2D-IR Spectroscopy for Serum Diagnostics
Lead Research Organisation:
University of Strathclyde
Department Name: Pure and Applied Chemistry
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
Publications
Cameron JM
(2022)
Clinical Spectroscopy: Lost in Translation?
in Applied spectroscopy
Rutherford S
(2023)
Optical Screening and Classification of Drug Binding to Proteins in Human Blood Serum
in Analytical Chemistry
Rutherford S
(2021)
Biofluid analysis and classification using IR and 2D-IR spectroscopy
in Chemometrics and Intelligent Laboratory Systems
Rutherford SH
(2021)
Detection of Glycine as a Model Protein in Blood Serum Using 2D-IR Spectroscopy.
in Analytical chemistry
Rutherford SH
(2023)
2D-IR spectroscopy of proteins in H2O-A Perspective.
in The Journal of chemical physics
Rutherford SH
(2022)
Detection of paracetamol binding to albumin in blood serum using 2D-IR spectroscopy.
in The Analyst
Rutherford SH
(2022)
Measuring proteins in H2O using 2D-IR spectroscopy: pre-processing steps and applications toward a protein library.
in The Journal of chemical physics
Description | The main achievements are: 1. The development of a workflow to standardise the pre-processing of 2D-IR spectra of proteins in water. This will enable spectra to be compared that have been acquired of different samples and on different instruments - a key requirement for the construction of a 2D-IR spectral library of proteins. Hence, this is an important step in the development of 2D-IR spectroscopy as an analytical tool for healthcare applications. 2. Detection and quantification of protein-bound drug molecules in blood serum at physiologically relevant levels using 2D-IR spectroscopy. 2D-IR spectroscopy offers a direct, label-free measurement with no additional sample processing. The ability to study protein-drug binding has potential application for the development of novel therapies and personalised medicines. |
Exploitation Route | This work is currently being taken forward by a collaborator who led the present work and is an expert in 2D-IR spectroscopy. This will ultimately enable the societal benefits from translation of 2D-IR spectroscopy into healthcare-related serum diagnostics applications. |
Sectors | Healthcare Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |