2D-IR Spectroscopy for Serum Diagnostics
Lead Research Organisation:
University of Strathclyde
Department Name: Pure and Applied Chemistry
Abstract
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Organisations
Publications
Cameron JM
(2022)
Clinical Spectroscopy: Lost in Translation?
in Applied spectroscopy
Rutherford S
(2023)
Optical Screening and Classification of Drug Binding to Proteins in Human Blood Serum
in Analytical Chemistry
Rutherford S
(2021)
Biofluid analysis and classification using IR and 2D-IR spectroscopy
in Chemometrics and Intelligent Laboratory Systems
Rutherford SH
(2021)
Detection of Glycine as a Model Protein in Blood Serum Using 2D-IR Spectroscopy.
in Analytical chemistry
Rutherford SH
(2023)
2D-IR spectroscopy of proteins in H2O-A Perspective.
in The Journal of chemical physics
Rutherford SH
(2022)
Detection of paracetamol binding to albumin in blood serum using 2D-IR spectroscopy.
in The Analyst
Rutherford SH
(2022)
Measuring proteins in H2O using 2D-IR spectroscopy: pre-processing steps and applications toward a protein library.
in The Journal of chemical physics
| Description | The main achievements are: 1. The development of a workflow to standardise the pre-processing of 2D-IR spectra of proteins in water. This will enable spectra to be compared that have been acquired of different samples and on different instruments - a key requirement for the construction of a 2D-IR spectral library of proteins. Hence, this is an important step in the development of 2D-IR spectroscopy as an analytical tool for healthcare applications. 2. Detection and quantification of protein-bound drug molecules in blood serum at physiologically relevant levels using 2D-IR spectroscopy. 2D-IR spectroscopy offers a direct, label-free measurement with no additional sample processing. The ability to study protein-drug binding has potential application for the development of novel therapies and personalised medicines. |
| Exploitation Route | This work is currently being taken forward by a collaborator who led the present work and is an expert in 2D-IR spectroscopy. This will ultimately enable the societal benefits from translation of 2D-IR spectroscopy into healthcare-related serum diagnostics applications. |
| Sectors | Healthcare Manufacturing including Industrial Biotechology Pharmaceuticals and Medical Biotechnology |