Virtual Formulation Laboratory for prediction and optimisation of manufacturability of advanced solids based formulations
Lead Research Organisation:
University of Leicester
Department Name: Engineering
Abstract
Solid dose forms are the backbone of many manufacturing industries. In pharmaceutical therapeutics, tablets, capsules, dry powder inhalers and powders for re-suspension cover the vast majority of the £5.6Bn sales by this industry in the UK. Food (sales £67Bn) is the single largest industry of the UK manufacturing sector which totalled £365Bn sales in 2014 (Office of National Statistics). In all these manufacturing processes and in final use, the physical behaviour of the powder is at least as important as the chemistry. Stability, weight and content uniformity, manufacturing difficulties and variable performance are determined by decisions made during the formulation process Manufacturing problems are ubiquitous; the Rand report (by E.W. Merrow, 1981) examined powder processes and found on average 2 year over-runs to get to full productivity, and development costs 210% of estimates, due to incompatibility between powder behaviour and process design. In the intervening years, plant engineering techniques have developed, but the rationalisation of formulation decisions has never received more than cursory, empirical study.
This project proposes to develop a Virtual Formulation Laboratory (VFL), a software tool for prediction and optimisation of manufacturability and stability of advanced solids-based formulations. The team has established expertise in powder flow, mixing and compaction which will be brought together for the first time to link formulation variables with manufacturability predictions.
The OVERALL AIMS of the project are (a) to develop the science base for understanding of surfaces, particulate structures and bulk behaviour to address physical, chemical and mechanical stability during processing and storage and (b) to incorporate these into a software tool (VFL) which accounts for a wide range of material types, particle structures and blend systems to enable the formulator to test the effects of formulation changes in virtual space and check for potential problems covering the majority of manufacturing difficulties experienced in production plants.
The VISION for VFL is to be employed widely in the development process of every new formulated powder product in food, pharmaceuticals and fine chemicals within five years of the completion of this project.
VFL will consider four processes: powder flow, mixing, compaction and storage; and will predict four manufacturability problems: poor flow/flooding, segregation/heterogeneity, powder caking and strength/breakage of compacts These account for the majority of practical problems in the processing of solid particulate materials
The OVERALL OBJECTIVES of the project are: (a) to fill the gaps in formulation science to link molecule to manufacturability, which will be achieved through experimental characterisation and numerical modelling, and (b) establish methodologies to deal with new materials, so that the virtual lab could make predictions for formulations with new materials without extensive experimental characterisation or numerical modelling. This will be achieved through developing functional relationships based on the scientific outcomes of the above investigations, while identifying the limits and uncertainties of these relationships.
This project proposes to develop a Virtual Formulation Laboratory (VFL), a software tool for prediction and optimisation of manufacturability and stability of advanced solids-based formulations. The team has established expertise in powder flow, mixing and compaction which will be brought together for the first time to link formulation variables with manufacturability predictions.
The OVERALL AIMS of the project are (a) to develop the science base for understanding of surfaces, particulate structures and bulk behaviour to address physical, chemical and mechanical stability during processing and storage and (b) to incorporate these into a software tool (VFL) which accounts for a wide range of material types, particle structures and blend systems to enable the formulator to test the effects of formulation changes in virtual space and check for potential problems covering the majority of manufacturing difficulties experienced in production plants.
The VISION for VFL is to be employed widely in the development process of every new formulated powder product in food, pharmaceuticals and fine chemicals within five years of the completion of this project.
VFL will consider four processes: powder flow, mixing, compaction and storage; and will predict four manufacturability problems: poor flow/flooding, segregation/heterogeneity, powder caking and strength/breakage of compacts These account for the majority of practical problems in the processing of solid particulate materials
The OVERALL OBJECTIVES of the project are: (a) to fill the gaps in formulation science to link molecule to manufacturability, which will be achieved through experimental characterisation and numerical modelling, and (b) establish methodologies to deal with new materials, so that the virtual lab could make predictions for formulations with new materials without extensive experimental characterisation or numerical modelling. This will be achieved through developing functional relationships based on the scientific outcomes of the above investigations, while identifying the limits and uncertainties of these relationships.
Planned Impact
A. Industry impact for improved process efficiency
Industry impact is a top priority of this project. Our partners have an outstanding impact track record, and this proposal has found an exceptionally strong pull from industry. Keys to maximising impact are (i) to make the toolkit easy to use, highly accessible and effective, and (ii) taking it to the beneficiaries pro-actively. The plans to achieve this are articulated below.
B. Accelerating the output up the TRL scale
Accessibility requires the software package to run on a popular platform, have a user-friendly Graphic User Interface, with strong expert support maintained over the foreseeable future, and multiple access routes to suit the needs of different companies. Without these features, such advanced science would be very difficult for practicing formulators and engineers in industry to use. The starting point is the Virtual Powder Blending Laboratory (DEFRA AFM276) (Bradley and Berry), which has a functional structure, an expandable, shareable database to enter and store the properties of materials characterised, and a user friendly interface, optimised with the DEFRA project partners. It will be used as a basis to build the output of this project into a usable toolkit, moving the basic science, of TRL2, up to a position of direct impact on manufacturing, TRL4 to 5.
C. Positive engagement of the industry partners during the programme
To facilitate this, an Industrial/Academic Advisory Board will be convened including all the contributors, to meet quarterly, advised by two consultants (high level research leaders in formulation). The board will steer the programme, provide the industry context and ensure relevance. Powder producers and users will take active roles in characterisation of their powders and processes and testing the toolkit as it evolves and will help pursue compatibility with their own tools. All will involve their personnel in training in use of the techniques. The participants will thus get a head start in exploiting the output.
D. Communication with beneficiaries beyond the project participants
Around 20 open access papers in archival journals, 40 conference publications, then trade journal articles, and workshops with learned and trade bodies (IMechE, IChemE, SHAPA etc, in which many of the investigators hold positions of influence e.g. chairmen & committee members).
The toolkit will be incorporated in Wolfson Centre short courses on powder processing. Annually, about 20 courses reach 250 to 300 people involved in formulation and manufacturing of powder products, in 60 to 70 different companies. Leeds organises complementary short courses in powder science, which will also promote the toolkit and the science behind it. Britest, PSE and NFC will also lead activities in marketing and taking to users.
E. Contributing to the health of academic disciplines worldwide
The advances in modelling, surface energy characterisation etc will significantly push forwards the ability of the community to model the behaviour of powders. These will be promoted to the academic community through publications, short courses and workshops for researchers, international conferences (AAPS/AIChE, APS, PARTEC, APT, CHoPS, ICBMH), exhibitions (Powtech), learned body meetings e.g. IChemE, IMechE, EFCE, and industry bodies eg SHAPA.
F. Public communication and engagement
The PIs are active in public lectures through IOM3, schools visits, science festivals, House of Commons annual science event etc. Case studies from this project should form an excellent showcase for the direct impact of research on efficiency and competitiveness of UK manufacturing.
Industry impact is a top priority of this project. Our partners have an outstanding impact track record, and this proposal has found an exceptionally strong pull from industry. Keys to maximising impact are (i) to make the toolkit easy to use, highly accessible and effective, and (ii) taking it to the beneficiaries pro-actively. The plans to achieve this are articulated below.
B. Accelerating the output up the TRL scale
Accessibility requires the software package to run on a popular platform, have a user-friendly Graphic User Interface, with strong expert support maintained over the foreseeable future, and multiple access routes to suit the needs of different companies. Without these features, such advanced science would be very difficult for practicing formulators and engineers in industry to use. The starting point is the Virtual Powder Blending Laboratory (DEFRA AFM276) (Bradley and Berry), which has a functional structure, an expandable, shareable database to enter and store the properties of materials characterised, and a user friendly interface, optimised with the DEFRA project partners. It will be used as a basis to build the output of this project into a usable toolkit, moving the basic science, of TRL2, up to a position of direct impact on manufacturing, TRL4 to 5.
C. Positive engagement of the industry partners during the programme
To facilitate this, an Industrial/Academic Advisory Board will be convened including all the contributors, to meet quarterly, advised by two consultants (high level research leaders in formulation). The board will steer the programme, provide the industry context and ensure relevance. Powder producers and users will take active roles in characterisation of their powders and processes and testing the toolkit as it evolves and will help pursue compatibility with their own tools. All will involve their personnel in training in use of the techniques. The participants will thus get a head start in exploiting the output.
D. Communication with beneficiaries beyond the project participants
Around 20 open access papers in archival journals, 40 conference publications, then trade journal articles, and workshops with learned and trade bodies (IMechE, IChemE, SHAPA etc, in which many of the investigators hold positions of influence e.g. chairmen & committee members).
The toolkit will be incorporated in Wolfson Centre short courses on powder processing. Annually, about 20 courses reach 250 to 300 people involved in formulation and manufacturing of powder products, in 60 to 70 different companies. Leeds organises complementary short courses in powder science, which will also promote the toolkit and the science behind it. Britest, PSE and NFC will also lead activities in marketing and taking to users.
E. Contributing to the health of academic disciplines worldwide
The advances in modelling, surface energy characterisation etc will significantly push forwards the ability of the community to model the behaviour of powders. These will be promoted to the academic community through publications, short courses and workshops for researchers, international conferences (AAPS/AIChE, APS, PARTEC, APT, CHoPS, ICBMH), exhibitions (Powtech), learned body meetings e.g. IChemE, IMechE, EFCE, and industry bodies eg SHAPA.
F. Public communication and engagement
The PIs are active in public lectures through IOM3, schools visits, science festivals, House of Commons annual science event etc. Case studies from this project should form an excellent showcase for the direct impact of research on efficiency and competitiveness of UK manufacturing.
Organisations
- University of Leicester (Lead Research Organisation)
- Nanjing Tech University (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- Universiti Teknologi MARA System (Collaboration)
- UNIVERSITY OF LEEDS (Collaboration)
- National Institute of Technology, Oita College (Collaboration)
- Brookfield Viscometers Ltd (UK) (Project Partner)
- GlaxoSmithKline (United Kingdom) (Project Partner)
- Process Systems Enterprise (United Kingdom) (Project Partner)
- AstraZeneca (United Kingdom) (Project Partner)
- Britest Limited (Project Partner)
- KP Snacks (Project Partner)
- Nestlé Foundation (Project Partner)
- Centre for Process Innovation (Project Partner)
- Procter & Gamble (United Kingdom) (Project Partner)
Publications
Ahmed M
(2020)
A simple method for assessing powder spreadability for additive manufacturing
in Powder Technology
Deng T
(2021)
An experimental study on free-surface rolling segregation and correlations with angle of repose and particle sphericity
in Powder Technology
Deng T
(2021)
Correlations between segregation intensity and material properties such as particle sizes and adhesions and novel methods for assessment
in Powder Technology
Di Pasquale N
(2020)
Shuttleworth equation: A molecular simulations perspective.
in The Journal of chemical physics
Di Pasquale N
(2019)
A unified description of Surface Free Energy and Surface Stress
Di Pasquale N
(2022)
Cleaving Method for Molecular Crystals and Its Application to Calculation of the Surface Free Energy of Crystalline ß-d-Mannitol at Room Temperature.
in The journal of physical chemistry. A
Di Pasquale N
(2024)
CLEAVING: a LAMMPS package to compute surface free energies
in Journal of Open Source Software
Edmans B
(2020)
Unloading of elastoplastic spheres from large deformations
in Powder Technology
Edmans B
(2020)
Numerical derivation of a normal contact law for compressible plastic particles
in Mechanics of Materials
Description | The concepts of Surface Stress, Surface tension and SFE are sometimes confused in the literature and applications. The equivalence of these concepts is true only for interfaces involving liquids, while for interfaces with solids, extra care should be taken when these quantities are calculated within molecular simulations or measured in experiments, as different methods of calculation or measurement lead to different results. |
Exploitation Route | New framework for the calculation of Surface Free Energy (SFE) and surface stress in solids and liquids. Verification of the Shuttleworth equation. Calculation of the SFE for organic crystals (mannitol). |
Sectors | Agriculture Food and Drink Chemicals Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |
Description | The VFL software toolkit was created by integrating our results on powder flow, segregation, compaction and caking. The toolkit has been used by industrial partners. Having developed special methodologies for the characterisation of single particle properties and implementation in our modelling capacity, the outcome attracted the attention of HP (Barcelona) for powder spreading for Additive Manufacturing. This led to a large consultancy for the group, involving six PDRAS and several publications. (see e.g. Nan, W., Pasha, M., Bonakdar, T., Lopez, A., Zafar, U., Nadimi, S. and Ghadiri, M., (2018). Jamming during particle spreading in additive manufacturing. Powder Technology. DOI: https://doi.org/10.1016/j.powtec.2018.07.030). Another outcome of this programme is a new line of research on impact deformation, as relevant to cold spraying, in collaboration with the University of Montpellier, France. |
Sector | Agriculture, Food and Drink,Chemicals,Healthcare,Manufacturing, including Industrial Biotechology,Pharmaceuticals and Medical Biotechnology |
Impact Types | Economic |
Description | EPSRC Industrial CASE (iCase) studentship award at Imperial College |
Amount | £108,580 (GBP) |
Funding ID | Voucher No. 16000114 |
Organisation | AstraZeneca |
Sector | Private |
Country | United Kingdom |
Start | 09/2017 |
End | 03/2021 |
Description | PhD Studentship (Part-time) at Imperial College |
Amount | £50,000 (GBP) |
Organisation | GlaxoSmithKline (GSK) |
Sector | Private |
Country | Global |
Start | 07/2017 |
End | 07/2022 |
Description | PhD Studentship at Imperial College |
Amount | £110,000 (GBP) |
Organisation | Johnson Matthey |
Sector | Private |
Country | United Kingdom |
Start | 09/2021 |
End | 04/2025 |
Description | VC Scholarship Scheme at the University of Greenwich |
Amount | £120,000 (GBP) |
Organisation | University of Greenwich |
Sector | Academic/University |
Country | United Kingdom |
Start | 09/2017 |
End | 09/2020 |
Title | Leeds: toolkit for prediction of flow behaviour |
Description | Leeds has now developed a toolkit for prediction of flow behaviour of formulated products based on their individual component properties such as size, adhesion, and density. |
Type Of Material | Improvements to research infrastructure |
Year Produced | 2019 |
Provided To Others? | No |
Impact | Leeds has now developed a toolkit for prediction of flow behaviour of formulated products based on their individual component properties such as size, adhesion, and density. |
Title | Novel Cellular Automaton model |
Description | Developed Novel Cellular Automaton model for assessing size segregation in fuel handling (University of Greenwich). A von Neumann automaton approach to model free surface segregation effects in handling of biomass fuel. |
Type Of Material | Improvements to research infrastructure |
Year Produced | 2019 |
Provided To Others? | No |
Impact | Anticipated impact will be to allow optimisation of storage reclaim strategy to minimise variation in dust content in wood pellet fuel in order to minimise explosion and health risks. |
Title | Novel Cellular Automaton model for assessing size segregation in fuel handling (University of Greenwich) |
Description | A von Neumann automaton approach to model free surface segregation effects in handling of biomass fuel |
Type Of Material | Improvements to research infrastructure |
Year Produced | 2017 |
Provided To Others? | No |
Impact | Anticipated impact will be to allow optimisation of storage reclaim strategy to minimise variation in dust content in wood pellet fuel in order to minimise explosion and health risks. |
Title | Leicester database: Multi-contact large-deformation particle contact response database |
Description | 500+ sets of xy data describing the load, deformation and volume reduction of spherical particles in contact with a rigid flat plane, in both loading and unloading. Data were obtained from finite element simulations, implementing a von Mises-perfectly plastic material model. Four parameters were varied to generate these data: ratio of stiffness to yield strength (1-1000), Poisson's ratio (0.0-0.45), coordination number (2-12) and deformation at unload (0.0 - 0.5D). |
Type Of Material | Database/Collection of data |
Year Produced | 2019 |
Provided To Others? | No |
Impact | This database is used as a input for the fragmentation-deformation PBD developed for predicting strength of compacts. The dataset may also be used for the development of novel contact laws and the Virtual Formulation Lab software toolkit. |
Title | Virtual Powder Blending Lab (University of Greenwich) |
Description | Further development and enhancement of a data base of bulk flow properties and particle properties built up from historical test data, that use an averaging technique to predict the flow properties of a blended powder. |
Type Of Material | Computer model/algorithm |
Year Produced | 2017 |
Provided To Others? | No |
Impact | Anticipated impact will be to assist the optimisation of the flow properties of blended materials. |
Description | Dr Koichiro Ogata: Analysis of FT4 specific flow energy for cohesive mixtures |
Organisation | National Institute of Technology, Oita College |
Country | Japan |
Sector | Academic/University |
PI Contribution | Training, development of contact model, material characterisation and providing test materials |
Collaborator Contribution | Analysis of FT4 specific flow energy by DEM simulations for binary mixtures |
Impact | Chemical Engineering and Mechanical Engineering |
Start Year | 2017 |
Description | Dr Muzammil Ali: Modelling of Flow Behaviour of Powders using Computational Fluid Dynamics (CFD) |
Organisation | University of Leeds |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Developed the rheological constitutive law for apparent viscosity |
Collaborator Contribution | Implementation of model in CFD and running simulation |
Impact | N/A |
Start Year | 2020 |
Description | Dr Sadegh Nadimi: Effect of surface roughness on inter-particle friction |
Organisation | University of Leeds |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Training, material characterisation, providing test materials, development of a technique for measuring the effective friction coefficient |
Collaborator Contribution | Providing an insight on the effect of particle roughness for adhesive contact |
Impact | Chemical Engineering and Mechanical Engineering |
Start Year | 2018 |
Description | Dr Siti S. Ramli: Moisture sorption characteristics of crystalline solids |
Organisation | Universiti Teknologi MARA System |
Department | Faculty of Applied Sciences |
Country | Malaysia |
Sector | Academic/University |
PI Contribution | Training, material characterisation and method development |
Collaborator Contribution | Analysis of moisture sorption characteristics of crystalline solids (sugars) using dynamic vapour sorption studies |
Impact | Chemical Engineering |
Start Year | 2020 |
Description | Dr Wenguang Nan: Analysis of elutriation segregation and powder flowability |
Organisation | Nanjing Tech University |
Country | China |
Sector | Academic/University |
PI Contribution | Training, material characterisation, providing test materials, developing the test rig and analysis of segregation experimentally |
Collaborator Contribution | Providing an insight on the effect of immersing/ permeating air on flowability and segregation |
Impact | 2 papers have been published |
Start Year | 2018 |
Description | Dr Zhitong Yao: Finite Dilution Inverse Gas Chromatography as a Versatile Tool for Surface Property Characterization of Biofillers |
Organisation | Imperial College London |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Training, material characterisation and method development |
Collaborator Contribution | Surface Property Characterisation using Finite Dilution IGC |
Impact | Chemical Engineering |
Start Year | 2018 |
Title | A new Wolfson drop tester for determining interparticle forces of cohesive powders (University of Greenwich) |
Description | An impact test that subjects a tablet of powder coated with a layer of particles of the same material (or different material) to a series of increasing decelerations, each time measuring the mass of particles detached from the surface. This when combined with the particle density and size gives an objective figure for the mechanical surface energy, force of adhesion and bond number. |
Type Of Technology | Physical Model/Kit |
Year Produced | 2019 |
Impact | Used for Virtual Formulation Lab toolkit development. |
Title | A new caking tester and uniaxial compression tester (University of Greenwich) |
Description | Tester outweighed the conventional uniaxial unconfined failure caking tester due to the defined location of the failure plane to maximise repeatability, the necessity for a lower quantity of powder, maximised exposed surface and lower wall friction as well as production costs. |
Type Of Technology | Physical Model/Kit |
Year Produced | 2020 |
Impact | Tester outweighed the conventional uniaxial unconfined failure caking tester due to the defined location of the failure plane to maximise repeatability, the necessity for a lower quantity of powder, maximised exposed surface and lower wall friction as well as production costs. |
Title | LAMMPS package for cleaving model calculations (University of Leicester) |
Description | Molecular Dynamics software: LAMMPS package for cleaving model calculations. |
Type Of Technology | Software |
Year Produced | 2017 |
Impact | The package is included in the LAMMPS distribution and is going to be available to the public. |
Title | MATLAB model for surface energy deconvolution (Imperial College London) |
Description | MATLAB software: Boltzmann probability distribution model to simulate the adsorption of gaseous probes for deconvolution of surface energy data |
Type Of Technology | Software |
Year Produced | 2018 |
Impact | Method implementation |
Title | MATLAB model for surface energy deconvolution (Imperial College London) |
Description | MATLAB software: Boltzmann probability distribution model to simulate the adsorption of gaseous probes for deconvolution of surface energy data obtained from IGC |
Type Of Technology | Software |
Year Produced | 2019 |
Impact | Method implementation |
Description | 2020 McBain Medal and Lecture |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Surface properties and Crystallisation |
Year(s) Of Engagement Activity | 2020 |
URL | https://www.soci.org/news/awards/mcbain/mcbain-award-2020-nominations-open |
Description | Application of DEM for Particle Flow, Mixing, Separation, and Segregation |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Application of DEM for Particle Flow, Mixing, Separation, and Segregation. Characterisation Advances in Particle Engineering (University of Cape Town, Nov 2018) |
Year(s) Of Engagement Activity | 2018 |
Description | Application of DEM for particle flow, mixing, separation and segregation |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Application of DEM for particle flow, mixing, separation and segregation. Characterisation Advances in Particle Engineering (University of Cape Town, Nov 2018). |
Year(s) Of Engagement Activity | 2018 |
Description | Cambridge Crystallographic Data Centre Meeting |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Dr Jerry Heng delivered an invited talk on the crystal and surface properties. |
Year(s) Of Engagement Activity | 2023 |
Description | Contact Mechanics: Deformation, Damping, and Adhesion |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Contact Mechanics: Deformation, Damping, and Adhesion, Short Course: Modelling of Particulate Systems using Distinct Element Method (University of Leeds September 2018) |
Year(s) Of Engagement Activity | 2018 |
Description | Department of Mathematics, University of Leicester. "Surface Properties in Liquid and Solids: Theory and Computations" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Undergraduate students |
Results and Impact | Department of Mathematics, University of Leicester. "Surface Properties in Liquid and Solids: Theory and Computations" |
Year(s) Of Engagement Activity | 2019 |
Description | Dr Nicodemo Di Pasquale, a PDRA on this project, participates in the 4th Midlands Computational Chemistry Meeting |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Presented a talk "Description of Surface Properties of Organic Crystals through Molecular Dynamics Simulations" |
Year(s) Of Engagement Activity | 2021 |
Description | Dr. Ben Edmans - Invited to give seminar at Brunel University, UK |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | Explored potential for future collaboration on fracture of particles |
Year(s) Of Engagement Activity | 2018 |
Description | Dr. Hamid Salehi: Lectures |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Undergraduate students |
Results and Impact | Teaching/lecturing. |
Year(s) Of Engagement Activity | 2019 |
Description | Dr. I.C. Sinka - organises a conference at Leicester: Future Formulation III with the RSC Formulation Science and Technology Group, Royal Society of Chemistry |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | The 1st Future Formulation meeting was held in Durham in 2017, just after the Future Formulation of Complex Products grants had started, so the 2nd Future Formulation meeting was an opportunity to hear about the exciting progress being made towards the future of formulation. During the 3rd Future "Future Formulation2 meeting will offer the researchers will get the opportunity to update on their individual projects and through interactive session provide further details and give you the opportunity to contribute to the development of the projects. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.formulation.org.uk/ff3 |
Description | Dr. I.C. Sinka talks at: Future formulation II. "Virtual Formulation Laboratory for prediction and optimisation of manufacturability of advanced solids based formulations" |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Talk at: Future formulation II. Virtual Formulation Laboratory for prediction and optimisation of manufacturability of advanced solids based formulations. Organised by The Formulation Science and Technology group (FSTG) of the Royal Society of Chemistry at the University of Nottingham. |
Year(s) Of Engagement Activity | 2018 |
Description | Dr. I.C. Sinka: Virtual Formulation Laboratory for prediction and optimisation of manufacturability of advanced solids based formulations. Talk at Manufacturing Classification System Working Group Meeting |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Virtual Formulation Laboratory for prediction and optimisation of manufacturability of advanced solids based formulations. Manufacturing Classification System Working Group Meeting (online). 28 September 2017. |
Year(s) Of Engagement Activity | 2017 |
Description | East Midlands Materials Society meeting - Dr. I.C. Sinka: Materials Selection for Powder Products, 15 November 2017 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Regional |
Primary Audience | Professional Practitioners |
Results and Impact | Invited talk: I.C. Sinka: Materials Selection for Powder Products. |
Year(s) Of Engagement Activity | 2017 |
Description | Full team presentation at Future formulation IV. Virtual Formulation Laboratory for prediction and optimisation of manufacturability of advanced solids based formulations |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Talk at meeting organised by The Formulation Science and Technology group (FSTG) of the Royal Society of Chemistry at the University of Edinburgh (on-line meeting). 23 June 2020. |
Year(s) Of Engagement Activity | 2020 |
Description | Full team presentation at: Future formulation III. Virtual Formulation Laboratory for prediction and optimisation of manufacturability of advanced solids based formulations |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Study participants or study members |
Results and Impact | Future formulation III. Virtual Formulation Laboratory for prediction and optimisation of manufacturability of advanced solids based formulations. Organised by The Formulation Science and Technology group (FSTG) of the Royal Society of Chemistry at the University of Leicester. 4th April 2019. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.rsc.org/events/detail/37545/future-formulation-3 |
Description | Imperial College: Participation by Dr Vikram Karde, a PDRA on this project, in the 4th David Grant Symposium 2018 organised by the University of Minnesota, College of Pharmacy at Minneapolis, MN on the current topics of importance in pharmaceutical drug product development. |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Participation by Dr Vikram Karde, a PDRA on this project, in the 4th David Grant Symposium, 2018 organised by the University of Minnesota, College of Pharmacy at Minneapolis, MN |
Year(s) Of Engagement Activity | 2018 |
Description | Jamming during Particle Spreading in Additive Manufacturing |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Jamming during Particle Spreading in Additive Manufacturing, DEM Powder Calibration Meeting (DEM Solutions, June 2018) |
Year(s) Of Engagement Activity | 2018 |
Description | Jamming during Particle Spreading in Additive Manufacturing |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Jamming during Particle Spreading in Additive Manufacturing, DEM Powder Calibration Meeting (DEM Solutions, June 2018) |
Year(s) Of Engagement Activity | 2018 |
Description | Jamming during Particle Spreading in Additive Manufacturing |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Jamming during Particle Spreading in Additive Manufacturing (Hewlett-Packard, Sep 2018) |
Year(s) Of Engagement Activity | 2018 |
Description | Joint organiser Dr. Jerry Heng, Imperial College: UK Particle Technology Forum (PTF) 2018 |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Joint organisation of the annual Particle Technology Forum (PTF) meeting, an IChemE's Particle Technology Subject Interest Group (PTSIG) forum, by Imperial College London along with UCL. |
Year(s) Of Engagement Activity | 2018 |
Description | Leeds: 16th European Symposium on Comminution and Classification |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | 16th European Symposium on Comminution and Classification. 2 - 4 September 2019, University of Leeds, Leeds, UK. |
Year(s) Of Engagement Activity | 2019 |
Description | Leeds: Analysis of Bulk Powder Flow Properties at High Strain Rate Conditions: A Predictive Approach |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited talk: Analysis of Bulk Powder Flow Properties at High Strain Rate Conditions: A Predictive Approach (DuPont, USA, July 2019) |
Year(s) Of Engagement Activity | 2019 |
Description | Leeds: Dynamic Flow Rules for Cohesive Powders |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Invited Talks: Dynamic Flow Rules for Cohesive Powders (University of Calabria, Italy, May 2019) |
Year(s) Of Engagement Activity | 2019 |
Description | Mechanical properties of particles |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Mechanical properties of particles. Characterisation Advances in Particle Engineering (University of Cape Town, Nov 2018). |
Year(s) Of Engagement Activity | 2018 |
Description | Organised at the University of Leicester: Future Formulation III. RSC Formulation Science and Technology Group, Royal Society of Chemistry. 4 April 2019. |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Study participants or study members |
Results and Impact | Future Formulation III. RSC Formulation Science and Technology Group, Royal Society of Chemistry. 4 April 2019. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.rsc.org/events/detail/37545/future-formulation-3 |
Description | Participation by Dr Vikram Karde, a PDRA on this project, in a conference on Design of Crystalline Products: IG/CCG Joint Autumn Meeting, 2017 at Cambridge. |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Participation by Dr Vikram Karde, a PDRA on this project, in a conference on Design of Crystalline Products: IG/CCG Joint Autumn Meeting, 2017 at Cambridge. |
Year(s) Of Engagement Activity | 2017 |
Description | Participation by Dr Vikram Karde, a PDRA on this project, in the 4th David Grant Symposium 2018 organised by the University of Minnesota, College of Pharmacy at Minneapolis, MN on the current topics of importance in pharmaceutical drug product development. |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Participation by Dr Vikram Karde, a PDRA on this project, in the 4th David Grant Symposium, 2018 organised by the University of Minnesota, College of Pharmacy at Minneapolis, MN. |
Year(s) Of Engagement Activity | 2018 |
Description | Particle Shape and Structure Characterisation |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Particle Shape and Structure Characterisation, Characterisation Advances in Particle Engineering (University of Cape Town, Nov 2018) |
Year(s) Of Engagement Activity | 2018 |
Description | Prediction of Flowability of Powder Mixtures at High Strain Rate Conditions by DEM |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Prediction of Flowability of Powder Mixtures at High Strain Rate Conditions by DEM, (HP, Barcelona, Sep 2018) |
Year(s) Of Engagement Activity | 2018 |
Description | Prof. I.C. Sinka presentation at: 7th Quality by Design Symposium "How Can Industry Better Support National Healthcare Systems" |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | 7th Quality by Design Symposium "How Can Industry Better Support National Healthcare Systems". Virtual Formulation Laboratory for pharmaceutical tablet compaction. De Montfort University, 26 March 2019. |
Year(s) Of Engagement Activity | 2019 |
Description | Professor Csaba Sinka - Gedeon Richter (online meeting) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Professor Csaba Sinka - A theoretical and numerical analysis of tabletting problems. Online talk at Gedeon Richter - pharmaceuticals. 04 May 2020. |
Year(s) Of Engagement Activity | 2020 |
Description | Professor Csaba Sinka - Novartis PHAD Academy lecture |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | prof. Csaba Sinka gave a talk "Digital tabletting: Numerical analysis of tabletting problems". Novartis PHAD Academy lecture. 22 September 2020. |
Year(s) Of Engagement Activity | 2020 |
Description | Professor MSA Bradley: Powders in the Ceramic AM Process |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Applications for Ceramics, in 3D printing / additive manufacturing, Special interest group |
Year(s) Of Engagement Activity | 2018 |
URL | https://ktn-uk.co.uk/events/applications-for-ceramics-in-3d-printingadditive-manufacturing-special-i... |
Description | Professor Mike Bradley conducts several short courses for industries |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Professor Mike Bradley conduct several short courses for industries in 2019-2020, see link below. |
Year(s) Of Engagement Activity | 2019 |
URL | https://www.gre.ac.uk/engsci/research/groups/wolfsoncentre/coupro/sc |
Description | Professors Jerry Heng and Csaba Sinka - Eli Lilly (online meeting) |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Industry/Business |
Results and Impact | Virtual Formulation Laboratory for prediction and optimisation of manufacturability of advanced solids based formulations. Talk delivered together by Professors Csaba Sinka and Jerry Heng. Eli Lilly (online meeting) 18 November 2020. |
Year(s) Of Engagement Activity | 2020 |
Description | Sampling and sample preparation for particle characterisation |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Sampling and sample preparation for particle characterisation. Characterisation Advances in Particle Engineering (University of Cape Town, Nov 2018) |
Year(s) Of Engagement Activity | 2018 |
Description | Shape Consideration in Discrete Element Modelling |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Shape Consideration in Discrete Element Modelling (HP, Barcelona, Sep 2018) |
Year(s) Of Engagement Activity | 2018 |
Description | Shape Consideration in Discrete Element Modelling |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Professional Practitioners |
Results and Impact | Shape Consideration in Discrete Element Modelling, Short Course: Modelling of Particulate Systems using Distinct Element Method (University of Leeds Sep 2018). |
Year(s) Of Engagement Activity | 2018 |
Description | Short Course: Modelling of Particulate Systems using Discrete Element Method (DEM). 5 - 6 September, University of Leeds, Leeds UK. |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Short Course: Modelling of Particulate Systems using Discrete Element Method (DEM). 5 - 6 September, University of Leeds, Leeds UK. |
Year(s) Of Engagement Activity | 2018 |
Description | Workshop: Discrete Element Method: Challenges and Trends. 7 September 2018, University of Leeds, Leeds UK. |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Organised Workshop: Discrete Element Method: Challenges and Trends. 7 September 2018, University of Leeds, Leeds UK. |
Year(s) Of Engagement Activity | 2018 |