Ultra-sensitive atomic magnetometry for brain function diagnostics
Lead Research Organisation:
University of Birmingham
Department Name: School of Physics and Astronomy
Abstract
The huge progress achieved in the manipulation of quantum systems is opening novel routes towards the generation of realistic quantum-based technology. Notably many counterintuitive manifestations of quantum mechanics are turning to be key features for the next generation devices, whose performances will beat those of classical machines. Quantum sensors, in particular, exploit the intrinsic "weakness" of quantum systems, their extreme sensitivity to external perturbations, to provide measurements of the perturbing fields with unprecedented sensitivity and stability. This project targets the realization of ultra-sensitive quantum magnetometers based on neutral atoms at room temperature, for studying the brain function by accessing its connectivity.
Detection of very small magnetic fields of biological origin allows a non-invasive study of the spatial and time dependence of bio-currents. Therefore, a logical and very promising direction of application of non-invasive ultra-sensitive quantum magnetometers is the realization of probes for measuring the magnetic fields generated by the neuronal activity of the human brain. Recent technological developments have made it possible to employ atomic magnetometers (AMs) in the context of magnetoencephalography (MEG) analysis. Here we propose to further develop AMs-based MEG for accessing information on the brain connectivity, by combining these quantum sensors with the technique of transcranial brain stimulation (TMS). Indeed, the nerve cells of the brain can be inductively stimulated by applying a short but strong magnetic pulse localized at a specific region of the brain. Causal brain connectivity will be directly studied by measuring the magnetic response of different brain areas to this stimulus. The aim is to estimate the directional coupling and the temporal interaction of different brain sectors, which requires sensors with large sensitivity, real-time operation, and adequate spatial resolution.
The core of this project is the realization of all-optical AMs compatible with TBS. The key point is that the sensors need to rapidly recover following a relatively strong magnetic stimulation, to record the brain signals no more than few tens ms after the pulse. The integration of AM sensors and TMS coil will be done in few steps, with the goal of both minimizing the effects induced by the TMS coil and shortening the sensor dead-time. The sensor will be then prepared for operation in a medical environment. In parallel, we will boost the miniaturization of the AMs, which is necessary for achieving a millimetre-spatial resolution and a dense package of the sensors over the head, and its measurement bandwidth. Miniaturization usually comes at the price of an important loss of sensitivity. To improve magnetic sensitivity in highly miniaturized sensors, we will prepare and use a class of entangled atomic states known as spin-squeezed states. We propose a novel, simple and robust way to achieve spin-squeezing, which has the potential to largely surpass state-of-the-art techniques in atomic magnetometry. Within this project, we expect to implement ultra-sensitive highly miniaturized AMs as innovative tools to directly measure human brain connectivity, for understanding healthy brain functionality, as well as for clinical diagnostics and treatment of brain injuries and neurological disorders.
Detection of very small magnetic fields of biological origin allows a non-invasive study of the spatial and time dependence of bio-currents. Therefore, a logical and very promising direction of application of non-invasive ultra-sensitive quantum magnetometers is the realization of probes for measuring the magnetic fields generated by the neuronal activity of the human brain. Recent technological developments have made it possible to employ atomic magnetometers (AMs) in the context of magnetoencephalography (MEG) analysis. Here we propose to further develop AMs-based MEG for accessing information on the brain connectivity, by combining these quantum sensors with the technique of transcranial brain stimulation (TMS). Indeed, the nerve cells of the brain can be inductively stimulated by applying a short but strong magnetic pulse localized at a specific region of the brain. Causal brain connectivity will be directly studied by measuring the magnetic response of different brain areas to this stimulus. The aim is to estimate the directional coupling and the temporal interaction of different brain sectors, which requires sensors with large sensitivity, real-time operation, and adequate spatial resolution.
The core of this project is the realization of all-optical AMs compatible with TBS. The key point is that the sensors need to rapidly recover following a relatively strong magnetic stimulation, to record the brain signals no more than few tens ms after the pulse. The integration of AM sensors and TMS coil will be done in few steps, with the goal of both minimizing the effects induced by the TMS coil and shortening the sensor dead-time. The sensor will be then prepared for operation in a medical environment. In parallel, we will boost the miniaturization of the AMs, which is necessary for achieving a millimetre-spatial resolution and a dense package of the sensors over the head, and its measurement bandwidth. Miniaturization usually comes at the price of an important loss of sensitivity. To improve magnetic sensitivity in highly miniaturized sensors, we will prepare and use a class of entangled atomic states known as spin-squeezed states. We propose a novel, simple and robust way to achieve spin-squeezing, which has the potential to largely surpass state-of-the-art techniques in atomic magnetometry. Within this project, we expect to implement ultra-sensitive highly miniaturized AMs as innovative tools to directly measure human brain connectivity, for understanding healthy brain functionality, as well as for clinical diagnostics and treatment of brain injuries and neurological disorders.
Planned Impact
The development of atomic sensors for the detection of magnetic fields with unprecedented sensitivity is one of the most effective real-world applications of Quantum Mechanics. Atomic magnetometers (AM) have indeed found recent application in measuring tiny magnetic fields of biological origin, as those generated by the human body. In particular, AMs are highly beneficial for Magnetoencephalography (MEG), a non-invasive neurophysiological technique which detects the magnetic fields generated by the neuronal activity of the brain.
Based on the promising state-of-the-art results obtained in the implementation of AMs for MEG, this project focusses on the further development of AMs-based MEG for realizing an integrated stimulus/measurement device directly accessing brain connectivity. Understanding the brain as a network is considered crucial for future developments of cognitive and clinical neuroscience, as also testified by the large NIH investment on the Human Connectome Project with the ambition to map the neural connections in human brain in their entirety. However, the experimental investigation of neural connections is still challenging. This project aims at developing atomic sensors which will surpass current technology and will impact the rapidly growing national and international academic community (Translational Medicine and Psychology) working on the topic. The AMs that we will realize hold the promise of better identifying the regions of the brain responding to a specific magnetic perturbation, quantifying how the brain connectivity is modulated in a task specific manner, assessing connectivity changes associated with brain injuries and neurological disorders. This is of interest for understanding healthy brain functionality, as well as for clinical diagnostics and, in a near future, for treatment of injuries and disorders via targeted magnetic stimulation of the brain.
Furthermore, the record sensitivity and spatial resolution which we aim to achieve by engineering spin-squeezed atomic states will impact the wider field of bio-magnetism imaging. The magnetometers used for these imaging applications have often to trade off sensitivity for physical size. Instead, the spin-squeezing generation technique which we propose in this project will allow reduction of the sensor head footprint to be achieved without loss of sensitivity with respect to wider (cm-sized) non-quantum enhanced devices. This will boost the realization of ultra-sensitive multichannel imaging systems consisting of several sensors packed together with spatial sensitivity on the order of few millimetres. We can also foresee application of these devices beyond bio-magnetism detection, for non-destructive testing and characterization of material samples, and for security applications.
Finally, the proposed project will provide advanced training for Master and PhD students in the field of atomic magnetometry, which is a rich interdisciplinary field with applications ranging from medicine to mapping of the magnetic field of the Earth, from characterization of materials to searching for dark matter and dark energy in the Universe. The experimental activity and the synergetic collaboration with the School of Psychology of the University of Birmingham, with NPL, and with the companies with whom we will interact along the duration of the project, will allow the students to develop technical skills and to learn advanced scientific methods in an environment which promotes translational and interdisciplinary research application.
Based on the promising state-of-the-art results obtained in the implementation of AMs for MEG, this project focusses on the further development of AMs-based MEG for realizing an integrated stimulus/measurement device directly accessing brain connectivity. Understanding the brain as a network is considered crucial for future developments of cognitive and clinical neuroscience, as also testified by the large NIH investment on the Human Connectome Project with the ambition to map the neural connections in human brain in their entirety. However, the experimental investigation of neural connections is still challenging. This project aims at developing atomic sensors which will surpass current technology and will impact the rapidly growing national and international academic community (Translational Medicine and Psychology) working on the topic. The AMs that we will realize hold the promise of better identifying the regions of the brain responding to a specific magnetic perturbation, quantifying how the brain connectivity is modulated in a task specific manner, assessing connectivity changes associated with brain injuries and neurological disorders. This is of interest for understanding healthy brain functionality, as well as for clinical diagnostics and, in a near future, for treatment of injuries and disorders via targeted magnetic stimulation of the brain.
Furthermore, the record sensitivity and spatial resolution which we aim to achieve by engineering spin-squeezed atomic states will impact the wider field of bio-magnetism imaging. The magnetometers used for these imaging applications have often to trade off sensitivity for physical size. Instead, the spin-squeezing generation technique which we propose in this project will allow reduction of the sensor head footprint to be achieved without loss of sensitivity with respect to wider (cm-sized) non-quantum enhanced devices. This will boost the realization of ultra-sensitive multichannel imaging systems consisting of several sensors packed together with spatial sensitivity on the order of few millimetres. We can also foresee application of these devices beyond bio-magnetism detection, for non-destructive testing and characterization of material samples, and for security applications.
Finally, the proposed project will provide advanced training for Master and PhD students in the field of atomic magnetometry, which is a rich interdisciplinary field with applications ranging from medicine to mapping of the magnetic field of the Earth, from characterization of materials to searching for dark matter and dark energy in the Universe. The experimental activity and the synergetic collaboration with the School of Psychology of the University of Birmingham, with NPL, and with the companies with whom we will interact along the duration of the project, will allow the students to develop technical skills and to learn advanced scientific methods in an environment which promotes translational and interdisciplinary research application.
Organisations
- University of Birmingham (Fellow, Lead Research Organisation)
- Magnetic Shields Ltd (Collaboration)
- National Physical Laboratory (Collaboration)
- INEX Microtechnology (Collaboration)
- Magnetic Shields Limited (Project Partner)
- National Physical Laboratory (Project Partner)
- Atomic Weapons Establishment (Project Partner)
People |
ORCID iD |
Vera Guarrera (Principal Investigator / Fellow) |
Publications
Zipfel J. D.
(2024)
Indirect pumping of alkali-metal gases in a miniature silicon-wafer cell
in arXiv e-prints
Bevington P.
(2024)
Optical control and coherent coupling of spin diffusive modes in thermal gases
in arXiv e-prints
Gartman R
(2018)
Linear and nonlinear coherent coupling in a Bell-Bloom magnetometer
in Physical Review A
Liu G
(2021)
Response dynamics of an alkali-metal-noble-gas hybrid trispin system
in Physical Review A
Guarrera V
(2019)
Parametric Amplification and Noise Squeezing in Room Temperature Atomic Vapors.
in Physical review letters
Guarrera V
(2021)
Spin-noise spectroscopy of a noise-squeezed atomic state
in Physical Review Research
Gartman R
(2019)
Linear and non-linear coherent coupling in a Bell-Bloom magnetometer
Guarrera V
(2020)
Spin noise spectroscopy of a noise-squeezed atomic state
Description | 1- We theoretically and experimentally demonstrated that nonlinear spin-exchange coupling, acting in an analogous way to a wave-mixing mechanism, can create additional modes of coherent excitation which inherit the magnetic properties of the natural Larmor coherence. The generated coherences further couple via linear spin-exchange interaction, leading to an increase of the natural coherence lifetime of the system. These strategies are important for the development of spin-exchange coupling into a resource for an improved measurement platform based on room-temperature alkali-metal vapors. 2- We used parametric excitation to coherently manipulate the collective spin state of an atomic vapor at room temperature for the first time. The amplitudes of the signal quadratures showed amplification and attenuation, and their noise distribution was characterized by a strong asymmetry, similar to those observed in mechanical oscillators. We find that the noise squeezing obtained by this technique enhances the signal-to-noise ratio of the measurements up to a factor of 10, and improves the performance of a Bell-Bloom magnetometer by a factor of 3. 3- Spin-noise spectroscopy is emerging as a powerful technique for studying the dynamics of various spin systems also beyond their thermal equilibrium and linear response. We demonstrated a nonstandard mode of the spin-noise analysis applied to an out-of-equilibrium nonlinear atomic system realized by a Bell-Bloom atomic magnetometer. Our work promotes spin-noise spectroscopy as a versatile technique for the study of noise squeezing in a wide range of spin-based magnetic sensors. 4- We studied the dynamics of a comagnetometer based on an alkali-metal-noble-gas hybrid tri-spin system by numerically solving coupled Bloch equations. The results showed that a linear increasing response of the comagnetometer signal is found when the noble-gas nuclear spin magnetization and the alkali-metal spin lifetime parameters satisfy an overdamping condition. We found also that an upper limit for the signal amplitude of the comagnetometer is imposed by the inherent dynamics of the hybrid tri-spin system. 5- We found that different stable spatial modes of the atoms, in a room temperature or heated gas, drive the collective spin response of magnetometers and co-magnetometers. The presence of different spatial modes allows the implementation of strategies for optimizing the magnetometry signal, while minimizing the negative effects (increased noise, and reduced accuracy) of the presence of a polarizing light field during the measurements in these spin-based sensors. We discovered that the modes can also coherently couple, even though spatially separated, which is of interest also for the field of quantum imaging and information. 6- We applied the above diffusive-mode analysis to the characterization of the signal obtained from miniaturized cells realized together with industrial partners. This allowed us to achieve excellent performances in a multi-purpose wafer-based miniature cell. |
Exploitation Route | The results obtained and the methodologies developed within the project are of interest for: - improving the sensitivity of atomic magnetometers (with applications ranging from detection of magnetic signals generated by the brain to magnetic inductive imaging, from navigation to fundamental Physics measurements); - studying noise squeezing in a wide range of spin-based magnetic sensors; - exploiting the presence of different stable spatial modes for optimizing and improving accuracy in atomic magnetometry and co-magnetometry; - exploiting coherent coupling between spatially separated modes in the context of quantum imaging and information; - optimizing the construction of buffer gas atomic cells, of interest for atomic magnetometers, gyros, and clocks. |
Sectors | Aerospace Defence and Marine Healthcare Other |
Description | -realization of an atomic gyro (with 2 spins co-magnetometry setting) for inertial navigation purposes; -realization and optimization of miniaturized wafer atomic cells for different quantum technology applications. |
Sector | Aerospace, Defence and Marine,Healthcare,Manufacturing, including Industrial Biotechology,Other |
Description | MPAGS Training Modules |
Geographic Reach | National |
Policy Influence Type | Influenced training of practitioners or researchers |
Impact | In the context of the Midlands Physics Alliance Graduate School, i delivered a short module on Gaussian Optics for preparing the first year PhD students to work in experimental physics laboratories involving the use and manipulation of laser sources. |
Description | Industrial CASE studentship |
Amount | £56,000 (GBP) |
Organisation | Atomic Weapons Establishment |
Sector | Private |
Country | United Kingdom |
Start | 09/2019 |
End | 10/2022 |
Description | Co-magnetometry collaboration with NPL |
Organisation | National Physical Laboratory |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | Studying co-magnetometry in high pressure cells with Rb. |
Collaborator Contribution | Studying co-magnetometry in high pressure cells with Cs. |
Impact | Scientific papers in preparation. |
Start Year | 2021 |
Description | Development of miniaturized atomic cells |
Organisation | INEX Microtechnology |
Country | United Kingdom |
Sector | Private |
PI Contribution | We contributed to the design and characterization of the holders, magnetic coils, and magnetic shield realized for the miniature cells; we contributed to the characterization of core cells and heaters, and interpretation of the physical results. |
Collaborator Contribution | INEX realized the miniature cells, implementing a design for the heating circuit and holder done by a third partner (NPL). NPL contributed also to the characterization of the core cells and heaters. |
Impact | A paper has been written, currently undergoign review at PR Applied, and it is available on the archive: - Indirect pumping of alkali-metal gases in a miniature silicon-wafer cell, J. D. Zipfel, P. Bevington, L. Wright, W. Chalupczak, G. Quick, B. Steele, J. Nicholson, V. Guarrera, arXiv:2402.16695 |
Start Year | 2021 |
Description | Development of miniaturized atomic cells |
Organisation | National Physical Laboratory |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | We contributed to the design and characterization of the holders, magnetic coils, and magnetic shield realized for the miniature cells; we contributed to the characterization of core cells and heaters, and interpretation of the physical results. |
Collaborator Contribution | INEX realized the miniature cells, implementing a design for the heating circuit and holder done by a third partner (NPL). NPL contributed also to the characterization of the core cells and heaters. |
Impact | A paper has been written, currently undergoign review at PR Applied, and it is available on the archive: - Indirect pumping of alkali-metal gases in a miniature silicon-wafer cell, J. D. Zipfel, P. Bevington, L. Wright, W. Chalupczak, G. Quick, B. Steele, J. Nicholson, V. Guarrera, arXiv:2402.16695 |
Start Year | 2021 |
Description | Magnetic shielding design |
Organisation | Magnetic Shields Ltd |
Country | United Kingdom |
Sector | Private |
PI Contribution | Selection of new materials for a mixed material shielding with high field attenuation and minimizing the residual magnetic field noise from high-permeability shields (e.g. Johnson noise) to below the fT/sqrt(Hz) sensitivity. |
Collaborator Contribution | Assembly of the different shielding parts and optimization of the mechanical stabiity of the whole shielding structure. |
Impact | - 10^6 magnetic field suppression - reduction of shielding induced magnetic noise to well below the 1 fT/sqrt(Hz) sensitivity - mechanical stability of a (>25 kg) shielding structure |
Start Year | 2019 |
Description | NPL Squeezing and fundamental physics |
Organisation | National Physical Laboratory |
Country | United Kingdom |
Sector | Academic/University |
PI Contribution | I have investigated non-linear effects leading to coherence transfer and spin-squeezing for achieving improved sensitivity in optically pumped atomic magnetometers. |
Collaborator Contribution | Partners have assisted with the experimental measurements and contributed with knowledge exchange. |
Impact | - Papers: R. Gartman, V. Guarrera, G. Bevilacqua, and W. Chalupczak, Phys. Rev. A 98, 061401(R) (2018) V. Guarrera, R. Gartman, G. Bevilacqua, G. Barontini, and W. Chalupczak, Phys. Rev. Lett. 123, 033601 (2019) - Additional grant submissions: 1) UK-Space (2019) 2) STFC-EPSRC call for Quantum Technologies for Fundamental Physics (under consideration) |
Start Year | 2018 |
Description | Optical pumped magnetometers workshop |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | National |
Primary Audience | Other audiences |
Results and Impact | Informative workshop organized by GCHQ. |
Year(s) Of Engagement Activity | 2022 |
Description | Organization and participation in QUAMP 2019 conference |
Form Of Engagement Activity | Participation in an activity, workshop or similar |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | The conference hosted several postgraduate students from UK and abroad. |
Year(s) Of Engagement Activity | 2019 |
Description | Physics East Building symposium |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | Gathering together all EPSRC-funded active researchers at the University of Birmingham, including PhD students, PDRAs, Academic Staff. |
Year(s) Of Engagement Activity | 2018 |
Description | Seminar for the extended group of Cold Atoms, Quantum Technology at the University of Birmingham |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | Local |
Primary Audience | Postgraduate students |
Results and Impact | 25 PhD students, 20 PDRAs, 10 University staff attended the seminar presenting my research activity, with questions and discussion afterwards. |
Year(s) Of Engagement Activity | 2018 |
Description | WOPM workshop 2022 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Other audiences |
Results and Impact | Attendance of the "Workshop in optically pumped magnetometers 2022", International audience of researchers and companies involved. VG chaired a session, postdoc and PhD student discussed a poster. |
Year(s) Of Engagement Activity | 2022 |
Description | YAO 2023 |
Form Of Engagement Activity | A talk or presentation |
Part Of Official Scheme? | No |
Geographic Reach | International |
Primary Audience | Postgraduate students |
Results and Impact | Presentation of our research done at the Young Atom Opticians conference. |
Year(s) Of Engagement Activity | 2023 |