armstrong A
(2014)
Tertiary amine-promoted enone aziridination: investigations into factors influencing enantioselective induction
in Tetrahedron: Asymmetry
Arrowsmith M
(2014)
Catalytic hydroacetylenation of carbodiimides with homoleptic alkaline earth hexamethyldisilazides.
in Dalton transactions (Cambridge, England : 2003)
Ashley AE
(2013)
FLP-mediated activations and reductions of CO2 and CO.
in Topics in current chemistry
Bakewell C
(2015)
Scandium and yttrium phosphasalen complexes as initiators for ring-opening polymerization of cyclic esters.
in Inorganic chemistry
Bakewell C
(2015)
Comparing a series of 8-quinolinolato complexes of aluminium, titanium and zinc as initiators for the ring-opening polymerization of rac-lactide.
in Dalton transactions (Cambridge, England : 2003)
Baran D
(2015)
Role of Polymer Fractionation in Energetic Losses and Charge Carrier Lifetimes of Polymer: Fullerene Solar Cells
in The Journal of Physical Chemistry C
Barreiro E
(2015)
HBF4-Catalysed Nucleophilic Substitutions of Propargylic Alcohols.
in European journal of organic chemistry
Barrett TN
(2014)
Cascade polyketide and polyene cyclizations: biomimetic total synthesis of hongoquercin B.
in Journal of the American Chemical Society
Barriga HM
(2015)
Temperature and pressure tuneable swollen bicontinuous cubic phases approaching nature's length scales.
in Soft matter
Barriga HM
(2014)
Droplet interface bilayer reconstitution and activity measurement of the mechanosensitive channel of large conductance from Escherichia coli.
in Journal of the Royal Society, Interface
Barriga HM
(2015)
Buffer-induced swelling and vesicle budding in binary lipid mixtures of dioleoylphosphatidylcholine:dioleoylphosphatidylethanolamine and dioleoylphosphatidylcholine:lysophosphatidylcholine using small-angle X-ray scattering and ³¹P static NMR.
in Langmuir : the ACS journal of surfaces and colloids
Barriga HM
(2015)
Pressure-temperature phase behavior of mixtures of natural sphingomyelin and ceramide extracts.
in Langmuir : the ACS journal of surfaces and colloids
Barriga HM
(2016)
The effect of hydrostatic pressure on model membrane domain composition and lateral compressibility.
in Physical chemistry chemical physics : PCCP
Bayazit MK
(2016)
Carbon nanotube anions for the preparation of gold nanoparticle-nanocarbon hybrids.
in Chemical communications (Cambridge, England)
Beatrup D
(2014)
Polaron stability in semiconducting polymer neat films.
in Chemical communications (Cambridge, England)
Bell A
(2020)
Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes
in Journal of Medicinal Chemistry
Berger RJ
(2014)
Gold(I) mediated rearrangement of [7]-helicene to give a benzo[cd]pyrenium cation embedded in a chiral framework.
in Chemical communications (Cambridge, England)
Billcliff PG
(2016)
OCRL1 engages with the F-BAR protein pacsin 2 to promote biogenesis of membrane-trafficking intermediates.
in Molecular biology of the cell
Bolognesi G
(2015)
Microfluidic generation of monodisperse ultra-low interfacial tension oil droplets in water
in RSC Advances
Bomparola R
(2014)
Lithium heterocuprates: the influence of the amido group on organoamidocuprate structures.
in Dalton transactions (Cambridge, England : 2003)
Boultwood T
(2014)
Synthesis and purification of iodoaziridines involving quantitative selection of the optimal stationary phase for chromatography.
in Journal of visualized experiments : JoVE
Boultwood T
(2015)
Studies on the synthesis of a-iodoaziridines and improved conditions for the synthesis of alkyl-a-iodoaziridines using ClMgCHI2
in Tetrahedron
Boultwood T
(2014)
Stereospecific functionalization of iodoaziridines via unstabilized aziridinyllithiums generated by iodine-lithium exchange.
in Organic letters
Braddock DC
(2014)
Studies towards the synthesis of halomon: asymmetric hexafunctionalisation of myrcene.
in Chemical communications (Cambridge, England)
Braddock DC
(2013)
An enantiospecific polyene cyclization initiated by an enantiomerically pure bromonium ion.
in Chirality
Braddock DC
(2014)
Proof-of-principle direct double cyclisation of a linear C15-precursor to a dibrominated bicyclic medium-ring ether relevant to Laurencia species.
in Chemical communications (Cambridge, England)
Braddock DC
(2013)
Epoxidation of bromoallenes connects red algae metabolites by an intersecting bromoallene oxide--Favorskii manifold.
in Chemical communications (Cambridge, England)
Bresme F
(2014)
Communication: minimum in the thermal conductivity of supercooled water: a computer simulation study.
in The Journal of chemical physics
Britovsek G
(2015)
Ethylene Oligomerization beyond Schulz-Flory Distributions
in ACS Catalysis
Britovsek G
(2015)
Single- and Double-Coordination Mechanism in Ethylene Tri- and Tetramerization with Cr/PNP Catalysts
in ACS Catalysis
Broncel M
(2015)
Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.
in Angewandte Chemie (International ed. in English)
Brooks N
(2014)
High Pressure X-ray Studies of Lipid Membranes and Lipid Phase Transitions
in Zeitschrift für Physikalische Chemie
Brooks NJ
(2014)
Pressure effects on lipids and bio-membrane assemblies.
in IUCrJ
Bruno A
(2014)
Ternary hybrid systems of P3HT-CdSe-WS2 nanotubes for photovoltaic applications.
in Physical chemistry chemical physics : PCCP
Buchaca-Domingo E
(2015)
Direct Correlation of Charge Transfer Absorption with Molecular Donor:Acceptor Interfacial Area via Photothermal Deflection Spectroscopy.
in Journal of the American Chemical Society
Bull J
(2015)
Recent Advances in the Synthesis of 2-Substituted Oxetanes
in Synlett
Bull J
(2015)
2-Sulfinyl Oxetanes: Synthesis, Stability and Reactivity
in Synlett
Burés J
(2016)
Explaining Anomalies in Enamine Catalysis: "Downstream Species" as a New Paradigm for Stereocontrol.
in Accounts of chemical research
Burés J
(2016)
A Simple Graphical Method to Determine the Order in Catalyst.
in Angewandte Chemie (International ed. in English)
Burés J
(2014)
Rationalization of an unusual solvent-induced inversion of enantiomeric excess in organocatalytic selenylation of aldehydes.
in Angewandte Chemie (International ed. in English)
Buyandelger B
(2015)
ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure.
in Circulation. Cardiovascular genetics
Description | Chemistry is the study and application of the science at the molecular scale. It provides some of the most basic understandings of how the world works and underpins many modern technologies. It provides both the most mundane of objects, such as the disposable cup that holds you coffee, and the most vital compounds, such as life-saving drugs. Chemistry relies on four core instrumental techniques to study molecules; Nuclear Magnetic Resonance, Mass Spectrometry, X-Ray Crystallography and molecular scale Microscopy. This grant gave the Chemistry Department at Imperial College the ability to update these facilities. These have enabled research in all areas of Chemistry, for example the building of artificial cells, the production of fuels from biomass to the development of new potential pharmaceuticals and diagnostic techniques. There are too many to list. |
Exploitation Route | There are many ways in which these results can be put to use in the wider world. |
Sectors | Aerospace Defence and Marine Agriculture Food and Drink Chemicals Energy Environment Healthcare Manufacturing including Industrial Biotechology Culture Heritage Museums and Collections Pharmaceuticals and Medical Biotechnology Security and Diplomacy Transport |
Description | Policy Briefing Document |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | Author of policy briefing document: Using Carbon Dioxide |
Year(s) Of Engagement Activity | 2017 |
Description | Presentation to stakeholders |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | Laura Barter was invited to the World Economic Forum in Davos to present her research investigating methods for increasing crop yields by promoting more efficient photosynthesis in the session on "Engineering Intelligent Food Systems". |
Year(s) Of Engagement Activity | 2018 |
Description | Radio Interview |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Andrew Ashley interviewed on BBC Radio 4's Inside Science explaining his group's recent discovery in N2 fixation |
Year(s) Of Engagement Activity | 2016 |
Description | Radio Interview |
Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Public/other audiences |
Results and Impact | BBC World Service's The Why Factor (8 February) on "Why is Water Exceptional?" |
Year(s) Of Engagement Activity | 2016 |
Description | Schools activity |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Schools |
Results and Impact | Salters Festival of Chemistry: Annual Salters Festival. Y7 and Y8 many schools attend with their teachers to undertake two chemistry-based challenges |
Year(s) Of Engagement Activity | 2018 |
Description | Stakeholder meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Public/other audiences |
Results and Impact | Laura Barter, Rudiger Wolcholski and Sarah Al-Beidh organised a Creativity and Ideas generation event for the Sainsbury's farming scholars which was also attended by Sainsbury's horticulture manager, academics from Imperial, Natural History Museum and other UK institutions. Followed by attending the Annual Sainsbury's Farming Conference to highlight the success of the Sainsbury's Farming Scholars Programme - a recent collaboration between Imperial College, AGRI-net and Sainsbury's. |
Year(s) Of Engagement Activity | 2015,2016 |
Description | UK Chemicals Stakeholder Forum. Presentation on measuring sustainability |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Policymakers/politicians |
Results and Impact | Presentation and discussion on sustainability metrics |
Year(s) Of Engagement Activity | 2016 |
Description | World Economic Forum meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Policymakers/politicians |
Results and Impact | Prof David Klug introduced the "Hyperconnected Healthcare" panel at the World Economic Forum meeting in Dalian and participated as a panel member. |
Year(s) Of Engagement Activity | 2015 |