Dynamically Adaptive Metal-organic Nanopores
Lead Research Organisation:
University of Cambridge
Department Name: Chemistry
Abstract
We propose to prepare and study a new class of synthetic ion channels based on dynamic metal-organic complexes that possess a pore-like central channel that will allow for substrate transport across a lipid bilayer.
These complexes are obtained through the condensation of simple organic building blocks around octahedral metal ion templates. The modular nature of these complexes and the dynamic nature of their imine bonds will allow us to tune the assemblies to confer different physical properties upon them, while retaining their overall structures. Through tuning we will identify the key characteristics of complexes that can be inserted into lipid bilayers. This project builds upon preliminary investigations that have shown that heptyl-chain-bearing derivatives allowed chloride ions to pass across a membrane, providing a point of departure for our investigations.
In other key precedent work we established that it is possible to induce reconstitution of the complexes into entirely different structures in the presence of different templating anions. We will investigate ways to exploit this phenomenon as an approach to controlling flux across a membrane by reversibly triggering reconstitution to form complexes that do not possess central channels, thus inhibiting ion transport.
Development of these tuneable, gating ion channels will pave the way to new industrial processes that are driven by the effective separation of high value compounds from impure mixtures, and new chemical transformations involving the selective gating of intermediate species between vesicular reaction chambers. In future, our technologies may also facilitate new treatments for those who suffer from forms of channelopathy.
These complexes are obtained through the condensation of simple organic building blocks around octahedral metal ion templates. The modular nature of these complexes and the dynamic nature of their imine bonds will allow us to tune the assemblies to confer different physical properties upon them, while retaining their overall structures. Through tuning we will identify the key characteristics of complexes that can be inserted into lipid bilayers. This project builds upon preliminary investigations that have shown that heptyl-chain-bearing derivatives allowed chloride ions to pass across a membrane, providing a point of departure for our investigations.
In other key precedent work we established that it is possible to induce reconstitution of the complexes into entirely different structures in the presence of different templating anions. We will investigate ways to exploit this phenomenon as an approach to controlling flux across a membrane by reversibly triggering reconstitution to form complexes that do not possess central channels, thus inhibiting ion transport.
Development of these tuneable, gating ion channels will pave the way to new industrial processes that are driven by the effective separation of high value compounds from impure mixtures, and new chemical transformations involving the selective gating of intermediate species between vesicular reaction chambers. In future, our technologies may also facilitate new treatments for those who suffer from forms of channelopathy.
Planned Impact
Beyond the academic community, the development of new synthetic ion channels in this project will have an impact on industry and the general public.
Industry: A key aim of this project is to develop a methodology for the generation of new types of reconfigurable membrane materials that could address some of the fundamental problems encountered in chemical industry, one of the largest manufacturing industries in the UK. Separations are central to a plethora of industrial processes and the use of membrane technologies that can selectively isolate valuable species from a mixture provides a low energy, high efficiency alternative. Pores and porins play key role in intercellular communication and drug development. Creating artificial gating pores will pave the way to the development of medical technologies that could treat those who suffer from forms of channelopathy.
Intellectual property (IP) will be protected and exploited in accordance with the published policy of the University of Cambridge to the benefit of all individuals and institutions involved. After the protection of any relevant IP, dissemination will be through publication in top international journals and domestic and international presentations. We will make sure that relevant IP is patented, potential licensees are recognised, and that possibilities for launching spin-outs are also properly identified.
General public: Appreciation and public support for scientific progress have underpinned technological progress in the UK ever since the practice of science became professionalised in the 19th century. We are committed to maintaining our side of this dialogue through explaining to the public what we do and why. One mechanism for this is press coverage of our research programme. The Nitschke group's 2009 Science paper generated a dozen stories in newspapers, TV, and radio across more than five countries, all with a positive bent. Another mechanism is structured outreach events; JRN will present his group's research to the 2014 international 'Pint of Science' festival (http://www.pintofscience.com/).
Education: In the context of undergraduate education, one of the Nitschke group's self-assembled systems are highlighted in a first-year undergraduate chemistry textbook (Chemistry: The Molecular Science, 4th ed, C. L. Stanitski, P.C. Jurs, M. Sanger, Brooks/Cole, Stamford CT USA, 2011; p. 1024) and has already been adapted for use in undergraduate practical exercises (at Harvey Mudd College in California).
Industry: A key aim of this project is to develop a methodology for the generation of new types of reconfigurable membrane materials that could address some of the fundamental problems encountered in chemical industry, one of the largest manufacturing industries in the UK. Separations are central to a plethora of industrial processes and the use of membrane technologies that can selectively isolate valuable species from a mixture provides a low energy, high efficiency alternative. Pores and porins play key role in intercellular communication and drug development. Creating artificial gating pores will pave the way to the development of medical technologies that could treat those who suffer from forms of channelopathy.
Intellectual property (IP) will be protected and exploited in accordance with the published policy of the University of Cambridge to the benefit of all individuals and institutions involved. After the protection of any relevant IP, dissemination will be through publication in top international journals and domestic and international presentations. We will make sure that relevant IP is patented, potential licensees are recognised, and that possibilities for launching spin-outs are also properly identified.
General public: Appreciation and public support for scientific progress have underpinned technological progress in the UK ever since the practice of science became professionalised in the 19th century. We are committed to maintaining our side of this dialogue through explaining to the public what we do and why. One mechanism for this is press coverage of our research programme. The Nitschke group's 2009 Science paper generated a dozen stories in newspapers, TV, and radio across more than five countries, all with a positive bent. Another mechanism is structured outreach events; JRN will present his group's research to the 2014 international 'Pint of Science' festival (http://www.pintofscience.com/).
Education: In the context of undergraduate education, one of the Nitschke group's self-assembled systems are highlighted in a first-year undergraduate chemistry textbook (Chemistry: The Molecular Science, 4th ed, C. L. Stanitski, P.C. Jurs, M. Sanger, Brooks/Cole, Stamford CT USA, 2011; p. 1024) and has already been adapted for use in undergraduate practical exercises (at Harvey Mudd College in California).
Publications
McConnell AJ
(2015)
Stimuli-Responsive Metal-Ligand Assemblies.
in Chemical reviews
Ronson TK
(2016)
Pathway-Dependent Post-assembly Modification of an Anthracene-Edged M(II)4L6 Tetrahedron.
in Journal of the American Chemical Society
Ramsay WJ
(2016)
Subtle Ligand Modification Inverts Guest Binding Hierarchy in M(II)8L6 Supramolecular Cubes.
in Journal of the American Chemical Society
Mosquera J
(2016)
Subcomponent Flexibility Enables Conversion between D4-Symmetric Cd(II)8L8 and T-Symmetric Cd(II)4L4 Assemblies.
in Journal of the American Chemical Society
Wood CS
(2016)
Dual stimuli-induced formation of a µ-hydroxido bridged [Zn9L5(µ-OH)6]12+ half-pipe.
in Chemical science
Kieffer M
(2016)
Perfluorinated Ligands Induce Meridional Metal Stereochemistry to Generate M8L12, M10L15, and M12L18 Prisms.
in Journal of the American Chemical Society
Rizzuto FJ
(2016)
Peripheral Templation Generates an M(II) 6 L4 Guest-Binding Capsule.
in Angewandte Chemie (International ed. in English)
Struch N
(2017)
An Octanuclear Metallosupramolecular Cage Designed To Exhibit Spin-Crossover Behavior.
in Angewandte Chemie (International ed. in English)
Mosquera J
(2017)
Sequence-selective encapsulation and protection of long peptides by a self-assembled FeII8L6 cubic cage.
in Nature communications
Haynes CJE
(2017)
Blockable Zn10 L15 Ion Channels through Subcomponent Self-Assembly.
in Angewandte Chemie (International ed. in English)
Zhang D
(2017)
Anion Binding in Water Drives Structural Adaptation in an Azaphosphatrane-Functionalized FeII4L4 Tetrahedron.
in Journal of the American Chemical Society
Pilgrim B
(2017)
Signal transduction in a covalent post-assembly modification cascade
Percástegui E
(2017)
Anion Exchange Renders Hydrophobic Capsules and Cargoes Water-Soluble
in Angewandte Chemie
Haynes C
(2017)
Blockable Zn 10 L 15 Ion Channels through Subcomponent Self-Assembly
in Angewandte Chemie
Pilgrim B
(2017)
Signal transduction in a covalent post-assembly modification cascade
in Nature Chemistry
Percástegui EG
(2017)
Anion Exchange Renders Hydrophobic Capsules and Cargoes Water-Soluble.
in Angewandte Chemie (International ed. in English)
Brenner W
(2017)
Separation and Selective Formation of Fullerene Adducts within an M(II)(8)L(6) Cage.
in Journal of the American Chemical Society
Chen K
(2018)
Digital Data Storage Using DNA Nanostructures and Solid-State Nanopores
in Nano Letters
Zhang D
(2018)
Selective Anion Extraction and Recovery Using a FeII4 L4 Cage.
in Angewandte Chemie (International ed. in English)
Kong J
(2018)
Specific Biosensing Using DNA Aptamers and Nanopores
in Advanced Functional Materials
Rizzuto F
(2018)
Quantified structural speciation in self-sorted CoII6L 4 cage systems
in Chemical Science
Fazio E
(2018)
A giant M2L3 metallo-organic helicate based on phthalocyanines as a host for electroactive molecules.
in Chemical communications (Cambridge, England)
Zhang D
(2018)
Selective Anion Extraction and Recovery Using a Fe II 4 L 4 Cage
in Angewandte Chemie
Zhang D
(2018)
Selective Anion Extraction and Recovery Using a FeII4L4 Cage
Rizzuto FJ
(2018)
Quantified structural speciation in self-sorted CoII6L4 cage systems.
in Chemical science
Zhang D
(2019)
Selective Separation of Polyaromatic Hydrocarbons by Phase Transfer of Coordination Cages
in Journal of the American Chemical Society
Zarkan A
(2019)
Indole Pulse Signalling Regulates the Cytoplasmic pH of E. coli in a Memory-Like Manner.
in Scientific reports
Chen K
(2019)
Secure data storage on DNA hard drives
Lu Z
(2019)
Reversible reduction drives anion ejection and C60 binding within an FeII 4L6 cage.
in Chemical science
Boškovic F
(2019)
Monitoring G-Quadruplex Formation with DNA Carriers and Solid-State Nanopores.
in Nano letters
Plajer AJ
(2019)
Tailoring the Binding Properties of Phosphazane Anion Receptors and Transporters.
in Journal of the American Chemical Society
Zhang D
(2019)
Temperature Controls Guest Uptake and Release from Zn4L4 Tetrahedra.
in Journal of the American Chemical Society
Zhu J
(2019)
FeII4L4 Tetrahedron Binds to Nonpaired DNA Bases.
Kong J
(2019)
Specific Biosensing Using DNA Aptamers and Nanopores
| Description | Initial results have validated our hypothesis - that metal-organic structures of the sort described in our proposal can indeed selectively gate anions (chloride, bromide) through a membrane, whilst excluding others. We have also seen that the presence of certain anions, such as the soap dodecylsulfate, can block the pores. A key publication has been accepted in the top journal Angewandte Chemie. Another publication is in a late stage of preparation. |
| Exploitation Route | There may be relevance to designing complex chemical systems consisting of membrane-bounded spaces, with channels serving as communication vectors between them. There might even be some relevance to channelopathy diseases - early days! |
| Sectors | Chemicals Education Energy Environment Healthcare Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
| URL | http://www-jrn.ch.cam.ac.uk/ |
| Title | CCDC 1432685: Experimental Crystal Structure Determination |
| Description | Related Article: William J. Ramsay, Felix J. Rizzuto, Tanya K. Ronson, Kenji Caprice, and Jonathan R. Nitschke|2016|J.Am.Chem.Soc.|138|7264|doi:10.1021/jacs.6b03858 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1k2tn3&sid=DataCite |
| Title | CCDC 1432686: Experimental Crystal Structure Determination |
| Description | Related Article: William J. Ramsay, Felix J. Rizzuto, Tanya K. Ronson, Kenji Caprice, and Jonathan R. Nitschke|2016|J.Am.Chem.Soc.|138|7264|doi:10.1021/jacs.6b03858 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1k2tp4&sid=DataCite |
| Title | CCDC 1439852: Experimental Crystal Structure Determination |
| Description | Related Article: Jesús Mosquera, Tanya K. Ronson, and Jonathan R. Nitschke|2016|J.Am.Chem.Soc.|138|1812|doi:10.1021/jacs.5b12955 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc1kb8v0&sid=DataCite |
| Title | CCDC 1439853: Experimental Crystal Structure Determination |
| Description | Related Article: Jesús Mosquera, Tanya K. Ronson, and Jonathan R. Nitschke|2016|J.Am.Chem.Soc.|138|1812|doi:10.1021/jacs.5b12955 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc1kb8w1&sid=DataCite |
| Title | CCDC 1442988: Experimental Crystal Structure Determination |
| Description | Related Article: Marion Kieffer, Ben S. Pilgrim, Tanya K. Ronson, Derrick A. Roberts, Mina Aleksanyan, and Jonathan R. Nitschke|2016|J.Am.Chem.Soc.|138|6813|doi:10.1021/jacs.6b02445 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1kfk0k&sid=DataCite |
| Title | CCDC 1442989: Experimental Crystal Structure Determination |
| Description | Related Article: Marion Kieffer, Ben S. Pilgrim, Tanya K. Ronson, Derrick A. Roberts, Mina Aleksanyan, and Jonathan R. Nitschke|2016|J.Am.Chem.Soc.|138|6813|doi:10.1021/jacs.6b02445 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1kfk1l&sid=DataCite |
| Title | CCDC 1442990: Experimental Crystal Structure Determination |
| Description | Related Article: Marion Kieffer, Ben S. Pilgrim, Tanya K. Ronson, Derrick A. Roberts, Mina Aleksanyan, and Jonathan R. Nitschke|2016|J.Am.Chem.Soc.|138|6813|doi:10.1021/jacs.6b02445 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1kfk2m&sid=DataCite |
| Title | CCDC 1442991: Experimental Crystal Structure Determination |
| Description | Related Article: Marion Kieffer, Ben S. Pilgrim, Tanya K. Ronson, Derrick A. Roberts, Mina Aleksanyan, and Jonathan R. Nitschke|2016|J.Am.Chem.Soc.|138|6813|doi:10.1021/jacs.6b02445 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2016 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1kfk3n&sid=DataCite |
| Title | CCDC 1485730: Experimental Crystal Structure Determination |
| Description | Related Article: Wolfgang Brenner, Tanya K. Ronson, and Jonathan R. Nitschke|2017|J.Am.Chem.Soc.|139|75|doi:10.1021/jacs.6b11523 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1lw0s8&sid=DataCite |
| Title | CCDC 1529220: Experimental Crystal Structure Determination |
| Description | Related Article: Dawei Zhang, Tanya K. Ronson, Jesús Mosquera, Alexandre Martinez, Laure Guy and Jonathan R. Nitschke|2017|J.Am.Chem.Soc.|139|6574|doi:10.1021/jacs.7b02950 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1nb8py&sid=DataCite |
| Title | CCDC 1540884: Experimental Crystal Structure Determination |
| Description | Related Article: Cally J. E. Haynes, Jinbo Zhu, Catalin Chimerel, Silvia Hernández-Ainsa, Imogen A. Riddell, Tanya K. Ronson, Ulrich F. Keyser, Jonathan R. Nitschke|2017|Angew.Chem.,Int.Ed.|56|15388|doi:10.1002/anie.201709544 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2017 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1nqdyq&sid=DataCite |
| Title | CCDC 1568164: Experimental Crystal Structure Determination |
| Description | Related Article: Felix J. Rizzuto, Marion Kieffer, Jonathan R. Nitschke|2018|Chemical Science|9|1925|doi:10.1039/C7SC04927G |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1pmsy1&sid=DataCite |
| Title | CCDC 1568165: Experimental Crystal Structure Determination |
| Description | Related Article: Felix J. Rizzuto, Marion Kieffer, Jonathan R. Nitschke|2018|Chemical Science|9|1925|doi:10.1039/C7SC04927G |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1pmsz2&sid=DataCite |
| Title | CCDC 1812469: Experimental Crystal Structure Determination |
| Description | Related Article: Dawei Zhang, Tanya K. Ronson, Jesús Mosquera, Alexandre Martinez, Jonathan R. Nitschke|2018|Angew.Chem.,Int.Ed.|57|3717|doi:10.1002/anie.201800459 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1yv0rk&sid=DataCite |
| Title | CCDC 1812470: Experimental Crystal Structure Determination |
| Description | Related Article: Dawei Zhang, Tanya K. Ronson, Jesús Mosquera, Alexandre Martinez, Jonathan R. Nitschke|2018|Angew.Chem.,Int.Ed.|57|3717|doi:10.1002/anie.201800459 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1yv0sl&sid=DataCite |
| Title | CCDC 1890516: Experimental Crystal Structure Determination |
| Description | Related Article: Alex J. Plajer, Jinbo Zhu, Patrick Proehm, Andrew D. Bond, Ulrich F. Keyser, Dominic S. Wright|2019|J.Am.Chem.Soc.|141|8807|doi:10.1021/jacs.9b00504 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc21g7d5&sid=DataCite |
| Title | CCDC 1890517: Experimental Crystal Structure Determination |
| Description | Related Article: Alex J. Plajer, Jinbo Zhu, Patrick Proehm, Andrew D. Bond, Ulrich F. Keyser, Dominic S. Wright|2019|J.Am.Chem.Soc.|141|8807|doi:10.1021/jacs.9b00504 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc21g7f6&sid=DataCite |
| Title | CCDC 1890521: Experimental Crystal Structure Determination |
| Description | Related Article: Alex J. Plajer, Jinbo Zhu, Patrick Proehm, Andrew D. Bond, Ulrich F. Keyser, Dominic S. Wright|2019|J.Am.Chem.Soc.|141|8807|doi:10.1021/jacs.9b00504 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc21g7kb&sid=DataCite |
| Title | CCDC 1890522: Experimental Crystal Structure Determination |
| Description | Related Article: Alex J. Plajer, Jinbo Zhu, Patrick Proehm, Andrew D. Bond, Ulrich F. Keyser, Dominic S. Wright|2019|J.Am.Chem.Soc.|141|8807|doi:10.1021/jacs.9b00504 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2021 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc21g7lc&sid=DataCite |
| Title | CCDC 1935513: Experimental Crystal Structure Determination |
| Description | Related Article: Zhenpin Lu, Tanya K. Ronson, Jonathan R. Nitschke|2020|Chemical Science|11|1097|doi:10.1039/C9SC05728E |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc22z1x1&sid=DataCite |
| Title | CCDC 1948842: Experimental Crystal Structure Determination |
| Description | Related Article: Alex J. Plajer, Jinbo Zhu, Patrick Pröhm, Felix J. Rizzuto, Ulrich F. Keyser, Dominic S. Wright|2019|J.Am.Chem.Soc.|142|1029|doi:10.1021/jacs.9b11347 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc23dxwb&sid=DataCite |
| Title | CCDC 1948843: Experimental Crystal Structure Determination |
| Description | Related Article: Alex J. Plajer, Jinbo Zhu, Patrick PrA A{paragraph}hm, Felix J. Rizzuto, Ulrich F. Keyser, Dominic S. Wright|2020|J.Am.Chem.Soc.|142|1029|doi:10.1021/jacs.9b11347 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc23dxxc&sid=DataCite |
| Title | CCDC 1948844: Experimental Crystal Structure Determination |
| Description | Related Article: Alex J. Plajer, Jinbo Zhu, Patrick PrA A{paragraph}hm, Felix J. Rizzuto, Ulrich F. Keyser, Dominic S. Wright|2020|J.Am.Chem.Soc.|142|1029|doi:10.1021/jacs.9b11347 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc23dxyd&sid=DataCite |
| Title | CCDC 1948845: Experimental Crystal Structure Determination |
| Description | Related Article: Alex J. Plajer, Jinbo Zhu, Patrick Pröhm, Felix J. Rizzuto, Ulrich F. Keyser, Dominic S. Wright|2019|J.Am.Chem.Soc.|142|1029|doi:10.1021/jacs.9b11347 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc23dxzf&sid=DataCite |
| Title | CCDC 1948846: Experimental Crystal Structure Determination |
| Description | Related Article: Alex J. Plajer, Jinbo Zhu, Patrick PrA A{paragraph}hm, Felix J. Rizzuto, Ulrich F. Keyser, Dominic S. Wright|2020|J.Am.Chem.Soc.|142|1029|doi:10.1021/jacs.9b11347 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc23dy0h&sid=DataCite |
| Title | CCDC 1948847: Experimental Crystal Structure Determination |
| Description | Related Article: Alex J. Plajer, Jinbo Zhu, Patrick PrA A{paragraph}hm, Felix J. Rizzuto, Ulrich F. Keyser, Dominic S. Wright|2020|J.Am.Chem.Soc.|142|1029|doi:10.1021/jacs.9b11347 |
| Type Of Material | Database/Collection of data |
| Year Produced | 2020 |
| Provided To Others? | Yes |
| URL | http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc23dy1j&sid=DataCite |
| Title | Research data supporting "Indole Pulse Signalling Regulates the Cytoplasmic pH of E. coli in a Memory-Like Manner" |
| Description | This dataset was collected by Fluorescence Spectroscopy and FlowCytometry |
| Type Of Material | Database/Collection of data |
| Year Produced | 2019 |
| Provided To Others? | Yes |
| URL | https://www.repository.cam.ac.uk/handle/1810/289929 |
| Description | Keyser collaboration |
| Organisation | University of Cambridge |
| Department | Department of Physics |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have made metal-organic nanopores |
| Collaborator Contribution | They have studied these groups as ion channels in bilayer membranes |
| Impact | Publication: "Blockable Zn10L15 ion channels via subcomponent self-assembly", C.J.E. Haynes, J. Zhu, C. Chimerel, S. Hernández-Ainsa, I.A. Riddell, T.K. Ronson, U.F. Keyser, J.R. Nitschke, Angew. Chem. Int. Ed. 2017, 56, 15388-15392. |
| Start Year | 2012 |