2D-IR Spectroscopy for Serum Diagnostics

Lead Research Organisation: University of Strathclyde
Department Name: Pure and Applied Chemistry

Abstract

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Publications

10 25 50
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Cameron JM (2022) Clinical Spectroscopy: Lost in Translation? in Applied spectroscopy

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Rutherford S (2021) Biofluid analysis and classification using IR and 2D-IR spectroscopy in Chemometrics and Intelligent Laboratory Systems

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Rutherford SH (2023) 2D-IR spectroscopy of proteins in H2O-A Perspective. in The Journal of chemical physics

 
Description The main achievements are:
1. The development of a workflow to standardise the pre-processing of 2D-IR spectra of proteins in water. This will enable spectra to be compared that have been acquired of different samples and on different instruments - a key requirement for the construction of a 2D-IR spectral library of proteins. Hence, this is an important step in the development of 2D-IR spectroscopy as an analytical tool for healthcare applications.
2. Detection and quantification of protein-bound drug molecules in blood serum at physiologically relevant levels using 2D-IR spectroscopy. 2D-IR spectroscopy offers a direct, label-free measurement with no additional sample processing. The ability to study protein-drug binding has potential application for the development of novel therapies and personalised medicines.
Exploitation Route This work is currently being taken forward by a collaborator who led the present work and is an expert in 2D-IR spectroscopy. This will ultimately enable the societal benefits from translation of 2D-IR spectroscopy into healthcare-related serum diagnostics applications.
Sectors Healthcare

Manufacturing

including Industrial Biotechology

Pharmaceuticals and Medical Biotechnology