Beyond Antibiotics
Lead Research Organisation:
University of Oxford
Department Name: Engineering Science
Abstract
The 2019 World Health Organisation (WHO) report on Antimicrobial Resistance (AMR) identifies it as: "one of the greatest threats we face as a global community." The evolution of drug-resistant bacteria, our over-use of antibiotics and failure to develop new methods for tackling infection could leave us without viable treatments for even the most trivial infections within the next 3 decades. There have been significant efforts by the WHO and national agencies to raise awareness of AMR and reduce the use of antibiotics, but there is still an urgent need to intensify these efforts and, crucially, to develop alternatives. The aim of the programme is to address this need.
The programme will consist of 4 interlinked work packages focussed on the core research objectives:
(1) The development of human organoid models for studying interactions between bacteria and the tissue microenvironment and larger scale interactions with the host microbiome.
(2) New microscopy methods to complement the organoid models and to facilitate rapid characterisation of bacteria for improved diagnosis.
(3) New antimicrobial therapeutics and targeted delivery techniques to improve the use of existing antibiotics and provide viable alternatives.
(4) "Drug-free" methods for treating infections and promoting immune function thereby further reducing the use of antibiotics and providing methods suitable for large scale environmental/industrial use.
These will be supported by 2 parallel translational activities to enable development of the translational pathway and wider engagement with clinical and industrial stakeholders, policy-makers and the public.
The programme will consist of 4 interlinked work packages focussed on the core research objectives:
(1) The development of human organoid models for studying interactions between bacteria and the tissue microenvironment and larger scale interactions with the host microbiome.
(2) New microscopy methods to complement the organoid models and to facilitate rapid characterisation of bacteria for improved diagnosis.
(3) New antimicrobial therapeutics and targeted delivery techniques to improve the use of existing antibiotics and provide viable alternatives.
(4) "Drug-free" methods for treating infections and promoting immune function thereby further reducing the use of antibiotics and providing methods suitable for large scale environmental/industrial use.
These will be supported by 2 parallel translational activities to enable development of the translational pathway and wider engagement with clinical and industrial stakeholders, policy-makers and the public.
Organisations
- University of Oxford (Lead Research Organisation)
- Oxford NanoImaging (Collaboration, Project Partner)
- PUBLIC HEALTH ENGLAND (Collaboration)
- Smith and Nephew (Collaboration)
- UNIVERSITY OF EXETER (Collaboration)
- University of Otago (Collaboration)
- Karl Storz GmbH & Co. KG (Collaboration)
- GlaxoSmithKline (GSK) (Collaboration)
- Boston Scientific (United States) (Collaboration, Project Partner)
- UNIVERSITY OF BRITISH COLUMBIA (Collaboration)
- National Biofilms Innovation Centre (Project Partner)
- Philips (Netherlands) (Project Partner)
- GlaxoSmithKline (United Kingdom) (Project Partner)
- Public Health England (Project Partner)
- Norbrook (United Kingdom) (Project Partner)
- Smith & Nephew plc (UK) (Project Partner)
- Karl Storz (Germany) (Project Partner)
Publications
Von Kügelgen A
(2022)
A multidomain connector links the outer membrane and cell wall in phylogenetically deep-branching bacteria
in Proceedings of the National Academy of Sciences
Sathiananthamoorthy S
(2023)
Application of Various Techniques to Gain Insights Into the Complex Urinary Tract Microbial Communities of Renal Transplant Recipients.
in Transplantation direct
Plazonic, F
(2022)
Bactericidal effect of ultrasound-responsive microbubbles and sub-inhibitory gentamicin against Pseudomonas aeruginosa biofilms on substrates with differing acoustic impedance
in Ultrasound in Medicine & Biology
Plazonic F
(2022)
Bactericidal Effect of Ultrasound-Responsive Microbubbles and Sub-inhibitory Gentamicin against Pseudomonas aeruginosa Biofilms on Substrates With Differing Acoustic Impedance.
in Ultrasound in medicine & biology
Murray B
(2021)
Recurrent Urinary Tract Infection: A Mystery in Search of Better Model Systems
in Frontiers in Cellular and Infection Microbiology
Morris CJ
(2023)
Effective Treatments of UTI-Is Intravesical Therapy the Future?
in Pathogens (Basel, Switzerland)
LuTheryn G
(2023)
Cationic Microbubbles for Non-Selective Binding of Cavitation Nuclei to Bacterial Biofilms.
in Pharmaceutics
LuTheryn G
(2022)
Bactericidal and anti-biofilm effects of uncharged and cationic ultrasound-responsive nitric oxide microbubbles on Pseudomonas aeruginosa biofilms.
in Frontiers in cellular and infection microbiology
Lasri Doukkali A
(2023)
A hybrid individual-based mathematical model to study bladder infections
in Frontiers in Applied Mathematics and Statistics
Krause S
(2022)
The importance of biofilm formation for cultivation of a Micrarchaeon and its interactions with its Thermoplasmatales host.
in Nature communications
| Description | we have so far demonstrated the efficacy of nitric oxide loaded microbubble against bacterial biofilms; the feasibility of disrupting biofilms and killing bacteria using ultrasound and cavitation nuclei; the feasibility of generating tissue mimicking organoids as models for human infection; the feasibility of targeted antimicrobial delivery using micro and nanoparticles activated by ultrasound; the efficacy of non-antibiotic drugs as potential alternatives to conventional antibiotics |
| Exploitation Route | we are now undertaking further clinical work to utilise microbubbles for drug delivery to promote bone healing and also treat bone infections |
| Sectors | Healthcare |
| URL | https://ibme.ox.ac.uk/ |
| Description | Dr Gareth LuTheryn led small discussion Labour Shadow Secretary of State for Education, Bridget Phillipson, on antimicrobial resistance |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Mr Eoin McMullan presented on the "Development of Novel Sensitisers for the use in Antimicrobial Photo- and Sono- Dynamic Therapy" and Medical Research Foundation National PhD Training Programme in AMR Research 2023, in Bristol, UK. |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Improved understanding of photo-and sonodynamic sensitisers to make existing antibiotics, to which some bacterial resistance has developed, effective against harmful bacteria again. |
| URL | https://www.medicalresearchfoundation.org.uk/projects/national-phd-training-programme-in-antimicrobi... |
| Description | Prof Rohn created content for urinary tract infection treatment resistance issues and the urinary microbiome for an upcoming Master Class and CPE , British Society for Antimicrobial Chemotherapy, 2023 |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Description | Prof. Dario Carugo participated in the National Biofilms Innovation Centre (NBIC) led workshop, titled "Biofilm Prevention." |
| Geographic Reach | National |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Improvements to prevention of early-stage microbial adhesion and colonisation events at surfaces and interfaces, and curtailing the development and maturation of early-stage biofilms. |
| Description | Prof. Dario Carugo's research was featured International Society for Therapeutic Ultrasound's Webinar "Sonobactericide for Treating Bacterial Infections" given by Dr Klazina Kooiman |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Increased knowledge of cutting edge scientific techniques that address the current shortage of effective antibiotics and antimicrobials. |
| URL | https://istu.org/istu-live/istu-live-april-28-2022/ |
| Description | Prof. Eleanor Stride contributed to National Engineering Policy Centre |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Prof. Eleanor Stride responded to the Department of Health and Social Care's consultation on antimicrobial resistance |
| Geographic Reach | National |
| Policy Influence Type | Contribution to a national consultation/review |
| URL | https://www.gov.uk/government/consultations/antimicrobial-resistance-national-action-plan-call-for-e... |
| Description | Prof. Rohn participated as a speaker in the RSC-iRISE Thought Leadership Roundtable on AMR organised by the Royal Society of Chemistry in September 2023. |
| Geographic Reach | Asia |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Prof. Stride appointed to Engineering Policy Committee at the Royal Academy of Engineering which reports directly to the UK Government |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Feedback provided to the Engineering Policy Committee at the Royal Academy of Engineering on matters related to antimicrobial resistance, improving drug delivery and infection preevntion. |
| Description | Prof. Stride is a signatory to the Engineering Kids' Futures campaign, led by the Institution of for Engineering & Technology, 2023. |
| Geographic Reach | National |
| Policy Influence Type | Implementation circular/rapid advice/letter to e.g. Ministry of Health |
| Description | Prof. Stride met with Chief Medical Officer, Prof. Chris Whitty, and the RAEng team to discuss the AMR burden from untreated sewage discharges into public waters. |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Description | Prof. Stride presents at Royal Academy of Engineering workshop to build a longer-term view of engineering in 2023 |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| Impact | Improved understanding of engineering and societal needs from the perspective of academia, research and training of the next generation of engineers. |
| URL | https://raeng.org.uk/ |
| Description | Prof. Stride, Prof. Carugo, Dr. Sara Keller, Victor Choi and Kester Campbell participated in the National Biofilms Innovation Centre (NBIC) Workshop, 2023 |
| Geographic Reach | National |
| Policy Influence Type | Contribution to new or improved professional practice |
| URL | https://biofilms.ac.uk/ |
| Description | Professors Stride, Cleveland and Coussios have contributed to the launch of the UK Chapter of the Focussed Ultrasound Foundation, 2023 |
| Geographic Reach | National |
| Policy Influence Type | Participation in a guidance/advisory committee |
| URL | https://www.fusfoundation.org/ |
| Title | Enhancing uptake of alternative therapeutic approaches to combat bacterial infections by the public, 2023. |
| Description | Prof. Stride has engaged with the Behavioural Insights Team and designed a systematic scoping exercise to understand the public's views on AMR and alternative therapeutic approaches to combat bacterial infections. This will include desk research and data collection from a representative sample of the public. Results and recommendations will be provided to the project team to enhance the uptake of research results and technological innovations for healthcare that will be developed as part of this project. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2023 |
| Provided To Others? | No |
| Impact | No impacts to date. |
| Title | Prof. Stride and Mr Mihir Sheth developed a survey instrument to assess the prevalence of chronic UTIs in the public, 2023. |
| Description | Prof. Stride and Mr Mihir Sheth developed a survey instrument to assess the prevalence of chronic UTIs in the public. Data are currently being collected from a representative sample of the UK public and a second international sample. Factor analyses will be conducted to validate the instrument in these two populations respectively. Results from data collections will also be used to inform GPs and health service providers to improve their communication of UTI symptoms, treatments, and management of symptoms to reduce the AMR burden. |
| Type Of Material | Physiological assessment or outcome measure |
| Year Produced | 2023 |
| Provided To Others? | No |
| Impact | Results from national prevalence data collection will be made available to the public and GPs to raise awareness of recurrent urinary tract infections and treatment options. |
| Description | Boston Scientific Corporation |
| Organisation | Boston Scientific |
| Country | United States |
| Sector | Private |
| PI Contribution | Knowledge exchange and advice on antimicrobial resistance for urinary tract infections and implantable devices for the bladder. |
| Collaborator Contribution | Doctoral studentship, doctoral student support and advice, ablation system, and proprietary device design data. |
| Impact | Advice and support for doctoral student. |
| Start Year | 2021 |
| Description | GlaxoSmithKline (GSK) Medicines Research Centre |
| Organisation | GlaxoSmithKline (GSK) |
| Department | GlaxoSmithKline Medicines Research Centre |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Advice and consultancy on research design. |
| Collaborator Contribution | Advice and membership of the International Advisory Board of the Beyond Antibiotics programme grant. |
| Impact | Outputs included presentations to the research team and advice on translation of research outputs into clinical practice. |
| Start Year | 2021 |
| Description | Karl Storz GmbH & Co. KG |
| Organisation | Karl Storz GmbH & Co. KG |
| Country | Germany |
| Sector | Private |
| PI Contribution | Knowledge exchange, consultancy on ultrasound devices. |
| Collaborator Contribution | Use of facilities and equipment relating to shockwave source. Consultancy and advice on shockwaves to encourage wound healing. |
| Impact | Ongoing collaboration. Initial outputs were research discussions, comments and advice on individual research projects to strengthen their scientific methodology. |
| Start Year | 2021 |
| Description | New collaboration set up between Prof. Eleanor Stride and Otago University, New Zealand |
| Organisation | University of Otago |
| Country | New Zealand |
| Sector | Academic/University |
| PI Contribution | New research partnership developed to facilitate the investigation of nitric oxide generating particles. This collaboration will leverage the impact biofilm disruption activities of the programme grant to more comprehensively address antimicrobial resistance without requiring additional resources. |
| Collaborator Contribution | Access to laboratory facilities and knowledge around particle development processes. |
| Impact | Improved research processes, as well as time and resource savings. |
| Start Year | 2021 |
| Description | Oxford NanoImaging |
| Organisation | Oxford Nanoimaging |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Knowledge exchange on imaging and advice on research design. |
| Collaborator Contribution | Imaging tools access and support for doctoral student, including supervision and advice. |
| Impact | Advice, support and supervision for doctoral student. Access to imaging tools. |
| Start Year | 2021 |
| Description | Smith+Nephew plc |
| Organisation | Smith and Nephew |
| Department | Smith and Nephew Wound Management |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Advice on ultrasound methodology and devices for wound healing. |
| Collaborator Contribution | Characterisation equipment, advice, steering committee membership, and researcher hosting. |
| Impact | Advice on ultrasound device translation into clinical practice. Shared data from human factors unit on factors that hindered uptake of new device in hospital setting by staff. |
| Start Year | 2021 |
| Description | UK Health Security Agency (formerly Public Health England) |
| Organisation | Public Health England |
| Department | Antimicrobial Resistance and Healthcare-Associated Infections Reference Unit |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Information and knowledge exchange on addressing antimicrobial resistance. |
| Collaborator Contribution | Provision of infection models, advice and steering committee membership. |
| Impact | Advice on quantifying treatment efficacy across a range of projects and active collaborations on infection models. |
| Start Year | 2021 |
| Description | University of British Columbia |
| Organisation | University of British Columbia |
| Department | UBC/BC Cancer Agency |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | Novel delivery system for antibiotics |
| Collaborator Contribution | Disease model for urinary tract infection |
| Impact | none yet, experiments underway |
| Start Year | 2022 |
| Description | University of Exeter |
| Organisation | University of Exeter |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Ultrasound system to enhance therapeutic agent delivery |
| Collaborator Contribution | Provision of antibiotic virus particles |
| Impact | experiments ongoing |
| Start Year | 2021 |
| Title | A phenothiazine-related compound conjugated to a peptide |
| Description | Callan JF; McHale AP; United Kingdom Patent Application No 2315857.9; University of Ulster IP Title: A phenothiazine-related compound conjugated to a peptide. |
| IP Reference | 2315857.9 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2023 |
| Licensed | Commercial In Confidence |
| Impact | patent application complted. |
| Description | Beyond Antibiotics Programme Grant Twitter social media channel established |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Beyond Antibiotics Programme Grant social media channel established on Twitter. Followers grown to 818, with 191 posts published, and 105,075 Tweet impressions generated since the grant's start date on October 1st, 2021. |
| Year(s) Of Engagement Activity | 2021,2022,2023 |
| URL | https://twitter.com/AMR_Research |
| Description | Beyond Antibiotics Programme Grant website developed |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Website developed to showcase the research of the Beyond Antibiotics Programme Grant and simultaneously raise awareness of antimicrobial resistance. |
| Year(s) Of Engagement Activity | 2021,2022,2023 |
| URL | https://beyondantibiotics.ox.ac.uk/ |
| Description | Dr Bharat delivered a lecture at the Harden Conference in Single Molecule Bacteriology, Abingdon, UK, 14th July 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Bharat delivered a lecture at the Harden Conference in Single Molecule Bacteriology, Abingdon, UK, 14th July 2022 "Molecular logic of prokaryotic surface layers." Impacts included discussions, networking and plans for future interdisciplinary research proposal submissions. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.emedevents.com/c/medical-conferences-2022/87th-harden-conference-single-molecule-bacteri... |
| Description | Dr Bharat delivered a lecture at the Next Generation Biophysics Meeting, Cambridge, UK, 28th September 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr Bharat delivers invited lecture titled, "Studying physiological processes inside bacterial cells using cryo-ET." This informed doctoral student and post doctoral researcher trainings delivered by the MRC Laboratory of Molecular Biology in Cambridge, UK. Impacts included discussions and requests for additional information to inform the design of future experiments. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Dr Bharat delivered a lecture at the Rosalind Franklin Institute, Harwell, UK 10th March 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Bharat delivered a lecture at the Rosalind Franklin Institute, Harwell, UK 10th March 2022 "Structural studies of prokaryotic cell surfaces." The lecture was followed by professional networking. Questions from doctoral students suggested learning outcomes at the levels of "analysis" and "evaluation" to improve future experiments. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Dr Bharat delivered a lecture at the University of Virginia, Structural Biology Seminar, 27th June 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Bharat delivered a lecture at the University of Virginia, Structural Biology Seminar, 27th June 2022 "Structural studies of prokaryotic cell surfaces." Questions, discussion and networking followed the lecture. Discussions helped doctoral students improve their experimental set up and reduce confounding variables. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Dr Bharat delivers talk at the EMBO Bacterial Networks Conference, St Feliu, Spain, 7th September 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Tanmay Bharat delivers talk titled, "Molecular logic of prokaryotic surface layers" at international conference. Questions and answers sparked discussions and professional networking followed. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://meetings.embo.org/event/21-bacnet |
| Description | Dr Ffion Hammond delivered a 15-minute oral presentation at the international conference: "One Health and antimicrobial resistance: role of antibiotics, antimicrobial peptides and biocides" at the Federal Institute for Material Research and Testing (BAM, Berlin, Germany). |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Ffion Hammond a 15-minute oral presentation at the international conference: "One Health and antimicrobial resistance: role of antibiotics, antimicrobial peptides and biocides" at the Federal Institute for Material Research and Testing (BAM, Berlin, Germany). The event was attended by an audience of academic researchers, students, policy officers and consultants, all with a research focus or interest in AMR. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://www.bam.de/Content/EN/Events/2024/2024-01-29-30-health-and-antimicrobia-resistance-workshop.... |
| Description | Dr Ffion Hammond hosted an outreach stand at the ATOM Festival of Science and Technology, in Abingdon-on-Thames, Oxfordshire |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | The ATOM Festival of Science and Technology was held in Abingdon-on-Thames on Saturday 11th March from 9:30 to15:00. Dr Ffion Hammond hosted an outreach stall in collaboration with the Nuffield Dept of Orthopaedics Rheumatology and Musculoskeletal Sciences at the University of Oxford's "The Gut Florists" group. This outreach activity was aimed at families and focused on the subject of bacteria and the microbiome in health and disease. The activity was to make a bacterial pom pom out of differently coloured wool, as well as having bacteria trivia questions to vote on. Whilst focusing on the microbiome, a key angle of this was how the gut microbiome is affected by antibiotics (loss of 'good' bacteria) and how this impacts health, and how some bacteria can resist antibiotics (allowing 'bad' bacteria to grow and cause infection). |
| Year(s) Of Engagement Activity | 2023 |
| Description | Dr Ffion Hammond presented flash talk on "antibiotic treatment causes increased dissemination of MDR-Klebsiella pneumoniae from the gut in a gnotobiotic murine model" at the 2023 European Network of Immunology Institutes |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Flash talk presented as part of researcher training delivered by the European network of immunology institutes. Discussions and networking opportunities arose following the flash talk for the junior researcher. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.enii.org/ |
| Description | Dr Ffion Hammond presented flash talk on "modelling drug resistant Klebsiella pneumoniae?in the gastrointestinal tract" at the Early Career Researcher conference: Multidisciplinary Approaches to AMR Hosted by the Ineos Oxford Institute for antimicrobial research 2023, in Oxford UK. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Flash talk followed by questions, discussions, and networking. Future plans for additional collaborations with the INEOS institute made. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.ineosoxford.ox.ac.uk/ |
| Description | Dr Ffion Hammond presents at the British Society for Immunology Congress 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster presentation titled, "Microbiome-targeted therapeutics to improve immunity and combat gut colonisation with antimicrobial resistant pathogens: a feasible approach?" given at research event attended by immunology researchers at various student and career stages and from various background including academic, clinical and industrial. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.bsicongress.com/bsi/frontend/reg/thome.csp?pageID=11575&eventID=13&CSPCHD=000001000000f4... |
| Description | Dr Gareth LuTheryn Presented at the 27th European Symposium on Ultrasound Contrast Imaging |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Conference presentation on antimicrobial and antibiofilm agents at 27th European Symposium on Ultrasound Contrast Imaging, which raised awareness of the importance of addressing biofilm disruption and dispersion as a mechanical way to increase the effectiveness of existing antimicrobial agents. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Dr Gareth LuTheryn conducted 30 hours of KS4 and KS5 outreach on impacts of biofilms and antimicrobial resistance on public health |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Dr Gareth LuTheryn conducted antimicrobial resistance (AMR) tutorials for KS5 with UTC Norwich (Online). In addition, KS4 tutorials with Dormers Wells School (Southall), and KS4 tutorials with Sir William Ramsay School were delivered for a combined total of 30 hours of tutorial content. Tutorials focused on biofilms, infection and AMR, as well as how they impact public health. Tutorials were followed by a literature research project on how we can use new treatments and technologies as interventions for these chronic infections. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Dr Gareth LuTheryn conducted KS3 and KS4 outreach in partnership with The Brilliant Club |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Introduction of the scientific research methodology and the issues associated with antimicrobial resistance and biofilms for human health. Raising awareness of the importance of antimicrobial stewardship and impacts of resistance on human health. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Dr Gareth LuTheryn conducted Outreach and engagement with KS3 pupils at Livingstone Academy Bournemouth |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Outreach and engagement with KS3 pupils at Livingstone Academy Bournemouth on antimicrobial resistance and antibiotic development. The process and challenges affecting new antibiotic developments were disucssed. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Dr Gareth LuTheryn conducted delivered KS4 tutorials |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Dr Gareth LuTheryn delivered a series of tutorials to KS4 students on antimicrobial resistance and antimicrobial drug delivery tutorials at Wexham School, Slough. Over the course of 5 weeks, 10 hours of tutorials were delivered reaching 14 Students and their parents. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Dr Gareth LuTheryn delivered 10 hours of Tutorials with KS4 students at Springfield School, Portsmouth |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Delivered 10 hours of Tutorials with KS4 students at Springfield School, Portsmouth on antimicrobial resistance and current research on drug development and delivery strategies. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Dr Gareth LuTheryn delivered 28 hours of tutorials on antibiotic resistance, novel treatment modalities and ultrasound mediated therapy for 24 students |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Dr Gareth LuTheryn delivered 28 hours of tutorials on antibiotic resistance, novel treatment modalities and ultrasound mediated therapy for 24 students (14 students from King Alfreds school, Wantage and 10 students from Idris Davies school, Wales) |
| Year(s) Of Engagement Activity | 2024 |
| Description | Dr Gareth LuTheryn delivered KS3 tutorials on AMR |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Dr Gareth LuTheryn delivered a series of tutorials on antimicrobial resistance to KS3 students at Bourne End Academy, Slough and The WREN School, Reading. Over the course of 5 Weeks, 20 hours of instruction were delivered and 28 students and their families were reached. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Dr Gareth LuTheryn met with Garfield Weston-super-Mare foundation to discuss funding opportunities for students from under represented backgrounds in higher education. Dr LuTheryn contributed to a panel review and questions and answers on engaging universities and communities. |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Dr Gareth LuTheryn met with Garfield Weston-super-Mare foundation to discuss funding opportunities for students from under represented backgrounds in higher education. Dr LuTheryn contributed to a panel review and questions and answers on engaging universities and communities. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Dr Gareth LuTheryn presented work on antimicrobial resistance at EuroBiofilms22, Mallorca. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Gareth LuTheryn presented work on antimicrobial applications of nitric oxide microbubbles to EuroBiofilms22, Mallorca. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://eurobiofilms2022.com/ |
| Description | Dr Hammond organised an outreach stall at the Oxford Science and Ideas Festival, 2022. |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Hammond organised an outreach stall for the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences at the Oxford Science and Ideas Festival. The activity focused on inspiring and informing children and families about ultrasound in knee surgeries and the importance of biopsies for research, October 2022. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Dr Hammond set up outreach stall at the Oxford Brookes Science Bazaar outreach event in 2023. |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Dr Hammond set up an outreach stall at the Oxford Brookes Science Bazaar. The outreach activity focused on the importance of the microbiome and impact of AMR. Activities included make your own bacteria out of a pom-pom, February 2023. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.brookes.ac.uk/science-bazaar |
| Description | Dr Heather Nesbitt presented a poster at the International Symposium for Therapeutic Ultrasound in Toronto |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster presentation on "New Sensitisers for Antimicrobial Sonodynamic/Photodynamic Therapy." |
| Year(s) Of Engagement Activity | 2022 |
| Description | Dr Keller appeared as guest speaker on an episode of Oxford Sparks podcast in 2023. |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Keller appeared as guest speaker on an episode of Oxford Sparks podcast organised by the University of Oxfords' mathematical, physical, engineering and life sciences division, May 2023. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.oxfordsparks.ox.ac.uk/podcasts/how-can-we-use-sound-waves-to-eliminate-infections/ |
| Description | Dr Keller presented at a science communication event, titled "Spotlight: Illuminating Engineering" on using sound to eliminate infections, 2023. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Keller presented at a science communication event, titled "Spotlight: Illuminating Engineering" on using sound to eliminate infections. The TED-Talk style event was held in Oxford in April 2023 and attended by secondary students. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://beyondantibiotics.ox.ac.uk/case-studies/science-engagement-activities-dr-sara-keller/ |
| Description | Dr Keller provided a lunchtime talk to primary school students on antimicrobial resistance in Abingdon, UK, 2023. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Dr Keller provided a lunchtime talk to primary school students on antimicrobial resistance at the Caldecott Primary School as part of their 'British Science Week' activities, March 2023. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Dr Keller, Dr Brans and Dr LuTheryn hosted a science demonstration on fighting harmful bacteria with sound at the Oxford Brookes University Science Bazaar, 2024. |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Researchers delivered interactive demonstrations and fun activities to spark curiosity and foster a deeper appreciation for science in participants of all ages. The outreach stand was focused on how ultrasound can be utilised to combat bacterial infections and antimicrobial resistance through demonstrations and interactive play, including: 1. Bacteria and Antibiotics Activities: Delving into Microscopic Worlds Shining a light on the underlying reasons for the research undertaken by the Beyond Antibiotics grant was an array of activities focused on bacteria, antibiotics, and drug resistance. Through coloring sheets, crosswords, and interactive demonstrations, participants gained insight into the complex relationship between bacteria and antibiotics. 2. "Pin the tail on the Donkey": A Creative Twist on Anatomy and Interactive App: Peering Inside the Human Body In a playful twist on the classic game, "Pin the tail on the Donkey," participants were challenged to identify various body parts depicted using different imaging techniques. From X-rays to MRIs, children and adults alike tested their knowledge of anatomy while learning about the importance of medical imaging (specifically ultrasound) in diagnosing and treating ailments. 3. Acoustic Fountain: Unveiling the Power of Ultrasound As a demonstration of the therapeutic potential of ultrasound, the team created an "acoustic fountain", where an ultrasound transducer was used to send focused sound waves at an air-liquid interface. This results in mild to violent disruption of the water surface and even cold steam generation. Participants were encouraged to connect the dots between the mechanical effects of ultrasound and the challenge of antibiotic penetration through biofilms. |
| Year(s) Of Engagement Activity | 2024 |
| URL | https://beyondantibiotics.ox.ac.uk/news/fighting-bacteria-with-sound-a-recap-of-our-outreach-day/ |
| Description | Dr LuTheryn delivered KS5 tutorials at UTC Reading and The Heathland School (Hounslow) in May 2023. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Dr LuTheryn delivered KS5 tutorials at UTC Reading and The Heathland School (Hounslow) in May 2023. The focus of the tutorials was on AMR and biofilms. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Dr LuTheryn delivered a series of 3 workshops at an outreach and engagement activity day organised by Magdalen College, Oxford in 2023. |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Dr LuTheryn delivered a series of 3 workshops on engineering solutions for biofilms and AMR at an outreach and engagement activity day for students from underprivileged backgrounds. Workshops were 75-minutes long and the event was organised by Magdalen College at the University of Oxford, October 2023. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Dr LuTheryn gave a presentation on science outreach and engagement at the Oxford-based "Inside Out" Event in September 2023 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Dr LuTheryn gave a presentation on science outreach and engagement at the Oxford-based "Inside Out" Event in September 2023. The focus of the talk was on inclusion and targeting students from the least advantaged backgrounds to support their progression to university. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.ox.ac.uk/research/recognition/oxford-inside-out |
| Description | Dr LuTheryn served as panellist at the all-staff away day of the Brilliant Club in May 2023. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Dr LuTheryn served as panellist at the all-staff away day of the Brilliant Club in May 2023. The focus of his presentation was on including the topics of biomedical engineering and AMR in the curriculum. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Dr Qiang Wu presented on "Correlating High Speed Imaging &Passive Acoustic Mapping of Cavitation Activity" at the 2022 meeting of the Acoustical Society of America, Denver, USA. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Scientific conference presentation on techniques to assess antibiotic-loaded bubble drug delivery to various locations of the human body. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://acousticalsociety.org/asa-meetings/ |
| Description | Dr Ramon Garcia-Maset presented a flash talk on "the role of urine microenvironment in biofilm and antibiotic response on uropathogens" at the 5th Annual UK Cellular Microbiology Meeting of the London School of Hygiene and Tropical Medicine 2023, in London, UK. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Brief scientific research presentation to improve understanding of the role of biofilms in treating uropathogens in urinary tract infections. Increased understanding of antibiotic drug delivery challenges in for bacteria colonising the bladder walls in attendees. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.lshtm.ac.uk/newsevents/events/5th-annual-uk-cellular-microbiology-meeting |
| Description | Dr Ramon Garcia-Maset presented research on AMR at EuroBioFilms2022 conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Ramon Garcia-Maset delivered an oral presentation titled, "Synergistic effects of synthetic nano-engineered antimicrobial -peptide polymers and antibiotics against S. aureus and P. aeruginosa biofilms in in vitro and ex vivo models." |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://eurobiofilms2022.com/scientific-program |
| Description | Dr Sara Keller presented a flash talk on "quantitative evaluation of ultrasound-mediated antibiotic therapy in S. aureus and P. aeruginosa biofilms" at the Early Career Researcher conference: Multidisciplinary Approaches to AMR Hosted by the Ineos Oxford Institute for antimicrobial research, 2023, held in Oxford UK. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Scientific information on quantitative evaluation of ultrasound-mediated antibiotic therapy presented to early career researchers interested in addressing antimicrobial resistance through a multi-disciplinary approach. Presentation sparked discussion and networking following the flash talk. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.ineosoxford.ox.ac.uk/multidisciplinary-approaches-amr |
| Description | Dr Sara Keller presented research at the 183rd Acoustical Society of America meeting. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Sara Keller presented research on strategies for addressing antimicrobial resistance in the presentation titled, "Spatio-temporal evaluation of anti-biofilm cavitation activity by passive acoustic mapping" at the 183rd Meeting of the Acoustical Society of America in Nashville, Tennessee, USA. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.fusfoundation.org/posts/meeting-report-183rd-meeting-of-acoustical-society-of-america-as... |
| Description | Dr Sara Keller presented research on "Spatiotemporal evaluation of anti-biofilm cavitation activity by passive acoustic mapping" at the 2023 Artimino Conference on Medical Ultrasound Technology, Artimino, Italy. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Scientific conference presentation followed by question and answer session. New scientific methodologies and results presented to researchers. New professional connections established for the junior researcher/presenter. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://sites.google.com/view/artiminoconference2023/home |
| Description | Dr. LuTheryn has additionally presented research on antimicrobial and antibiofilm agents at the cross-disciplinary UCL LGBTQ+ in STEM symposium, 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr. LuTheryn has additionally presented research on antimicrobial and antibiofilm agents at the cross-disciplinary UCL LGBTQ+ in STEM symposium, engaging with clinicians and academics on using a multidisciplinary approach to tackling issues surrounding AMR. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.ucl.ac.uk/human-resources/equality-diversity-inclusion-committees-and-networks/lgbtq-ste... |
| Description | Mr Christopher Campbell presented a poster on "optimising the loading of Nitric Oxide into Perfluorocarbon droplet emulsions" at the UKICRS Symposium 2023, held at the UCL School of Pharmacy. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Scientific information on optimising antibiotic drug delivery presented to undergraduate and graduate researchers. Questions, discussion and networking resulted from the poster presentation. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.ukicrs.org/2023-symposium.html |
| Description | Mr Christopher Campbell presented at the 28th European symposium on Ultrasound Contrast Imaging |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Mr Christopher Campbell delivered a poster presentation at the 28th European symposium on Ultrasound Contrast Imaging. The presentation focused on the topic of optimising the formulation of perfluorocarbon nanodroplets for nitric oxide delivery to chronic wound biofilms in an effort to address antimicrobial resistance. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://wfumb.info/event/european-symposium-on-ultrasound-contrast-imaging-in-rotterdam/ |
| Description | Mr Christopher Campbell presents poster at EuroBioFilms 2023 conference. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Poster presentation delivered by Mr Christopher Campbell, et al., at EuroBioFilms 2023 conference. The presentation was titled, "Measuring the Nitric Oxide Capacity of Perfluoropentane Droplets for the Treatment of Chronic Wound Biofilms." Authors: Christopher K. Campbell, Aaron Crowther, Jeremy S. Webb, Gareth LuTheryn, Eleanor Stride, Dario Carugo |
| Year(s) Of Engagement Activity | 2023 |
| Description | Mr Victor Choi presented on biofilms and ultrasound-responsive mechanical disruption of at Keystone Symposia, Banff, AB, Canada. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Mr Victor Choi delivered a conference presentation titled, "Combatting Pathogenic Biofilms through Ultrasound-Responsive Platforms for Mechanical Disruption and Drug Delivery, Novel Approaches Against Emerging Antimicrobial Resistance" at Keystone Symposia, Banff, AB, Canada in December of 2022. This was delivered as part of a chaired session with the title, "Challenges and Novel Pathways to Develop Alternative Therapies". |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.keystonesymposia.org/ |
| Description | Prof Rohn delivered a research talk on UTIs and antimicrobial treatment resistance for an invited seminar at Nationwide Children's Hospital, Columbus Ohio USA, 2024 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk or presentation: Prof Rohn delivered a research talk on UTIs and antimicrobial treatment resistance for an invited seminar for Nephrology Urology Research Affinity Group (NURAG), for CPE Credit, at Nationwide Children's Hospital, Columbus Ohio USA March 2024 |
| Year(s) Of Engagement Activity | 2024 |
| Description | Prof Rohn delivered a research talk on UTIs and antimicrobial treatment resistance for an invited seminar at the Institute for Structural and Molecular Biology, London, 2024 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk or presentation: Prof Rohn delivered a research talk on UTIs and antimicrobial treatment resistance for an invited seminar at the Institute for Structural and Molecular Biology, Birkbeck London in February 2024 |
| Year(s) Of Engagement Activity | 2024 |
| Description | Prof Rohn delivered a research talk on UTIs and antimicrobial treatment resistance for the British Society for Antimicrobial Chemotherapy conference, 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof Rohn delivered a research talk on UTIs and antimicrobial treatment resistance for the British Society for Antimicrobial Chemotherapy conference, "The Challenge of Urinary Tract Infections", London June 2023 |
| Year(s) Of Engagement Activity | 2023 |
| Description | Prof Rohn delivered a research talk on treatment resistance of UTI for an invited seminar for NHS , Royal Free Hospital, London UK, 2024practitioners the Urines Working Group, |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | A talk or presentation: Prof Rohn delivered a research talk on treatment resistance of UTI for an invited seminar for NHS practitioners the Urines Working Group, and gave expert practical advice on antimicrobial resistance issues, at the Royal Free Hospital, London UK, March 2024 |
| Year(s) Of Engagement Activity | 2024 |
| Description | Prof Rohn delivered talk to Early Career Researchers at the European Molecular Biology Laboratory, Heidelberg,2024 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof Rohn was asked to deliver a talk on career resilience and academic progression to Early Career Researchers at the European Molecular Biology Laboratory, Heidelberg, Feb 2024. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Prof. Carugo delivered a lecture to the Institution of Engineering and Technology (IET) Berkshire, 16th September 2022. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof. Carugo delivered a lecture: "The use of ultrasound waves in therapeutic drug delivery" to the Institution of Engineering and Technology (IET) Berkshire, 16th September 2022. Discussions and professional networking followed the lecture. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://events.theiet.org/our-events/ |
| Description | Prof. Eleanor Stride appointed to Engineering Policy Committee (Royal Academy of Engineering) |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Prof. Eleanor Stride appointed to Engineering Policy Committee (Royal Academy of Engineering), which led to the development of educational resources for use in primary and secondary schools, as well as information provided to policy makers on the urgency of antimicrobial resistance. |
| Year(s) Of Engagement Activity | 2021 |
| Description | Prof. Eleanor Stride collaborated with the Royal Academy of Engineering |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Prof. Eleanor Stride collaborated with the Royal Academy of Engineering education team to compile educational resource packet on water pollution and antimicrobial resistance for use in schools. The educational resource is designed to provide practical and contextualised applications where students and teachers can see the role that STEM-based learning plays in real-world engineering scenarios. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://stemresources.raeng.org.uk/resources/enrich/this-is-engineering-water/ |
| Description | Prof. Eleanor Stride contributed to workshop series on "Bubble Activity in Therapeutic Ultrasound" delivered by the Focused Ultrasound Foundation |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The Focused Ultrasound Foundation and the American Institute of Ultrasound in Medicine's Future Fund hosted a virtual workshop series on Detecting, Mapping, and Quantifying Bubble Activity in Therapeutic Ultrasound. The objectives of the workshop were to identify the levels of knowledge, gaps in knowledge, and best practices in bubble activity dosimetry for ultrasound therapy. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.fusfoundation.org/posts/bubble-activity-in-therapeutic-ultrasound-workshop-series/ |
| Description | Prof. Eleanor Stride delivered a talk to the John Radcliffe Hospital multidisciplinary team meeting on research to address antimicrobial resistance |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof. Eleanor Stride delivered a talk to the John Radcliffe Hospital multidisciplinary team meeting on research to address antimicrobial resistance as part of the Beyond Antibiotics programme grant. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Prof. Eleanor Stride has been invited to speak at a symposium titled "New Strategies Against Antimicrobial Resistance" at the Bio-Medical Centre (BMC) of the Ludwig-Maximilians-University Munich, Germany. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof. Eleanor Stride has been invited to speak at a symposium titled "New Strategies Against Antimicrobial Resistance". This event took place on February 22nd and 23rd at the state-of-the-art Bio-Medical Centre (BMC) of the Ludwig-Maximilians-University Munich, Germany. |
| Year(s) Of Engagement Activity | 2024 |
| URL | http://www.bayresq.net |
| Description | Prof. Eleanor Stride joined editorial board of Journal of Antibiotics in Clinical Settings |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof. Stride joined the Associate Editor Board of Antibiotics in Clinical Settings, which is a specialty section of the Journal, titled "Frontiers in Antibiotics". Associate Editors make an important contribution to the quality and strategic development of the section. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Prof. Eleanor Stride moderated a webinar for the Focused Ultrasound Foundation for early career researchers in 2023. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof. Eleanor Stride moderated a webinar for the Focused Ultrasound Foundation for early career researchers in 2023. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://istu.org/istu-live-26-oct-2023/ |
| Description | Prof. Eleanor Stride was invited to speak at All Party Parliamentary Engineering Group in the House of Lords |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Prof. Eleanor Stride was invited to speak at All Party Parliamentary Engineering Group in the House of Lords in March 2024 . The event was well attended by parliamentarians, sponsoring companies (with their young engineers) and school students from around the country. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Prof. Powrie and Dr Hammond set up an outreach stall at Glastonbury festival in June 2023 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Prof. Powrie and Dr Hammond set up an outreach stall at Glastonbury festival in June 2023, which was funded by the British Society of Immunology and the Microbiology Society. The stall informed the public about the gut microbiome and research undertaken at Oxford on how the microbiome is implicated in health and disease, including AMR. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Prof. Rohn delivered a public engagement performance on antimicrobial resistance titled "Why we should be angry about UTIs" at Finding Ada Live, London's?Royal Institution in October 2023. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Prof. Rohn delivered a public engagement performance for the general public about urinary tract infection and AMR at Finding Ada Live, London's Royal Institution in October 2023. This lecture is available on YouTube. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.youtube.com/watch?v=WRPbQEQ98LQ |
| Description | Prof. Rohn delivered a public engagement performance on antimicrobial resistance, 2024 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | A talk or presentation: Prof Rohn delivered a public engagement performance on antimicrobial resistance entitled "Outsmarting UTI" at #FuturePub, Digital Science, Farringdon London, March 2024 |
| Year(s) Of Engagement Activity | 2024 |
| Description | Prof. Rohn invited Invited to participate in an International Thought Leadership Roundtable on "Tackling AMR in India", 2023 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Invited to participate in an International Thought Leadership Roundtable on "Tackling AMR in India" organised by the Royal Society of Chemistry in partnership with iRISE and the Indian Government, Bristol, September 2023 |
| Year(s) Of Engagement Activity | 2023 |
| Description | Prof. Rohn presents an invited seminar organised by the University of Basel Biozentrum. in 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof. Rohn presented an invited seminar organised by the University of Basel Biozentrum. The seminar was titled "Antiresist" (a Swiss national AMR initiative), and Prof. Rohn's presentation focused on "Surface tension: the battle for bacterial supremacy at the human urothelial interface". October 17th, 2023. Plans for future research collaborations were made. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Prof. Rohn presents invited seminar at Nottingham Trent University in 2023 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof. Rohn presented an invited seminar titled, "Bacterial pathogens and commensals share survival strategies in the human bladder microenvironment" at Nottingham Trent University on February 8th, 2023. A discussion and professional networking followed the seminar. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Prof. Stride contributed served as invited speaker on panel session at the 8th International Symposium on Focused Ultrasound in 2022 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof. Stride contributed served as invited speaker on panel session at the 8th International Symposium on Focused Ultrasound, Oct 23-27th 2022 (hybrid meeting). This event sparked discussions and invitations for further contributions to reach professional practitioners and policy makers to communicate the benefits of using focused ultrasound to address antimicrobial resistance. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://www.fusfoundation.org/posts/symposium-2022-proceedings-now-available/ |
| Description | Prof. Stride contributed to a new initiative on healthcare inequality: "Health for All" |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof. Stride contributed to the development of a new initiative seeking to address healthcare inequality. The website "Health for All" provides an engaging way to read stories and listen to podcasts. Prof. Stride contributed a story featured permanently on this website on accommodating diversity in healthcare and engineering to provide a more inclusive environment for women. |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://nooneleftbehind.co.uk/resources |
| Description | Prof. Stride contributed to a radio podcast on urinary tract infection and participated in an even organised by Bladder Health UK on novel therapies in February 2023. |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Prof. Stride contributed to a radio podcast on urinary tract infection and participated in an even organised by Bladder Health UK on novel therapies in February 2023. |
| Year(s) Of Engagement Activity | 2023 |
| Description | Prof. Stride delivered an invited lecture at the Vascular Society annual meeting in Dublin on November 23, 2023. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof. Stride delivered an invited lecture at the Vascular Society annual meeting in Dublin on November 23, 2023. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.svtgbi.org.uk/annual-scientific-meeting/ |
| Description | Prof. Stride delivers career-focused talk to encourage scholarship applications in STEM from women from low-and middle-income countries, 2024 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Prof. Stride delivers career-focused talk and advice as part of the the Optiver Foundation scholarships at the University of Oxford. The scholarships encourage applications to complete Master's degrees STEM subjects from women from low-and middle-income countries, 2024 |
| Year(s) Of Engagement Activity | 2024 |
| Description | Prof. Stride delivers outreach talk to Year 3-6 pupil at at Bevois Town Primary School in Southampton, 2024 |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Prof. Stride delivers outreach talk to Year 3-6 pupil at at Bevois Town Primary School in Southampton, 2024. The presentation was part of Science Week Meet the Scientist" sessions for our pupils. The purpose of the talk was to raise awareness of engineering science and to inspire children with stories from real scientists. |
| Year(s) Of Engagement Activity | 2024 |
| Description | Prof. Stride featured on Engineering Icons Tube Map produced by RAEng for National Engineering Day 2023. |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Prof. Stride featured on Engineering Icons Tube Map produced by RAEng for National Engineering Day 2023 in collaboration with Transport for London. https://londonblog.tfl.gov.uk/2023/11/01/engineering-icons-tube-map/ |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://londonblog.tfl.gov.uk/2023/11/01/engineering-icons-tube-map/ |
| Description | Prof. Stride served as panel member on BBC Radio 4 show "Best Medicine" |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Prof. Eleanor Stride served as panel member on BBC Radio 4 show "Best Medicine" released on 07/07/2022. The programme informed the public about research using nano-bubbles to address AMR and for cancer therapy. |
| Year(s) Of Engagement Activity | 2022 |
| Description | Prof. Stride serves as panel member at The Division of Fluid Dynamics of the American Physical Society, 2023 |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof. Stride participated in virtual expert panel addressing the importance of fluid dynamics on societal matters, including cancer therapy and antimicrobial resistance. The event took place in November, 2023 and was organised by The Division of Fluid Dynamics of the American Physical Society, 2023. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.linkedin.com/posts/hooshanginejad_apsdfd-apswebinars-activity-7119695826515292161-B1j2?u... |
| Description | Prof. Stride's participation on "Best Medicine" BBC podcast inspired production of new 10-episode podcast series, 2023 |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Prof. Stride was a panel member on BBC Radio 4 show "Best Medicine" released on 07/07/2022. This Best Medicine podcast episode inspired the production of a 10- episode best medicine podcast series aired in October/November 2023. Anectdotal evidence from the producers also suggests that a listener used Prof. Stride's contribution to the podcast in her medical school application, which was successful. |
| Year(s) Of Engagement Activity | 2023 |
| URL | https://www.bbc.co.uk/programmes/m0018x4q/episodes/downloads |
| Description | Professors Stride, Carugo and Coussios delivered an invited presentation as part of a workshop organised by the Focused Ultrasound Foundation in 2021 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Professors Stride, Carugo and Coussios delivered an invited presentation as part of a workshop titled, "Bubble Activity in Therapeutic Ultrasound Workshop Series" organised by the Focused Ultrasound Foundation in 2021. Transcript available at https://www.fusfoundation.org/news/bubble-activity-in-therapeutic-ultrasound-workshop-series |
| Year(s) Of Engagement Activity | 2021 |
| URL | https://www.fusfoundation.org/news/bubble-activity-in-therapeutic-ultrasound-workshop-series |
| Description | Profs. Stride, Rohn and Carugo's research on microbubbles for antibiotic delivery and biofilm dispersal featured in webinar by the International Society for Therapeutic Ultrasound |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Profs. Stride, Rohn and Carugo's research on microbubbles for antibiotic delivery and biofilm dispersal was featured in the ISTU Webinar "Sonobactericide for Treating Bacterial Infections" given by Dr Klazina Kooiman on 28th April 2022. The webinar is available at https://istu.org/istu-live/istu-live-april-28-2022/ |
| Year(s) Of Engagement Activity | 2022 |
| URL | https://istu.org/istu-live/istu-live-april-28-2022/ |