Anatomy-Driven Brain Connectivity Mapping
Lead Research Organisation:
University College London
Department Name: Computer Science
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
People |
ORCID iD |
Daniel Alexander (Principal Investigator) | |
Hui Zhang (Co-Investigator) |
Publications
Slattery C
(2015)
IC-P-134: Neurite orientation dispersion and density imaging (NODDI) in young-onset Alzheimer's disease and its syndromic variants
in Alzheimer's & Dementia
Grussu F
(2017)
Neurite dispersion: a new marker of multiple sclerosis spinal cord pathology?
in Annals of clinical and translational neurology
Zhang J
(2018)
In vivo characterization of white matter pathology in premanifest huntington's disease.
in Annals of neurology
Sepehrband F
(2016)
Parametric Probability Distribution Functions for Axon Diameters of Corpus Callosum.
in Frontiers in neuroanatomy
Parker TD
(2018)
Cortical microstructure in young onset Alzheimer's disease using neurite orientation dispersion and density imaging.
in Human brain mapping
Chandran K
(2022)
Docking simulation and ADMET prediction based investigation on the phytochemical constituents of Noni (Morinda citrifolia) fruit as a potential anticancer drug.
in In silico pharmacology
Grussu F
(2016)
A framework for optimal whole-sample histological quantification of neurite orientation dispersion in the human spinal cord.
in Journal of neuroscience methods
Shemesh N
(2016)
Conventions and nomenclature for double diffusion encoding NMR and MRI.
in Magnetic resonance in medicine
Slator PJ
(2018)
Placenta microstructure and microcirculation imaging with diffusion MRI.
in Magnetic resonance in medicine
Drobnjak I
(2016)
PGSE, OGSE, and sensitivity to axon diameter in diffusion MRI: Insight from a simulation study.
in Magnetic resonance in medicine
Slattery CF
(2017)
ApoE influences regional white-matter axonal density loss in Alzheimer's disease.
in Neurobiology of aging
Ferizi U
(2015)
White matter compartment models for in vivo diffusion MRI at 300mT/m.
in NeuroImage
Ganepola T
(2018)
Using diffusion MRI to discriminate areas of cortical grey matter.
in NeuroImage
Palombo M
(2019)
A generative model of realistic brain cells with application to numerical simulation of the diffusion-weighted MR signal.
in NeuroImage
Graham MS
(2016)
Realistic simulation of artefacts in diffusion MRI for validating post-processing correction techniques.
in NeuroImage
Alfaro-Almagro F
(2018)
Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank
in NeuroImage
Tariq M
(2016)
Bingham-NODDI: Mapping anisotropic orientation dispersion of neurites using diffusion MRI.
in NeuroImage
Bastiani M
(2017)
Improved tractography using asymmetric fibre orientation distributions.
in NeuroImage
Batalle D
(2017)
Early development of structural networks and the impact of prematurity on brain connectivity.
in NeuroImage
Palombo M
(2020)
SANDI: A compartment-based model for non-invasive apparent soma and neurite imaging by diffusion MRI.
in NeuroImage
Graham M
(2018)
A supervised learning approach for diffusion MRI quality control with minimal training data
in NeuroImage
Kaden E
(2016)
Multi-compartment microscopic diffusion imaging.
in NeuroImage
Alexander DC
(2017)
Image quality transfer and applications in diffusion MRI.
in NeuroImage
Grussu F
(2015)
Neurite orientation dispersion and density imaging of the healthy cervical spinal cord in vivo.
in NeuroImage
Alexander DC
(2019)
Imaging brain microstructure with diffusion MRI: practicality and applications.
in NMR in biomedicine
Ferizi U
(2017)
Diffusion MRI microstructure models with in vivo human brain Connectome data: results from a multi-group comparison.
in NMR in biomedicine
Alexander D
(2017)
Imaging brain microstructure with diffusion MRI: practicality and applications
in NMR in Biomedicine
Sepehrband F
(2016)
Towards higher sensitivity and stability of axon diameter estimation with diffusion-weighted MRI.
in NMR in biomedicine
Timmers I
(2016)
Assessing Microstructural Substrates of White Matter Abnormalities: A Comparative Study Using DTI and NODDI.
in PloS one
Graham MS
(2017)
Quantitative assessment of the susceptibility artefact and its interaction with motion in diffusion MRI.
in PloS one
Kelly CJ
(2017)
Impaired development of the cerebral cortex in infants with congenital heart disease is correlated to reduced cerebral oxygen delivery.
in Scientific reports
GHOSH A
(2016)
Computational Diffusion MRI
Ianus A
(2016)
Simulation and Synthesis in Medical Imaging
Rowe M
(2016)
Diffusion Tensor Imaging - A Practical Handbook
Description | Two key findings so far: - Using non-symmetric fibre orientation patterns improves brain connectivity mapping via tractography. Within the grant we have developed a method for estimating non-symmetric fibre configurations from MRI data using neighbourhood information and shown that embedding these new objects within existing tractography algorithms resolves long-standing ambiguities in brain connectivity mapping. - Dispersion is often mistaken for crossing in diffusion MRI. Various studies suggest that fibre crossing configurations arise in a large proportion of MRI voxels in white matter of the brain. Within this grant we have challenges that view noting that more continuous patterns of fibre dispersion can appear as crossing although in fact should be considered separately. Experimental work reveals that many of the voxels previously identified as containing crossings in fact are more likely to contain dispersed fibre configurations. This influences the design of future tractography algorithms for brain connectivity mapping. |
Exploitation Route | These findings prompt further development of tractography algorithms and the underlying models they use, both of which are evolving fast. |
Sectors | Healthcare,Pharmaceuticals and Medical Biotechnology |
Description | EPSRC Centre for Doctoral Training in Intelligent, Integrated Imaging In Healthcare (i4health) |
Amount | £6,034,274 (GBP) |
Funding ID | EP/S021930/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2019 |
End | 03/2028 |
Description | Enabling clinical decisions from low-power MRI in developing nations through image quality transfer |
Amount | £1,020,000 (GBP) |
Funding ID | EP/R014019/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 02/2018 |
End | 01/2021 |
Description | Image Quality Transfer |
Amount | £60,000 (GBP) |
Organisation | Microsoft Research |
Sector | Private |
Country | Global |
Start | 10/2015 |
End | 09/2018 |
Description | Learning MRI and histology image mappings for cancer diagnosis and prognosis |
Amount | £774,000 (GBP) |
Funding ID | EP/R006032/1 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 12/2017 |
End | 01/2020 |