Bioresorbable 2D and 3D ordered mesoporous phosphate glasses for bone tissue regeneration and drug delivery
Lead Research Organisation:
University of Surrey
Department Name: Chemistry
Abstract
Regeneration or repair of hard and soft tissues represents a major challenge of the modern society. The number of patients that require an implant in order to replace damaged tissue is growing due to the increase of life expectancy. Therefore, the development of new and more efficient biomaterials is a great scientific and human challenge as it has an effect on the everyday life of millions of people worldwide. It has been forecasted that the global market for biomaterials will reach about $130B by 2020.
The function of biomaterials has evolved with time. The first generation of biomaterials had a pure mechanical role with no interaction with the physiological environment (e.g. metals). More recently, a second generation of biomaterials, defined as bioactive, based on calcium silicate glasses has been developed. Their key feature is the capability of their surface to spontaneously with physiological fluids in the human body generating a bone-like layer of hydroxyapatite Ca10(PO4)6(OH)2. Human cells grow and proliferate on this layer promoting a tight bond between the implant and the living tissue. As silicate based glasses are non-soluble in physiological fluids, a subsequent surgery is needed to remove the implant with increased risk for the patient and a lengthening of the total recovery time.
This proposal refers to the latest generation of biomaterials also called "third generation". In addition to the bioactivity, they also show bioresorbability as they react and dissolve over time in the physiological fluid and they are replaced by regenerated hard or soft tissue. The use of soluble bioresorbable materials avoids the necessity of a second surgery. Phosphate-based glasses, differently from the commercially used polymers, are ideal bioresorbable materials being totally biocompatible as any of the degradation products can cause inflammation.
The aim of this proposal is to design, for the first time, phosphate-based glasses with highly ordered structure of mesopores (2-50 nm) and high textural properties (large surface area, pore size and volume, narrow pore size distribution) using a combination of supramolecular chemistry and sol-gel. Phosphate based glasses with ordered 2D channels of mesopores aligned in one direction and 3D ordered cubic network of interconnected pores are excellent candidates for multifunctional biomaterials, being able to combining simultaneously anti-bacterial/anti-cancer activity with cell stimulation and vascularisation.
This makes them ideal materials to be used in two major clinical applications: orthopedics (bone pins and anchors, bone platelets, joint replacements, tissue fixation screws) and drug delivery (e.g. anticancer drugs, antimicrobial agents, growth factors, DNA).
I will demonstrate this potentiality through synthesis and textural/structural characterisation of phosphate glasses with composition close to the bone (P2O5-CaO-Na2O) with and without addition of antimicrobial ions (Ag+/Cu2+/Zn2+) followed by dissolution and biocompatibility tests.
The function of biomaterials has evolved with time. The first generation of biomaterials had a pure mechanical role with no interaction with the physiological environment (e.g. metals). More recently, a second generation of biomaterials, defined as bioactive, based on calcium silicate glasses has been developed. Their key feature is the capability of their surface to spontaneously with physiological fluids in the human body generating a bone-like layer of hydroxyapatite Ca10(PO4)6(OH)2. Human cells grow and proliferate on this layer promoting a tight bond between the implant and the living tissue. As silicate based glasses are non-soluble in physiological fluids, a subsequent surgery is needed to remove the implant with increased risk for the patient and a lengthening of the total recovery time.
This proposal refers to the latest generation of biomaterials also called "third generation". In addition to the bioactivity, they also show bioresorbability as they react and dissolve over time in the physiological fluid and they are replaced by regenerated hard or soft tissue. The use of soluble bioresorbable materials avoids the necessity of a second surgery. Phosphate-based glasses, differently from the commercially used polymers, are ideal bioresorbable materials being totally biocompatible as any of the degradation products can cause inflammation.
The aim of this proposal is to design, for the first time, phosphate-based glasses with highly ordered structure of mesopores (2-50 nm) and high textural properties (large surface area, pore size and volume, narrow pore size distribution) using a combination of supramolecular chemistry and sol-gel. Phosphate based glasses with ordered 2D channels of mesopores aligned in one direction and 3D ordered cubic network of interconnected pores are excellent candidates for multifunctional biomaterials, being able to combining simultaneously anti-bacterial/anti-cancer activity with cell stimulation and vascularisation.
This makes them ideal materials to be used in two major clinical applications: orthopedics (bone pins and anchors, bone platelets, joint replacements, tissue fixation screws) and drug delivery (e.g. anticancer drugs, antimicrobial agents, growth factors, DNA).
I will demonstrate this potentiality through synthesis and textural/structural characterisation of phosphate glasses with composition close to the bone (P2O5-CaO-Na2O) with and without addition of antimicrobial ions (Ag+/Cu2+/Zn2+) followed by dissolution and biocompatibility tests.
Planned Impact
This proposal comprises leading edge physical and materials chemistry/science and aims to manufacture bioresorbable implants with synergic biocompatibility and controlled drug delivery to benefit society and improve the quality of life within the UK.
A direct output of the proposed project in short term (1-2 years window) will be highly skilled researchers (a postdoctoral researcher, a PhD student, MRes students and undergraduates interns) who will have developed multidisciplinary skills and will have experienced a broad range of technological fields that are important to the development of functional biomaterials, from the synthesis to the in-vitro testing for biocompatibility and antimicrobial activity.
Moreover, the research programme will introduce several new collaborations with UK and overseas Universities (UCL, Kent, Warwick, Queen Mary in the UK and Cagliari in Italy). In particular, the collaboration with Eastman Dental Institute, UCL will give me the opportunity to directly translate the novel materials into development of novel treatments and therapies for treating oral disorders. The UK and international partners are committed to supporting aspects of this project within their own research capacity. Further collaborations with leading groups and the development of multidisciplinarity research projects will be fostered during this project.
Commercial beneficiaries of the research (wealth generation in 5-25 years) will be companies in the UK and worldwide in, or part of the supply chain for, bioresorbable implants. In particular, healthcare companies through the design of new materials with antimicrobial properties and localised drug delivery and medical device manufacturers through the design of implants for orthopaedics and dentistry, devices to assist with brain injuries (dissolvable sensors to monitor patients with traumatic brain injuries), neurodegenerative diseases (nerve conduits) and wound repair (resorbable sutures).
Research on new materials and recipes that could facilitate advanced bioresorbable implants could impact these industries in the long term by incorporating these concepts within their product technologies. There is a significant gap in the research relating to bioresorbable materials alternative to polymers. The strategy of this proposal bears significant impact for the bioresorbable materials industry, as I foresee the reshaping of the existing market of polymeric materials, with the potential to facilitate novel applications that in turn could provoke further R&D investments for auxiliary exploitation in emerging products and services. Besides, the spin-off consulting company SPINODE, world leader in taking bioactive glass technology to market is actively supporting this proposal (see letter of support), being particularly interested in the potential of ordered mesoporous phosphate glasses technology, offering expert advice and opportunities for translation. The SPINODE support demonstrates a clear commitment for realising industrial research impact, but also attracting additional investments to capitalize on this technology.
On successful commercialisation, society will ultimately benefit (25-50 year longer term) as breakthroughs in the proposed technology sector will have a huge impact on quality of life of people suffering traumatic injuries preventing bacterial infections and promoting natural healing process.
This proposal aims to realise research impact through academic excellence and a willingness to work in an interdisciplinary environment. Although this proposal is aimed at addressing bioresorbable phosphate glasses synthesis challenges, the culminating impact stems from all research activities planned throughout the project, concurrently providing insights into science's fundamentals.
A direct output of the proposed project in short term (1-2 years window) will be highly skilled researchers (a postdoctoral researcher, a PhD student, MRes students and undergraduates interns) who will have developed multidisciplinary skills and will have experienced a broad range of technological fields that are important to the development of functional biomaterials, from the synthesis to the in-vitro testing for biocompatibility and antimicrobial activity.
Moreover, the research programme will introduce several new collaborations with UK and overseas Universities (UCL, Kent, Warwick, Queen Mary in the UK and Cagliari in Italy). In particular, the collaboration with Eastman Dental Institute, UCL will give me the opportunity to directly translate the novel materials into development of novel treatments and therapies for treating oral disorders. The UK and international partners are committed to supporting aspects of this project within their own research capacity. Further collaborations with leading groups and the development of multidisciplinarity research projects will be fostered during this project.
Commercial beneficiaries of the research (wealth generation in 5-25 years) will be companies in the UK and worldwide in, or part of the supply chain for, bioresorbable implants. In particular, healthcare companies through the design of new materials with antimicrobial properties and localised drug delivery and medical device manufacturers through the design of implants for orthopaedics and dentistry, devices to assist with brain injuries (dissolvable sensors to monitor patients with traumatic brain injuries), neurodegenerative diseases (nerve conduits) and wound repair (resorbable sutures).
Research on new materials and recipes that could facilitate advanced bioresorbable implants could impact these industries in the long term by incorporating these concepts within their product technologies. There is a significant gap in the research relating to bioresorbable materials alternative to polymers. The strategy of this proposal bears significant impact for the bioresorbable materials industry, as I foresee the reshaping of the existing market of polymeric materials, with the potential to facilitate novel applications that in turn could provoke further R&D investments for auxiliary exploitation in emerging products and services. Besides, the spin-off consulting company SPINODE, world leader in taking bioactive glass technology to market is actively supporting this proposal (see letter of support), being particularly interested in the potential of ordered mesoporous phosphate glasses technology, offering expert advice and opportunities for translation. The SPINODE support demonstrates a clear commitment for realising industrial research impact, but also attracting additional investments to capitalize on this technology.
On successful commercialisation, society will ultimately benefit (25-50 year longer term) as breakthroughs in the proposed technology sector will have a huge impact on quality of life of people suffering traumatic injuries preventing bacterial infections and promoting natural healing process.
This proposal aims to realise research impact through academic excellence and a willingness to work in an interdisciplinary environment. Although this proposal is aimed at addressing bioresorbable phosphate glasses synthesis challenges, the culminating impact stems from all research activities planned throughout the project, concurrently providing insights into science's fundamentals.
Organisations
- University of Surrey (Lead Research Organisation)
- Friedrich-Alexander University Erlangen-Nuremberg (Collaboration)
- University College London (Collaboration)
- ISIS Neutron Source Facility (Collaboration)
- ASTON UNIVERSITY (Collaboration)
- FOURTH STATE MEDICINE LTD (Collaboration)
- National Physical Laboratory (Collaboration)
- University of Cagliari (Collaboration, Project Partner)
- University of Warwick (Collaboration)
- Medical University of Innsbruck (Collaboration)
- QUEEN MARY UNIVERSITY OF LONDON (Collaboration)
- Hull York Medical School (Collaboration)
- University of Modena and Reggio Emilia (Collaboration)
- UNIVERSITY OF KENT (Collaboration)
- Spinode Consulting (Project Partner)
- University College London (Project Partner)
- University of Kent (Project Partner)
- Queen Mary University of London (Project Partner)
- University of Warwick (Project Partner)
People |
ORCID iD |
Daniela Carta (Principal Investigator) |
Publications
Carta D;
(2022)
Phosphate and borate Bioactive glasses
Kyffin Benjamin Alexander
(2022)
Phosphate-based glasses prepared via coacervation and sol-gel : synthesis and characterization
Kyffin B
(2021)
Atomic-Scale Structural Characterization of Silver-Doped Phosphate-Based Glasses Prepared by Coacervation
in The Journal of Physical Chemistry C
Nikolaou A
(2022)
Silver-doped phosphate coacervates to inhibit pathogenic bacteria associated with wound infections: an in vitro study.
in Scientific reports
Foroutan F
(2023)
Highly porous phosphate-based glasses for controlled delivery of antibacterial Cu ions prepared via sol-gel chemistry.
in RSC advances
Kyffin BA
(2019)
Antibacterial silver-doped phosphate-based glasses prepared by coacervation.
in Journal of materials chemistry. B
Foroutan F
(2020)
Mesoporous Strontium-Doped Phosphate-Based Sol-Gel Glasses for Biomedical Applications
in Frontiers in Chemistry
Foroutan F
(2020)
Mesoporous Phosphate-Based Glasses Prepared via Sol-Gel.
in ACS biomaterials science & engineering
Foroutan F
(2019)
Antibacterial Copper-Doped Calcium Phosphate Glasses for Bone Tissue Regeneration.
in ACS biomaterials science & engineering
Description | Mesoporous phosphate-based glasses in the system P2O5-CaO-Na2O undoped and doped with copper, zinc, gallium cerium and strontium ions have been prepared for the first time. Mesoporosity can be clearly identified in all samples. Ordered arrays of pores have been assessed by SEM imaging and low angle X-ray scattering . All samples show antibacterial activity against E.coli, S. aureus, P aeruginosa, E faecalis. Glasses also show good cytocompatibility tested on MG64, Saos (osteosarcoma cells ) and fibroblasts. These results show that phosphate based glasses prepared via the in solution techniques sol-gel have great potential in the repair of both hard and soft tissues. |
Exploitation Route | Mesoporous phosphate-based glasses were prepared for the first time. A synthesis protocol has been established that can be used for preparing mesoporous phosphate glasses doped with different antibacterial ions but also therapeutic molecules and growth factors. The synthesis is highly versatile and composition / porosity can be tailored to the application. Therefore, the new route can be used to prepare porous phosphate glasses not only to be used in biomedicine but also but also in catalysis, electronics ( for fast ions conduction) and energy (glass to metal seals for solid oxide fuel cells). |
Sectors | Chemicals Energy Environment Healthcare |
Description | Preliminary results performed on ex vivo wound tissues have shown that the phosphate based glasses have impressive wound healing capabilities. ON the basis of this new findings we are now closely working with Hull York Medical School to investigate further. The novel materials proposed will have immediate benefits to the quality of life of people that suffer of extensive skin damage caused by injury (acute wounds) or diseases (chronic wounds). In addition, a metal-based antimicrobial strategy overcomes the global issue of antimicrobial resistance (AMR) providing an alternative to the use of common antibiotics. |
First Year Of Impact | 2018 |
Sector | Chemicals,Education,Healthcare |
Impact Types | Cultural Societal Economic |
Description | Chemistry Degree MChem course. Final year Advanced Topics inPhysical Chemistry module |
Geographic Reach | Europe |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | Result of reserch have been included in the final year module Advanced topics in Physical chemistry, taught at the University of Surrey |
Description | "Multifunctional antibacterial phosphate-based glass nanofibres for wound healing" |
Amount | £4,000 (GBP) |
Funding ID | R21-7668912428 |
Organisation | Royal Society of Chemistry |
Sector | Charity/Non Profit |
Country | United Kingdom |
Start | 09/2022 |
End | 10/2023 |
Description | Capital Award Competition |
Amount | £153,000 (GBP) |
Funding ID | EP/S017771/1 to University of Surrey |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2018 |
End | 03/2020 |
Description | Doctoral College Studentship Award |
Amount | £70,000 (GBP) |
Organisation | Fourth State Medicine Ltd |
Sector | Private |
Country | United Kingdom |
Start | 09/2018 |
End | 10/2021 |
Description | EPSRC Doctoral Training Partnership DTP-UKRI: PhD studentship: Synthesis and characterisation of mesoporous phosphate-based glasses for biomedical applications |
Amount | £80,000 (GBP) |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 09/2022 |
End | 10/2026 |
Description | EPSRC Industrial CASE (ICASE) "Effect of mechanical properties and surface nanostructure on phosphate-based coacervates biomedical performance" |
Amount | £117,000 (GBP) |
Funding ID | 220023 ICase voucher |
Organisation | United Kingdom Research and Innovation |
Sector | Public |
Country | United Kingdom |
Start | 03/2022 |
End | 04/2027 |
Description | FEPS HEIF |
Amount | £22,000 (GBP) |
Organisation | Higher Education Innovation Funding (HEIF) |
Sector | Public |
Country | United Kingdom |
Start | 11/2023 |
End | 07/2024 |
Description | IAA Capital Award 2023 Smart Porous Phosphate Scaffolds as controlled delivery systems for wound healing and skin regeneration |
Amount | £27,500 (GBP) |
Funding ID | IAA Capital Award 2023 |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2023 |
Description | Impact Acceleration Account |
Amount | £60,000 (GBP) |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 11/2018 |
End | 07/2019 |
Description | Impact Acceleration Account Smart Porous Phosphate Scaffolds as controlled delivery systems for wound healing and skin regeneration |
Amount | £127,322 (GBP) |
Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
Sector | Public |
Country | United Kingdom |
Start | 07/2022 |
End | 05/2023 |
Description | MRC Confidence in Concept (CiC) Round 1 2020/23 - Phosphate-based glasses fibres for wound healing |
Amount | £149,400 (GBP) |
Organisation | Medical Research Council (MRC) |
Sector | Public |
Country | United Kingdom |
Start | 03/2021 |
End | 04/2022 |
Title | A novel technique for production of mesoporous phosphate-based glasses |
Description | A protocol for the synthesis of mesoporous antibacterial phosphate-based glasses containing silver, copper and zinc ions has been established. A WO patent has been filed 'mesoporous phosphate glass' published as WO2020/260892 |
Type Of Material | Improvements to research infrastructure |
Year Produced | 2018 |
Provided To Others? | No |
Impact | Increased bioactivity of the glasses proved by acceleration of hydroxyapatite formation and fibroblast/osteoblastcell growth/ increase Tetracycline uptake/controlled release |
URL | https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020260892 |
Title | Production of porous phosphate glass fibers for controlled drug delivery |
Description | We are using surfactant to manufacture porous phosphate glass fibers and glasses. The method has been filed for IP protection in January 2023 (CHP/124682GB1). |
Type Of Material | Improvements to research infrastructure |
Year Produced | 2023 |
Provided To Others? | Yes |
Impact | Controlled drug delivery increase surface area higher bioactivity |
Description | 4SM_LTD |
Organisation | Fourth State Medicine Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | Expertise in biomaterials/antibacterial synthesis and characterisation |
Collaborator Contribution | Equipment access and expertise in plasma for wound healing. Plasma box for testing antibacterial efficacy of cold plasma alone and in combination with biomaterial coacervates |
Impact | 4SM has half funded a PhD studentship (2018-2021) on the effect of plasma treatment on bacteria |
Start Year | 2018 |
Description | Aston Antimicrobial |
Organisation | Aston University |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Give expertise in phosphate glasses made via sol-gel and coacervation. Relationship antimicrobial structure-composition |
Collaborator Contribution | They performed antimicrobial testing on our samples, provide access to their equipment and staff time |
Impact | Multidisciplinary research chemistry / microbiologists Joint publication: https://doi.org/10.1039/C9TB02195G |
Start Year | 2017 |
Description | Collaboration on skin modelling |
Organisation | Medical University of Innsbruck |
Country | Austria |
Sector | Academic/University |
PI Contribution | Thanks to this Institute, I am able to take part to the EU cost action 21 Netskin model, in particular work package 2. I have since then created many new contacts through the network and attended an interdisciplinary meeting in February 24. |
Collaborator Contribution | Professor Sandrine Dubrac leader of the Epidermal Biology Laboratory at the Department of Dermatology, Venereology and Allergology has invited me to take part to the EU cost action 21 Netskin model. |
Impact | Interdisciplinary meeting netskin rome in february 2024 and follow up meeting and papers in production |
Start Year | 2023 |
Description | FAU_biomaterials |
Organisation | Friedrich-Alexander University Erlangen-Nuremberg |
Country | Germany |
Sector | Academic/University |
PI Contribution | Privide expertise in the preparation of phosphate based glasses made via sol-gel and coacervation. |
Collaborator Contribution | Expertise in biomaterial glasses and controlled delivery of natural molecules. Staff time. testing bioactivity, cellular culture on our glasses |
Impact | Joint application of an IAA ESPRC grant in January 2021: Phosphate-based glasses for controlled delivery of natural therapeutic molecules. FAU has given an in kind contribution of 7000 GBP. Outcome still to be announced |
Start Year | 2020 |
Description | HYMS_Wound healing |
Organisation | Hull York Medical School |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We are providing fibers scaffolds for wound healing dressings. Expertise in fibres fabrication |
Collaborator Contribution | Access to medical school facilities, expertise in wound healing, provide contact with clinicians and medical stakeholders |
Impact | Outcome from collaboration are in progress |
Start Year | 2020 |
Description | Hull York Medical School |
Organisation | Hull York Medical School |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We are in charge of design and optimisation of samples tested at the Hull York medical School for their properties in wound healing. |
Collaborator Contribution | HYMS has performed advanced and targeted testing of our materials for wound healing applications. In particular, in vitro cytocompatibility, scratch tests and ex vivo studies on a variety of compositions |
Impact | The collaboration is truly multi disciplinary bringing together an interdisciplinary team of chemists, bioscientists, and clinicians. We have just submitted me as a PI and members of HYMS as Co-I a 1.2m EPSRC grant for the Healthcare technologies: investigator-led research project grant scheme entitled "WEAVE: Wound healing via Electrospun coacerVatE phosphate glass fibres" |
Start Year | 2020 |
Description | Kent_X-ray diffraction and absorption |
Organisation | University of Kent |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | input on preparation of sol-gel phosphate glasses |
Collaborator Contribution | Access to low angle X-ray diffraction facility expertise in amorphous system data analysis Assistance in synchrotron experiments |
Impact | Joint publication https://doi.org/10.1021/acsbiomaterials.9b01896 |
Start Year | 2017 |
Description | NPL_Ultrasound |
Organisation | National Physical Laboratory |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We provided phosphate based glass nanospheres made via electrospraying for use as ultrasound contrast agents, expertise and staff time |
Collaborator Contribution | NPL provided access to the ultrasound facilities, training of staff and expertise in ultrasound testing |
Impact | joint manuscript in preparation |
Start Year | 2018 |
Description | Queen Mary London_Solid state NMR |
Organisation | Queen Mary University of London |
Department | School of Biological and Chemical Science QMUL |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Expertise on phosphate baseg glasses prepared via sol-gel and coacervation |
Collaborator Contribution | Access to solid state NMR and technical support for 31P measurements |
Impact | Multidisciplinary physics/chemistry 2 joint publications: https://doi.org/10.3389/fchem.2020.00249 https://doi.org/10.1021/acsbiomaterials.9b01896 |
Start Year | 2017 |
Description | Structural Uni Cagliari |
Organisation | University of Cagliari |
Country | Italy |
Sector | Academic/University |
PI Contribution | Collaborative discussion on the comparison phosphate glasses and silicate glasses. We have provided phosphate systems for comparison and characterisation |
Collaborator Contribution | Availability of transmission electron microscope and surface absorption instruments, staff time, technical expertise |
Impact | manuscript in preparation |
Start Year | 2017 |
Description | UCL_Dissolution Studies |
Organisation | University College London |
Department | Eastman Dental Institute |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Expertise in sol-gel and coacervate phosphate glasses |
Collaborator Contribution | Access to ion chromatography, academic expertiese and technical support for dissolution studies of phosphate based glasses |
Impact | multidsciplinary chemistry-biomaterials Joint publications: https://doi.org/10.3389/fchem.2020.00249 https://doi.org/10.1021/acsbiomaterials.9b01896 https://doi.org/10.1021/acsbiomaterials.9b01291 |
Start Year | 2017 |
Description | UNIMORE Italy |
Organisation | University of Modena and Reggio Emilia |
Country | Italy |
Sector | Academic/University |
PI Contribution | We have prepared mesoporous phosphate glasses ceria doped to be tested at UNIMORE for functionalisation and impregnation with antioxidants and antibiotics for controlled release |
Collaborator Contribution | They made instrumentation and expertise available for functionalisation of mesoporous glasses |
Impact | Physicists, chemists, materials scientists, bioscientists |
Start Year | 2021 |
Description | Vesuvio Neutron diffraction of phosphate glasses |
Organisation | ISIS Neutron Source Facility |
Country | United Kingdom |
Sector | Learned Society |
PI Contribution | Matthew Krzystyniak, lead instrument scientist on the VESUVIO neutron spectrometer at the ISIS Neutron and Muon Source. We have written a proposal to apply for Vesuvio beamtime for atomic structural characterisation of coacervate phosphate glasses |
Collaborator Contribution | Knowledge and expertise on neutron diffraction. Contribution to experiment design and writing of the proposal |
Impact | we are going to submit the application for next Vesuvio round, neutron diffraction |
Start Year | 2023 |
Description | Warwick NMR |
Organisation | University of Warwick |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We have provided novel phosphate based materials for a novel structural study based on solid state NMR |
Collaborator Contribution | They gave access to state of the art NMR facilities (EPSRC hub) and staff time/expertise |
Impact | This is an interdisciplinary collaboration between Department of Physics (Warwick) and Department of Chemistry (Surrey) We have published a join article https://doi.org/10.1021/acsbiomaterials.9b01291 |
Start Year | 2017 |
Description | Warwick University_MAS NMR |
Organisation | University of Warwick |
Department | Department of Physics |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Expertise in sol-gel and coacervate made phosphate glasses |
Collaborator Contribution | Access to MAS NMR equipment and technical support |
Impact | Multidisciplinary chemistry-physics Joint publication https://doi.org/10.1021/acsbiomaterials.9b01291 |
Start Year | 2017 |
Title | MESOPOROUS PHOSPHATE BASED GLASS |
Description | The disclosure provides a method of producing a mesoporous phosphate-based glass. The method comprises (a) contacting a phosphate with an alcohol and/or a glycol ether to create a reaction mixture; (b) contacting the reaction mixture with alkali metal cations and/or alkaline earth metal cations; (c) contacting the alcohol, the glycol ether or the reaction mixture with a surfactant, wherein the surfactant is configured to provide channel-like pores in the resultant mesoporous phosphate-based glass; (d) allowing the reaction mixture to gel; and (e) calcinating the gel to obtain the mesoporous phosphate-based glass. |
IP Reference | WO2020260892 |
Protection | Patent application published |
Year Protection Granted | 2020 |
Licensed | No |
Impact | The publication of the IP has paved the way for further links/collaborations Hull York Medical School (HYWS). We are currently testing more specific molecules for controlled release including natural products and specific antibacterial ions for wound healing. Having observed very promising results, we expect the involvement of industrial partners in the next month. |
Description | Attendance to the RSC Chemical Nanoscience and Nanotechnology Network Annual Symposium London 26-27th January 2023 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Attendance to the RSC Chemical Nanoscience and Nanotechnology Network Annual Symposium. Poster presentation of " phosphate-based glass fibers preapred by coacervation" attracted great interest to the topic and questions. |
Year(s) Of Engagement Activity | 2023 |
Description | EU NetSkin model |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | 150 experts from different countries have taken part to this engagement networking activity (Feb 2024). Follow up meetings have been set up for the next few months |
Year(s) Of Engagement Activity | 2024 |
Description | Presentation of the research at Queen Mary University, London |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Undergraduate students |
Results and Impact | Several undergraduates attended the talk entitled: "Antibacterial phosphate-based glasses for biomedical applications" and a discussion has arisen on the topic |
Year(s) Of Engagement Activity | 2018 |
Description | Royal Society of Chemistry Materials tackling infectious disease workshop November 2021 |
Form Of Engagement Activity | A formal working group, expert panel or dialogue |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Professional Practitioners |
Results and Impact | Participation to the Royal Society of Chemistry Materials tackling infectious disease workshop. Talk on "Coacervate and sol-gel phosphate-based glasses containing metallic ions as antibacterial agents". Presentation has sparkled interested in the audience and in the topic |
Year(s) Of Engagement Activity | 2021 |